Conserved Higher-Order Chromatin Regulates NMDA Receptor Gene Expression and Cognition
Open accessAbstract
Three-dimensional chromosomal conformations regulate transcription by moving enhancers and regulatory elements into spatial proximity with target genes. Here we describe activity-regulated long-range loopings bypassing up to 0.5 Mb of linear genome to modulate NMDA glutamate receptor GRIN2B expression in human and mouse prefrontal cortex. Distal intronic and 3' intergenic loop formations competed with repressor elements to access promoter-proximal sequences, and facilitated expression via a "cargo" of AP-1 and NRF-1 transcription factors and TALE-based transcriptional activators. Neuronal deletion or overexpression of Kmt2a/Mll1 H3K4- and Kmt1e/Setdb1 H3K9-methyltransferase was associated with higher-order chromatin changes at distal regulatory Grin2b sequences and impairments in working memory. Genetic polymorphisms and isogenic deletions of loop-bound sequences conferred liability for cognitive performance and decreased GRIN2B expression. Dynamic regulation of chromosomal conformations emerges as a novel layer for transcriptional mechanisms impacting neuronal signaling and cognition.
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Schizophrenia GWAS SNPs occur more often than chance in cis-regulatory functional genomic elements such as enhancers or eQTL SNPs.
“Indeed, GWAS SNPs associated with SCZ risk occur more often than expected by chance in cis-regulatory functional genomic elements, such as enhancers or eQTL SNPs3,21–24.”
From Gene expression elucidates functional impact of polygenic risk for schizophrenia (2016) · cites this paper as [24]
GWAS SNPs associated with schizophrenia risk occur more often than expected by chance in cis-regulatory functional genomic elements, such as enhancers or eQTL SNPs.
“Indeed, GWAS SNPs associated with SCZ risk occur more often than expected by chance in cis-regulatory functional genomic elements, such as enhancers or eQTL SNPs3,21–24.”
From Gene expression elucidates functional impact of polygenic risk for schizophrenia (2016) · cites this paper as [24]
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An integrated encyclopedia of DNA elements in the human genome
The ENCODE Project Consortium (2012) · Nature · doi:10.1038/nature11247 · Cited by 18,072 · see citing works
Genome engineering using the CRISPR-Cas9 system
Ran, F. A., Hsu, P. D., Wright, J., Agarwala, V., Scott, D. A., & Zhang, F. (2013) · Nature Protocols · doi:10.1038/nprot.2013.143 · Cited by 11,133 · see citing works
Shrestha, S., & Offer, S. M. (2016) · Medical Epigenetics · doi:10.1159/000444713 · Cited by 8,949 · see citing works
Biological insights from 108 schizophrenia-associated genetic loci
Schizophrenia Working Group of the Psychiatric Genomics Consortium (2014) · Nature · doi:10.1038/nature13595 · Cited by 7,577 · see citing works
Topological domains in mammalian genomes identified by analysis of chromatin interactions
Dixon, J. R., Selvaraj, S., Yue, F., Kim, A., Li, Y., Shen, Y., Hu, M., Liu, J. S., & Ren, B. (2012) · Nature · doi:10.1038/nature11082 · Cited by 6,829 · see citing works
Breaking the Code of DNA Binding Specificity of TAL-Type III Effectors
Boch, J., Scholze, H., Schornack, S., Landgraf, A., Hahn, S., Kay, S., Lahaye, T., Nickstadt, A., & Bonas, U. (2009) · Science · doi:10.1126/science.1178811 · Cited by 2,707 · see citing works
The accessible chromatin landscape of the human genome
Thurman, R. E., Rynes, E., Humbert, R., Vierstra, J., Maurano, M. T., Haugen, E., Sheffield, N. C., Stergachis, A. B., Wang, H., Vernot, B., et al. (2012) · Nature · doi:10.1038/nature11232 · Cited by 2,679 · see citing works
An atlas of active enhancers across human cell types and tissues
The FANTOM Consortium, Andersson, R., Gebhard, C., Miguel-Escalada, I., Hoof, I., Bornholdt, J., Boyd, M., Chen, Y., Zhao, X., Schmidl, C., et al. (2014) · Nature · doi:10.1038/nature12787 · Cited by 2,550 · see citing works
A Simple Cipher Governs DNA Recognition by TAL Effectors
Moscou, M., & Bogdanove, A. J. (2009) · Science · doi:10.1126/science.1178817 · Cited by 1,992 · see citing works
A promoter-level mammalian expression atlas
The FANTOM Consortium and the RIKEN PMI and CLST (DGT) (2014) · Nature · doi:10.1038/nature13182 · Cited by 1,982 · see citing works
Genome-wide association study identifies five new schizophrenia loci
The Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium (2011) · Nature Genetics · doi:10.1038/ng.940 · Cited by 1,919 · see citing works
Genetic enhancement of learning and memory in mice
Tang, Y., Shimizu, E., Dubé, G., Rampon, C., Kerchner, G. A., Zhuo, M., Liu, G., & Tsien, J. Z. (1999) · Nature · doi:10.1038/43432 · Cited by 1,867 · see citing works
Expression of a β-globin gene is enhanced by remote SV40 DNA sequences
Banerji, J., Rusconi, S., & Schaffner, W. (1981) · Cell · doi:10.1016/0092-8674(81)90413-x · Cited by 1,724 · see citing works
Genome-wide association analysis identifies 13 new risk loci for schizophrenia
Multicenter Genetic Studies of Schizophrenia Consortium, Ripke, S., Psychosis Endophenotypes International Consortium, Wellcome Trust Case Control Consortium 2, O'Dushlaine, C., Chambert, K., Moran, J. L., Kähler, A. K., Akterin, S., Bergen, S. E., et al. (2013) · Nature Genetics · doi:10.1038/ng.2742 · Cited by 1,496 · see citing works
Self-citationArchitecture of the human regulatory network derived from ENCODE data
Gerstein, M., Kundaje, A. B., Hariharan, M., Landt, S. G., Yan, K., Cheng, C., Mu, X. J., Khurana, E., Rozowsky, J. S., Alexander, R. P., et al. (2012) · Nature · doi:10.1038/nature11245 · Cited by 1,418 · see citing works
Self-citationMultiplex Targeted Sequencing Identifies Recurrently Mutated Genes in Autism Spectrum Disorders
O’Roak, B. J., Vives, L., Fu, W., Egertson, J. D., Stanaway, I. B., Phelps, I. G., Carvill, G., Kumar, A., Lee, C., Ankenman, K., et al. (2012) · Science · doi:10.1126/science.1227764 · Cited by 1,240 · see citing works
Charting histone modifications and the functional organization of mammalian genomes
Zhou, V. W., Goren, A., & Bernstein, B. E. (2011) · Nature Reviews Genetics · doi:10.1038/nrg2905 · Cited by 1,147 · see citing works
Enhancer function: new insights into the regulation of tissue-specific gene expression
Ong, C.-T., & Corces, V. G. (2011) · Nature Reviews Genetics · doi:10.1038/nrg2957 · Cited by 929 · see citing works
Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects
Shen, B., Zhang, W., Zhang, J., Zhou, J., Wang, J.-Y., Chen, L., Wang, L., Hodgkins, A., Iyer, V., Huang, X., et al. (2014) · Nature Methods · doi:10.1038/nmeth.2857 · Cited by 827 · see citing works
Shaw, G., Morse, S., Ararat, M., & Graham, F. L. (2002) · The FASEB Journal · doi:10.1096/fj.01-0995fje · Cited by 797 · see citing works
Insulators: exploiting transcriptional and epigenetic mechanisms
Gaszner, M., & Felsenfeld, G. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1925 · Cited by 649 · see citing works
Talkowski, M. E., Rosenfeld, J. A., Blumenthal, I., Pillalamarri, V., Chiang, C., Heilbut, A., Ernst, C., Hanscom, C., Rossin, E., Lindgren, A. M., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.028 · Cited by 577 · see citing works
Histone Methylation Regulates Memory Formation
Gupta, S., Kim, S. Y., Artis, S., Molfese, D. L., Schumacher, A., Sweatt, J. D., Paylor, R. E., & Lubin, F. D. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3732-09.2010 · Cited by 562 · see citing works
Genome-wide chromatin state transitions associated with developmental and environmental cues
Zhu, J., Adli, M., Zou, J., Verstappen, G., Coyne, M. J., Zhang, X.-L., Durham, T. J., Miri, M., Deshpande, V., Jager, P. D., et al. (2013) · Cell · doi:10.1016/j.cell.2012.12.033 · Cited by 553 · see citing works
From neural development to cognition: unexpected roles for chromatin
Ronan, J. L., Wu, W., & Crabtree, G. R. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3413 · Cited by 544 · see citing works
Beerli, R. R., Segal, D. J., Dreier, B., & Barbas, C. F. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.14628 · Cited by 539 · see citing works
Enhancer loops appear stable during development and are associated with paused polymerase
Ghavi-Helm, Y., Klein, F. A., Pakozdi, T., Ciglar, L., Noordermeer, D., Huber, W., & Furlong, E. E. M. (2014) · Nature · doi:10.1038/nature13417 · Cited by 536 · see citing works
Endele, S., Rosenberger, G., Geider, K., Popp, B., Tamer, C., Stefanova, I., Milh, M., Kortüm, F., Fritsch, A., Pientka, F. K., et al. (2010) · Nature Genetics · doi:10.1038/ng.677 · Cited by 499 · see citing works
Looping Back to Leap Forward: Transcription Enters a New Era
Levine, M., Cattoglio, C., & Tjian, R. (2014) · Cell · doi:10.1016/j.cell.2014.02.009 · Cited by 481 · see citing works
Epigenetic mechanisms in neurological disease
Jakovcevski, M., & Akbarian, S. (2012) · Nature Medicine · doi:10.1038/nm.2828 · Cited by 450 · see citing works
Self-citationMutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss
Klein, C. J., Botuyan, M. V., Wu, Y., Ward, C. J., Nicholson, G. A., Hammans, S. R., Hojo, K., Yamanishi, H., Karpf, A. R., Wallace, D. C., et al. (2011) · Nature Genetics · doi:10.1038/ng.830 · Cited by 407 · see citing works
Fallin, M. D., Lasseter, V. K., Avramopoulos, D., Nicodemus, K. K., Wolyniec, P. S., McGrath, J. A., Steel, G., Nestadt, G., Liang, K., Huganir, R. L., et al. (2005) · The American Journal of Human Genetics · doi:10.1086/497703 · Cited by 391 · see citing works
Ayalew, M., Le-Niculescu, H., Levey, D. F., Jain, N., Changala, B., Patel, S. D., Winiger, E. A., Breier, A. F., Shekhar, A., AMDUR, R. L., et al. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.37 · Cited by 389 · see citing works
Nuclear Aggregation of Olfactory Receptor Genes Governs Their Monogenic Expression
Clowney, E. J., LeGros, M., Mosley, C., Clowney, F., Markenscoff-Papadimitriou, E., Myllys, M., Barnea, G., Larabell, C. A., & Lomvardas, S. (2012) · Cell · doi:10.1016/j.cell.2012.09.043 · Cited by 362 · see citing works
Global and Hox-specific roles for the MLL1 methyltransferase
Guenther, M. G., Jenner, R. G., Chevalier, B. S., Nakamura, T., Croce, C. M., Canaani, E., & Young, R. A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503072102 · Cited by 357 · see citing works
Spatial organization of gene expression: the active chromatin hub
de Laat, W. L., & Grosveld, F. G. (2003) · Chromosome Research · doi:10.1023/a:1024922626726 · Cited by 349 · see citing works
CTCF and Cohesin: Linking Gene Regulatory Elements with Their Targets
Merkenschlager, M., & Odom, D. T. (2013) · Cell · doi:10.1016/j.cell.2013.02.029 · Cited by 345 · see citing works
Enhancer biology and enhanceropathies
Smith, E. R., & Shilatifard, A. (2014) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2784 · Cited by 310 · see citing works
De Novo Mutations in MLL Cause Wiedemann-Steiner Syndrome
Jones, W. D., Dafou, D., McEntagart, M., Woollard, W. J., Elmslie, F., Holder‐Espinasse, M., Irving, M. D., Saggar, A. K., Smithson, S., Trembath, R. C., et al. (2012) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2012.06.008 · Cited by 280 · see citing works
Mutations in DNMT1 cause autosomal dominant cerebellar ataxia, deafness and narcolepsy
Winkelmann, J., Lin, L., Schormair, B., Kornum, B. R., Faraco, J. H., Plazzi, G., Melberg, A., Cornelio, F., Urban, A. E., Pizza, F., et al. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds035 · Cited by 267 · see citing works
Condensin and cohesin complexity: the expanding repertoire of functions
Wood, A. J., Severson, A. F., & Meyer, B. J. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2794 · Cited by 254 · see citing works
von Engelhardt, J., Doganci, B., Jensen, V., Hvalby, Ø., Göngrich, C., Taylor, A., Barkus, C., Sanderson, D. J., Rawlins, J. N. P., Seeburg, P. H., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.09.039 · Cited by 250 · see citing works
Cheung, I., Shulha, H. P., Jiang, Y., Matevossian, A., Wang, J., Weng, Z., & Akbarian, S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1001702107 · Cited by 235 · see citing works
Self-citationMolecular evidence of N-methyl-D-aspartate receptor hypofunction in schizophrenia
Weickert, C. S., Fung, S. J., Catts, V. S., Schofield, P. R., Allen, K. M., Moore, L., Newell, K. A., Pellen, D., Huang, X.-F., Catts, S. V., et al. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.137 · Cited by 234 · see citing works
Ciernia, A. V., Matheos, D. P., Barrett, R. M., Kramár, E. A., Azzawi, S., Chen, Y., Magnan, C. N., Zeller, M. D., Sylvain, A. S., Häettig, J., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3359 · Cited by 234 · see citing works
Self-citationLocus control regions: coming of age at a decade plus
Li, Q., Harju, S., & Peterson, K. R. (1999) · Trends in Genetics · doi:10.1016/s0168-9525(99)01780-1 · Cited by 229 · see citing works
ENCODE: The human encyclopaedia
Maher, B. (2012) · Nature · doi:10.1038/489046a · Cited by 224 · see citing works
Loss-of-Function Variants in Schizophrenia Risk and SETD1A as a Candidate Susceptibility Gene
Takata, A., Xu, B., Ionita-Laza, I., Roos, J. L., Gogos, J. A., & Karayiorgou, M. (2014) · Neuron · doi:10.1016/j.neuron.2014.04.043 · Cited by 204 · see citing works
Herzig, R. P., Scacco, S., & Scarpulla, R. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.17.13134 · Cited by 197 · see citing works
Verschure, P. J., van der Kraan, I., de Leeuw, W., van der Vlag, J., Carpenter, A. E., Belmont, A. S., & van Driel, R. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.11.4552-4564.2005 · Cited by 183 · see citing works
de Quervain, D. J. ‐., & Papassotiropoulos, A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510212103 · Cited by 167 · see citing works
De Novo Mutations in the Genome Organizer CTCF Cause Intellectual Disability
Gregor, A., Oti, M., Kouwenhoven, E. N., Hoyer, J., Sticht, H., Ekici, A. B., Kjærgaard, S., Rauch, A. M., Stunnenberg, H. G., Uebe, S., et al. (2013) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2013.05.007 · Cited by 161 · see citing works
Factor, D. C., Corradin, O., Zentner, G. E., Saiakhova, A., Song, L., Chenoweth, J. G., McKay, R. D. G., Crawford, G. E., Scacheri, P. C., & Tesar, P. J. (2014) · Cell stem cell · doi:10.1016/j.stem.2014.05.005 · Cited by 159 · see citing works
Martucci, L., Wong, A. H. C., Luca, V. D., Likhodi, O., Wong, G. W. H., King, N. A., & Kennedy, J. L. (2006) · Schizophrenia Research · doi:10.1016/j.schres.2006.02.001 · Cited by 137 · see citing works
Vollema, M. G., Sitskoorn, M. M., Appels, M. C. M., & Kahn, R. S. (2002) · Schizophrenia Research · doi:10.1016/s0920-9964(01)00350-4 · Cited by 134 · see citing works
A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB
Need, A. C., Attix, D. K., McEvoy, J. M., Cirulli, E. T., Linney, K. L., Hunt, P., Ge, D., Heinzen, E. L., Maia, J. M., Shianna, K. V., et al. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp413 · Cited by 133 · see citing works
Wittmann, M., Queisser, G., Eder, A., Wiegert, J. S., Bengtson, C. P., Hellwig, A., Wittum, G., & Bading, H. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1160-09.2009 · Cited by 122 · see citing works
Jiang, Y., Jakovcevski, M., Bharadwaj, R., Connor, C., Schroeder, F. A., Lin, C. L., Straubhaar, J., Martin, G., & Akbarian, S. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1314-10.2010 · Cited by 118 · see citing works
Self-citationJia, P., Wang, L., Fanous, A. H., Pato, C. N., Edwards, T. L., & Zhao, Z. (2012) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002587 · Cited by 110 · see citing works
Balancing histone methylation activities in psychiatric disorders
Peter, C. J., & Akbarian, S. (2011) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2011.02.003 · Cited by 110 · see citing works
Self-citationChromatin and epigenetic features of long-range gene regulation
Harmston, N., & Lenhard, B. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt499 · Cited by 107 · see citing works
Characterization of Enhancer Function from Genome-Wide Analyses
Maston, G. A., Landt, S. G., Snyder, M. P., & Green, M. R. (2012) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-090711-163723 · Cited by 97 · see citing works
Cukier, H. N., Lee, J. M., Ma, D., Young, J. I., Mayo, V., Butler, B. L., Ramsook, S. S., Rantus, J. A., Abrams, A. J., Whitehead, P. L., et al. (2012) · Autism Research · doi:10.1002/aur.1251 · Cited by 89 · see citing works
Dhar, S. S., & Wong‐Riley, M. T. T. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.3704-08.2009 · Cited by 85 · see citing works
TALE-mediated modulation of transcriptional enhancers in vivo
Crocker, J., & Stern, D. L. (2013) · Nature Methods · doi:10.1038/nmeth.2543 · Cited by 78 · see citing works
Crepaldi, L., Policarpi, C., Coatti, A., Sherlock, W. T., Jongbloets, B. C., Down, T. A., & Riccio, A. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003699 · Cited by 76 · see citing works
Personality traits and schizophrenia: evidence from a case–control study and meta-analysis
Ohi, K., Hashimoto, R., Yasuda, Y., Fukumoto, M., Yamamori, H., Iwase, M., Kazui, H., & Takeda, M. (2012) · Psychiatry Research · doi:10.1016/j.psychres.2011.12.018 · Cited by 69 · see citing works
Bharadwaj, R. A., Jiang, Y., Mao, W., Jakovcevski, M., Dincer, A., Krueger, W., Garbett, K., Whittle, C., Tushir, J. S., Liu, J., et al. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1252-13.2013 · Cited by 68 · see citing works
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Walczak, A., Szczepankiewicz, A. A., Ruszczycki, B., Magalska, A., Zamłyńska, K., Dzwonek, J., Wilczek, E., Żybura-Broda, K., Rylski, M., Malinowska, M., et al. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1085-12.2013 · Cited by 63 · see citing works
Roussos, P., Giakoumaki, S. G., Adamaki, E., & Bitsios, P. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.09.009 · Cited by 61 · see citing works
Self-citationThe Genome in Three Dimensions: A New Frontier in Human Brain Research
Mitchell, A., Bharadwaj, R. A., Whittle, C., Krueger, W. H., Mirnics, K., Hurd, Y. L., Rasmussen, T. P., & Akbarian, S. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.07.015 · Cited by 57 · see citing works
Self-citationMund, A., Schubert, T., Staege, H., Kinkley, S., Reumann, K., Kriegs, M., Fritsch, L., Battisti, V., Ait‐Si‐Ali, S., Hoffbeck, A.-S., et al. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks868 · Cited by 45 · see citing works
Communication of genome regulatory elements in a folded chromosome
Razin, S. V., Gavrilov, A. A., Ioudinkova, E. S., & Iarovaia, O. V. (2013) · FEBS Letters · doi:10.1016/j.febslet.2013.04.027 · Cited by 42 · see citing works
Functional anatomy of distant-acting mammalian enhancers
Dickel, D. E., Visel, A., & Pennacchio, L. A. (2013) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2012.0359 · Cited by 40 · see citing works
Qiang, M., & Ticku, M. K. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03464.x · Cited by 37 · see citing works
Roussos, P., Giakoumaki, S. G., Adamaki, E., Georgakopoulos, A., Nikos, R. K., & Bitsios, P. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.49 · Cited by 35 · see citing works
Self-citationDhar, S. S., Ongwijitwat, S., & Wong‐Riley, M. T. T. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.019976 · Cited by 33 · see citing works
Fatemi, S. H., Folsom, T. D., Reutiman, T. J., Novak, J., & Engel, R. H. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2011.11.013 · Cited by 30 · see citing works
Priya, A., Johar, K., & Wong‐Riley, M. T. T. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.10.014 · Cited by 20 · see citing works
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- Authors
- Bharadwaj, R., Peter, C. J., Jiang, Y., Roussos, P., Vogel-Ciernia, A., Shen, E. Y., Mitchell, A. C., Mao, W., Whittle, C., Dincer, A., Jakovcevski, M., Pothula, V., Rasmussen, T. P., Giakoumaki, S. G., Bitsios, P., Sherif, A., Gardner, P. D., Ernst, P., Ghose, S., Sklar, P., Haroutunian, V., Tamminga, C., Myers, R. H., Futai, K., Wood, M. A., & Akbarian, S.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- James J. Peters VA Medical Center (US)
- University of Massachusetts Chan Medical School (US)
- Max Planck Institute of Psychiatry (DE)
- University of Connecticut (US)
- University of Crete (GR)
- Dartmouth College (US)
- The University of Texas Southwestern Medical Center (US)
- Boston University (US)
- University of California, Irvine (US)
- Corresponding author
- Akbarian, Schahram
- ORCID
- Bharadwaj, Rahul
- Peter, Cyril J.
- Jiang, Yan
- Roussos, Panos
- Mitchell, Amanda C.
- Mao, Wenjie
- Dincer, Aslihan
- Jakovcevski, Mira
- Pothula, Venu
- Rasmussen, Theodore P.
- Giakoumaki, Stella G.
- Gardner, Paul D.
- Ernst, Patricia
- Sklar, Pamela
- Haroutunian, Vahram
- Tamminga, Carol
- Myers, Richard H.
- Futai, Kensuke
- Wood, Marcelo A.
- Akbarian, Schahram
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2014-12
- Volume
- 84
- Issue
- 5
- Pages
- 997-1008
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC4258154
- OpenAlex
- W2057487421
- Cited by
- 84
- References
- 79
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 6 · 2023: 7 · 2022: 6 · 2021: 6 · 2020: 7 · 2019: 11 · 2018: 4 · 2017: 16 · 2016: 9 · 2015: 6
- FWCI
- 4.23
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship@UMassChan (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- U.S. Department of Veterans Affairs (I01BX002395)
- National Institute of Mental Health (P50MH096890, R01MH101491, R01MH086509)
- National Institute on Drug Abuse (R01DA036984)
- National Institute of Neurological Disorders and Stroke (R01NS088538, R01NS073947)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- 3D genome organization, NMDA receptor, NR2B subunit, prefrontal cortex, working memory, H3K4 methylation, H3K9 methylation, AP-1 transcription factor, NRF1, enhancer-promoter interactions, cognitive performance, genetic polymorphism, neuronal gene expression
- MeSH terms
- Aged, Aged, 80 and over, Animals, Animals, Newborn, Cells, Cultured, Cerebral Cortex, Chromatin, Cognition, Female, Gene Expression Regulation, Humans, Male, Mice, Inbred C57BL, Mice, Transgenic, Middle Aged, Neurons, Schizophrenia, Antipsychotic Agents, Transcription Factors, Signal Transduction, Receptors, N-Methyl-D-Aspartate, Polymorphism, Single Nucleotide, Mice, HEK293 Cells
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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