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Cited by 115Neural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on BehaviorAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

Dissociable recruitment of rostral anterior cingulate and inferior frontal cortex in emotional response inhibition

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Chiu, Pearl H., Holmes, Avram J., Pizzagalli, Diego A.·2008·NeuroImage
DOI 10.1016/j.neuroimage.2008.04.248PMC PMC2604817
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Abstract

The integrity of decision-making under emotionally evocative circumstances is critical to navigating complex environments, and dysfunctions in these processes may play an important role in the emergence and maintenance of various psychopathologies. The goal of the present study was to examine the spatial and temporal dynamics of neural responses to emotional stimuli and emotion-modulated response inhibition. High-density event-related brain potentials (ERPs) were measured as participants (N=25) performed an emotional Go/NoGo task that required button presses to words of a "target" emotional valence (i.e., positive, negative, neutral) and response inhibition to words of a different "distractor" valence. Using scalp ERP analyses in conjunction with source-localization techniques, we identified distinct neural responses associated with affective salience and affect-modulated response inhibition, respectively. Both earlier (approximately 300 ms) and later (approximately 700 ms) ERP components were enhanced with successful response inhibition to emotional distractors. Only ERPs to target stimuli differentiated affective from neutral cues. Moreover, source localization analyses revealed right ventral lateral prefrontal cortex (VLPFC) activation in affective response inhibition regardless of emotional valence, whereas rostral anterior cingulate activation (rACC) was potentiated by emotional valence but was not modulated by response inhibition. This dissociation was supported by a significant Region x Trial Type x Emotion interaction, confirming that distinct regional dynamics characterize neural responses to affective valence and affective response-inhibition. The results are discussed in the context of an emerging affective neuroscience literature and implications for understanding psychiatric pathologies characterized by a detrimental susceptibility to emotional cues, with an emphasis on major depressive disorder.

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  • Ventral ACC is a critical area for modulating emotional biasing effects on cognition.

    “Using an affective Go/NoGo task, Elliott et al. (2000) also identified ventral ACC as a critical area for modulating emotional biasing effects on cognition, a finding corroborated by a recent study (Chiu et al., 2008).”

    From Affective Cognition and its Disruption in Mood Disorders (2011) · cites this paper as Chiu et al., 2008

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  1. Beck AT, Steer RA, Brown GK. Beck Depression Inventory Manual. 2nd Ed. San Antonio: The Psychological Corporation; 1996. [Google Scholar]
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Authors
Chiu, P. H., Holmes, A. J., & Pizzagalli, D. A.
Affiliations
Harvard University (US)
Corresponding author
Chiu, Pearl H.
ORCID
Venue
NeuroImage
Publisher
Elsevier BV
Published
2008-08
Volume
42
Issue
2
Pages
988-997
ISSN
1053-8119 (ISSN-L)
DOI
10.1016/j.neuroimage.2008.04.248
PMC
PMC2604817
OpenAlex
W2170151899
Cited by
115
References
101
Citations by year
2026: 1 · 2025: 5 · 2024: 7 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 6 · 2019: 5 · 2018: 5 · 2017: 8 · 2016: 4 · 2015: 5 · 2014: 6 · 2013: 16 · 2012: 12
FWCI
4.32
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • NeuroImage (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
Funders
National Institute of Mental Health (R01MH068376, T32MH018882, T32MH18882, F31MH078346, R01 MH68376)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
rostral anterior cingulate cortex, inferior frontal cortex, emotional valence, affective salience, go/no-go task, event-related potentials, source localization, major depressive disorder, emotional vulnerability
MeSH terms
Decision Making, Emotions, Female, Frontal Lobe, Gyrus Cinguli, Humans, Inhibition, Psychological, Male, Neuronal Plasticity, Task Performance and Analysis, Young Adult

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