The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Dopamine Is Required for Learning and Forgetting in Drosophila
Open accessAbstract
SUMMARY Psychological studies in humans and behavioral studies of model organisms suggest that forgetting is a common and biologically regulated process, but the molecular, cellular, and circuit mechanisms underlying forgetting are poorly understood. Here we show that the bidirectional modulation of a small subset of dopamine neurons (DANs) after olfactory learning regulates the rate of forgetting of both punishing (aversive) and rewarding (appetitive) memories. Two of these DANs, MP1 and MV1, exhibit synchronized ongoing activity in the mushroom body neuropil in alive and awake flies before and after learning, as revealed by functional cellular imaging. Furthermore, while the mushroom-body-expressed dDA1 dopamine receptor is essential for the acquisition of memory, we show that the dopamine receptor DAMB, also highly expressed in mushroom body neurons, is required for forgetting. We propose a dual role for dopamine: memory acquisition through dDA1 signaling and forgetting through DAMB signaling in the mushroom body neurons.
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Cites
Dopamine, learning and motivation.
Wise, R. A. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1406 · Cited by 3,379 · cited 2×
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The physiology, signaling, and pharmacology of dopamine receptors
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Multiple dopamine functions at different time courses
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Genetic dissection of consolidated memory in Drosophila
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Cited by
Sun, F., Zeng, J., Jing, M., Zhou, J., Feng, J., Owen, S. F., Luo, Y., Li, F., Wang, H., Yamaguchi, T., et al. (2018) · Cell · doi:10.1016/j.cell.2018.06.042 · Cited by 837
Coordinated and compartmentalized neuromodulation shapes sensory processing in Drosophila
Cohn, R., Morantte, I., & Ruta, V. (2015) · Cell · doi:10.1016/j.cell.2015.11.019 · Cited by 430
Decay happens: the role of active forgetting in memory
Hardt, O., Nader, K., & Nadel, L. (2013) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2013.01.001 · Cited by 416
A connectome of a learning and memory center in the adult Drosophila brain
Takemura, S.-Y., Aso, Y., Hige, T., Wong, A., Lu, Z., Xu, C. S., Rivlin, P. K., Hess, H., Zhao, T., Parag, T., et al. (2017) · eLife · doi:10.7554/elife.26975 · Cited by 367
Tsao, C.-H., Chen, C.-C., Lin, C.-H., Yang, H.-Y., & Lin, S. (2018) · eLife · doi:10.7554/elife.35264 · Cited by 214
Associative Learning in Invertebrates
Hawkins, R. D., & Byrne, J. H. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a021709 · Cited by 199
Forgetting as a form of adaptive engram cell plasticity
Ryan, T. J., & Frankland, P. W. (2022) · Nature reviews. Neuroscience · doi:10.1038/s41583-021-00548-3 · Cited by 182
Aso, Y., Ray, R. P., Long, X., Bushey, D., Cichewicz, K., Ngo, T.-T., Sharp, B., Christoforou, C., Hu, A., Lemire, A. L., et al. (2019) · eLife · doi:10.7554/elife.49257 · Cited by 141
Hippocampal activation of Rac1 regulates the forgetting of object recognition memory
Liu, Y., Du, S., Lv, L., Lei, B., Shi, W., Tang, Y., Wang, L., & Zhong, Y. (2016) · Current Biology · doi:10.1016/j.cub.2016.06.056 · Cited by 114
Scribble Scaffolds a Signalosome for Active Forgetting
Cervantes-Sandoval, I., Chakraborty, M., MacMullen, C., & Davis, R. L. (2016) · Neuron · doi:10.1016/j.neuron.2016.05.010 · Cited by 100
Self-citationSerotonin, neural markers, and memory
Meneses, A. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00143 · Cited by 90
A unified mechanism for innate and learned visual landmark guidance in the insect central complex
Goulard, R., Buehlmann, C., Niven, J. E., Graham, P., & Webb, B. (2021) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1009383 · Cited by 51
Costanzi, M., Cianfanelli, B., Santirocchi, A., Lasaponara, S., Spataro, P., Rossi-Arnaud, C., & Cestari, V. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11040241 · Cited by 39
Metadata
- Authors
- Berry, J. A., Cervantes-Sandoval, I., Nicholas, E. P., & Davis, R. L.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2012-05
- Volume
- 74
- Issue
- 3
- Pages
- 530-542
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2040751411
- Cited by
- 291
- References
- 6
- FWCI
- 6.61
- Type
- journal article
- Language
- en
- Open access
- bronze
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