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Place-Selective Firing of CA1 Pyramidal Cells during Sharp Wave/Ripple Network Patterns in Exploratory Behavior
Open accessAbstract
We observed sharp wave/ripples (SWR) during exploration within brief (<2.4 s) interruptions of or during theta oscillations. CA1 network responses of SWRs occurring during exploration (eSWR) and SWRs detected in waking immobility or sleep were similar. However, neuronal activity during eSWR was location dependent, and eSWR-related firing was stronger inside the place field than outside. The eSPW-related firing increase was stronger than the baseline increase inside compared to outside, suggesting a "supralinear" summation of eSWR and place-selective inputs. Pairs of cells with similar place fields and/or correlated firing during exploration showed stronger coactivation during eSWRs and subsequent sleep-SWRs. Sequential activation of place cells was not required for the reactivation of waking co-firing patterns; cell pairs with symmetrical cross-correlations still showed reactivated waking co-firing patterns during sleep-SWRs. We suggest that place-selective firing during eSWRs facilitates initial associations between cells with similar place fields that enable place-related ensemble patterns to recur during subsequent sleep-SWRs.
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“These studies uniformly confirmed that signs of assembly reactivation occur in the hippocampus and several other regions of the brain also during sleep after exploration (870, 871, 985).”
From About Sleep's Role in Memory (2013) · cites this paper as [870]
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“Neuron assemblies linked to place fields that were longer or more frequently explored during waking showed stronger reactivation during succeeding sleep (870, 871).”
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“They also occur conjointly with SW-Rs that are observed at somewhat lower rates during wakefulness than during SWS (159,191,870).”
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Metadata
- Authors
- O'Neill, J., Senior, T., & Csicsvari, J.
- Affiliations
- University of Oxford (GB)
- Corresponding author
- Csicsvari, Jozsef
- ORCID
- Csicsvari, Jozsef
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2006-01
- Volume
- 49
- Issue
- 1
- Pages
- 143-155
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2129356785
- Cited by
- 281
- References
- 67
- Citations by year
- 2026: 6 · 2025: 16 · 2024: 11 · 2023: 5 · 2022: 11 · 2021: 13 · 2020: 6 · 2019: 28 · 2018: 22 · 2017: 16 · 2016: 10 · 2015: 14 · 2014: 19 · 2013: 17 · 2012: 10
- FWCI
- 8.06
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- Funders
- Wellcome Trust
- Medical Research Council
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- place cells, CA1 pyramidal neurons, place fields, exploratory behavior, theta oscillations, sleep, memory reactivation, ensemble coding, correlated firing, hippocampus
- MeSH terms
- Action Potentials, Animals, Electrophysiology, Exploratory Behavior, Male, Rats, Inbred Strains, Sleep Stages, Space Perception, Theta Rhythm, Wakefulness, Pyramidal Cells, Rats
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