Altered spontaneous activity in Alzheimer's disease and mild cognitive impairment revealed by Regional Homogeneity
Abstract
Alzheimer's disease (AD), the most prevalent cause of dementia in the elderly, is characterized by progressive cognitive and intellectual deficits. Most patients with mild cognitive impairment (MCI) are thought to be in a very early stage of AD. Resting-state functional magnetic resonance imaging reflects spontaneous brain activities and/or the endogenous/background neurophysiological process of the human brain. Regional Homogeneity (ReHo) can provide a fast method for mapping regional activity across the whole brain. Little has been previously published about where or how spontaneous activity differs between MCI and AD, although many previous fMRI studies have shown that the activity pattern is altered in MCI/AD. In the present study, we first used the ReHo method to explore differences in regional spontaneous activities throughout the whole brain between normal controls (NC) and people with MCI and with AD. A one-way ANOVA was performed to determine the regions in which the ReHo differs between the three groups, and then a post hoc analysis was performed to evaluate differences in the pattern among the three groups. Finally a correlation analysis was done between the ReHo index of these regions and clinical variables in order to evaluate the relationship between ReHo and cognitive measures in the AD and MCI groups. An exploratory classification analysis also demonstrated that ReHo measures were able to correctly separate subjects in 71.4% of the cases. Altered brain spontaneous activations were found in the medial prefrontal cortex, the bilateral posterior cingulate gyrus/precuneus and the left inferior parietal lobule (IPL) in both MCI and AD. In MCI, the ReHo index in the left IPL was higher than that of the NC, which could indicate the presence of a compensatory mechanism in MCI. More obviously, the correlation analysis indicated that the lower the memory and other cognitive abilities, the lower the ReHo in patients with MCI and AD. Combining our findings with the results in earlier studies, we propose that the spontaneous activity pattern in the resting state could potentially be used as a clinical marker for MCI/AD.
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Altered ReHo in the putamen has been repeatedly reported in meditation studies.
“This structure has been repeatedly reported in meditation studies [14, 77–80] but, distinct from the other main regions frequently reported, was not revealed by our connectivity analyses.”
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- Authors
- Zhang, Z., Liu, Y., Jiang, T., Zhou, B., An, N., Dai, H., Wang, P., Niu, Y., Wang, L., & Zhang, X.
- Affiliations
- Chinese PLA General Hospital (CN)
- Chinese Academy of Sciences (CN)
- University of Electronic Science and Technology of China (CN)
- Corresponding author
- Wang, Luning
- Zhang, Xi
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2012-01
- Volume
- 59
- Issue
- 2
- Pages
- 1429-1440
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W2029132563
- Cited by
- 255
- References
- 89
- Citations by year
- 2026: 6 · 2025: 16 · 2024: 4 · 2023: 11 · 2022: 18 · 2021: 26 · 2020: 22 · 2019: 19 · 2018: 19 · 2017: 20 · 2016: 32 · 2015: 22 · 2014: 19 · 2013: 10 · 2012: 10
- FWCI
- 6.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Natural Science Foundation of China (60831004, 30900476)
- National Basic Research Program of China (2011CBA00408)
- National High Technology Research and Development Program of China (2009AA02Z302)
- International Cooperation and Exchanges Projects (2009DFB10500)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- Alzheimer's disease, mild cognitive impairment, regional homogeneity, spontaneous brain activity, resting-state functional connectivity, medial prefrontal cortex, posterior cingulate cortex, precuneus, inferior parietal lobule, compensatory mechanisms, memory impairment, clinical biomarkers
- MeSH terms
- Aged, Algorithms, Alzheimer Disease, Biological Clocks, Brain, Cognition Disorders, Female, Humans, Image Enhancement, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Male, Sensitivity and Specificity, Reproducibility of Results
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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