Do stars govern our actions? Astrocyte involvement in rodent behavior
Open accessAbstract
Astrocytes have emerged as important partners of neurons in information processing. Important progress has been made in the past two decades in understanding the role of astrocytes in the generation of neuron-astrocyte network outputs resulting in behavior. We review evidence for astrocyte involvement across four different behavioral domains: cognition, emotion, motor, and sensory processing. Accumulating evidence from animal models has provided a wealth of data that largely supports a direct involvement of astrocytes on diverse aspects of behavior. The development of tools for selectively controlling the temporal and spatial properties of astrocyte activity will help to consolidate our knowledge of the mechanisms underlying this involvement.
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Recent evidence implicates glial and mitochondrial CB1R in eCB-mediated mnemonic processes, together with a known role for astrocytes and mitochondria in stress- and anxiety-related processes.
“recent evidence for glial (Han et al., 2012) and mitochondrial CB1R (Hebert-Chatelain et al., 2016) in eCB-mediated mnemonic processes, together with a known role for astrocytes (Oliveira et al., 2015) and mitochondria (Manji et al., 2012) in stress- and anxiety-related processes.”
From The endocannabinoid system as a target for novel anxiolytic drugs (2017) · cites this paper as Oliveira et al., 2015
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“Emerging evidence demonstrates the critical role that non-neuronal cell types play in cortical development, network function, and behavior ( 62 – 67 ).”
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Interfacing with the Brain: How Nanotechnology Can Contribute
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Self-citation
- Authors
- Oliveira, J. F., Sardinha, V. M., Guerra-Gomes, S., Araque, A., & Sousa, N.
- Affiliations
- University of Minho (PT)
- University of Minnesota (US)
- Corresponding author
- Oliveira, João Filipe
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2015-09
- Volume
- 38
- Issue
- 9
- Pages
- 535-549
- ISSN
- 0166-2236 (ISSN-L)
- OpenAlex
- W1646393677
- Cited by
- 189
- References
- 120
- Citations by year
- 2026: 5 · 2025: 17 · 2024: 15 · 2023: 22 · 2022: 15 · 2021: 24 · 2020: 21 · 2019: 23 · 2018: 15 · 2017: 17 · 2016: 14 · 2015: 1
- FWCI
- 1.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- RepositóriUM (Universidade do Minho) (submittedVersion, other-oa)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, cc-by-nc-nd)
- Funders
- European Commission (273936)
- National Science Council
- Fundação Bial
- Fundação para a Ciência e a Tecnologia (SFRH/BD/101298/2014, COMPETE, PTDC/SAU-NSC/118194/2010, SFRH/BPD/97281/2013)
- FP7 People: Marie-Curie Actions
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- astrocytes, astrocyte-neuron interaction, behavior, cognition, emotions, motor behavior, sensory processing, rodent models
- MeSH terms
- Animals, Astrocytes, Behavior, Animal, Mental Processes, Neurons, Rodentia
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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