Inferior frontal white matter microstructure and patterns of psychopathology in women with borderline personality disorder and comorbid attention-deficit hyperactivity disorder
Abstract
Background Inferior frontal white matter circuits are likely to be relevant to dysfunctional affect regulation, aggression, dissociative symptoms, neuropsychological functioning and psychopathology in women with borderline personality disorder (BPD) and comorbid attention-deficit hyperactivity disorder (ADHD).Methods 20 women with BPD and comorbid ADHD and 20 healthy women were investigated, and groups were matched for age, education and premorbid intelligence. Mean diffusivity and fractional anisotropy were measured bilaterally in the inferior frontal white matter by diffusion tensor imaging (DTI). Conflict resolution was assessed by the Attention Network Test, sustained vigilance by the Degraded-Stimulus Continuous Performance Test.Results Among women with BPD and comorbid ADHD, increased mean diffusivity in inferior frontal white matter was associated with higher levels of dysfunctional affect regulation, anger-hostility, dissociative symptoms, and general psychopathology (p<.05, uncorrected). Poor conflict resolution during the attention task was positively associated with anger-hostility, psychopathology, dissociation and the number of ADHD-symptoms, but not related to DTI variables. Both groups did not differ significantly with respect to DTI variables or neuropsychological performance. In the BPD group, a lifetime history of major depression or a current eating disorder were associated with impaired inferior frontal white matter integrity, while a history of sexual abuse or a current posttraumatic stress disorder were not.Conclusions Inferior frontal white matter microstructural abnormalities may be linked to key aspects of psychopathology in women with BPD and comorbid ADHD and add to alterations in orbitofrontal and limbic areas. The relationship between neuropsychological functioning and white matter structure remains unclear.
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Rusch et al. (2007) found that mean diffusivity in inferior frontal white matter was associated with higher trait dissociation (DES), but also with measures of general psychopathology.
“Mean diffusivity in inferior frontal white matter was associated with higher trait dissociation (DES), but also with measures of general psychopathology.”
From Dissociation and Alterations in Brain Function and Structure: Implications for Borderline Personality Disorder (2017) · cites this paper as [151]
Adults with ADHD have reduced connectivity in the orbito-medial prefrontal cortex, right anterior cingulate, right anterior corona radiata, and superior as well as inferior longitudinal fasciculus.
“Some studies support that ADHD is associated with lifelong abnormal connectivity by showing that adults with ADHD have reduced connectivity in the orbito-medial prefrontal cortex, right anterior cingulate, right anterior corona radiata and the superior as well as inferior longitudinal fasciculus among other regions [18–21]”
From The brain anatomy of attention-deficit/hyperactivity disorder in young adults—a magnetic resonance imaging study (2017) · cites this paper as [20]
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- Authors
- Rüsch, N., Weber, M., Il’yasov, K. A., Lieb, K., Ebert, D., Hennig, J., & van Elst, L. T.
- Affiliations
- University of Freiburg (DE)
- Corresponding author
- Rüsch, Nicolas
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2007-04
- Volume
- 35
- Issue
- 2
- Pages
- 738-747
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W2033337100
- Cited by
- 93
- References
- 65
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2022: 5 · 2021: 1 · 2020: 6 · 2019: 4 · 2018: 3 · 2017: 5 · 2016: 5 · 2015: 10 · 2014: 6 · 2013: 5 · 2012: 11
- FWCI
- 7.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Keywords
- borderline personality disorder, attention deficit hyperactivity disorder, comorbidities, white matter microstructure, mean diffusivity, fractional anisotropy, emotion regulation, anger-hostility, dissociative symptoms, psychopathology, conflict resolution, major depressive disorder, eating disorders, sexual abuse, post-traumatic stress disorder, women
- MeSH terms
- Adult, Attention Deficit Disorder with Hyperactivity, Borderline Personality Disorder, Female, Frontal Lobe, Humans, Magnetic Resonance Imaging, Anisotropy
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