The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
GABA Neurons of the VTA Drive Conditioned Place Aversion
Open accessAbstract
SUMMARY Salient but aversive stimuli inhibit the majority of dopamine (DA) neurons in the ventral tegmental area (VTA) and cause conditioned place aversion (CPA). The cellular mechanism underlying DA neuron inhibition has not been investigated and the causal link to behavior remains elusive. Here, we show that GABA neurons of the VTA inhibit DA neurons through neurotransmission at GABAA receptors. We also observe that GABA neurons increase their firing in response to a footshock and provide evidence that driving GABA neurons with optogenetic effectors is sufficient to affect behavior. Taken together, our data demonstrate that synaptic inhibition of DA neurons drives place aversion.
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Cites
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Self-citation
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The brain reward circuitry in mood disorders
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Input-specific control of reward and aversion in the ventral tegmental area
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Self-citationNeuronal Reward and Decision Signals: From Theories to Data
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Metadata
- Authors
- Tan, K. R., Yvon, C., Turiault, M., Mirzabekov, J. J., Doehner, J., Labouèbe, G., Deisseroth, K., Tye, K. M., & Lüscher, C.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2012-03
- Volume
- 73
- Issue
- 6
- Pages
- 1173-1183
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1970226919
- Cited by
- 651
- References
- 18
- FWCI
- 19.22
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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