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Cited by 273Memory and Neural MechanismsMemory Processes and InfluencesCognitive Functions and Memory

Mind the Gap: Binding Experiences across Space and Time in the Human Hippocampus

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Staresina, Bernhard P., Davachi, Lila·2009·Neuron
DOI 10.1016/j.neuron.2009.06.024PMC PMC2726251
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Abstract

A fundamental goal in memory research is to understand what class of learning problem the hippocampus is uniquely designed to solve. While much controversy surrounds the particular types of memories the hippocampus is thought to support, one hypothesized function possibly linking divergent frameworks is the capacity to bind mnemonic representations across spatial and temporal gaps in our experience. In our current functional magnetic resonance imaging (fMRI) study, we systematically controlled the extent to which a target and an event detail have to be integrated across spatiotemporal discontiguities during associative memory formation. Although the encoding task, the type of association, and subsequent memory performance were held constant, engagement of the hippocampus during successful associative binding was directly modulated by increases in spatial and temporal discontiguities across episodic elements. These results suggest that a core mnemonic function of the hippocampus is to bridge representational gaps in our experience.

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  • The hippocampal pallium of teleost fish is critical for the temporal dimension of associative memories required for trace classical conditioning.

    “These deficits are strikingly similar to those reported in hippocampal-lesioned mammals [216,226,227,228,229,230,231], and reveal that the hippocampal pallium of teleost fish is critical for the temporal dimension of the associative memories required for trace classical conditioning.”

    From Spatial Cognition in Teleost Fish: Strategies and Mechanisms (2021) · cites this paper as [231]

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Cited by

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Authors
Staresina, B. P., & Davachi, L.
Affiliations
New York University (US)
Corresponding author
  • Staresina, Bernhard P.
  • Davachi, Lila
ORCID
Venue
Neuron
Publisher
Elsevier BV
Published
2009-07
Volume
63
Issue
2
Pages
267-276
ISSN
0896-6273 (ISSN-L)
DOI
10.1016/j.neuron.2009.06.024
PMC
PMC2726251
OpenAlex
W2106567407
Cited by
273
References
5
Citations by year
2026: 6 · 2025: 18 · 2024: 9 · 2023: 12 · 2022: 20 · 2021: 21 · 2020: 12 · 2019: 19 · 2018: 15 · 2017: 17 · 2016: 20 · 2015: 16 · 2014: 24 · 2013: 17 · 2012: 17
FWCI
7.61
Type
journal article
Language
en
Open access
Licence
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Mental Health (MH074692)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
Keywords
hippocampus, associative memory, memory binding, episodic memory, memory encoding, hippocampal function, spatiotemporal integration
MeSH terms
Adolescent, Adult, Association Learning, Female, Hippocampus, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Memory, Reaction Time, Spatial Behavior, Time Factors, Young Adult

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