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Transcriptional Architecture of the Primate Neocortex
Open accessAbstract
Genome-wide transcriptional profiling was used to characterize the molecular underpinnings of neocortical organization in rhesus macaque, including cortical areal specialization and laminar cell-type diversity. Microarray analysis of individual cortical layers across sensorimotor and association cortices identified robust and specific molecular signatures for individual cortical layers and areas, prominently involving genes associated with specialized neuronal function. Overall, transcriptome-based relationships were related to spatial proximity, being strongest between neighboring cortical areas and between proximal layers. Primary visual cortex (V1) displayed the most distinctive gene expression compared to other cortical regions in rhesus and human, both in the specialized layer 4 as well as other layers. Laminar patterns were more similar between macaque and human compared to mouse, as was the unique V1 profile that was not observed in mouse. These data provide a unique resource detailing neocortical transcription patterns in a nonhuman primate with great similarity in gene expression to human.
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“expression in human differs from that in mouse (Fig. 5d) and rhesus monkey (Fig. 5e), where CALB1 is robustly expressed in CA1 and CA2 in addition to dentate gyrus.”
From An anatomically comprehensive atlas of the adult human brain transcriptome (2012) · cites this paper as [23]
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“In contrast, the mouse neocortex transcriptome is markedly different from the primate transcriptome.”
From Genetic Changes Shaping the Human Brain (2015) · cites this paper as Bernard et al., 2012
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Metadata
- Authors
- Bernard, A., Lubbers, L. S., Tanis, K. Q., Luo, R., Podtelezhnikov, A. A., Finney, E. M., McWhorter, M. M. E., Serikawa, K., Lemon, T., Morgan, R., Copeland, C., Smith, K., Cullen, V., Davis-Turak, J., Lee, C.-K., Sunkin, S. M., Loboda, A. P., Levine, D. M., Stone, D. J., Hawrylycz, M. J., Roberts, C. J., Jones, A. R., Geschwind, D. H., & Lein, E. S.
- Affiliations
- Allen Institute for Brain Science (US)
- Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
- University of California, Los Angeles (US)
- Corresponding author
- Lein, Ed S.
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2012-03
- Volume
- 73
- Issue
- 6
- Pages
- 1083-1099
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC3628746
- OpenAlex
- W2064274168
- Cited by
- 224
- References
- 50
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 14 · 2023: 14 · 2022: 11 · 2021: 10 · 2020: 15 · 2019: 12 · 2018: 19 · 2017: 20 · 2016: 21 · 2015: 21 · 2014: 16 · 2013: 27 · 2012: 13
- FWCI
- 8.29
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (R37MH060233)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- neocortex, rhesus monkeys, cortical transcriptome, cortical laminar organization, primary visual cortex, layer 4, sensorimotor cortex, association cortex, primate evolution, human-macaque comparison, mouse comparison, gene expression signatures
- MeSH terms
- Analysis of Variance, Animals, Female, Humans, Macaca mulatta, Male, Membrane Proteins, Nerve Tissue Proteins, Neural Pathways, Neurons, Transcription Factors, Neocortex, Principal Component Analysis, Microdissection, Microarray Analysis, Mice, Transcriptome
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