A Cellular Perspective on Brain Energy Metabolism and Functional Imaging

On the origin of cancer cells

Warburg, O. (1956) · Science · doi:10.1126/science.123.3191.309 · Cited by 13,425

Neurophysiological investigation of the basis of the fMRI signal

Logothetis, N. K., Pauls, J., Augath, M., Trinath, T., & Oeltermann, A. (2001) · Nature · doi:10.1038/35084005 · Cited by 6,551

Brain magnetic resonance imaging with contrast dependent on blood oxygenation.

Ogawa, S., Lee, T. M., Kay, A. R., & Tank, D. W. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.24.9868 · Cited by 6,483

THE [ 14 C]DEOXYGLUCOSE METHOD FOR THE MEASUREMENT OF LOCAL CEREBRAL GLUCOSE UTILIZATION: THEORY, PROCEDURE, AND NORMAL VALUES IN THE CONSCIOUS AND ANESTHETIZED ALBINO RAT 1

Sokoloff, L., Reivich, M., Kennedy, C., Rosiers, M. H. D., Patlak, C. S., Pettigrew, K. D., Sakurada, O., & Shinohara, M. (1977) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1977.tb10649.x · Cited by 6,000

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β

Iliff, J. J., Wang, M., Liao, Y., Plogg, B. A., Peng, W., Gundersen, G. A., Benveniste, H., Vates, G. E., Deane, R., Goldman, S. A., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003748 · Cited by 5,824

Astrocytes: Biology and pathology

Sofroniew, M. V., & Vinters, H. V. (2010) · Acta Neuropathologica · doi:10.1007/s00401-009-0619-8 · Cited by 5,196

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

Zhang, Y., Chen, K., Sloan, S. A., Bennett, M. L., Scholze, A. R., O'Keeffe, S., Phatnani, H. P., Guarnieri, P., Caneda, C., Ruderisch, N., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.1860-14.2014 · Cited by 4,875

Glutamate uptake

Danbolt, N. C. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00067-8 · Cited by 4,227

An Energy Budget for Signaling in the Grey Matter of the Brain

Attwell, D., & Laughlin, S. B. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200110000-00001 · Cited by 3,543

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

Ward, P. S., & Thompson, C. B. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.02.014 · Cited by 3,233

Lactate in the brain: from metabolic end-product to signalling molecule

Magistretti, P. J., & Allaman, I. (2018) · Nature Reviews Neuroscience · doi:10.1038/nrn.2018.19 · Cited by 1,298

13 reasons why the brain is susceptible to oxidative stress

Cobley, J. N., Fiorello, M. L., & Bailey, D. M. (2018) · Redox Biology · doi:10.1016/j.redox.2018.01.008 · Cited by 1,215

Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation

Johnson, E. C. B., Dammer, E. B., Duong, D. M., Ping, L., Zhou, M., Yin, L., Higginbotham, L. A., Guajardo, A., White, B., Troncoso, J. C., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0815-6 · Cited by 1,001

Brain Glucose Metabolism: Integration of Energetics with Function

Dienel, G. A. (2018) · Physiological Reviews · doi:10.1152/physrev.00062.2017 · Cited by 911

Cellular mitophagy: Mechanism, roles in diseases and small molecule pharmacological regulation

Lü, Y., Li, Z., Zhang, S., Zhang, T., Liu, Y., & Zhang, L. (2023) · Theranostics · doi:10.7150/thno.79876 · Cited by 738

In vivo evidence for a lactate gradient from astrocytes to neurons

Mächler, P., Wyss, M. T., Elsayed, M., Stobart, J., Gutierrez, R., von Faber-Castell, A., Kaelin, V., Zuend, M., San Martín, A., Romero-Gómez, I., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.10.010 · Cited by 571

An energetic view of stress: Focus on mitochondria

Picard, M. A., McEwen, B. S., Epel, E. S., & Sandi, C. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.01.001 · Cited by 584

Involvement of Astrocytes in Alzheimer’s Disease from a Neuroinflammatory and Oxidative Stress Perspective

González-Reyes, R. E., Nava-Mesa, M. O., Vargas-Sánchez, K., Ariza-Salamanca, D. F., & Mora-Muñoz, L. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00427 · Cited by 541

Neuroprotective Effect of Antioxidants in the Brain

Lee, K. H., Cha, M., & Lee, B. H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197152 · Cited by 543

Neuron–glia interactions in the pathophysiology of epilepsy

Patel, D. C., Tewari, B. P., Chaunsali, L., & Sontheimer, H. W. (2019) · Nature reviews. Neuroscience · doi:10.1038/s41583-019-0126-4 · Cited by 478

Microbiota-derived metabolites as drivers of gut–brain communication

Ahmed, H., Leyrolle, Q., Koistinen, V., Kärkkäinen, O., Layé, S., Delzenne, N., & Hanhineva, K. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2102878 · Cited by 462

Direct cell reprogramming: approaches, mechanisms and progress

Wang, H., Yang, Y., Liu, J., & Li, Q. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00335-z · Cited by 463

Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes

Agarwal, A., Wu, P.-H., Hughes, E. G., Fukaya, M., Tischfield, M. A., Langseth, A. J., Wirtz, D., & Bergles, D. E. (2017) · Neuron · doi:10.1016/j.neuron.2016.12.034 · Cited by 441

A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells

Maoz, B. M., Herland, A., Fitzgerald, E. A., Grevesse, T., Vidoudez, C., Pacheco, A. R., Sheehy, S. P., Park, T., Dauth, S., Mannix, R. J., et al. (2018) · Nature Biotechnology · doi:10.1038/nbt.4226 · Cited by 437

Functional Near-Infrared Spectroscopy (fNIRS) for Assessing Cerebral Cortex Function During Human Behavior in Natural/Social Situations: A Concise Review

Quaresima, V., & Ferrari, M. (2016) · Organizational Research Methods · doi:10.1177/1094428116658959 · Cited by 423

Sex differences in the developing brain: insights from multimodal neuroimaging

Kaczkurkin, A. N., Raznahan, A., & Satterthwaite, T. D. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-018-0111-z · Cited by 403

Epigenetic Regulation in Neurodegenerative Diseases

Berson, A., Nativio, R., Berger, S. L., & Bonini, N. M. (2018) · Trends in Neurosciences · doi:10.1016/j.tins.2018.05.005 · Cited by 408

Integrated proteomics reveals brain-based cerebrospinal fluid biomarkers in asymptomatic and symptomatic Alzheimer’s disease

Higginbotham, L., Ping, L., Dammer, E. B., Duong, D. M., Zhou, M., Gearing, M., Hurst, C., Glass, J. D., Factor, S. A., Johnson, E. C. B., et al. (2020) · Science Advances · doi:10.1126/sciadv.aaz9360 · Cited by 367

Integrated Proteomics Reveals Brain-Based Cerebrospinal Fluid Biomarkers in Asymptomatic and Symptomatic Alzheimer’s Disease

Higginbotham, L., Ping, L., Dammer, E. B., Duong, D. M., Zhou, M., Gearing, M., Johnson, E. C. B., Hajjar, I., Lah, J. J., Levey, A. I., et al. (2019) · doi:10.1101/806752 · Cited by 367

Mutant Huntingtin Disrupts the Nuclear Pore Complex

Grima, J. C., Daigle, J. G., Arbez, N., Cunningham, K. M., Zhang, K., Ochaba, J., Smith-Geater, C., Morozko, E. L., Stocksdale, J. T., Glatzer, J. C., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.03.023 · Cited by 358

The Link Between Angiogenesis and Endothelial Metabolism

Potente, M., & Carmeliet, P. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105134 · Cited by 360

Altered cellular metabolism in gliomas — an emerging landscape of actionable co-dependency targets

Bi, J., Chowdhry, S., Wu, S., Zhang, W., Masui, K., & Mischel, P. S. (2019) · Nature reviews. Cancer · doi:10.1038/s41568-019-0226-5 · Cited by 359

Lactate and pyruvate promote oxidative stress resistance through hormetic ROS signaling

Tauffenberger, A., Fiumelli, H., Almustafa, S., & Magistretti, P. J. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1877-6 · Cited by 352

Single-cell multiregion dissection of Alzheimer’s disease

Mathys, H., Boix, C. A., Akay, L. A., Xia, Z., Davila-Velderrain, J., Ng, A. P., Jiang, X., Abdelhady, G., Galani, K., Mantero, J., et al. (2024) · Nature · doi:10.1038/s41586-024-07606-7 · Cited by 343

Short Overview of ROS as Cell Function Regulators and Their Implications in Therapy Concepts

Milković, L., Gašparović, A. Č., Cindrić, M., Mouthuy, P., & Žarković, N. (2019) · Cells · doi:10.3390/cells8080793 · Cited by 330

Impairment of Glycolysis-Derived L-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer's Disease

Douce, J. L., Maugard, M., Veran, J., Matos, M., Jégo, P., Vigneron, P.-A., Faivre, É., Toussay, X., Vandenberghe, M. E., Balbastre, Y., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2020.02.004 · Cited by 336

Going the Extra (Synaptic) Mile: Excitotoxicity as the Road Toward Neurodegenerative Diseases

Armada‐Moreira, A., Gomes, J. I., Pina, C. C., Savchak, O. K., Gonçalves‐Ribeiro, J., Rei, N., Pinto, S., Morais, T. P., Martins, R. S., Ribeiro, F. F., et al. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00090 · Cited by 337

Astrogliosis: An integral player in the pathogenesis of Alzheimer's disease

Osborn, L. M., Kamphuis, W., Wadman, W. J., & Hol, E. M. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.01.001 · Cited by 312

The Role of Mitochondria in Reactive Oxygen Species Generation and Its Implications for Neurodegenerative Diseases

Kausar, S., Wang, F., & Cui, H. (2018) · Cells · doi:10.3390/cells7120274 · Cited by 327

Microglial metabolic flexibility supports immune surveillance of the brain parenchyma

Bernier, L., York, E. M., Kamyabi, A., Choi, H. B., Weilinger, N. L., & MacVicar, B. A. (2020) · Nature Communications · doi:10.1038/s41467-020-15267-z · Cited by 316

Astrocytes as Key Regulators of Brain Energy Metabolism: New Therapeutic Perspectives

Béard, E., Lengacher, S., Dias, S., Magistretti, P. J., & Finsterwald, C. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2021.825816 · Cited by 326

Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism

Hasel, P., Dando, O., Jiwaji, Z., Baxter, P. S., Todd, A., Heron, S., Márkus, N. M., McQueen, J., Hampton, D. W., Torvell, M., et al. (2017) · Nature Communications · doi:10.1038/ncomms15132 · Cited by 311

Capillary-associated microglia regulate vascular structure and function through PANX1-P2RY12 coupling in mice

Bisht, K., Okojie, K. A., Sharma, K. P., Lentferink, D. H., Sun, Y., Chen, H., Uweru, J. O., Amancherla, S., Calcuttawala, Z., Campos-Salazar, A. B., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25590-8 · Cited by 311

Energy matters: presynaptic metabolism and the maintenance of synaptic transmission

Li, S., & Sheng, Z. (2021) · Nature reviews. Neuroscience · doi:10.1038/s41583-021-00535-8 · Cited by 285

Bioenergetics and redox adaptations of astrocytes to neuronal activity

Bolaños, J. P. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13486 · Cited by 262

Energy metabolism in ALS: an underappreciated opportunity?

Vandoorne, T., Bock, K. D., & Bosch, L. V. D. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1835-x · Cited by 260

Pleiotropic Mitochondria: The Influence of Mitochondria on Neuronal Development and Disease

Rangaraju, V., Lewis, T. L., Hirabayashi, Y., Bergami, M., Motori, E., Cartoni, R., Kwon, S., & Courchet, J. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.1157-19.2019 · Cited by 271

Spatially aware dimension reduction for spatial transcriptomics

Shang, L., & Zhou, X. (2022) · Nature Communications · doi:10.1038/s41467-022-34879-1 · Cited by 256

Fatigue, Sleep, and Autoimmune and Related Disorders

Zielinski, M. R., Systrom, D. M., & Rose, N. R. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01827 · Cited by 281

Antioxidant Therapy in Oxidative Stress-Induced Neurodegenerative Diseases: Role of Nanoparticle-Based Drug Delivery Systems in Clinical Translation

Ashok, A., Andrabi, S. S., Mansoor, S., Kuang, Y., Kwon, B. K., & Labhasetwar, V. D. (2022) · Antioxidants · doi:10.3390/antiox11020408 · Cited by 270

Alzheimer’s Disease: From Firing Instability to Homeostasis Network Collapse

Frère, S. G. A., & Slutsky, I. (2018) · Neuron · doi:10.1016/j.neuron.2017.11.028 · Cited by 242

New insights into the role of mitochondrial dynamics in oxidative stress-induced diseases

Chen, S., Li, Q., Shi, H., Li, F., Duan, Y., & Guo, Q. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117084 · Cited by 250

RNA-binding proteins in neurodegeneration: mechanisms in aggregatePreprint

Conlon, E. G., & Manley, J. L. (2017) · Genes & Development · doi:10.1101/gad.304055.117 · Cited by 229

An astroglial basis of major depressive disorder? An overview

Wang, Q., Jie, W., Liu, J., Yang, J., & Gao, T. (2017) · Glia · doi:10.1002/glia.23143 · Cited by 222

Mitochondria, energy, and metabolism in neuronal health and disease

Trigo, D., Avelar, C., Fernandes, M., Sá, J., & Silva, O. A. B. D. C. E. (2022) · FEBS Letters · doi:10.1002/1873-3468.14298 · Cited by 225

Upregulated energy metabolism in the Drosophila mushroom body is the trigger for long-term memory

Plaçais, P.-Y., de Tredern, É., Scheunemann, L., Trannoy, S., Goguel, V., Han, K.-A., Isabel, G., & Préat, T. (2017) · Nature Communications · doi:10.1038/ncomms15510 · Cited by 213

Astrocytic mitochondrial ROS modulate brain metabolism and mouse behaviour

Vicente‐Gutiérrez, C., Bonora, N., Bobo-Jiménez, V., Jiménez-Blasco, D., López-Fabuel, I., Fernández, E., Joséphine, C., Bonvento, G., Enrı́quez, J. A., Almeida, Á., et al. (2019) · Nature Metabolism · doi:10.1038/s42255-018-0031-6 · Cited by 205

Astrocytic β 2 -adrenergic receptors mediate hippocampal long-term memory consolidation

Gao, V., Suzuki, A., Magistretti, P. J., Lengacher, S., Pollonini, G., Steinman, M. Q., & Alberini, C. M. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1605063113 · Cited by 207

Gut Microbiome–Brain Alliance: A Landscape View into Mental and Gastrointestinal Health and Disorders

Sasso, J. M., Ammar, R. M., Tenchov, R., Lemmel, S. A., Kelber, O., Grieswelle, M., & Zhou, Q. A. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00127 · Cited by 229

Elimination of substances from the brain parenchyma: efflux via perivascular pathways and via the blood–brain barrier

Hladky, S. B., & Barrand, M. A. (2018) · Fluids and Barriers of the CNS · doi:10.1186/s12987-018-0113-6 · Cited by 206

Glia-neuron energy metabolism in health and diseases: New insights into the role of nervous system metabolic transporters

Jha, M. K., & Morrison, B. M. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2018.07.009 · Cited by 203

Connexin 43-Mediated Astroglial Metabolic Networks Contribute to the Regulation of the Sleep-Wake Cycle

Clasadonte, J., Scemes, E., Wang, Z., Boison, D., & Haydon, P. G. (2017) · Neuron · doi:10.1016/j.neuron.2017.08.022 · Cited by 200

Mitochondrial metabolism in astrocytes regulates brain bioenergetics, neurotransmission and redox balance

Rose, J., Brian, C., Pappa, A., Panayiotidis, M. I., & Franco, R. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.536682 · Cited by 196

Alternative Splicing in Neurogenesis and Brain Development

Su, C.-H., Dhananjaya, D., & Tarn, W. (2018) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2018.00012 · Cited by 204

Pathophysiological subtypes of Alzheimer’s disease based on cerebrospinal fluid proteomics

Tijms, B. M., Gobom, J., Reus, L. M., Jansen, I. E., Hong, S., Dobričić, V., Kilpert, F., ten Kate, M., Barkhof, F., Tsolaki, M., et al. (2020) · Brain · doi:10.1093/brain/awaa325 · Cited by 200

Fatty acid oxidation organizes mitochondrial supercomplexes to sustain astrocytic ROS and cognition

Morant-Ferrando, B., Jiménez-Blasco, D., Alonso-Batan, P., Agulla, J., Lapresa, R., García-Rodríguez, D., Yunta-Sanchez, S., López-Fabuel, I., Fernández, E., Carmeliet, P., et al. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00835-6 · Cited by 195

Unique Metabolic Adaptations Dictate Distal Organ-Specific Metastatic Colonization

Schild, T., Low, V., Blenis, J., & Gomes, A. P. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.02.001 · Cited by 187

Mitochondria, Metabolism, and Redox Mechanisms in Psychiatric Disorders

Kim, Y., Vadodaria, K. C., Lenkei, Z., Kato, T., Gage, F. H., Marchetto, M. C., & Santos, R. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2018.7606 · Cited by 193

The neuropathobiology of multiple sclerosis

Woo, M. S., Engler, J. B., & Friese, M. A. (2024) · Nature reviews. Neuroscience · doi:10.1038/s41583-024-00823-z · Cited by 205

Oxidative stress and neurodegeneration: the involvement of iron

Carocci, A., Catalano, A. A., Sinicropi, M. S., & Genchi, G. (2018) · BioMetals · doi:10.1007/s10534-018-0126-2 · Cited by 188

Direct Neuronal Reprogramming: Achievements, Hurdles, and New Roads to Success

Gascón, S., Masserdotti, G., Russo, G. L., & Götz, M. (2017) · Cell stem cell · doi:10.1016/j.stem.2017.06.011 · Cited by 183

The interplay among oxidative stress, brain insulin resistance and AMPK dysfunction contribute to neurodegeneration in type 2 diabetes and Alzheimer disease

Barone, E., Domenico, F. D., Marzia Perluigi, A., & Butterfield, D. A. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.09.006 · Cited by 182

Increased glycolysis correlates with elevated immune activity in tumor immune microenvironment

Jiang, Z., Liu, Z., Li, M., Chen, C., & Wang, X. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.03.068 · Cited by 171

Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer’s disease

Johnson, E. C. B., Bian, S., Haque, R. U., Carter, E. K., Watson, C. M., Gordon, B. A., Ping, L., Duong, D. M., Epstein, M. P., McDade, E., et al. (2023) · Nature Medicine · doi:10.1038/s41591-023-02476-4 · Cited by 170

Lack of appropriate stoichiometry: Strong evidence against an energetically important astrocyte-neuron lactate shuttle in brain

Dienel, G. A. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.24015 · Cited by 168

Glutamate and GABA Homeostasis and Neurometabolism in Major Depressive Disorder

Sarawagi, A., Soni, N. D., & Patel, A. B. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.637863 · Cited by 184

Energy Metabolism Decline in the Aging Brain—Pathogenesis of Neurodegenerative Disorders

Błaszczyk, J. W. (2020) · Metabolites · doi:10.3390/metabo10110450 · Cited by 166

Metabolic Dysfunction in Parkinson’s Disease: Bioenergetics, Redox Homeostasis and Central Carbon Metabolism

Anandhan, A., Jacome, M. S., Lei, S., Hernández-Franco, P., Pappa, A., Panayiotidis, M. I., Powers, R., & Franco, R. (2017) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2017.03.009 · Cited by 165

Mitochondrial dysfunctions induce PANoptosis and ferroptosis in cerebral ischemia/reperfusion injury: from pathology to therapeutic potential

She, R., Liu, D., Liao, J., Wang, G., Ge, J., & Mei, Z. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1191629 · Cited by 163

mTOR/AMPK signaling in the brain: Cell metabolism, proteostasis and survival

Garza-Lombó, C., Schroder, A. L., Reyes‐Reyes, E. M., & Franco, R. (2018) · Current Opinion in Toxicology · doi:10.1016/j.cotox.2018.05.002 · Cited by 169

The solute carrier transporters and the brain: Physiological and pharmacological implications

Hu, C., Tao, L., Cao, X., & Chen, L. (2019) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2019.09.002 · Cited by 165

Brain Fuel Utilization in the Developing Brain

Steiner, P. (2019) · Annals of Nutrition and Metabolism · doi:10.1159/000508054 · Cited by 164

Microglia-Specific Metabolic Changes in Neurodegeneration

Aldana, B. I. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.03.006 · Cited by 158

Brain energy metabolism: Astrocytes in neurodegenerative diseases.

Chen, Z., Yuan, Z., Yang, S., Zhu, Y., Xue, M., Zhang, J., & Leng, L. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13982 · Cited by 153

Respiration-Deficient Astrocytes Survive As Glycolytic Cells In Vivo

Supplie, L. M., Düking, T., Campbell, G., Diaz, F., Moraes, C. T., Götz, M., Hamprecht, B., Boretius, S., Mahad, D., & Nave, K.-A. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.0756-16.2017 · Cited by 153

Stress and Psychiatric Disorders: The Role of Mitochondria

Daniels, T. E., Olsen, E. M., & Tyrka, A. R. (2020) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-082719-104030 · Cited by 157

Dysfunction of ABC transporters at the blood-brain barrier: Role in neurological disorders

Gil-Martins, E., Barbosa, D. J., Silva, V., Remião, F., & Silva, R. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107554 · Cited by 152

Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative damage

Wei, Y., Miao, Q., Zhang, Q., Mao, S., Li, M., Xu, X., Xia, X., Wei, K., Fan, Y., Zheng, X., et al. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01476-4 · Cited by 153

Reactive Oxygen Species: Beyond Their Reactive Behavior

Tauffenberger, A., & Magistretti, P. J. (2021) · Neurochemical Research · doi:10.1007/s11064-020-03208-7 · Cited by 157

The Glutamate/ GABA ‐Glutamine Cycle: Insights, Updates, and Advances

Andersen, J. V. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70029 · Cited by 170

The Interconnected Mechanisms of Oxidative Stress and Neuroinflammation in Epilepsy

Parsons, A. L. M., Bucknor, E. M. V., Castroflorio, E., Soares, T. R., Oliver, P. L., & Rial, D. (2022) · Antioxidants · doi:10.3390/antiox11010157 · Cited by 147

Astroglial glutamate transporters coordinate excitatory signaling and brain energetics

Robinson, M. B., & Jackson, J. G. (2016) · Neurochemistry International · doi:10.1016/j.neuint.2016.03.014 · Cited by 150

Linking deregulation of non-coding RNA to the core pathophysiology of Alzheimer’s disease: An integrative review

Millan, M. J. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.03.004 · Cited by 151

Glucose metabolism in nerve terminals

Ashrafi, G., & Ryan, T. A. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.03.007 · Cited by 151

Drp1/Fis1 interaction mediates mitochondrial dysfunction, bioenergetic failure and cognitive decline in Alzheimer's disease

Joshi, A. U., Saw, N. L., Shamloo, M., & Mochly‐Rosen, D. (2017) · Oncotarget · doi:10.18632/oncotarget.23640 · Cited by 150

3D neuronal mitochondrial morphology in axons, dendrites, and somata of the aging mouse hippocampus

Faitg, J., Lacefield, C., Davey, T., White, K., Laws, R., Kosmidis, S., Reeve, A. K., Kandel, E. R., Vincent, A. E., & Picard, M. A. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109509 · Cited by 139

Glial cells in Alzheimer’s disease: From neuropathological changes to therapeutic implications

Uddin, M. S., & Lim, L. W. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101622 · Cited by 154

Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome

Inak, G., Rybak‐Wolf, A., Lisowski, P., Pentimalli, T. M., Jüttner, R., Glažar, P., Uppal, K., Bottani, E., Brunetti, D., Secker, C., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22117-z · Cited by 151

The Energy Homeostasis Principle: Neuronal Energy Regulation Drives Local Network Dynamics Generating Behavior

Vergara, R. C., Jaramillo-Riveri, S., Luarte, A., Moënne‐Loccoz, C., Fuentes, R., Couve, A., & Maldonado, P. (2019) · Frontiers in Computational Neuroscience · doi:10.3389/fncom.2019.00049 · Cited by 149

Molecular Communication of a Dying Neuron in Stroke

Puig, B., Brenna, S., & Magnus, T. U. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092834 · Cited by 146

Insulin Resistance at the Crossroad of Alzheimer Disease Pathology: A Review

Berlanga‐Acosta, J., Guillén, G. E., Rodríguez-Rodríguez, N., Bringas-Vega, M. L., García-del-Barco-Herrera, D., Berlanga-Saez, J. O., Ojalvo, A. G., Valdés-Sosa, M. J., & Valdes-Sosa, P. A. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.560375 · Cited by 143

Synapses: The Brain’s Energy-Demanding Sites

Faria‐Pereira, A., & Morais, V. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073627 · Cited by 152

Energy Dynamics in the Brain: Contributions of Astrocytes to Metabolism and pH Homeostasis

Deitmer, J. W., Theparambil, S. M., Ruminot, I., Noor, S. I., & Becker, H. M. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01301 · Cited by 137

Imaging Adenosine Triphosphate (ATP)

Rajendran, M., Dane, E. L., Conley, J. M., & Tantama, M. (2016) · Biological Bulletin · doi:10.1086/689592 · Cited by 145

Astrocytes and brain-derived neurotrophic factor (BDNF)

Albini, M., Krawczun-Rygmaczewska, A., & Cesca, F. (2023) · Neuroscience Research · doi:10.1016/j.neures.2023.02.001 · Cited by 145

Glycolytic Metabolism, Brain Resilience, and Alzheimer’s Disease

Zhang, X., Alshakhshir, N., & Zhao, L. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.662242 · Cited by 134

Emerging Roles of Astrocytes in Neuro-Vascular Unit and the Tripartite Synapse With Emphasis on Reactive Gliosis in the Context of Alzheimer’s Disease

Liu, C.-Y., Yang, Y., Ju, W.-N., Wang, X., & Zhang, H.-L. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00193 · Cited by 131

Genes, Cells and Brain Areas of Intelligence

Goriounova, N. A., & Mansvelder, H. D. (2019) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2019.00044 · Cited by 148

The neurovascular unit and systemic biology in stroke — implications for translation and treatment

Tiedt, S., Buchan, A. M., Dichgans, M., Lizasoaín, I., Moro, M. Á., & Lo, E. H. (2022) · Nature Reviews Neurology · doi:10.1038/s41582-022-00703-z · Cited by 135

Brain Iron Homeostasis: A Focus on Microglial Iron

Nnah, I. C., & Wessling‐Resnick, M. (2018) · Pharmaceuticals · doi:10.3390/ph11040129 · Cited by 131

Brain Energy Metabolism

Magistretti, P. J. (2004) · Elsevier eBooks · doi:10.1016/b978-012148660-0/50004-4 · Cited by 16

The Cellular Bases of Functional Brain Imaging: Evidence for Astrocyte-Neuron Metabolic Coupling

Magistretti, P. J., & Pellerin, L. (1997) · The Neuroscientist · doi:10.1177/107385849700300608 · Cited by 15

Cellular mechanisms of brain energy metabolism and their relevance to functional brain imaging

Magistretti, P. J., & Pellerin, L. (1999) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1999.0471 · Cited by 750

Cellular Bases of Brain Energy Metabolism and Their Relevance to Functional Brain Imaging: Evidence for a Prominent Role of Astrocytes

Magistretti, P. J., & Pellerin, L. (1996) · Cerebral Cortex · doi:10.1093/cercor/6.1.50 · Cited by 243

Brain energy metabolism: focus on Astrocyte-neuron metabolic cooperation

Bélanger, M., Allaman, I., & Magistretti, P. J. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.08.016 · Cited by 2,313