Cited by 189Neuroscience and Neuropharmacology ResearchNeuroinflammation and Neurodegeneration MechanismsNeural dynamics and brain function

Do stars govern our actions? Astrocyte involvement in rodent behavior

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Oliveira, João Filipe, Sardinha, Vanessa Morais, Guerra-Gomes, Sónia, Araque, Alfonso, Sousa, Nuno·2015·Trends in Neurosciences

Abstract

Astrocytes have emerged as important partners of neurons in information processing. Important progress has been made in the past two decades in understanding the role of astrocytes in the generation of neuron-astrocyte network outputs resulting in behavior. We review evidence for astrocyte involvement across four different behavioral domains: cognition, emotion, motor, and sensory processing. Accumulating evidence from animal models has provided a wealth of data that largely supports a direct involvement of astrocytes on diverse aspects of behavior. The development of tools for selectively controlling the temporal and spatial properties of astrocyte activity will help to consolidate our knowledge of the mechanisms underlying this involvement.

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Crossref · 10.1016/j.tins.2015.07.006

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  • Recent evidence implicates glial and mitochondrial CB1R in eCB-mediated mnemonic processes, together with a known role for astrocytes and mitochondria in stress- and anxiety-related processes.

    “recent evidence for glial (Han et al., 2012) and mitochondrial CB1R (Hebert-Chatelain et al., 2016) in eCB-mediated mnemonic processes, together with a known role for astrocytes (Oliveira et al., 2015) and mitochondria (Manji et al., 2012) in stress- and anxiety-related processes.”

    From The endocannabinoid system as a target for novel anxiolytic drugs (2017) · cites this paper as Oliveira et al., 2015

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Authors
Oliveira, J. F., Sardinha, V. M., Guerra-Gomes, S., Araque, A., & Sousa, N.
Affiliations
  • University of Minho (PT)
  • University of Minnesota (US)
Corresponding author
Oliveira, João Filipe
Venue
Trends in Neurosciences
Publisher
Elsevier BV
Published
2015-09
Volume
38
Issue
9
Pages
535-549
ISSN
0166-2236 (ISSN-L)
OpenAlex
W1646393677
Cited by
189
References
120
Citations by year
2026: 5 · 2025: 17 · 2024: 15 · 2023: 22 · 2022: 15 · 2021: 24 · 2020: 21 · 2019: 23 · 2018: 15 · 2017: 17 · 2016: 14 · 2015: 1
FWCI
1.86
Type
journal article
Language
en
Open access
Locations
  • Trends in Neurosciences (publishedVersion)
  • PubMed (publishedVersion)
  • RepositóriUM (Universidade do Minho) (submittedVersion, other-oa)
  • Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, cc-by-nc-nd)
Funders
  • European Commission (273936)
  • National Science Council
  • Fundação Bial
  • Fundação para a Ciência e a Tecnologia (SFRH/BD/101298/2014, COMPETE, PTDC/SAU-NSC/118194/2010, SFRH/BPD/97281/2013)
  • FP7 People: Marie-Curie Actions
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
astrocytes, astrocyte-neuron interaction, behavior, cognition, emotions, motor behavior, sensory processing, rodent models
MeSH terms
Animals, Astrocytes, Behavior, Animal, Mental Processes, Neurons, Rodentia

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