Abnormalities of intrinsic functional connectivity in autism spectrum disorders
Open accessAbstract
Autism spectrum disorders (ASD) impact social functioning and communication, and individuals with these disorders often have restrictive and repetitive behaviors. Accumulating data indicate that ASD is associated with alterations of neural circuitry. Functional MRI (FMRI) studies have focused on connectivity in the context of psychological tasks. However, even in the absence of a task, the brain exhibits a high degree of functional connectivity, known as intrinsic or resting connectivity. Notably, the default network, which includes the posterior cingulate cortex, retro-splenial, lateral parietal cortex/angular gyrus, medial prefrontal cortex, superior frontal gyrus, temporal lobe, and parahippocampal gyrus, is strongly active when there is no task. Altered intrinsic connectivity within the default network may underlie offline processing that may actuate ASD impairments. Using FMRI, we sought to evaluate intrinsic connectivity within the default network in ASD. Relative to controls, the ASD group showed weaker connectivity between the posterior cingulate cortex and superior frontal gyrus and stronger connectivity between the posterior cingulate cortex and both the right temporal lobe and right parahippocampal gyrus. Moreover, poorer social functioning in the ASD group was correlated with weaker connectivity between the posterior cingulate cortex and the superior frontal gyrus. In addition, more severe restricted and repetitive behaviors in ASD were correlated with stronger connectivity between the posterior cingulate cortex and right parahippocampal gyrus. These findings indicate that ASD subjects show altered intrinsic connectivity within the default network, and connectivity between these structures is associated with specific ASD symptoms.
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Initial R-fMRI work has revealed ASD-related increases in FC between STG and PCC.
“For example, initial R-fMRI work has revealed ASD-related increases in FC between STG and PCC (28) and increased regional homogeneity of temporal cortices including STG (92).”
From Aberrant Striatal Functional Connectivity in Children with Autism (2011) · cites this paper as [28]
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- Authors
- Monk, C. S., Peltier, S. J., Wiggins, J. L., Weng, S.-J., Carrasco, M., Risi, S., & Lord, C.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Monk, Christopher S.
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2009-08
- Volume
- 47
- Issue
- 2
- Pages
- 764-772
- ISSN
- 1053-8119 (ISSN-L)
- PMC
- PMC2731579
- OpenAlex
- W2158200838
- Cited by
- 578
- References
- 71
- Citations by year
- 2026: 15 · 2025: 26 · 2024: 24 · 2023: 31 · 2022: 31 · 2021: 48 · 2020: 24 · 2019: 27 · 2018: 30 · 2017: 36 · 2016: 41 · 2015: 46 · 2014: 31 · 2013: 61 · 2012: 36
- FWCI
- 17.26
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- University of Michigan
- National Institute of Mental Health (R01MH066496, MH-066496, K22MH068017)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (U19-HD 35482, U19HD035482)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- autism spectrum disorder, intrinsic functional connectivity, resting-state functional connectivity, default mode network, posterior cingulate cortex, superior frontal gyrus, parahippocampal gyrus, right temporal lobe, social functioning, restricted and repetitive behaviors, neural circuits
- MeSH terms
- Adult, Autistic Disorder, Brain, Brain Mapping, Female, Humans, Magnetic Resonance Imaging, Male, Neural Pathways
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