Extraction of prefronto-amygdalar pathways by combining probability maps
Abstract
Many recent studies reported altered functional connectivity within the frontolimbic circuitry in a wide range of neuropsychiatric disorders. However, functional connectivity must rely on structural connections. In this study we applied a novel probabilistic fiber tracking method to assess the structural connectivity between the amygdala and different prefrontal brain regions in vivo. Twenty healthy subjects were investigated with diffusion tensor imaging. Probabilistic fiber tracking was started from the amygdala and different prefrontal brain regions. Resulting probability maps were combined using an extended multiplication of probabilistic maps to identify the most probable anatomical pathways connecting these structures. We found one ventral pathway through the uncinate fascicle, connecting the amygdala and the medial and lateral orbitofrontal cortices. In addition to this ventral pathway, we depicted distinct dorsal pathways (medial and lateral), which connect the amygdala with the anterior cingulate cortex and the dorsolateral prefrontal cortex. The dorso-medial pathway proceeds through the inferior thalamic peduncle, while the dorsolateral pathway travels through the external capsule. We believe that our approach provides a promising tool to assess the integrity of specific structural connections in patients with neuropsychiatric disorders.
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The amygdala has tight structural connections and reciprocal feedback loops with the mPFC and orbitofrontal cortex as well as with the dorsolateral PFC and ACC.
“The amygdala has tight structural connections and reciprocal feedback loops with the mPFC and orbitofrontal cortex11 as well as with the dorsolateral PFC12 and ACC.13”
From Altered resting-state amygdala functional connectivity in men with posttraumatic stress disorder (2012) · cites this paper as [12]
Cites
MR diffusion tensor spectroscopy and imaging
Basser, P. J., Mattiello, J., & LeBihan, D. (1994) · Biophysical Journal · doi:10.1016/s0006-3495(94)80775-1 · Cited by 5,970 · see citing works
Maldjian, J. A., Laurienti, P. J., Kraft, R., & Burdette, J. H. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00169-1 · Cited by 5,066 · see citing works
Probabilistic diffusion tractography with multiple fibre orientations: What can we gain?
Behrens, T. E. J., Berg, H. J., Jbabdi, S., Rushworth, M. F. S., & Woolrich, M. W. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2006.09.018 · Cited by 3,471 · see citing works
Ongur, D. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.206 · Cited by 2,627 · see citing works
Fiber tracking: principles and strategies – a technical review
Mori, S., & van Zijl, P. C. M. (2002) · NMR in Biomedicine · doi:10.1002/nbm.781 · Cited by 2,019 · see citing works
Pezawas, L., Meyer-Lindenberg, A., Drabant, E. M., Verchinski, B. A., Munoz, K. E., Kolachana, B. S., Egan, M. F., Mattay, V. S., Hariri, A. R., & Weinberger, D. R. (2005) · Nature Neuroscience · doi:10.1038/nn1463 · Cited by 1,980 · see citing works
Virtual in vivo interactive dissection of white matter fasciculi in the human brain
Catani, M., Howard, R. J., Pajevic, S., & Jones, D. K. (2002) · NeuroImage · doi:10.1006/nimg.2002.1136 · Cited by 1,637 · see citing works
Ventral and dorsal pathways for language
Saur, D., Kreher, B. W., Schnell, S., Kümmerer, D., Kellmeyer, P., Vry, M., Umarova, R. M., Musso, M., Glauche, V., Abel, S., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805234105 · Cited by 1,555 · see citing works
Self-citationBarrett, L. F., Mesquita, B., Ochsner, K. N., & Gross, J. J. (2007) · Annual Review of Psychology · doi:10.1146/annurev.psych.58.110405.085709 · Cited by 1,425 · see citing works
DAMASIO, A. (1990) · Behavioural Brain Research · doi:10.1016/0166-4328(90)90144-4 · Cited by 1,275 · see citing works
Intermediate phenotypes and genetic mechanisms of psychiatric disorders
Meyer-Lindenberg, A., & Weinberger, D. R. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1993 · Cited by 1,216 · see citing works
Limbic connections of the orbital and medial prefrontal cortex in macaque monkeys
Carmichael, S. T., & Price, J. L. (1995) · Journal of Comparative Neurology · doi:10.1002/cne.903630408 · Cited by 1,197 · see citing works
Schmahmann, J. D., & Pandya, D. N. (2006) · doi:10.1093/acprof:oso/9780195104233.001.0001 · Cited by 1,157 · see citing works
Castellanos, F. X., Margulies, D. S., Kelly, C., Uddin, L. Q., Ghaffari, M., Kirsch, A., Shaw, D., Shehzad, Z., Di Martino, A., Biswal, B., et al. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.06.025 · Cited by 854 · see citing works
A review of diffusion tensor imaging studies in schizophrenia
Kubicki, M., McCarley, R., Westin, C.-F., Park, H.-J., Maier, S., Kikinis, R., Jolesz, F. A., & Shenton, M. E. (2007) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2005.05.005 · Cited by 769 · see citing works
Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter
Heinz, A., Braus, D. F., Smolka, M. N., Wrase, J., Puls, I., Hermann, D., Vollstädt‐Klein, S., Grüsser, S. M., Flor, H., Schumann, G., et al. (2004) · Nature Neuroscience · doi:10.1038/nn1366 · Cited by 700 · see citing works
Cortical and subcortical afferents to the amygdala of the rhesus monkey (Macaca mulatta)
Aggleton, J. P., Burton, M. J., & Passingham, R. E. (1980) · Brain Research · doi:10.1016/0006-8993(80)90279-6 · Cited by 610 · see citing works
The Human Central Nervous System: A Synopsis and Atlas
Nieuwenhuys, R., Voogd, J., & van Huijzen, C. (2012) · Medical Entomology and Zoology · Cited by 543 · see citing works
Parker, G. J. M., Haroon, H. A., & Wheeler‐Kingshott, C. A. M. (2003) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.10350 · Cited by 527 · see citing works
Silbersweig, D., Clarkin, J. F., Goldstein, M., Kernberg, O. F., Tuescher, O., Levy, K. N., Brendel, G., Pan, H., Beutel, M., Pavony, M. T., et al. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.06010126 · Cited by 411 · cited 3× · see citing works
“For example, in a recent functional imaging study, failure of inhibitory function in the medial orbitofrontal cortex and the subgenual anterior cingulate and hyperactivity of the amygdala in turn were demonstrated inpatientswith borderline personality disorder (Silbersweig et al., 2007).”
InfluentialThe amygdalostriatal projections in the monkey. An anterograde tracing study
Russchen, F. T., Bakst, I., Amaral, D. G., & Price, J. L. (1985) · Brain Research · doi:10.1016/0006-8993(85)90530-x · Cited by 395 · cited 1× · see citing works
“…behaviours whereas the (dorsal) striatum is linkedwith the dlPFC. Evidence fromhistological humanbrain sections (e.g. Nieuwenhuys et al., 2007, p.411, p.285 fig.9) and tract tracing studies (Russchen et al., 1985; Schmahmann and Pandya, 2006, p.476, p.528, p.530) in monkeys support this assumption.”
Makris, N., Worth, A. J., Papadimitriou, G., Stakes, J. W., Caviness, V. S., Kennedy, D. N., Pandya, D. Ν., Kaplan, E., Sorensen, A. G., Wu, O., et al. (1997) · Annals of Neurology · doi:10.1002/ana.410420617 · Cited by 377 · see citing works
Nieuwenhuys, R., Voogd, J., van Huijzen, C., & Papa, M. (2010) · Springer eBooks · doi:10.1007/978-88-470-1140-3 · Cited by 364 · see citing works
Frontolimbic brain abnormalities in patients with borderline personality disorder
van Elst, L. T., Heßlinger, B., Thiel, T., Geiger, E. V., Haegele, K., Lemieux, L., Lieb, K., Bohus, M., Hennig, J., & Ebert, D. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01743-2 · Cited by 349 · see citing works
Self-citationProjections from the amygdala to basoventral and mediodorsal prefrontal regions in the rhesus monkey
Barbas, H., & de Olmos, J. (1990) · Journal of Comparative Neurology · doi:10.1002/cne.903000409 · Cited by 324 · see citing works
Sussmann, J. E., Lymer, G. K. S., McKirdy, J. W., Moorhead, T. W. J., Maniega, S. M., Job, D. E., Hall, J., Bastin, M. E., Johnstone, E. C., Lawrie, S. M., et al. (2009) · Bipolar Disorders · doi:10.1111/j.1399-5618.2008.00646.x · Cited by 273 · see citing works
Diffusion tensor imaging correlates of memory and language impairments in temporal lobe epilepsy
McDonald, C. R., Ahmadi, M. E., Hagler, D. J., Tecoma, E. S., Iragui, V. J., Gharapetian, L., Dale, A. M., & Halgren, E. (2008) · Neurology · doi:10.1212/01.wnl.0000327824.05348.3b · Cited by 267 · see citing works
Taylor, W. D., MacFall, J. R., Payne, M. E., McQuoid, D. R., Provenzale, J. M., Steffens, D. C., & Krishnan, K. R. R. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.7.1293 · Cited by 230 · see citing works
Adler, C. M., Adams, J., DelBello, M. P., Holland, S. K., Schmithorst, V. J., Levine, A. D., Jarvis, K., & Strakowski, S. M. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.2.322 · Cited by 214 · see citing works
Structural Connectivity for Visuospatial Attention: Significance of Ventral Pathways
Umarova, R. M., Saur, D., Schnell, S., Kaller, C. P., Vry, M., Glauche, V., Rijntjes, M., Hennig, J., Kiselev, V. G., & Weiller, C. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp086 · Cited by 180 · see citing works
Self-citationHouenou, J., Wessa, M., Douaud, G., Leboyer, M., Chanraud, S., Perrin, M., Poupon, C., Martinot, J., & Paillère-Martinot, M. L. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002010 · Cited by 172 · see citing works
Cortical White Matter Microstructural Abnormalities in Bipolar Disorder
Beyer, J. L., Taylor, W. D., MacFall, J. R., Kuchibhatla, M. N., Payne, M. E., Provenzale, J. M., Cassidy, F., & Krishnan, K. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300802 · Cited by 155 · see citing works
White matter abnormalities and brain activation in schizophrenia: A combined DTI and fMRI study
Schlösser, R. G. M., Nenadić, I., Wagner, G., Güllmar, D., von Consbruch, K., Köhler, S., Schultz, C. C., Koch, K., Fitzek, C., Matthews, P. M., et al. (2006) · Schizophrenia Research · doi:10.1016/j.schres.2006.09.007 · Cited by 151 · see citing works
Li, L., Ma, N., Li, Z., Tan, L., Liu, J., Gong, G., Shu, N., He, Z., Jiang, T., & Xu, L. (2007) · Brain Research · doi:10.1016/j.brainres.2007.06.094 · Cited by 133 · see citing works
Fujiwara, H., Namiki, C., Hirao, K., Miyata, J., Shimizu, M., Fukuyama, H., Sawamoto, N., Hayashi, T., & Murai, T. (2007) · Schizophrenia Research · doi:10.1016/j.schres.2007.05.044 · Cited by 126 · see citing works
White matter tracts in first-episode psychosis: A DTI tractography study of the uncinate fasciculus
Price, G. W., Cercignani, M., Parker, G. J. M., Altmann, D. R., Barnes, T. R. E., Barker, G. J., Joyce, E. M., & Ron, M. A. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.09.012 · Cited by 120 · see citing works
Heckers, S., Curran, T., GOFF, D. C., Rauch, S. L., Fischman, A. J., Alpert, N. M., & Schacter, D. L. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00919-7 · Cited by 109 · see citing works
Cohen, M. X., Elger, C. E., & Weber, B. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.10.004 · Cited by 106 · see citing works
Rüsch, N., Weber, M., Il’yasov, K. A., Lieb, K., Ebert, D., Hennig, J., & van Elst, L. T. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2006.12.007 · Cited by 93 · see citing works
Self-citationROSENBERGER, G., KUBICKI, M., NESTOR, P., CONNOR, E., BUSHELL, G., MARKANT, D., NIZNIKIEWICZ, M., WESTIN, C., KIKINIS, R., & JSAYKIN, A. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2008.04.019 · Cited by 89 · see citing works
Human Subinsular Asymmetry Studied by Diffusion Tensor Imaging and Fiber Tracking
Rodrigo, S., Naggara, O. N., Oppenheim, C., Golestani, N., Poupon, C., Cointepas, Y., Mangin, J., Bihan, D. L., & Méder, J.-F. (2007) · American Journal of Neuroradiology · doi:10.3174/ajnr.a0584 · Cited by 77 · see citing works
Diffusion-Weighted Magnetic Resonance Imaging
Mukherji, S. K., Chenevert, T. L., & Castillo, M. (2002) · Journal of Neuro-Ophthalmology · doi:10.1097/00041327-200206000-00013 · Cited by 76 · see citing works
Connecting and merging fibres: Pathway extraction by combining probability maps
Kreher, B., Schnell, S., Mader, I., Il'yasov, K. A., Hennig, J., Kiselev, V. G., & Saur, D. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.06.023 · Cited by 68 · see citing works
Self-citationRüsch, N., Eileen Luders, A., Lieb, K., Zahn, R., Ebert, D., Thompson, P. M., Toga, A. W., & van Elst, L. T. (2007) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0741 · Cited by 49 · see citing works
Self-citationArchitectonic analysis of the human retrosplenial cortex
Morris, R., Paxinos, G., & Petrides, M. (2000) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(20000522)421:1 · Cited by 43 · see citing works
Feasibility of 1.6-mm isotropic voxel diffusion tensor tractography in depicting limbic fibers
Fujiwara, S., Sasaki, M., Kanbara, Y., et al. (2007) · Neuroradiology · doi:10.1007/s00234-007-0317-y · Cited by 26 · see citing works
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- Authors
- Bracht, T., Tüscher, O., Schnell, S., Kreher, B., Rüsch, N., Glauche, V., Lieb, K., Ebert, D., Il'yasov, K. A., Hennig, J., Weiller, C., van Elst, L. T., & Saur, D.
- Affiliations
- University of Freiburg (DE)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- Kazan Federal University (RU)
- University Medical Center Freiburg (DE)
- ORCID
- Venue
- Psychiatry Research: Neuroimaging
- Publisher
- Elsevier BV
- Published
- 2009-12
- Volume
- 174
- Issue
- 3
- Pages
- 217-222
- ISSN
- 0925-4927 (ISSN-L)
- OpenAlex
- W2036713747
- Cited by
- 55
- References
- 46
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 1 · 2022: 5 · 2021: 4 · 2020: 4 · 2019: 1 · 2018: 5 · 2017: 1 · 2016: 2 · 2015: 4 · 2014: 2 · 2013: 7 · 2012: 4
- FWCI
- 4.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatry Research Neuroimaging (publishedVersion)
- PubMed (publishedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- amygdala, prefrontal cortex, structural connectivity, probabilistic tractography, uncinate fasciculus, orbitofrontal cortex, anterior cingulate cortex, dorsolateral prefrontal cortex, external capsule, diffusion tensor imaging
- MeSH terms
- Adolescent, Adult, Amygdala, Brain Mapping, Female, Humans, Middle Aged, Nerve Fibers, Myelinated, Nerve Net, Neural Pathways, Probability, Prefrontal Cortex, Diffusion Magnetic Resonance Imaging, Young Adult
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