An unfolded map of the cerebellar dentate nucleus and its projections to the cerebral cortex
Abstract
We have used retrograde transneuronal transport of neurotropic viruses to examine the organization of the projections from the dentate nucleus of the cerebellum to “motor” and “nonmotor” areas of the cerebral cortex. To perform this analysis we created an unfolded map of the dentate. Plotting the results from current and prior experiments on this unfolded map revealed important features about the topography of function in the dentate. We found that the projections to the primary motor and premotor areas of the cerebral cortex originated from dorsal portions of the dentate. In contrast, projections to prefrontal and posterior parietal areas of cortex originated from ventral portions of the dentate. Thus the dentate contains anatomically separate and functionally distinct motor and nonmotor domains.
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The hemispheric parts of the cerebellum (mainly Crus I and Crus II) are connected with various cortical association areas through DN.
“Strick and his colleagues eventually established that the hemispheric parts of the cerebellum (mainly Crus I and Crus II) are connected with various cortical association areas through DN (Middleton and Strick, 1994; Dum and Strick, 2003; Kelly and Strick, 2003).”
From The Cerebro-Cerebellum as a Locus of Forward Model: A Review (2020) · cites this paper as Dum and Strick, 2003
The Kalman-filter model is at least compatible with the non-motor part of the cerebro-cerebellum if the two inputs to non-motor parts of DN are proven to have different origins in future studies.
“Overall, the Kalman-filter model is at least compatible with the non-motor part of the cerebro-cerebellum if the two inputs to non-motor parts of DN (Dum and Strick, 2003) are proven to have different origins in future studies.”
From The Cerebro-Cerebellum as a Locus of Forward Model: A Review (2020) · cites this paper as Dum and Strick, 2003
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- Authors
- Dum, R. P., & Strick, P. L.
- Affiliations
- Center for the Neural Basis of Cognition (US)
- University of Pittsburgh (US)
- ORCID
- Strick, Peter L.
- Venue
- Journal of Neurophysiology
- Publisher
- American Physiological Society
- Published
- 2003-01-01
- Volume
- 89
- Issue
- 1
- Pages
- 634-639
- ISSN
- 0022-3077 (ISSN-L)
- 1522-1598
- OpenAlex
- W2104308975
- Cited by
- 684
- References
- 0
- Citations by year
- 2026: 24 · 2025: 36 · 2024: 27 · 2023: 33 · 2022: 27 · 2021: 45 · 2020: 37 · 2019: 30 · 2018: 47 · 2017: 30 · 2016: 35 · 2015: 33 · 2014: 28 · 2013: 38 · 2012: 32
- FWCI
- 8.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neurophysiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R01MH056661, MH 45156, MH-56661, P50MH045156)
- National Institute of Neurological Disorders and Stroke (NS-24328, R01NS024328)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- dentate nucleus, cerebellum, retrograde tracing, neurotropic viruses, primary motor cortex, premotor cortex, prefrontal cortex, posterior parietal cortex
- MeSH terms
- Animals, Brain Mapping, Cebus, Cerebellar Nuclei, Cerebral Cortex, Neural Pathways, Thalamus, Herpesvirus 1, Human
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