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Evolution of the cerebellar cortex: The selective expansion of prefrontal-projecting cerebellar lobules
Open accessAbstract
It has been suggested that interconnected brain areas evolve in tandem because evolutionary pressures act on complete functional systems rather than on individual brain areas. The cerebellar cortex has reciprocal connections with both the prefrontal cortex and motor cortex, forming independent loops with each. Specifically, in capuchin monkeys cerebellar cortical lobules Crus I and Crus II connect with prefrontal cortex, whereas the primary motor cortex connects with cerebellar lobules V, VI, VIIb, and VIIIa. Comparisons of extant primate species suggest that the prefrontal cortex has expanded more than cortical motor areas in human evolution. Given the enlargement of the prefrontal cortex relative to motor cortex in humans, our hypothesis would predict corresponding volumetric increases in the parts of the cerebellum connected to the prefrontal cortex, relative to cerebellar lobules connected to the motor cortex. We tested the hypothesis by comparing the volumes of cerebellar lobules in structural MRI scans in capuchins, chimpanzees and humans. The fractions of cerebellar volume occupied by Crus I and Crus II were significantly larger in humans compared to chimpanzees and capuchins. Our results therefore support the hypothesis that in the cortico-cerebellar system, functionally related structures evolve in concert with each other. The evolutionary expansion of these prefrontal-projecting cerebellar territories might contribute to the evolution of the higher cognitive functions of humans.
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“Recent allometric analyses reveal that, although absolute and proportional frontal region size increased rapidly in hominins, this change was associated with size increase in other areas and whole brain size, rather than with specialization for enlarged frontal lobes specifically [57,61–63].”
From Embodied cognitive evolution and the cerebellum (2012) · cites this paper as [61]
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“This does not suggest that the frontal lobes were unimportant in cognitive evolution, just that their importance needs to be interpreted in terms of the areas with which they connect and with which they have co-evolved, including the cerebellum [61,62].”
From Embodied cognitive evolution and the cerebellum (2012) · cites this paper as [61]
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Cites
Jenkinson, M., Bannister, P., Brady, M., & Smith, S. (2002) · NeuroImage · doi:10.1006/nimg.2002.1132 · Cited by 11,888
Handbook of Sensory Physiology
Sanders, M. D. (1975) · British Journal of Ophthalmology · doi:10.1136/bjo.59.2.111-c · Cited by 7,166
Marr, D. (1969) · The Journal of Physiology · doi:10.1113/jphysiol.1969.sp008820 · Cited by 3,253
The Cerebellum as a Neuronal Machine
Eccles, J. C., Ito, M., & Szentágothai, J. (1967) · Springer eBooks · doi:10.1007/978-3-662-13147-3 · Cited by 3,229
A theory of cerebellar function
Albus, J. S. (1971) · Mathematical Biosciences · doi:10.1016/0025-5564(71)90051-4 · Cited by 2,539
Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging
Behrens, T. E. J., Johansen-Berg, H., Woolrich, M. W., Smith, S. M., Wheeler-Kingshott, C. A. M., Boulby, P. A., Barker, G. J., Sillery, E. L., Sheehan, K., Ciccarelli, O., et al. (2003) · Nature Neuroscience · doi:10.1038/nn1075 · Cited by 2,330
EVOLUTION OF THE BRAIN AND INTELLIGENCE
Radinsky, L., & Jerison, H. J. (1975) · Evolution · doi:10.2307/2407154 · Cited by 1,982
Cerebellar loops with motor cortex and prefrontal cortex of a nonhuman primate
Kelly, R. M., & Strick, P. L. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-23-08432.2003 · Cited by 1,595
A probabilistic MR atlas of the human cerebellum
Diedrichsen, J., Balsters, J. H., Flavell, J. C., Cussans, E., & Ramnani, N. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.01.045 · Cited by 1,370
Self-citationLinked Regularities in the Development and Evolution of Mammalian Brains
Finlay, B. L., & Darlington, R. B. (1995) · Science · doi:10.1126/science.7777856 · Cited by 1,217
Cocker, L. J. L. D., van Veluw, S. J., Fowkes, M. E., Luijten, P. R., Mali, W. P. T. M., & Hendrikse, J. (2013) · Cerebrovascular Diseases · doi:10.1159/000353668 · Cited by 1,163
Principles of brain evolution.
Striedter, G. (2005) · Choice Reviews Online · doi:10.5860/choice.42-5260 · Cited by 1,124
The primate cortico-cerebellar system: anatomy and function
Ramnani, N. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1953 · Cited by 1,011
Self-citationA spatially unbiased atlas template of the human cerebellum
Diedrichsen, J. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.05.056 · Cited by 989
Self-citationNew and Revised Data on Volumes of Brain Structures in Insectivores and Primates
Stephan, H., Frahm, H. D., & Baron, G. (1981) · Folia Primatologica · doi:10.1159/000155963 · Cited by 877
A cytoarchitectural study of the prefrontal area of the macaque monkey
Walker, A. E. (1940) · The Journal of Comparative Neurology · doi:10.1002/cne.900730106 · Cited by 803
Mosaic evolution of brain structure in mammals
Barton, R. A., & Harvey, P. H. (2000) · Nature · doi:10.1038/35016580 · Cited by 797
Three-Dimensional MRI Atlas of the Human Cerebellum in Proportional Stereotaxic Space
Schmahmann, J. D., Doyon, J., McDonald, D., Holmes, C. J., Lavoie, K., Hurwitz, A. S., Kabani, N. J., Toga, A. W., Evans, A. C., & Petrides, M. (1999) · NeuroImage · doi:10.1006/nimg.1999.0459 · Cited by 782
Schmahmann, J. D., & Pandya, D. N. (1997) · International Review of Neurobiology · doi:10.1016/s0074-7742(08)60346-3 · Cited by 774
An unfolded map of the cerebellar dentate nucleus and its projections to the cerebral cortex
Dum, R. P., & Strick, P. L. (2003) · Journal of Neurophysiology · doi:10.1152/jn.00626.2002 · Cited by 684
MRI Atlas of the Human Cerebellum
Schmahmann, J. D., Doyon, J., Toga, A. W., Petrides, M., & Evans, A. C. (2000) · Cited by 575
Microcircuitry and function of the inferior olive
De Zeeuw, C. I., Hoogenraad, C. C., Koekkoek, S. K. E., Ruigrok, T. J. H., Galjart, N., & Simpson, J. I. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01310-1 · Cited by 466
Humans and great apes share a large frontal cortex
Semendeferi, K., Lu, A., Schenker, N., & Damasio, H. (2002) · Nature Neuroscience · doi:10.1038/nn814 · Cited by 440
Prefrontal white matter volume is disproportionately larger in humans than in other primates
Schoenemann, P. T., Sheehan, M. J., & Glotzer, L. D. (2005) · Nature Neuroscience · doi:10.1038/nn1394 · Cited by 406
The primate neocortex in comparative perspective using magnetic resonance imaging
Rilling, J. K., & Insel, T. R. (1999) · Journal of Human Evolution · doi:10.1006/jhev.1999.0313 · Cited by 406
Self-citationMechanisms of motor learning in the cerebellum11Published on the World Wide Web on 24 November 2000.
Ito, M. (2000) · Brain Research · doi:10.1016/s0006-8993(00)03142-5 · Cited by 394
Jacob, F. (1982) · DigitalGeorgetown (Georgetown University Library) · Cited by 392
(1972) · Annals of Internal Medicine · doi:10.7326/0003-4819-77-5-826_1 · Cited by 379
Correlated evolution and independent contrasts
Price, T. D. (1997) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1997.0036 · Cited by 338
Ever Since Darwin: Reflections in Natural History
Gould, S. J. (1977) · Cited by 335
Functional Organization of Spinocerebellar Paths
OSCARSSON, O. (1973) · Handbook of sensory physiology · doi:10.1007/978-3-642-65438-1_12 · Cited by 330
The Comparative Anatomy and Histology of the Cerebellum from Monotremes through Apes.
(1971) · Annals of Internal Medicine · doi:10.7326/0003-4819-74-2-307_3 · Cited by 309
Ramnani, N., Behrens, T. E. J., Johansen‐Berg, H., Richter, M. C., Pinsk, M. A., Andersson, J., Rudebeck, P. H., Ciccarelli, O., Richter, W., Thompson, A. J., et al. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhj024 · Cited by 287
Self-citationA quantitative study of the human cerebellum with unbiased stereological techniques
Andersen, B. B., Korbo, L., & Pakkenberg, B. (1992) · Journal of Comparative Neurology · doi:10.1002/cne.903260405 · Cited by 276
Descending connections to the inferior olive. An experimental study in the cat
Walberg, F. (1956) · The Journal of Comparative Neurology · doi:10.1002/cne.901040107 · Cited by 247
Bearder, S. K., & Passingham, R. E. (1983) · Man · doi:10.2307/2801447 · Cited by 227
Human and nonhuman primate brains: Are they allometrically scaled versions of the same design?
Rilling, J. K. (2006) · Evolutionary Anthropology Issues News and Reviews · doi:10.1002/evan.20095 · Cited by 214
Self-citationEver Since Darwin: Reflections on Natural History.
Macbeth, N., & Gould, S. J. (1978) · Systematic Zoology · doi:10.2307/2412991 · Cited by 212
Expansion of the neocerebellum in Hominoidea
MacLeod, C. (2003) · Journal of Human Evolution · doi:10.1016/s0047-2484(03)00028-9 · Cited by 174
Evolution of the Brain and Intelligence
Gould, S. J. (1974) · Science · doi:10.1126/science.185.4149.400.a · Cited by 160
Cerebellar contributions to working memory
Hayter, A., Langdon, D. W., & Ramnani, N. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.03.011 · Cited by 159
Self-citationThe meaning of evolution, a study of the history of life and of its significance for man.
Simpson, G. G. (1949) · Yale University Press eBooks · doi:10.5962/bhl.title.40704 · Cited by 153
Korbo, L., Andersen, B. B., Ladefoged, O., & Møller, A. (1993) · Brain Research · doi:10.1016/0006-8993(93)90881-m · Cited by 147
Reflex control of posture and movement
Matthews, P. B. C. (1981) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(81)90051-4 · Cited by 143
Whiting, B. A., & Barton, R. A. (2003) · Journal of Human Evolution · doi:10.1016/s0047-2484(02)00162-8 · Cited by 137
Rilling, J. K., & Insel, T. R. (1998) · Brain, Behavior and Evolution · doi:10.1159/000006575 · Cited by 131
Self-citationReflex control of posture and movement
Westbury, D. R. (1980) · Neuroscience · doi:10.1016/0306-4522(80)90030-5 · Cited by 130
Binocularity and brain evolution in primates
Barton, R. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401955101 · Cited by 127
The Comparative Anatomy and Histology of the Cerebellum of Monotremes Through Apes
CARPENTER, M. B. (1971) · Neurology · doi:10.1212/wnl.21.2.205-a · Cited by 123
Chapter 2 Transverse and longitudinal patterns in the mammalian cerebellum
Voogd, J., & Ruigrok, T. J. H. (1997) · Progress in brain research · doi:10.1016/s0079-6123(08)63356-7 · Cited by 122
Makris, N., Schlerf, J. E., Hodge, S. M., Haselgrove, C., Albaugh, M. D., Seidman, L. J., Rauch, S. L., Harris, G. J., Biederman, J., Caviness, V. S., et al. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2004.12.056 · Cited by 99
Brodal, P., & Brodal, A. (1981) · The Journal of Comparative Neurology · doi:10.1002/cne.902010306 · Cited by 96
Surface‐Based Atlases of Cerebellar Cortex in the Human, Macaque, and Mouse
Essen, D. C. V. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb07588.x · Cited by 85
The Scaling of White Matter to Gray Matter in Cerebellum and Neocortex
Bush, E. C., & Allman, J. M. (2003) · Brain, Behavior and Evolution · doi:10.1159/000068880 · Cited by 81
What is special about the human brain?
Passingham, R. E. (2008) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780199230136.001.0001 · Cited by 80
Information Carried by the Spinocerebellar Paths
Ekerot, C. ‐., Larson, B., & OSCARSSON, O. (1979) · Progress in brain research · doi:10.1016/s0079-6123(08)60809-2 · Cited by 72
Symbolic representations of action in the human cerebellum
Balsters, J. H., & Ramnani, N. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.07.010 · Cited by 65
Self-citationMorphology of the inferior olivary complex of the rhesus monkey (Macaca mulatta)
Bowman, J. P., & Sladek, J. R. (1973) · The Journal of Comparative Neurology · doi:10.1002/cne.901520306 · Cited by 65
The frontal cortex: does size matter?
Passingham, R. E. (2002) · Nature Neuroscience · doi:10.1038/nn0302-190 · Cited by 41
Cortical development in brown capuchin monkeys: A structural MRI study
Phillips, K. A., & Sherwood, C. C. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.08.031 · Cited by 38
Self-citationPhillips, K. A., & Hopkins, W. D. (2007) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2007.02.010 · Cited by 37
Self-citationOlivo-cortico-nuclear localizations within crus I of the cerebellum
Herrero, L., Yu, M., Walker, F., Armstrong, D. M., & Apps, R. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.20976 · Cited by 9
Matano, S. (1992) · The Journal of Anthropological Society of Nippon · doi:10.1537/ase1911.100.69 · Cited by 8
Fryer, L. (2024) · Routledge eBooks · doi:10.4324/9781032648293-5 · Cited by 3
Learning Rules: Investigating Prefrontal-Cerebellar Connectivity with Granger Causality
Saalmann, Y. B., Balsters, J. H., Wright, M. J., & Ramnani, N. (2009) · NeuroImage · doi:10.1016/s1053-8119(09)70825-0 · Cited by 2
Self-citationEvolution and Scaling in Mammalian Brains
Bush, E. (2004) · CaltechTHESIS (California Institute of Technology) · doi:10.7907/p9fg-7k79 · Cited by 2
Research works printed but not linked: 1
- Streidter, 2005, Concerted and mosaic evolution (Chapter 5)
Cited by
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A probabilistic MR atlas of the human cerebellum
Diedrichsen, J., Balsters, J. H., Flavell, J. C., Cussans, E., & Ramnani, N. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.01.045 · Cited by 1,370
Self-citationConsensus Paper: The Cerebellum's Role in Movement and Cognition
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Metadata
- Authors
- Balsters, J. H., Cussans, E., Diedrichsen, J., Phillips, K. A., Preuss, T. M., Rilling, J. K., & Ramnani, N.
- Affiliations
- Royal Holloway University of London (GB)
- Bangor University (GB)
- Trinity University (US)
- Emory University (US)
- Corresponding author
- Ramnani, N.
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2010-02
- Volume
- 49
- Issue
- 3
- Pages
- 2045-2052
- ISSN
- 1053-8119 (ISSN-L)
- PMC
- PMC6436533
- OpenAlex
- W2098598592
- Cited by
- 241
- References
- 69
- Citations by year
- 2026: 17 · 2025: 11 · 2024: 16 · 2023: 15 · 2022: 19 · 2021: 18 · 2020: 13 · 2019: 14 · 2018: 9 · 2017: 15 · 2016: 13 · 2015: 19 · 2014: 14 · 2013: 22 · 2012: 11
- FWCI
- 11.27
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Digital Commons - Trinity University (Trinity University) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- James S. McDonnell Foundation
- National Research Centre
- Wellcome Trust
- National Institutes of Health (P51OD011132)
- Biotechnology and Biological Sciences Research Council (1590-1573)
- Royal Holloway, University of London
- National Institute on Aging (P01AG026423)
- National Center for Research Resources (RR-00 165, P51RR000165)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Primate Behavior and Ecology
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- prefrontal cortex, cerebellar lobules, Crus I, Crus II, primary motor cortex, capuchin monkeys, chimpanzees, human evolution, higher cognition
- MeSH terms
- Adult, Animals, Cebus, Cerebellum, Cerebral Cortex, Pan troglodytes, Biological Evolution, Female, Humans, Magnetic Resonance Imaging, Male, Neural Pathways, Young Adult
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