Cited by 413Memory and Neural MechanismsMemory Processes and InfluencesHemispheric Asymmetry in Neuroscience

Sex-related difference in amygdala activity during emotionally influenced memory storage

Cahill, Larry, Haier, Richard J., White, Nathan S., Fallon, James, Kilpatrick, Lisa, Lawrence, Chris, Potkin, Steven G., Alkire, Michael T.·2001·Neurobiology of Learning and Memory

Abstract

We tested the possibility suggested by previous imaging studies that amygdala participation in the storage of emotionally influenced memory is differentially lateralized in men and women. Male and female subjects received two PET scans for regional cerebral glucose-one while viewing a series of emotionally provocative (negative) films, and a second while viewing a series of matched, but emotionally more neutral, films. Consistent with suggestions from several previously published studies, enhanced activity of the right, but not the left, amygdala in men was related to enhanced memory for the emotional films. Conversely, enhanced activity of the left, but not the right, amygdala in women was related to enhanced memory for the emotional films. These results demonstrate a clear gender-related lateralization of amygdala involvement in emotionally influenced memory, and indicate that theories of the neurobiology of emotionally influenced memory must begin to account for the influence of gender.

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Crossref · 10.1006/nlme.2000.3999

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  • Given the small sample size, only females were included to control for sex-related differences in responses to affectively negative stimuli.

    “Given the small sample size in the current study, only females were included to control for sex-related differences in responses to affectively negative stimuli (Cahill et al., 2001).”

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Authors
Cahill, L., Haier, R. J., White, N. S., Fallon, J., Kilpatrick, L., Lawrence, C., Potkin, S. G., & Alkire, M. T.
Affiliations
University of California, Irvine (US)
Venue
Neurobiology of Learning and Memory
Publisher
Elsevier BV
Published
2001-01
Volume
75
Issue
1
Pages
1-9
ISSN
1074-7427 (ISSN-L)
OpenAlex
W2000053993
Cited by
413
References
29
Citations by year
2026: 6 · 2025: 4 · 2024: 3 · 2023: 5 · 2022: 7 · 2021: 8 · 2020: 7 · 2019: 12 · 2018: 13 · 2017: 19 · 2016: 14 · 2015: 14 · 2014: 23 · 2013: 18 · 2012: 21
FWCI
13.59
Type
journal article
Language
en
Open access
closed
Locations
  • Neurobiology of Learning and Memory (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Mental Health (MH57508-02)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Hemispheric Asymmetry in Neuroscience
Keywords
amygdala, sex differences, emotional memory, memory consolidation, hemispheric lateralization, regional cerebral glucose metabolism, gender differences in memory
MeSH terms
Adult, Affect, Amygdala, Arousal, Brain, Cerebrovascular Circulation, Female, Glucose, Humans, Functional Laterality, Male, Memory, Sex Factors, Tomography, Emission-Computed

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