Cited by 44Gut microbiota and healthGastrointestinal motility and disordersProbiotics and Fermented Foods

Increased Abundance of Lactobacillales in the Colon of Beta-Adrenergic Receptor Knock Out Mouse Is Associated With Increased Gut Bacterial Production of Short Chain Fatty Acids and Reduced IL17 Expression in Circulating CD4+ Immune Cells

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Bartley, Akeem, Yang, Tao, Arocha, Rebeca, Malphurs, Wendi L., Larkin, Riley, Magee, Kacy L., Vickroy, Thomas W., Zubcevic, Jasenka·2018·Frontiers in Physiology

Abstract

Emerging evidence suggests an associative link between gut dysbiosis, the autonomic nervous system (ANS) and the immune system (IS) in pathophysiology of neurogenic hypertension (HTN). However, the close interplay between these three systems presents us with difficulties in deciphering the cause-effect relationship in disease. The present study utilized beta 1 and 2 adrenergic receptor knock out (AdrB1tm1BkkAdrB2tm1Bkk/J KO) mice to isolate the effects of reduced overall sympathetic drive on gut microbiota and systemic IS. We observed the following: (i) Diminished beta adrenergic signaling mainly reflects in shifts in the Firmicutes phyla, with a significant increase in abundance of largely beneficial Bacilli Lactobacillales in the KO mice; (ii) This was associated with increased colonic production of beneficial short chain fatty acids (SCFAs) butyrate, acetate and propionate, confirming functional microbiota shifts in the KO mice; (iii) Dampened systemic immune responses in the KO mice reflected in reduction on circulating CD4+.IL17+ T cells and increase in young neutrophils, both previously associated with shifts in the gut microbiota. Taken together, these observations demonstrate that reduction in the sympathetic nervous system may lead to beneficial shifts in the gut microbiota and lower specific immune response. This suggests that dietary intervention, through probiotics, may be a viable option in correcting gut dysbiosis and treatment of symptoms of neurogenic HTN.

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Crossref · 10.3389/fphys.2018.01593

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  • ADRs may modulate microbial abundance, as observed in β-adrenergic receptor knockout mice.

    “Interestingly, ADRs may also in turn modulate microbial abundance as observed in beta-adrenergic receptor knockout mice149.”

    From Gut microbiota and cardiovascular disease. (2020) · cites this paper as [149]

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Authors
Bartley, A., Yang, T., Arocha, R., Malphurs, W. L., Larkin, R., Magee, K. L., Vickroy, T. W., & Zubcevic, J.
Affiliations
University of Florida (US)
Corresponding author
Zubcevic, Jasenka
Venue
Frontiers in Physiology
Published
2018-11-13
Volume
9
Pages
1593-1593
ISSN
1664-042X (ISSN-L)
OpenAlex
W2901620643
Cited by
44
References
69
Citations by year
2025: 3 · 2024: 5 · 2023: 7 · 2022: 6 · 2021: 9 · 2020: 10 · 2019: 4
FWCI
2.05
Type
journal article
Language
en
Open access
Locations
  • Frontiers in Physiology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
American Heart Association
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords
gut microbiota, Lactobacillales, short-chain fatty acids, butyrate, acetate, propionate, IL-17, CD4+ T cells, neutrophils, sympathetic nervous system, neurogenic hypertension, gut dysbiosis, Firmicutes, probiotics

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