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Cited by 489

The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.

The AP-1 Transcription Factor c-Jun Is Required for Efficient Axonal Regeneration

Open access
Raivich, Gennadij, Bohatschek, Marion, Da Costa, Clive, Iwata, Osuke, Galiano, Matthias, Hristova, Maria, Nateri, Abdolrahman S, Makwana, Milan, Riera-Sans, Lluı́s, Wolfer, David P, Lipp, Hans-Peter, Aguzzi, Adriano, Wagner, Erwin F, Behrens, Axel·2004·Neuron
DOI 10.1016/j.neuron.2004.06.005
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Abstract

Nerve injury triggers numerous changes in the injured neurons and surrounding nonneuronal cells that ultimately result in successful target reinnervation or cell death. c-Jun is a component of the heterodimeric AP-1 transcription factor, and c-Jun is highly expressed in response to neuronal trauma. Here we have investigated the role of c-jun during axonal regeneration using mice lacking c-jun in the central nervous system. After transection of the facial nerve, the absence of c-Jun caused severe defects in several aspects of the axonal response, including perineuronal sprouting, lymphocyte recruitment, and microglial activation. c-Jun-deficient motorneurons were atrophic, resistant to axotomy-induced cell death, and showed reduced target muscle reinnervation. Expression of CD44, galanin, and alpha7beta1 integrin, molecules known to be involved in regeneration, was greatly impaired, suggesting a mechanism for c-Jun-mediated axonal growth. Taken together, our results identify c-Jun as an important regulator of axonal regeneration in the injured central nervous system.

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Crossref · 10.1016/j.neuron.2004.06.005

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Metadata

Authors
Raivich, G., Bohatschek, M., Da Costa, C., Iwata, O., Galiano, M., Hristova, M., Nateri, A. S., Makwana, M., Riera-Sans, L., Wolfer, D. P., Lipp, H.-P., Aguzzi, A., Wagner, E. F., & Behrens, A.
Venue
Neuron
Publisher
Elsevier BV
Published
2004-07
Volume
43
Issue
1
Pages
57-67
ISSN
0896-6273 (ISSN-L)
DOI
10.1016/j.neuron.2004.06.005
OpenAlex
W1992900501
Cited by
489
References
56
FWCI
9.07
Type
journal article
Language
en
Open access
hybrid

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