The interaction of emotional and cognitive neural systems in emotionally guided response inhibition
Abstract
The ability to generate appropriate responses in social situations often requires the integration of emotional information conveyed through facial expressions with ongoing cognitive processes. Neuroimaging studies have begun to address how cognitive and emotional neural systems interact, but most of these studies have used emotional oddball stimuli as distractors in order to dissociate emotional from cognitive neural systems. Therefore, the manner in which these systems interact when behavioral responses must be directly guided by the emotional content of stimuli remains elusive. Here, we used functional magnetic resonance imaging (fMRI) to investigate the neural systems involved in response inhibition for faces conveying particular emotions. Participants performed go/no-go tasks involving either letters or happy and sad faces. The fMRI results indicated that inhibiting responses to emotional faces activated inferior frontal/insular cortex, whereas response inhibition during the letter task did not strongly engage this region. In addition, distinct regions of ventral anterior cingulate were preferentially activated for sad faces in the go and no-go conditions. These findings suggest that inhibition within an emotional context recruits a distinct set of brain regions that includes areas beyond those normally activated by response inhibition tasks and that can be modulated by emotional valence.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In responding to infant social cues, mothers need to integrate affective and cognitive information about their baby, and evaluate competing demands, before choosing the most appropriate behavioral response.
“In responding to infant social cues, whether positive or negative, mothers need to integrate both affective and cognitive information about their baby, and evaluate competing demands, before choosing the most appropriate behavioral response (52;53).”
From What’s in a smile? Maternal brain responses to infant facial cues (2008) · cites this paper as [52]
Cites
Co-Planar Stereotaxic Atlas of the Human Brain
Talairach, J., & Tournoux, P. (1988) · Medical Entomology and Zoology · Cited by 11,798 · see citing works
Co-planar stereotaxic atlas of the human brain
Laitinen, L. (1989) · Clinical Neurology and Neurosurgery · doi:10.1016/0303-8467(89)90128-5 · Cited by 7,565 · see citing works
Cognitive and emotional influences in anterior cingulate cortex
Bush, G., Luu, P., & Posner, M. I. (2000) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(00)01483-2 · Cited by 6,259 · see citing works
Ekman, P. (1976) · Medical Entomology and Zoology · Cited by 4,345 · see citing works
Empathy for Pain Involves the Affective but not Sensory Components of Pain
Singer, T., Seymour, B., O'Doherty, J., Kaube, H., Dolan, R. J., & Frith, C. D. (2004) · Science · doi:10.1126/science.1093535 · Cited by 3,929 · see citing works
Functional neuroanatomy of emotion: A meta-analysis of emotion activation studies in PET and fMRI
Phan, K. L., Wager, T., Taylor, S. F., & Liberzon, I. (2002) · NeuroImage · doi:10.1006/nimg.2002.1087 · Cited by 3,502 · see citing works
Contributions of anterior cingulate cortex to behaviour
Devinsky, O., Morrell, M. J., & Vogt, B. A. (1995) · Brain · doi:10.1093/brain/118.1.279 · Cited by 3,377 · see citing works
The neural basis of economic decision-making in the Ultimatum Game.
Sanfey, A. G., Rilling, J. K., Aronson, J. A., Nystrom, L. E., & Cohen, J. D. (2003) · Science · doi:10.1126/science.1082976 · Cited by 3,375 · see citing works
Anterior Cingulate Cortex, Error Detection, and the Online Monitoring of Performance
Carter, C. S., Braver, T. S., Barch, D. M., Botvinick, M. M., Noll, D., & Cohen, J. D. (1998) · Science · doi:10.1126/science.280.5364.747 · Cited by 3,273 · see citing works
Forman, S. D., Cohen, J. D., Fitzgerald, M., Eddy, W. F., Mintun, M. A., & Noll, D. C. (1995) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910330508 · Cited by 3,202 · see citing works
Cohen, J., MacWhinney, B., Flatt, M., & Provost, J. (1993) · Behavior Research Methods, Instruments, & Computers · doi:10.3758/bf03204507 · Cited by 2,802 · see citing works
Mayberg, H. S., Liotti, M., Brannan, S. K., McGinnis, S., Mahurin, R. K., Jerabek, P. A., Silva, J. A., Tekell, J. L., Martin, C. C., Lancaster, J. L., et al. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.5.675 · Cited by 2,416 · see citing works
Both of Us Disgusted in My Insula
Wicker, B., Keysers, C., Plailly, J., Royet, J.-P., Gallese, V., & Rizzolatti, G. (2003) · Neuron · doi:10.1016/s0896-6273(03)00679-2 · Cited by 2,185 · see citing works
Emotion and motivation: the role of the amygdala, ventral striatum, and prefrontal cortex
Cardinal, R. N., Parkinson, J. A., Hall, J., & Everitt, B. J. (2002) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(02)00007-6 · Cited by 2,129 · see citing works
Subcortical and cortical brain activity during the feeling of self-generated emotions
Damasio, A. R., Grabowski, T. J., Bechara, A., Damasio, H., Ponto, L. L. B., Parvizi, J., & Hichwa, R. D. (2000) · Nature Neuroscience · doi:10.1038/79871 · Cited by 2,117 · see citing works
Neural mechanisms of empathy in humans: a relay from neural systems for imitation to limbic areas
Carr, L., Iacoboni, M., Dubeau, M.-C., Mazziotta, J. C., & Lenzi, G. L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0935845100 · Cited by 1,978 · see citing works
A specific neural substrate for perceiving facial expressions of disgust
Phillips, M. L., Young, A. W., Senior, C., Brammer, M., Andrew, C., Calder, A. J., Bullmore, E. T., Perrett, D. I., Rowland, D., Williams, S. C. R., et al. (1997) · Nature · doi:10.1038/39051 · Cited by 1,609 · see citing works
The Orbitofrontal Cortex and Reward
Rolls, E. T. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.284 · Cited by 1,595 · see citing works
Depression: Perspectives from Affective Neuroscience
Davidson, R. J., Pizzagalli, D., Nitschke, J. B., & Putnam, K. (2002) · Annual Review of Psychology · doi:10.1146/annurev.psych.53.100901.135148 · Cited by 1,138 · see citing works
A developmental functional MRI study of prefrontal activation during performance of a go-no-go task
Casey, B. J., Trainor, R. J., Orendi, J. L., Schubert, A. B., Nystrom, L. E., Giedd, J. N., Castellanos, F. X., Haxby, J. V., Noll, D. C., Cohen, J. D., et al. (1997) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.1997.9.6.835 · Cited by 1,106 · see citing works
Rubia, K., Russell, T., Overmeyer, S., Brammer, M. J., Bullmore, E. T., Sharma, T., Simmons, A., Williams, S. C. R., Giampietro, V., Andrew, C. M., et al. (2001) · NeuroImage · doi:10.1006/nimg.2000.0685 · Cited by 999 · see citing works
Allman, J. M., Hakeem, A. Y., Erwin, J. M., Nimchinsky, E. A., & Hof, P. R. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb03476.x · Cited by 903 · see citing works
Rubia, K., Smith, A. B., Brammer, M. J., & Taylor, E. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00275-1 · Cited by 852 · see citing works
Konishi, S., Nakajima, K., Uchida, I., Kikyo, H., Kameyama, M., & Miyashita, Y. (1999) · Brain · doi:10.1093/brain/122.5.981 · Cited by 823 · see citing works
Neuroanatomical correlates of happiness, sadness, and disgust
Lane, R. D., Reiman, E. M., Ahern, G. L., SCHWARTZ, G. E. R., & Davidson, R. J. (1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.7.926 · Cited by 742 · see citing works
Brain activity during transient sadness and happiness in healthy women
(1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.3.341 · Cited by 737 · see citing works
Neuroanatomical correlates of externally and internally generated human emotion
(1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.7.918 · Cited by 711 · see citing works
Neural structures associated with recognition of facial expressions of basic emotions
Sprengelmeyer, R., Rausch, M., Eysel, U. T., & Przuntek, H. (1998) · Proceedings of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rspb.1998.0522 · Cited by 664 · see citing works
A large-scale distributed network for covert spatial attention
Gitelman, D. R., Nobre, A. C., Parrish, T. B., LaBar, K. S., Kim, Y., Meyer, J. R., & Mesulam, M. M. (1999) · Brain · doi:10.1093/brain/122.6.1093 · Cited by 658 · see citing works
Whalen, P. J., Bush, G., McNally, R. J., Wilhelm, S., McInerney, S. C., Jenike, M. A., & Rauch, S. L. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00251-0 · Cited by 650 · see citing works
Maturation of Brain Function Associated With Response Inhibition
TAMM, L., MENON, V., & REISS, A. L. (2002) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200210000-00013 · Cited by 586 · see citing works
LaBar, K. S., Gitelman, D. R., Parrish, T. B., & Mesulam, M. M. (1999) · NeuroImage · doi:10.1006/nimg.1999.0503 · Cited by 514 · see citing works
Dissociable prefrontal brain systems for attention and emotion
Yamasaki, H., LaBar, K. S., & McCarthy, G. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182176499 · Cited by 476 · see citing works
Liotti, M., Mayberg, H. S., Brannan, S. K., McGinnis, S., Jerabek, P., & Fox, P. T. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00874-x · Cited by 424 · see citing works
Winston, J. S., O’Doherty, J. P., & Dolan, R. J. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00303-3 · Cited by 398 · see citing works
Functional MRI Study of the Cognitive Generation of Affect
Teasdale, J. D., Howard, R. J., Cox, S. G., Ha, Y., Brammer, M. J., Williams, S., & Checkley, S. A. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.2.209 · Cited by 288 · see citing works
Kirino, E., Belger, A., Goldman-Rakic, P., & McCarthy, G. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-17-06612.2000 · Cited by 226 · see citing works
Brain regions involved in recognizing facial emotion or identity: an oxygen-15 PET study
George, M. S., Ketter, T. A., Gill, D. S., Haxby, J. V., Ungerleider, L. G., Herscovitch, P., & Post, R. M. (1993) · Journal of Neuropsychiatry · doi:10.1176/jnp.5.4.384 · Cited by 221 · see citing works
Neural Activation during Covert Processing of Positive Emotional Facial Expressions
Dolan, R. J., Fletcher, P. C., Morris, J., Kapur, N., Deakin, J. F. W., & Frith, C. (1996) · NeuroImage · doi:10.1006/nimg.1996.0070 · Cited by 217 · see citing works
Selective attention to emotional stimuli in a verbal go/no-go task: an fMRI study
Elliott, R., Rubinsztein, J. S., Sahakian, B. J., & Dolan, R. J. (2000) · NeuroReport · doi:10.1097/00001756-200006050-00028 · Cited by 199 · see citing works
Emotion?attention network interactions during a visual oddball task
Fichtenholtz, H. M., Dean, H. L., Dillon, D. G., Yamasaki, H., McCarthy, G., & LaBar, K. S. (2004) · Cognitive Brain Research · doi:10.1016/j.cogbrainres.2004.01.006 · Cited by 161 · see citing works
Sensitivity of prefrontal cortex to changes in target probability: a functional MRI study
Casey, B. J., Forman, S. D., Franzen, P., Berkowitz, A., Braver, T. S., Nystrom, L. E., Thomas, K. M., & Noll, D. C. (2001) · Human Brain Mapping · doi:10.1002/hbm.1022 · Cited by 160 · see citing works
Liddle (2001) · doi:10.1002/1097-0193(200102)12:2
Activation of Broca's area by syntactic processing under conditions of concurrent articulation
Caplan, D., Alpert, N., Waters, G., & Olivieri, A. (2000) · Human Brain Mapping · doi:10.1002/(sici)1097-0193(200002)9:2
Flagged first, then by citations
Cited by
Sorted by citations
Neural mechanisms of the cognitive model of depression.
Disner, S. G., Beevers, C. G., Haigh, E. A. P., & Beck, A. T. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3027 · Cited by 1,718 · see citing works
Basic Emotions, Natural Kinds, Emotion Schemas, and a New Paradigm
Izard, C. E. (2007) · Perspectives on Psychological Science · doi:10.1111/j.1745-6916.2007.00044.x · Cited by 1,110 · see citing works
What’s in a smile? Maternal brain responses to infant facial cues
Strathearn, L., Li, J., Fonagy, P., & Montague, P. R. (2008) · Pediatrics · doi:10.1542/peds.2007-1566 · Cited by 460 · see citing works
Hung, Y., Gaillard, S. L., Yarmak, P., & Arsalidou, M. (2018) · Human Brain Mapping · doi:10.1002/hbm.24232 · Cited by 212 · see citing works
Wang, L., LaBar, K. S., Smoski, M., Rosenthal, M. Z., Dolcos, F., Lynch, T. R., Krishnan, R. R., & McCarthy, G. (2008) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2007.10.004 · Cited by 210 · see citing works
Localization of asymmetric brain function in emotion and depression
Herrington, J. D., Heller, W., Mohanty, A., Engels, A. S., Banich, M. T., Webb, A. G., & Miller, G. A. (2010) · Psychophysiology · doi:10.1111/j.1469-8986.2009.00958.x · Cited by 169 · see citing works
Sex-related differences in neural activity during emotion regulation
Mak, A. K. Y., Hu, Z.-G., Zhang, J. X. X., Xiao, Z., & Lee, T. M. C. (2009) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2009.06.017 · Cited by 160 · see citing works
Berkman, E. T., Burklund, L., & Lieberman, M. D. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.04.084 · Cited by 146 · see citing works
Development of neural systems for processing social exclusion from childhood to adolescence
Bolling, D. Z., Pitskel, N. B., Deen, B., Crowley, M. J., Mayes, L. C., & Pelphrey, K. A. (2011) · Developmental Science · doi:10.1111/j.1467-7687.2011.01087.x · Cited by 125 · see citing works
Veit, R., Singh, V., Sitaram, R., Caria, A., Rauss, K., & Birbaumer, N. (2012) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsr061 · Cited by 117 · see citing works
Chiu, P. H., Holmes, A. J., & Pizzagalli, D. A. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.04.248 · Cited by 115 · see citing works
Acute aerobic exercise hastens emotional recovery from a subsequent stressor
Bernstein, E. E., & McNally, R. J. (2017) · Health Psychology · doi:10.1037/hea0000482 · Cited by 93 · see citing works
Vercammen, A., Morris, R., Green, M. J., Lenroot, R., Kulkarni, J., Carr, V. J., Weickert, C. S., & Weickert, T. W. (2012) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.110088 · Cited by 54 · see citing works
Differential brain responses to social exclusion by one's own versus opposite-gender peers
Bolling, D. Z., Pelphrey, K. A., & Vander Wyk, B. C. (2012) · Social Neuroscience · doi:10.1080/17470919.2011.623181 · Cited by 32 · see citing works
- Authors
- Shafritz, K. M., Collins, S. H., & Blumberg, H. P.
- Affiliations
- Drew University (US)
- Yale University (US)
- Corresponding author
- Shafritz, Keith M.
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2006-05
- Volume
- 31
- Issue
- 1
- Pages
- 468-475
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W1990494474
- Cited by
- 167
- References
- 44
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 6 · 2023: 1 · 2022: 4 · 2021: 11 · 2020: 10 · 2019: 9 · 2018: 10 · 2017: 13 · 2016: 9 · 2015: 10 · 2014: 5 · 2013: 11 · 2012: 12
- FWCI
- 4.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
- Social Sciences › Psychology › Social Psychology › Deception detection and forensic psychology
- Keywords
- response inhibition, emotional facial expressions, facial expression recognition, emotional valence, inferior frontal cortex, insula, ventral anterior cingulate cortex, go/no-go task, social cognition
- MeSH terms
- Adolescent, Adult, Attention, Brain Mapping, Cerebral Cortex, Cognition, Discrimination Learning, Emotions, Facial Expression, Female, Frontal Lobe, Gyrus Cinguli, Humans, Image Processing, Computer-Assisted, Inhibition, Psychological, Magnetic Resonance Imaging, Male, Nerve Net, Pattern Recognition, Visual, Psychomotor Performance
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
