Distinct roles for dorsal CA3 and CA1 in memory for sequential nonspatial events
Open accessAbstract
Previous studies have suggested that dorsal hippocampal areas CA3 and CA1 are both involved in representing sequences of events that compose unique episodes. However, it is uncertain whether the contribution of CA3 is restricted to spatial information, and it is unclear whether CA1 encodes order per se or contributes by an active maintenance of memories of sequential events. Here, we developed a new behavioral task that examines memory for the order of sequential nonspatial events presented as trial-unique odor pairings. When the interval between odors within a studied pair was brief (3 sec), bilateral dorsal CA3 lesions severely disrupted memory for their order, whereas dorsal CA1 lesions did not affect performance. However, when the inter-item interval was extended to 10 sec, CA1 lesions, as well as CA3 lesions, severely disrupted performance. These findings suggest that the role of CA3 in sequence memory is not limited to spatial information, but rather appears to be a fundamental property of CA3 function. In contrast, CA1 becomes involved when memories for events must be held or sequenced over long intervals. Thus, CA3 and CA1 are both involved in memory for sequential nonspatial events that compose unique experiences, and these areas play different roles that are distinguished by the duration of time that must be bridged between key events.
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CA3-lesioned rats had deficits in both the 10-second and 3-second inter-trial intervals in a non-spatial temporal-order task.
“while the CA3 lesioned rats had deficits in both intervals”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Farovik et al., 2010
Rats with a CA1 lesion showed deficits in a non-spatial temporal-order task when the inter-trial interval was 10 seconds, but not 3 seconds.
“rats with the CA1 lesion showed deficits in a non-spatial temporal-order task if the inter-trial interval was 10, but not 3, seconds”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Farovik et al., 2010
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- Authors
- Farovik, A., Dupont, L. M., & Eichenbaum, H.
- Affiliations
- Boston University (US)
- Venue
- Learning & Memory
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2009-12-22
- Volume
- 17
- Issue
- 1
- Pages
- 12-17
- ISSN
- 1072-0502 (ISSN-L)
- 1549-5485
- PMC
- PMC2807176
- OpenAlex
- W2127372311
- Cited by
- 140
- References
- 40
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 3 · 2023: 5 · 2022: 12 · 2021: 8 · 2020: 8 · 2019: 4 · 2018: 14 · 2017: 12 · 2016: 16 · 2015: 10 · 2014: 10 · 2013: 16 · 2012: 8
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Learning & Memory (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH 52090, R01MH052090)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- dorsal hippocampus, CA3, CA1, sequence memory, memory maintenance, hippocampal lesions, episodic memory
- MeSH terms
- Animals, Male, Memory, Odorants, Time Factors, Rats, Long-Evans, Rats, CA1 Region, Hippocampal, CA3 Region, Hippocampal
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