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Photoinactivation of Native AMPA Receptors Reveals Their Real-Time Trafficking
Open accessAbstract
AMPA receptors mediate the majority of the fast excitatory transmission in the central nervous system. Much evidence suggests that the fast trafficking of AMPA receptors into and out of the postsynaptic membrane underlies changes in synaptic strength thought to be necessary for higher cognitive functions such as learning and memory. Despite the abundance of research conducted in this area, a direct, real-time functional assay that measures the trafficking of native AMPA receptors has been lacking. Toward this aim, we use a photoreactive, irreversible antagonist of AMPA receptors, ANQX, to rapidly silence surface AMPA receptors and investigate directly the trafficking of native AMPA receptors in real time. We find that the most dynamic movement of AMPA receptors occurs by lateral movement across the surface of neurons. Fast cycling of surface AMPA receptors with receptors from internal stores does occur but exclusively at extrasynaptic somatic sites. The cycling of synaptic AMPA receptors only occurs on a much longer timescale with complete exchange requiring at least 16 hr. This cycling is not dependent on protein synthesis or action potential driven network activity. These data suggest a revised model of AMPA receptor trafficking wherein a large internal store of AMPA receptors exchanges rapidly with extrasynaptic somatic AMPA receptors, and these newly inserted AMPA receptors then travel laterally along dendrites to reside stably at synapses.
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“Lateral diffusion of receptors through the plasma membrane and activity-triggered exocytosis of receptors from internal endosomal compartments have become generally accepted regulation mechanisms for synaptic plasticity, although their respective contributions have remained unresolved”
From Barriers in the brain: resolving dendritic spine morphology and compartmentalization (2014) · cites this paper as Adesnik et al., 2005
In the citing paper
“although their respective contributions have remained unresolved (Passafaro et al., 2001; Borgdorff and Choquet, 2002; Adesnik et al., 2005; Ashby et al., 2006; Park et al., 2006; Ehlers et al., 2007; Heine et al., 2008; Newpher and Ehlers, 2008; Yang et al., 2008; Kennedy et al., 2010; Opazo and Choquet, 2011; Czöndör et al., 2012; Czöndör and Thoumine, 2013).”
From Barriers in the brain: resolving dendritic spine morphology and compartmentalization (2014) · cites this paper as Adesnik et al., 2005
Citations
Cites
A synaptic model of memory: long-term potentiation in the hippocampus
Bliss, T. V. P., & Collingridge, G. L. (1993) · Nature · doi:10.1038/361031a0 · Cited by 11,566
Long-Term Potentiation--A Decade of Progress?
Malenka, R. C., & Nicoll, A. R. A. (1999) · Science · doi:10.1126/science.285.5435.1870 · Cited by 2,729
AMPA Receptor Trafficking and Synaptic Plasticity
Malinow, R., & Malenka, R. C. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142758 · Cited by 2,588
Activity-dependent scaling of quantal amplitude in neocortical neurons
Turrigiano, G. G., Leslie, K. R., Desai, N. S., Rutherford, L. C., & Nelson, S. B. (1998) · Nature · doi:10.1038/36103 · Cited by 2,226
Rapid Spine Delivery and Redistribution of AMPA Receptors After Synaptic NMDA Receptor Activation
Shi, S.-H., Hayashi, Y., Petralia, R. S., Zaman, S. H., Wenthold, R. J., Svoboda, K., & Malinow, R. (1999) · Science · doi:10.1126/science.284.5421.1811 · Cited by 1,276
AMPA receptor trafficking at excitatory synapses
Bredt, D. S., & Nicoll, R. A. (2003) · Neuron · doi:10.1016/s0896-6273(03)00640-8 · Cited by 1,150
Self-citationReinsertion or Degradation of AMPA Receptors Determined by Activity-Dependent Endocytic Sorting
Ehlers, M. D. (2000) · Neuron · doi:10.1016/s0896-6273(00)00129-x · Cited by 1,096
Definition of the readily releasable pool of vesicles at hippocampal synapses.
Rosenmund, C., & Stevens, C. (1996) · Neuron · doi:10.1016/s0896-6273(00)80146-4 · Cited by 1,084
Receptor trafficking and synaptic plasticity
Collingridge, G. L., Isaac, J. T. R., & Wang, Y. T. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1556 · Cited by 1,046
Evidence for multiple AMPA receptor complexes in hippocampal CA1/CA2 neurons
Wenthold, R., Petralia, R., Blahos J, II, & Niedzielski, A. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-06-01982.1996 · Cited by 850
Regulation of AMPA receptors during synaptic plasticity
Song, I., & Huganir, R. L. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02270-1 · Cited by 798
Regulation of AMPA receptor endocytosis by a signaling mechanism shared with LTD
Beattie, E. C., Carroll, R. C., Yu, X., Morishita, W., Yasuda, H., von Zastrow, M., & Malenka, R. C. (2000) · Nature Neuroscience · doi:10.1038/81823 · Cited by 745
Postsynaptic signaling and plasticity mechanisms
Sheng, M., & Kim, M. J. (2002) · Science · doi:10.1126/science.1075333 · Cited by 731
Recycling Endosomes Supply AMPA Receptors for LTP
Park, M., Penick, E. C., Edwards, J. G., Kauer, J. A., & Ehlers, M. D. (2004) · Science · doi:10.1126/science.1102026 · Cited by 730
Role of AMPA Receptor Cycling in Synaptic Transmission and Plasticity
Lüscher, C., Xia, H., Beattie, E. C., Carroll, R. C., von Zastrow, M., Malenka, R. C., & Nicoll, R. A. (1999) · Neuron · doi:10.1016/s0896-6273(00)81119-8 · Cited by 692
Self-citationSubunit-specific temporal and spatial patterns of AMPA receptor exocytosis in hippocampal neurons
Passafaro, M., Piëch, V., & Sheng, M. (2001) · Nature Neuroscience · doi:10.1038/nn0901-917 · Cited by 655
Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization
Lin, J., Ju, W. H., Foster, K. A., Lee, S. H., Ahmadian, G., Wyszynski, M. W., Wang, Y. T., & Sheng, M. (2000) · Nature Neuroscience · doi:10.1038/81814 · Cited by 562
NSF Binding to GluR2 Regulates Synaptic Transmission
Nishimune, A., Isaac, J. T. R., Molnár, E., Noël, J., Nash, S. R., Tagaya, M., Collingridge, G. L., Nakanishi, S., & Henley, J. M. (1998) · Neuron · doi:10.1016/s0896-6273(00)80517-6 · Cited by 545
Regulation of AMPA receptor lateral movements
Borgdorff, A. J., & Choquet, D. (2002) · Nature · doi:10.1038/nature00780 · Cited by 542
Contributions of Quisqualate and NMDA Receptors to the Induction and Expression of LTP
Müller, D., Joly, M., & LYNCH, G. S. (1988) · Science · doi:10.1126/science.2904701 · Cited by 509
A persistent postsynaptic modification mediates long-term potentiation in the hippocampus
Kauer, J. A., Malenka, R. C., & Nicoll, R. A. (1988) · Neuron · doi:10.1016/0896-6273(88)90148-1 · Cited by 497
Self-citationMobile NMDA Receptors at Hippocampal Synapses
Tovar, K. R., & Westbrook, G. L. (2002) · Neuron · doi:10.1016/s0896-6273(02)00658-x · Cited by 448
Lee, S. H., Liu, L., Wang, Y. T., & Sheng, M. (2002) · Neuron · doi:10.1016/s0896-6273(02)01024-3 · Cited by 441
Direct imaging of lateral movements of AMPA receptors inside synapses
Tardin, C., Cognet, L., Bats, C., Lounis, B., & Choquet, D. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg463 · Cited by 384
Hippocampal LTD Expression Involves a Pool of AMPARs Regulated by the NSF–GluR2 Interaction
Lüthi, A., Chittajallu, R., Duprat, F., Palmer, M. J., Benke, T. A., Kidd, F. L., Henley, J. M., Isaac, J. T. R., & Collingridge, G. L. (1999) · Neuron · doi:10.1016/s0896-6273(00)80852-1 · Cited by 298
Gardner, S. M., Takamiya, K., Xia, J., Suh, J., Johnson, R. C., Yu, S., & Huganir, R. L. (2005) · Neuron · doi:10.1016/j.neuron.2005.02.026 · Cited by 245
Dynamic mobility of functional GABAA receptors at inhibitory synapses
Thomas, P., Mortensen, M., Hosie, A. M., & Smart, T. G. (2005) · Nature Neuroscience · doi:10.1038/nn1483 · Cited by 183
Lester, R. A. J., Quarum, M., Parker, J. D., Weber, E., & Jahr, C. E. (1989) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)11422-3 · Cited by 148
Imaging of receptor trafficking by using α-bungarotoxin-binding-site-tagged receptors
Sekine‐Aizawa, Y., & Huganir, R. L. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407563101 · Cited by 147
Akaaboune, M., Grady, R. M., Turney, S., Sanes, J. R., & Lichtman, J. W. (2002) · Neuron · doi:10.1016/s0896-6273(02)00739-0 · Cited by 97
Weissman, A. M., Klausner, R. D., Rao, K., & Harford, J. B. (1986) · The Journal of Cell Biology · doi:10.1083/jcb.102.3.951 · Cited by 96
Kleckner, N. W., & Dingledine, R. J. (1989) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)09309-5 · Cited by 90
Photochemically Knocking Out Glutamate Receptors in Vivo
Chambers, J. J., Gouda, H., Young, D. M., Kuntz, I. D., & England, P. M. (2004) · Journal of the American Chemical Society · doi:10.1021/ja048331p · Cited by 34
Self-citationGrünfeld, C. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.8.2508 · Cited by 24
Bouron, A. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00135-x · Cited by 15
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Sheng, M., & Hoogenraad, C. C. (2007) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.76.060805.160029 · Cited by 1,003
The cell biology of synaptic plasticity: AMPA receptor trafficking
Shepherd, J. D., & Huganir, R. L. (2007) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.23.090506.123516 · Cited by 978
Balancing Structure and Function at Hippocampal Dendritic Spines
Bourne, J. N., & Harris, K. M. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.31.060407.125646 · Cited by 916
Superresolution Imaging of Chemical Synapses in the Brain
Dani, A., Huang, B., Bergan, J. F., Dulac, C. G., & Zhuang, X. (2010) · Neuron · doi:10.1016/j.neuron.2010.11.021 · Cited by 748
Subunit Composition of Synaptic AMPA Receptors Revealed by a Single-Cell Genetic Approach
Lu, W., Shi, Y., Jackson, A. C., Bjorgan, K., During, M. J., Sprengel, R., Seeburg, P. H., & Nicoll, R. A. (2009) · Neuron · doi:10.1016/j.neuron.2009.02.027 · Cited by 660
Self-citation
Metadata
- Authors
- Adesnik, H., Nicoll, R. A., & England, P. M.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Nicoll, Roger A.
- England, Pamela M.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2005-12
- Volume
- 48
- Issue
- 6
- Pages
- 977-985
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2161458381
- Cited by
- 234
- References
- 36
- Citations by year
- 2024: 2 · 2022: 1 · 2021: 5 · 2020: 4 · 2019: 7 · 2018: 7 · 2017: 5 · 2016: 4 · 2015: 9 · 2014: 14 · 2013: 12 · 2012: 16
- FWCI
- 10.97
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Keywords
- AMPA receptors, receptor trafficking, photoinactivation, extrasynaptic receptors, synaptic plasticity, lateral diffusion, dendritic transport, excitatory synaptic transmission, learning and memory
- MeSH terms
- Animals, Animals, Newborn, Brain, Cell Membrane, Cells, Cultured, Dendrites, Endocytosis, Models, Neurological, Synaptic Transmission, Neurochemistry, Neurons, Nitro Compounds, Photochemistry, Quinolines, Time Factors, Rats, Sprague-Dawley, Receptors, AMPA, Excitatory Amino Acid Antagonists, Protein Transport, Rats
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