Cited by 1,285Neuroscience and Neuropharmacology ResearchAdvanced MRI Techniques and ApplicationsNeuroinflammation and Neurodegeneration Mechanisms

The DOI matches its Crossref record; 203 of the 204 references it cites were found in a registry or an index.

A Cellular Perspective on Brain Energy Metabolism and Functional Imaging

Open access

Magistretti, Pierre J., Allaman, Igor·2015·Neuron

DOI 10.1016/j.neuron.2015.03.035

Open this paper in CoChat — free account Open PDF

Abstract

The energy demands of the brain are high: they account for at least 20% of the body's energy consumption. Evolutionary studies indicate that the emergence of higher cognitive functions in humans is associated with an increased glucose utilization and expression of energy metabolism genes. Functional brain imaging techniques such as fMRI and PET, which are widely used in human neuroscience studies, detect signals that monitor energy delivery and use in register with neuronal activity. Recent technological advances in metabolic studies with cellular resolution have afforded decisive insights into the understanding of the cellular and molecular bases of the coupling between neuronal activity and energy metabolism and point at a key role of neuron-astrocyte metabolic interactions. This article reviews some of the most salient features emerging from recent studies and aims at providing an integration of brain energy metabolism across resolution scales.

Integrity signals

Registry

Crossref · 10.1016/j.neuron.2015.03.035

Cites

203 of 203 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

On the origin of cancer cells
Warburg, O. (1956) · Science · doi:10.1126/science.123.3191.309 · Cited by 13,425
Neurophysiological investigation of the basis of the fMRI signal
Logothetis, N. K., Pauls, J., Augath, M., Trinath, T., & Oeltermann, A. (2001) · Nature · doi:10.1038/35084005 · Cited by 6,551
Brain magnetic resonance imaging with contrast dependent on blood oxygenation.
Ogawa, S., Lee, T. M., Kay, A. R., & Tank, D. W. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.24.9868 · Cited by 6,483
THE [ 14 C]DEOXYGLUCOSE METHOD FOR THE MEASUREMENT OF LOCAL CEREBRAL GLUCOSE UTILIZATION: THEORY, PROCEDURE, AND NORMAL VALUES IN THE CONSCIOUS AND ANESTHETIZED ALBINO RAT 1
Sokoloff, L., Reivich, M., Kennedy, C., Rosiers, M. H. D., Patlak, C. S., Pettigrew, K. D., Sakurada, O., & Shinohara, M. (1977) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1977.tb10649.x · Cited by 6,000
A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β
Iliff, J. J., Wang, M., Liao, Y., Plogg, B. A., Peng, W., Gundersen, G. A., Benveniste, H., Vates, G. E., Deane, R., Goldman, S. A., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003748 · Cited by 5,824
Astrocytes: Biology and pathology
Sofroniew, M. V., & Vinters, H. V. (2010) · Acta Neuropathologica · doi:10.1007/s00401-009-0619-8 · Cited by 5,196
An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex
Zhang, Y., Chen, K., Sloan, S. A., Bennett, M. L., Scholze, A. R., O'Keeffe, S., Phatnani, H. P., Guarnieri, P., Caneda, C., Ruderisch, N., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.1860-14.2014 · Cited by 4,875
Glutamate uptake
Danbolt, N. C. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00067-8 · Cited by 4,227
An Energy Budget for Signaling in the Grey Matter of the Brain
Attwell, D., & Laughlin, S. B. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200110000-00001 · Cited by 3,543
Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate
Ward, P. S., & Thompson, C. B. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.02.014 · Cited by 3,233

Show all 204 references

Research works printed but not linked: 1

Andriezen, 1893, On a system of fibre-like cells surrounding the blood vessels of the brain of man and mammals, and its physiological significance, Int. Monatsschr. Anat. Physiol., 10, 532

Sorted by citations

Items 301–400 of 1,002

Stem Cell Therapy for Modulating Neuroinflammation in Neuropathic Pain
Joshi, H. P., Jo, H. J., Kim, Y. H., An, S. B., Park, C., & Han, I. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094853 · Cited by 49
Mitochondrial Dysfunction in Down Syndrome: From Pathology to Therapy
Tan, K.-L., Lee, H.-C., Cheah, P.-S., & Ling, K.-H. (2023) · Neuroscience · doi:10.1016/j.neuroscience.2022.12.003 · Cited by 44
Genetically Encoded ATP Biosensors for Direct Monitoring of Cellular ATP Dynamics
White, D., & Yang, Q. (2022) · Cells · doi:10.3390/cells11121920 · Cited by 48
Gut metagenomic characteristics of ADHD reveal low Bacteroides ovatus -associated host cognitive impairment
Li, Y., Sun, H., Huang, Y., Yin, A., Zhang, L., Han, J., Lyu, Y., Xu, X., Zhai, Y., Sun, H., et al. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2125747 · Cited by 44
Neuron–astrocyte metabolic coupling facilitates spinal plasticity and maintenance of inflammatory pain
Marty-Lombardi, S., Lu, S., Ambroziak, W., Schrenk-Siemens, K., Wang, J., DePaoli-Roach, A. A., Hagenston, A. M., Wende, H., Tappe‐Theodor, A., Simonetti, M., et al. (2024) · Nature Metabolism · doi:10.1038/s42255-024-01001-2 · Cited by 50
Mitochondria: the hidden engines of traumatic brain injury-driven neurodegeneration
Olatona, O. A., Sterben, S. P., Kansakar, S. B. S., Symes, A. J., & Liaudanskaya, V. (2025) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2025.1570596 · Cited by 46
Type 2 diabetes induced oxidative brain injury involves altered cerebellar neuronal integrity and elemental distribution, and exacerbated Nrf2 expression: therapeutic potential of raffia palm (Raphia hookeri) wine
Erukainure, O. L., Ijomone, O. M., Sanni, O., Aschner, M., & Islam, M. S. (2019) · Metabolic Brain Disease · doi:10.1007/s11011-019-00444-x · Cited by 49
Astrocytes and neurons communicate via a monocarboxylic acid shuttle
Roosterman, D., & Cottrell, G. (2020) · AIMS Neuroscience · doi:10.3934/neuroscience.2020007 · Cited by 34
Mini-review: Brain energy metabolism and its role in animal models of depression, bipolar disorder, schizophrenia and autism
Kolář, D., Kletečková, L., Brožka, H., & Valeš, K. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.136003 · Cited by 46
Parvalbumin Role in Epilepsy and Psychiatric Comorbidities: From Mechanism to Intervention
Godoy, L. D., Prizon, T., Rossignoli, M. T., Leite, J. P., & Liberato, J. L. (2022) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2022.765324 · Cited by 45
Prevention of Oxidative Stress and Diseases by Antioxidant Supplementation
Martemucci, G., Portincasa, P., Centonze, V., Mariano, M., Khalil, M., & D‘Alessandro, A. G. (2022) · Medicinal Chemistry · doi:10.2174/1573406419666221130162512 · Cited by 48
Iron and Ferroptosis More than a Suspect: Beyond the Most Common Mechanisms of Neurodegeneration for New Therapeutic Approaches to Cognitive Decline and Dementia
Cerasuolo, M., Meo, I. D., Auriemma, M. C., Trojsi, F., Maiorino, M. I., Cirillo, M., Esposito, F., Polito, R., Colangelo, A. M., Paolisso, G., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119637 · Cited by 47
Neuron–Glial Interactions: Implications for Plasticity, Behavior, and Cognition
Rangel‐Gomez, M., Alberini, C. M., Deneen, B., Drummond, G. T., Manninen, T., Sur, M., & Vicentic, A. (2024) · Journal of Neuroscience · doi:10.1523/jneurosci.1231-24.2024 · Cited by 49
Mitochondrial form, function and signalling in aging
Amigo, I., da Cunha, F. M., Forni, M. F., Garcia-Neto, W., Kakimoto, P. A., Luévano‐Martínez, L. A., Macedo, F. P., Menezes‐Filho, S. L., Peloggia, J., & Kowaltowski, A. J. (2016) · Biochemical Journal · doi:10.1042/bcj20160451 · Cited by 42
Endogenous Two-Photon Excited Fluorescence Imaging Characterizes Neuron and Astrocyte Metabolic Responses to Manganese Toxicity
Stuntz, E., Gong, Y., Sood, D., Liaudanskaya, V., Pouli, D., Quinn, K. P., Alonzo, C., Liu, Z., Kaplan, D. L., & Georgakoudi, I. (2017) · Scientific Reports · doi:10.1038/s41598-017-01015-9 · Cited by 43
Cerebrospinal Fluid-Contacting Neurons Sense pH Changes and Motion in the Hypothalamus
Jalalvand, E., Robertson, B., Tostivint, H., Löw, P., Wallén, P., & Grillner, S. E. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.3359-17.2018 · Cited by 50
Equine Neonatal Encephalopathy
Toribio, R. E. (2019) · Veterinary Clinics of North America Equine Practice · doi:10.1016/j.cveq.2019.03.004 · Cited by 43
Neuronal lactate levels depend on glia‐derived lactate during high brain activity in Drosophila
González‐Gutiérrez, A., Ibacache, A., Esparza, A., Barros, L. F., & Sierralta, J. A. (2019) · Glia · doi:10.1002/glia.23772 · Cited by 49
Cell-to-cell lactate shuttle operates in heart and is important in age-related heart failure
Gizak, A., McCubrey, J. A., & Rakus, D. (2020) · Aging · doi:10.18632/aging.102818 · Cited by 44
Highlights in targeted nanoparticles as a delivery strategy for glioma treatment
Luiz, M. T., Filippo, L. D. D., Tofani, L. B., de Araújo, J. T. C., Dutra, J. A. P., Marchetti, J. M., & Chorilli, M. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.120758 · Cited by 44
l-Lactate: Food for Thoughts, Memory and Behavior
Castillo, M. F. V., Magistretti, P. J., & Calì, C. (2021) · Metabolites · doi:10.3390/metabo11080548 · Cited by 43
Self-citation
Emerging Roles of Microfluidics in Brain Research: From Cerebral Fluids Manipulation to Brain-on-a-Chip and Neuroelectronic Devices Engineering
Wan, J., Zhou, S., Mea, H. J., Guo, Y., Ku, H., & Urbina, B. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00480 · Cited by 45
Semaphorin 4D is upregulated in neurons of diseased brains and triggers astrocyte reactivity
Evans, E. E., Mishra, V., Mallow, C., Gersz, E. M., Balch, L., Howell, A., Reilly, C., Smith, E. S., Fisher, T. L., & Zauderer, M. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02509-8 · Cited by 44
Mitochondria and neuroprotection in stroke: Cationic arginine-rich peptides (CARPs) as a novel class of mitochondria-targeted neuroprotective therapeutics
MacDougall, G., Anderton, R. S., Mastaglia, F. L., Knuckey, N. W., & Meloni, B. P. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.09.010 · Cited by 41
ALDH 2 conferred neuroprotection on cerebral ischemic injury by alleviating mitochondria-related apoptosis through JNK/caspase-3 signing pathway
Xia, P., Zhang, F., Yuan, Y., Chen, C., Huang, Y., Li, L., Wang, E., Guo, Q., & Ye, Z. (2020) · International Journal of Biological Sciences · doi:10.7150/ijbs.38962 · Cited by 42
Can neurofeedback provide evidence of direct brain-behavior causality?
Kvamme, T. L., Ros, T., & Overgaard, M. S. (2022) · NeuroImage · doi:10.1016/j.neuroimage.2022.119400 · Cited by 46
Appraising the Role of Astrocytes as Suppliers of Neuronal Glutathione Precursors
Pérez‐Sala, D., & Pajares, M. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24098059 · Cited by 42
Type 3 diabetes and metabolic reprogramming of brain neurons: causes and therapeutic strategies
Meng, X., Zhang, H., Zhao, Z., Li, S., Zhang, X., Guo, R., Li, H., Yuan, Y., Li, W., Song, Q., et al. (2025) · Molecular Medicine · doi:10.1186/s10020-025-01101-z · Cited by 47
Reversible reduction in brain myelin content upon marathon running
Ramos‐Cabrer, P., Cabrera‐Zubizarreta, A., Padró, D., Matute‐González, M., Rodríguez-Antigüedad, A., & Matute, C. (2025) · Nature Metabolism · doi:10.1038/s42255-025-01244-7 · Cited by 46
Metabolite transport across the mammalian and insect brain diffusion barriers
Weiler, A., Volkenhoff, A., Hertenstein, H., & Schirmeier, S. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.02.008 · Cited by 46
AMPK signaling linked to the schizophrenia-associated 1q21.1 deletion is required for neuronal and sleep maintenance
Nagy, S., Maurer, G. W., Hentze, J. L., Kondo, S., Rose, M., Werge, T. M., & Rewitz, K. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007623 · Cited by 38
Mitochondria-Targeted Therapeutics for Alzheimer's Disease: The Good, the Bad, the Potential
Mi, Y., Qi, G., Brinton, R. D., & Yin, F. (2021) · Antioxidants & Redox Signaling · doi:10.1089/ars.2020.8070 · Cited by 43
N-acetyl-L-cysteine ameliorates mitochondrial dysfunction in ischemia/reperfusion injury via attenuating Drp-1 mediated mitochondrial autophagy
Ali, M., Tabassum, H., Alam, M. M., & Parvez, S. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120338 · Cited by 41
Local and dynamic regulation of neuronal glycolysis in vivo
Wolfe, A. D., Koberstein, J. N., Smith, C. B., Stewart, M. L., Gonzalez, I. J., Hammarlund, M., Hyman, A. A., Stork, P. A., Goodman, R. H., & Colón‐Ramos, D. A. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2314699121 · Cited by 38
Schizophrenia, a disease of impaired dynamic metabolic flexibility: A new mechanistic framework
Sarnyai, Z., & Ben‐Shachar, D. (2024) · Psychiatry Research · doi:10.1016/j.psychres.2024.116220 · Cited by 39
Human astrocytes are distinct contributors to the complexity of synaptic function
Krencik, R., van Asperen, J. V., & Ullian, E. M. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.08.012 · Cited by 43
The Dual Role of AQP4 in Cytotoxic and Vasogenic Edema Following Spinal Cord Contusion and Its Possible Association With Energy Metabolism via COX5A
Huang, Y., Li, S., Zhou, X., Zhang, L., Chen, G.-X., Wang, T., Xia, Q., Liang, N., & Zhang, X. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00584 · Cited by 40
Sex-Specific Effects of Early Life Stress on Brain Mitochondrial Function, Monoamine Levels and Neuroinflammation
González‐Pardo, H., Arias, J. L., Gómez-Lázaro, E., López-Taboada, I., & Conejo, N. M. (2020) · Brain Sciences · doi:10.3390/brainsci10070447 · Cited by 40
Metabolomics in degenerative brain diseases
Escobar, M. Q., Pontes, J. G. D. M., & Tasić, L. (2021) · Brain Research · doi:10.1016/j.brainres.2021.147704 · Cited by 41
Mechanistic and therapeutic role of Drp1 in the pathogenesis of Alzheimer's disease
Bera, A., Lavanya, G., Reshmi, R., Dev, K., & Kumar, R. K. (2022) · European Journal of Neuroscience · doi:10.1111/ejn.15611 · Cited by 43
LDHB Deficiency Promotes Mitochondrial Dysfunction Mediated Oxidative Stress and Neurodegeneration in Adult Mouse Brain
Park, J. S., Saeed, K. M., Jo, M. H., Kim, M. W., Lee, H. J., Park, C.-B., Lee, G., & Kim, M. O. (2022) · Antioxidants · doi:10.3390/antiox11020261 · Cited by 41
Iron Deposition in Brain: Does Aging Matter?
Ficiarà, E., Stura, I., & Guiot, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231710018 · Cited by 40
DNA damage response in neurodevelopment and neuromaintenance
Qing, X., Zhang, G., & Wang, Z. (2022) · FEBS Journal · doi:10.1111/febs.16535 · Cited by 42
A Promising Strategy to Treat Neurodegenerative Diseases by SIRT3 Activation
Tyagi, A., & Pugazhenthi, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021615 · Cited by 41
Neurotransmitters in Type 2 Diabetes and the Control of Systemic and Central Energy Balance
Al-Sayyar, A., Hammad, M. M., Williams, M. R., Al‐Onaizi, M., Abubaker, J. A., & Alzaïd, F. (2023) · Metabolites · doi:10.3390/metabo13030384 · Cited by 45
Target modulation of glycolytic pathways as a new strategy for the treatment of neuroinflammatory diseases
Wang, H., Liu, S., Sun, Y., Chen, C., Hu, Z., Li, Q., Long, J., Yan, Q., Liang, J., Lin, Y., et al. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102472 · Cited by 39
Cable energy function of cortical axons
Ju, H., Hines, M. L., & Yu, Y. (2016) · Scientific Reports · doi:10.1038/srep29686 · Cited by 39
Metabolism and inflammation: implications for traumatic brain injury therapeutics
Killen, M. J., Giorgi-Coll, S., Helmy, A. E., Hutchinson, P. J., & Carpenter, K. L. H. (2019) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2019.1582332 · Cited by 39
CYP1B1: A key regulator of redox homeostasis.
Falero-Perez, J., Song, Y., Sorenson, C. M., & Sheibani, N. (2018) · PubMed · Cited by 39
Glucocorticoids, metabolism and brain activity
Jaszczyk, A., & Juszczak, G. R. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.03.007 · Cited by 45
Lysosomal Functions in Glia Associated with Neurodegeneration
Kreher, C., Favret, J., Maulik, M., & Shin, D. (2021) · Biomolecules · doi:10.3390/biom11030400 · Cited by 38
Intermittent hypoxia conditioning as a potential prevention and treatment strategy for ischemic stroke: Current evidence and future directions
Yuan, H., Liu, J., Gu, Y., Ji, X., & Nan, G. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1067411 · Cited by 37
Imaging and spectroscopic approaches to probe brain energy metabolism dysregulation in neurodegenerative diseases
Bonvento, G., Valette, J., Flament, J., Mochel, F., & Brouillet, E. (2017) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x17697989 · Cited by 38
Stage-specific metabolic features of differentiating neurons: Implications for toxicant sensitivity
Delp, J., Gutbier, S., Cerff, M., Zasada, C., Niedenführ, S., Zhao, L., Smirnova, L., Härtung, T., Borlinghaus, H., Schreiber, F., et al. (2017) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2017.12.013 · Cited by 38
Carbon-Fiber Microbiosensor for Monitoring Rapid Lactate Fluctuations in Brain Tissue Using Fast-Scan Cyclic Voltammetry
Smith, S. K., Gosrani, S. P., Lee, C. A., McCarty, G. S., & Sombers, L. A. (2018) · Analytical Chemistry · doi:10.1021/acs.analchem.8b03694 · Cited by 39
Enhanced white matter reorganization and activated brain glucose metabolism by enriched environment following ischemic stroke: Micro PET/CT and MRI study
Li, M.-Z., Zhao, Y., Zhan, Y., Yang, L. J., Feng, X., Lu, Y., Lei, J., Zhao, T., Wang, L., & Zhao, H. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108202 · Cited by 36
Alteration of Iron Concentration in Alzheimer’s Disease as a Possible Diagnostic Biomarker Unveiling Ferroptosis
Ficiarà, E., Munir, Z., Boschi, S., Caligiuri, M. E., & Guiot, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094479 · Cited by 40
Extracellular Calcium Influx Pathways in Astrocyte Calcium Microdomain Physiology
Ahmadpour, N., Kantroo, M., & Stobart, J. L. (2021) · Biomolecules · doi:10.3390/biom11101467 · Cited by 43
Astrocyte Gliotransmission in the Regulation of Systemic Metabolism
Murat, C. D. B., & García‐Cáceres, C. (2021) · Metabolites · doi:10.3390/metabo11110732 · Cited by 38
Functional enrichment of alternative splicing events with NEASE reveals insights into tissue identity and diseases
Louadi, Z., Elkjaer, M. L., Klug, M., Lio, C. T., Fenn, A. M., Illés, Z., Bongiovanni, D., Baumbach, J., Kacprowski, T., List, M., et al. (2021) · Genome biology · doi:10.1186/s13059-021-02538-1 · Cited by 36
Astrocytes and Microglia in Stress-Induced Neuroinflammation: The African Perspective
Olude, M. A., Mouihate, A., Mustapha, O. A., Farina, C., Quintana, F. J., & Olopade, J. O. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.795089 · Cited by 37
Physiology of PNS axons relies on glycolytic metabolism in myelinating Schwann cells
Deck, M., van Hameren, G., Campbell, G. R., Bernard‐Marissal, N., Devaux, J. J., Berthelot, J., Lattard, A., Médard, J., Gautier, B., Guelfi, S., et al. (2022) · PLoS ONE · doi:10.1371/journal.pone.0272097 · Cited by 39
Optogenetic investigation of the variable neurovascular coupling along the interhemispheric circuits
Iordanova, B. E., Vazquez, A. L., Kozai, T. D. Y., Fukuda, M., & Kim, S. (2018) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x18755225 · Cited by 36
PPARs and Energy Metabolism Adaptation during Neurogenesis and Neuronal Maturation
d’Angelo, M., Antonosante, A., Castelli, V., Catanesi, M., Moorthy, N. K., Iannotta, D., Cimini, A., & Benedetti, E. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19071869 · Cited by 37
Cellular Specificity and Inter-cellular Coordination in the Brain Bioenergetic System: Implications for Aging and Neurodegeneration
Qi, G., Mi, Y., & Yin, F. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2019.01531 · Cited by 38
Age-Related Alterations in Brain Perfusion, Venous Oxygenation, and Oxygen Metabolic Rate of Mice: A 17-Month Longitudinal MRI Study
Wei, Z., Chen, L., Hou, X., van Zijl, P. C. M., Xu, J., & Lu, H. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00559 · Cited by 38
Astrocyte-Derived Lactate Modulates the Passive Coping Response to Behavioral Challenge in Male Mice
Yin, Y., Hu, J., Wei, Y., Li, Z., Luo, Z.-C., Wang, R., Yang, K.-X., Li, S.-J., Li, X., Yang, J., et al. (2020) · Neuroscience Bulletin · doi:10.1007/s12264-020-00553-z · Cited by 39
Transcriptomic Analysis of Human Astrocytes In Vitro Reveals Hypoxia-Induced Mitochondrial Dysfunction, Modulation of Metabolism, and Dysregulation of the Immune Response
Allen, S. P., Seehra, R. S., Heath, P. R., Hall, B., Bates, J., Garwood, C. J., Matuszyk, M. M., Wharton, S. B., & Simpson, J. E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218028 · Cited by 42
Memory recall involves a transient break in excitatory-inhibitory balance
Koolschijn, R. S., Shpektor, A., Ip, I. B., Clarke, W. T., Dupret, D., Emir, U. E., & Barron, H. C. (2021) · eLife · doi:10.7554/elife.70071 · Cited by 40
Metabolic Bypass Rescues Aberrant S‐nitrosylation‐Induced TCA Cycle Inhibition and Synapse Loss in Alzheimer's Disease Human Neurons
Andreyev, A. Y., Yang, H., Doulias, P., Dolatabadi, N., Zhang, X., Luevanos, M., Blanco, M., Baal, C., Putra, I., Nakamura, T., et al. (2024) · Advanced Science · doi:10.1002/advs.202306469 · Cited by 35
Prophylactic Neuroprotection of Total Glucosides of Paeoniae Radix Alba against Semen Strychni-Induced Neurotoxicity in Rats: Suppressing Oxidative Stress and Reducing the Absorption of Toxic Components
Li, S., Chu, Y., Zhang, R., Sun, L., & Chen, X. (2018) · Nutrients · doi:10.3390/nu10040514 · Cited by 36
As time flies by: Investigating cardiac aging in the short-lived Drosophila model
Blice‐Baum, A. C., Guida, M. C., Hartley, P. S., Adams, P. D., Bodmer, R., & Cammarato, A. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.11.010 · Cited by 41
Correlated Gene Expression and Anatomical Communication Support Synchronized Brain Activity in the Mouse Functional Connectome
Mills, B. D., Grayson, D. S., Shunmugavel, A., Miranda-Domínguez, Ó., Feczko, E., Earl, E., Neve, K. A., & Fair, D. A. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.2910-17.2018 · Cited by 33
Brain energetics, mitochondria, and traumatic brain injury
Benaroya, H. (2020) · Reviews in the Neurosciences · doi:10.1515/revneuro-2019-0086 · Cited by 37
Characterisation of Haemodynamic Activity in Resting State Networks by Fractal Analysis
Porcaro, C., Mayhew, S. D., Marino, M., Mantini, D., & Bagshaw, A. P. (2020) · International Journal of Neural Systems · doi:10.1142/s0129065720500616 · Cited by 36
Reactive astrogliosis is associated with higher cerebral glucose consumption in the early Alzheimer’s continuum
Salvadó, G., Milà-Alomà, M., Shekari, M., Ashton, N. J., Operto, G., Falcon, C., Cacciaglia, R., Minguillon, C., Fauria, K., Niñerola-Baizán, A., et al. (2022) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-022-05897-4 · Cited by 36
The multifaceted roles of the brain glycogen
Markussen, K. H., Corti, M., Byrne, B. J., Kooi, C. W. V., Sun, R. C., & Gentry, M. S. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15926 · Cited by 35
Intestinal endogenous metabolites affect neuroinflammation in 5×FAD mice by mediating “gut-brain” axis and the intervention with Chinese Medicine
Gu, X., Zhou, Y., Zhang, Y., Wang, L., Gao, W., Luo, K., Sun, B., Li, T., Wang, H., Si, N., et al. (2024) · Alzheimer s Research & Therapy · doi:10.1186/s13195-024-01587-5 · Cited by 39
New Therapeutics to Modulate Mitochondrial Function in Neurodegenerative Disorders
Wilkins, H., & Morris, J. K. (2017) · Current Pharmaceutical Design · doi:10.2174/1381612822666161230144517 · Cited by 34
Astrocytic changes with aging and Alzheimer's disease‐type pathology in chimpanzees
Munger, E. L., Edler, M. K., Hopkins, W. D., Ely, J. J., ERWIN, J. M., Perl, D. P., Mufson, E. J., Hof, P. R., Sherwood, C. C., & Raghanti, M. A. (2018) · The Journal of Comparative Neurology · doi:10.1002/cne.24610 · Cited by 37
Lactate: A Novel Signaling Molecule in Synaptic Plasticity and Drug Addiction
Wang, Q., Hu, Y. C., Wan, J., Dong, B., & Sun, J. (2019) · BioEssays · doi:10.1002/bies.201900008 · Cited by 37
The Contribution of Microglia to the Development and Maturation of the Visual System
Dixon, M., Greferath, U., Fletcher, E. L., & Jobling, A. I. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.659843 · Cited by 40
Adropin correlates with aging-related neuropathology in humans and improves cognitive function in aging mice
Banerjee, S., Ghoshal, S., Clemence, G., DeMars, K. M., Yang, C., Niehoff, M. L., Nguyen, A. D., Jayanth, P., Hoelscher, B., Xu, F., et al. (2021) · npj Aging and Mechanisms of Disease · doi:10.1038/s41514-021-00076-5 · Cited by 36
Lactate as an Astroglial Signal Augmenting Aerobic Glycolysis and Lipid Metabolism
Horvat, A., Zorec, R., & Vardjan, N. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.735532 · Cited by 42
Ketone Bodies and Brain Metabolism: New Insights and Perspectives for Neurological Diseases
López-Ojeda, W., & Hurley, R. A. (2023) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.20230017 · Cited by 35
Stargazing: Monitoring subcellular dynamics of brain astrocytes
Kacerovsky, J. B., & Murai, K. K. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.07.007 · Cited by 35
Neuronal culture microenvironments determine preferences in bioenergetic pathway use
Sünwoldt, J., Bosche, B., Meisel, A., & Mergenthaler, P. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00305 · Cited by 34
Altered Brain Energy Metabolism Related to Astrocytes in Alzheimer's Disease
Hirata, K., Matsuoka, K., Tagai, K., Endo, H., Tatebe, H., Ono, M., Kokubo, N., Oyama, A., Shinotoh, H., Takahata, K., et al. (2023) · Annals of Neurology · doi:10.1002/ana.26797 · Cited by 35
When S -Nitrosylation Gets to Mitochondria: From Signaling to Age-Related Diseases
Montagna, C., Cirotti, C., Rizza, S., & Filomeni, G. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2019.7872 · Cited by 35
Stuttering: A Disorder of Energy Supply to Neurons?
Alm, P. A. (2021) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2021.662204 · Cited by 35
Deactivation of mitochondrial complex I after hypoxia–ischemia in the immature brain
Степанова, А., Konràd, C., Guerrero‐Castillo, S., Manfredi, G., Vannucci, S. J., Arnold, S., & Galkin, A. S. (2018) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x18770331 · Cited by 31
Reprogramming of Thyroid Cancer Metabolism: from Mechanism to Therapeutic Strategy
Wan, Y., Li, G., Cui, G., Duan, S., & Chang, S. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02263-4 · Cited by 36
Electroencephalographic evidence for improved visual working memory performance during standing and exercise
Dodwell, G., Müller, H. J., & Töllner, T. (2018) · British Journal of Psychology · doi:10.1111/bjop.12352 · Cited by 31
Diabetes and the link between neuroplasticity and glutamate in the aging human motor cortex
Fried, P. J., Pascual‐Leone, Á., & Bolo, N. R. (2019) · Clinical Neurophysiology · doi:10.1016/j.clinph.2019.04.721 · Cited by 35
Alzheimer’s Disease (AD) Therapeutics—2: Beyond Amyloid—Re-Defining AD and Its Causality to Discover Effective Therapeutics
Mullane, K., & Williams, M. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.09.027 · Cited by 32
Astroglial functions
Verkhratsky, A., & Butt, A. M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-821565-4.00008-0 · Cited by 31
Brain Mitochondrial Bioenergetics in Genetic Neurodevelopmental Disorders: Focus on Down, Rett and Fragile X Syndromes
Valenti, D., & Vacca, R. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241512488 · Cited by 33
Exercise as a protective mechanism against the negative effects of oxidative stress in first-episode psychosis: a biomarker-led study
Fisher, E., Wood, S. J., Elsworthy, R. J., Upthegrove, R., & Aldred, S. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-00927-x · Cited by 32
Blood-based mitochondrial respiratory chain function in major depression
Fernström, J., Mellon, S. H., McGill, M. A., Picard, M. A., Reus, V. I., Hough, C. M., Lin, J., Epel, E. S., Wolkowitz, O. M., & Lindqvist, D. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01723-x · Cited by 39
The Potential Role of the Ketogenic Diet in Serious Mental Illness: Current Evidence, Safety, and Practical Advice
Róg, J., Wingralek, Z. J., Nowak, K., Grudzień, M., Grunwald, A., Banaszek, A., & Karakuła‐Juchnowicz, H. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13102819 · Cited by 31

Authors: Magistretti, P. J., & Allaman, I.
Affiliations: École Polytechnique Fédérale de Lausanne (CH)
Corresponding author: Magistretti, Pierre J.
ORCID: Magistretti, Pierre J.
Allaman, Igor
Venue: Neuron
Publisher: Elsevier BV
Published: 2015-05
Volume: 86
Issue: 4
Pages: 883-901
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/j.neuron.2015.03.035
OpenAlex: W1797578063
Semantic Scholar: 5422412ef48292717365807c1d50dd7887db3879
Cited by: 1,285
References: 204
Citations by year: 2026: 148 · 2025: 145 · 2024: 136 · 2023: 117 · 2022: 145 · 2021: 128 · 2020: 125 · 2019: 99 · 2018: 103 · 2017: 75 · 2016: 49 · 2015: 14
FWCI: 9.55
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 385 d)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
IRIS (submittedVersion)
King Abdullah University of Science and Technology Repository (King Abdullah University of Science and Technology) (submittedVersion)
SERVAL (Université de Lausanne) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: brain energy metabolism, glucose utilization, neuronal activity, astrocytes, energy metabolism genes, functional MRI, PET, cellular resolution
MeSH terms: Animals, Astrocytes, Brain, Energy Metabolism, Glucose, Humans, Magnetic Resonance Imaging, Neurons

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

A Cellular Perspective on Brain Energy Metabolism and Functional Imaging

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks