Sex-related differences in amygdala functional connectivity during resting conditions
Abstract
Recent neuroimaging studies have established a sex-related hemispheric lateralization of amygdala involvement in memory for emotionally arousing material. Here, we examine the possibility that sex-related differences in amygdala involvement in memory for emotional material develop from differential patterns of amygdala functional connectivity evident in the resting brain. Seed voxel partial least square analyses of regional cerebral blood flow data revealed significant sex-related differences in amygdala functional connectivity during resting conditions. The right amygdala was associated with greater functional connectivity in men than in women. In contrast, the left amygdala was associated with greater functional connectivity in women than in men. Furthermore, the regions displaying stronger functional connectivity with the right amygdala in males (sensorimotor cortex, striatum, pulvinar) differed from those displaying stronger functional connectivity with the left amygdala in females (subgenual cortex, hypothalamus). These differences in functional connectivity at rest may link to sex-related differences in medical and psychiatric disorders.
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Prior studies in adults have found sex differences in the shape and volume of amygdala sub-regions and in resting-state functional connectivity of non-limbic brain regions.
“Previous studies in adults have reported sex differences in amygdala sub-region shape and volume (Kim et al., 2011, Kim et al., 2012) and in RSFC of non-limbic brain regions using a variety of analytic methods (Kilpatrick et al., 2006, Biswal et al., 2010, Tian et al., 2011, Casanova et al., 2012, Satterthwaite et al., 2014).”
From Developmental sex differences in resting state functional connectivity of amygdala sub-regions (2015) · cites this paper as Kilpatrick et al., 2006
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- Authors
- Kilpatrick, L. A., Zald, D. H., Pardo, J. V., & Cahill, L. F.
- Affiliations
- University of California, Irvine (US)
- Vanderbilt University (US)
- Minneapolis VA Health Care System (US)
- Corresponding author
- Kilpatrick, L.A.
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2006-04
- Volume
- 30
- Issue
- 2
- Pages
- 452-461
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W1971276070
- Cited by
- 204
- References
- 67
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 6 · 2023: 6 · 2022: 8 · 2021: 6 · 2020: 13 · 2019: 7 · 2018: 15 · 2017: 15 · 2016: 14 · 2015: 16 · 2014: 12 · 2013: 14 · 2012: 10
- FWCI
- 4.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Veterans Affairs
- National Institute of Mental Health (F32MH011641, MH 57508, MH11641)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hemispheric Asymmetry in Neuroscience
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- sex differences, amygdala, functional connectivity, resting state, hemispheric lateralization, emotional memory, regional cerebral blood flow, sensorimotor cortex, striatum, pulvinar, hypothalamus
- MeSH terms
- Adult, Amygdala, Brain, Cerebrovascular Circulation, Data Interpretation, Statistical, Emotions, Female, Humans, Image Processing, Computer-Assisted, Functional Laterality, Male, Nerve Net, Neural Pathways, Sex Characteristics, Least-Squares Analysis, Positron-Emission Tomography
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