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A Cellular Perspective on Brain Energy Metabolism and Functional Imaging

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Magistretti, Pierre J., Allaman, Igor·2015·Neuron

DOI 10.1016/j.neuron.2015.03.035

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Abstract

The energy demands of the brain are high: they account for at least 20% of the body's energy consumption. Evolutionary studies indicate that the emergence of higher cognitive functions in humans is associated with an increased glucose utilization and expression of energy metabolism genes. Functional brain imaging techniques such as fMRI and PET, which are widely used in human neuroscience studies, detect signals that monitor energy delivery and use in register with neuronal activity. Recent technological advances in metabolic studies with cellular resolution have afforded decisive insights into the understanding of the cellular and molecular bases of the coupling between neuronal activity and energy metabolism and point at a key role of neuron-astrocyte metabolic interactions. This article reviews some of the most salient features emerging from recent studies and aims at providing an integration of brain energy metabolism across resolution scales.

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On the origin of cancer cells
Warburg, O. (1956) · Science · doi:10.1126/science.123.3191.309 · Cited by 13,425
Neurophysiological investigation of the basis of the fMRI signal
Logothetis, N. K., Pauls, J., Augath, M., Trinath, T., & Oeltermann, A. (2001) · Nature · doi:10.1038/35084005 · Cited by 6,551
Brain magnetic resonance imaging with contrast dependent on blood oxygenation.
Ogawa, S., Lee, T. M., Kay, A. R., & Tank, D. W. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.24.9868 · Cited by 6,483
THE [ 14 C]DEOXYGLUCOSE METHOD FOR THE MEASUREMENT OF LOCAL CEREBRAL GLUCOSE UTILIZATION: THEORY, PROCEDURE, AND NORMAL VALUES IN THE CONSCIOUS AND ANESTHETIZED ALBINO RAT 1
Sokoloff, L., Reivich, M., Kennedy, C., Rosiers, M. H. D., Patlak, C. S., Pettigrew, K. D., Sakurada, O., & Shinohara, M. (1977) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1977.tb10649.x · Cited by 6,000
A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β
Iliff, J. J., Wang, M., Liao, Y., Plogg, B. A., Peng, W., Gundersen, G. A., Benveniste, H., Vates, G. E., Deane, R., Goldman, S. A., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003748 · Cited by 5,824
Astrocytes: Biology and pathology
Sofroniew, M. V., & Vinters, H. V. (2010) · Acta Neuropathologica · doi:10.1007/s00401-009-0619-8 · Cited by 5,196
An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex
Zhang, Y., Chen, K., Sloan, S. A., Bennett, M. L., Scholze, A. R., O'Keeffe, S., Phatnani, H. P., Guarnieri, P., Caneda, C., Ruderisch, N., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.1860-14.2014 · Cited by 4,875
Glutamate uptake
Danbolt, N. C. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00067-8 · Cited by 4,227
An Energy Budget for Signaling in the Grey Matter of the Brain
Attwell, D., & Laughlin, S. B. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200110000-00001 · Cited by 3,543
Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate
Ward, P. S., & Thompson, C. B. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.02.014 · Cited by 3,233
A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function
Cahoy, J. D., Emery, B., Kaushal, A., Foo, L. C., Zamanian, J. L., Christopherson, K. S., Xing, Y., Lubischer, J. L., Krieg, P. A., Krupenko, S. A., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4178-07.2008 · Cited by 3,129
Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization.
Pellerin, L., & Magistretti, P. J. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.22.10625 · Cited by 2,927
Self-citation
Glial and neuronal control of brain blood flow
Attwell, D., Buchan, A. M., Charpak, S., Lauritzen, M., MacVicar, B. A., & Newman, E. A. (2010) · Nature · doi:10.1038/nature09613 · Cited by 2,511
Brain energy metabolism: focus on Astrocyte-neuron metabolic cooperation
Bélanger, M., Allaman, I., & Magistretti, P. J. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.08.016 · Cited by 2,313
Self-citation
The expensive-tissue hypothesis: The brain and the digestive system in human and primate evolution
Aiello, L. C., & Wheeler, P. (1995) · Current Anthropology · doi:10.1086/204350 · Cited by 2,291
Oxygenation‐sensitive contrast in magnetic resonance image of rodent brain at high magnetic fields
Ogawa, S., Lee, T., Nayak, A. S., & Glynn, P. (1990) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910140108 · Cited by 2,269
Focal physiological uncoupling of cerebral blood flow and oxidative metabolism during somatosensory stimulation in human subjects.
Fox, P. T., & Raichle, M. E. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.4.1140 · Cited by 2,056
EVOLUTION OF THE BRAIN AND INTELLIGENCE
Radinsky, L., & Jerison, H. J. (1975) · Evolution · doi:10.2307/2407154 · Cited by 1,982
On the Regulation of the Blood‐supply of the Brain
Roy, C., & Sherrington, C. (1890) · The Journal of Physiology · doi:10.1113/jphysiol.1890.sp000321 · Cited by 1,834
Nonoxidative Glucose Consumption During Focal Physiologic Neural Activity
Fox, P. T., Raichle, M. E., Mintun, M. A., & Dence, C. (1988) · Science · doi:10.1126/science.3260686 · Cited by 1,796
Synaptic Energy Use and Supply
Harris, J. J., Jolivet, R., & Attwell, D. (2012) · Neuron · doi:10.1016/j.neuron.2012.08.019 · Cited by 1,747
Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation
Suzuki, A., Stern, S. A., Bozdagi, O., Huntley, G. W., Walker, R. H., Magistretti, P. J., & Alberini, C. M. (2011) · Cell · doi:10.1016/j.cell.2011.02.018 · Cited by 1,711
Self-citation
Oligodendroglia metabolically support axons and contribute to neurodegeneration
Lee, Y., Morrison, B. M., Li, Y., Lengacher, S., Farah, M. H., Hoffman, P. N., Liu, Y., Tsingalia, A., Jin, L., Zhang, P.-W., et al. (2012) · Nature · doi:10.1038/nature11314 · Cited by 1,664
Self-citation
BRAIN WORK AND BRAIN IMAGING
Raichle, M. E., & Mintun, M. A. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.112819 · Cited by 1,630
Protoplasmic Astrocytes in CA1 Stratum Radiatum Occupy Separate Anatomical Domains
Bushong, E. A., Martone, M. E., Jones, Y. Z., & Ellisman, M. H. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-01-00183.2002 · Cited by 1,578
Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity
Fünfschilling, U., Supplie, L. M., Mahad, D., Boretius, S., Saab, A. S., Edgar, J., Brinkmann, B. G., Kassmann, C. M., Tzvetanova, I. D., Möbius, W., et al. (2012) · Nature · doi:10.1038/nature11007 · Cited by 1,523
Brain magnetic resonance imaging with contrast-dependent oxygenation
Ogawa, S. (1990) · Medical Entomology and Zoology · Cited by 1,367
New roles for astrocytes: redefining the functional architecture of the brain.
Nedergaard, M., Ransom, B., & Goldman, S. A. (2003) · Trends in Neurosciences · doi:10.1016/j.tins.2003.08.008 · Cited by 1,334 · cited 1×
“Indeed, astrocytes feature multiple processes that define spherical volumes of cortex approximately 80–100 mm in diameter (Bushong et al., 2002; Nedergaard et al., 2003; Sofroniew and Vinters, 2010).”
Background
The SLC2 (GLUT) family of membrane transporters
Mueckler, M., & Thorens, B. (2013) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.07.001 · Cited by 1,328
Glial regulation of the cerebral microvasculature
Iadecola, C., & Nedergaard, M. (2007) · Nature Neuroscience · doi:10.1038/nn2003 · Cited by 1,153
The cost of cortical computation.
Lennie, P. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00135-0 · Cited by 1,134
Fundamental Neuroscience
Arbuthnott, G. W. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(99)01495-2 · Cited by 1,124
The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer
Bak, L. K., Schousboe, A., & Waagepetersen, H. S. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03913.x · Cited by 1,114
Interactions Between Electrical Activity and Cortical Microcirculation Revealed by Imaging Spectroscopy: Implications for Functional Brain Mapping
Malonek, D., & Grinvald, A. (1996) · Science · doi:10.1126/science.272.5261.551 · Cited by 1,109
Metabolic coupling between glia and neurons
Tsacopoulos, M., & Magistretti, P. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-03-00877.1996 · Cited by 1,006
Self-citation
Astroglial Metabolic Networks Sustain Hippocampal Synaptic Transmission
Rouach, N., Koulakoff, A., Abudara, V., Willecke, K., & Giaume, C. (2008) · Science · doi:10.1126/science.1164022 · Cited by 912
The perivascular astroglial sheath provides a complete covering of the brain microvessels: An electron microscopic 3D reconstruction
Mathiisen, T. M., Lehre, K. P., Danbolt, N. C., & Ottersen, O. (2010) · Glia · doi:10.1002/glia.20990 · Cited by 893
Primate Cognition
Seed, A. M., & Tomasello, M. (2010) · Topics in Cognitive Science · doi:10.1111/j.1756-8765.2010.01099.x · Cited by 854
The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C-Cdh1
Herrero-Mendez, A., Almeida, A., Fernández, E., Maestre, C., Moncada, S., & Bolaños, J. P. (2009) · Nature Cell Biology · doi:10.1038/ncb1881 · Cited by 844
Activity-driven local ATP synthesis is required for synaptic function
Rangaraju, V., Calloway, N., & Ryan, T. A. (2014) · Cell · doi:10.1016/j.cell.2013.12.042 · Cited by 836
Supply and demand in cerebral energy metabolism: the role of nutrient transporters
Simpson, I. A., Carruthers, A., & Vannucci, S. J. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600521 · Cited by 812
Activity-dependent regulation of energy metabolism by astrocytes: an update
Pellerin, L., Bouzier‐Sore, A., Aubert, A., Serres, S., Merle, M., Costalat, R., & Magistretti, P. J. (2007) · Glia · doi:10.1002/glia.20528 · Cited by 805
Self-citation
Astroglial networks: a step further in neuroglial and gliovascular interactions
Giaume, C., Koulakoff, A., Roux, L., Holcman, D., & Rouach, N. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2757 · Cited by 789
Neuron-glia metabolic coupling and plasticity
Magistretti, P. J. (2006) · Experimental Physiology · doi:10.1113/expphysiol.2010.053157 · Cited by 781
Self-citation
Sweet Sixteen for ANLS
Pellerin, L., & Magistretti, P. J. (2011) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2011.149 · Cited by 760
Self-citation
Cellular mechanisms of brain energy metabolism and their relevance to functional brain imaging
Magistretti, P. J., & Pellerin, L. (1999) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1999.0471 · Cited by 750
Self-citation
Monocarboxylate transporters in the central nervous system: distribution, regulation and function
Pierre, K., & Pellerin, L. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03168.x · Cited by 744
Neural activity triggers neuronal oxidative metabolism followed by astrocytic glycolysis
Kasischke, K. A., Vishwasrao, H. D., Fisher, P. J., Zipfel, W. R., & Webb, W. W. (2004) · Science · doi:10.1126/science.1096485 · Cited by 742
Regional aerobic glycolysis in the human brain
Vaishnavi, S. N., Vlassenko, A. G., Rundle, M. M., Snyder, A. Z., Mintun, M. A., & Raichle, M. E. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010459107 · Cited by 738
Relative brain size and basal metabolic rate in terrestrial vertebrates
Martin, R. D. (1981) · Nature · doi:10.1038/293057a0 · Cited by 711
Coupling Mechanism and Significance of the BOLD Signal: A Status Report
Hillman, E. M. C. (2014) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071013-014111 · Cited by 667
Behind the scenes of functional brain imaging: A historical and physiological perspective
Raichle, M. E. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.3.765 · Cited by 616
Lactate rise detected by 1H NMR in human visual cortex during physiologic stimulation.
Prichard, J. W., Rothman, D. L., Novotny, E. J., Petroff, O. A. C., Kuwabara, T., Avison, M. J., Howseman, A., Hanstock, C. C., & Shulman, R. G. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.13.5829 · Cited by 612
Ratio of central nervous system to body metabolism in vertebrates: its constancy and functional basis
Mink, J. W., Blumenschine, R. J., & Adams, D. B. (1981) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1981.241.3.r203 · Cited by 597
Lactate-supported synaptic function in the rat hippocampal slice preparation.
Schurr, A., West, C. A., & Rigor, B. (1988) · Science · doi:10.1126/science.3375817 · Cited by 594
Gesammelte Abhandlungen zur wissenschaftlichen Medicin
Virchow, R. (1862) · Cited by 590
Energy metabolism in astrocytes: High rate of oxidative metabolism and spatiotemporal dependence on glycolysis/glycogenolysis
Hertz, L., Peng, L., & Dienel, G. A. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600343 · Cited by 587
Signaling at the Gliovascular Interface
Simard, M., Arcuino, G., Takano, T., Liu, Q. S., & Nedergaard, M. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-27-09254.2003 · Cited by 586
Metabolic costs and evolutionary implications of human brain development
Kuzawa, C. W., Chugani, H. T., Grossman, L. I., Lipovich, L., Muzik, O., Hof, P. R., Wildman, D. E., Sherwood, C. C., Leonard, W. R., & Lange, N. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1323099111 · Cited by 585 · cited 1×
“It also appears that brain energy metabolism is inversely correlated during development, suggesting that the high metabolic cost of brain function is compensated by a slowing of the body growth rate (Kuzawa et al., 2014).”
Background
Localization of Functional Activity in the Central Nervous System by Measurement of Glucose Utilization with Radioactive Deoxyglucose
Sokoloff, L. (1981) · Journal of Cerebral Blood Flow and Metabolism · doi:10.1038/jcbfm.1981.4 · Cited by 560
Blood lactate is an important energy source for the human brain.
van Hall, G., Stømstad, M., Rasmussen, P., Jans, Ø., Zaar, M., Gam, C., Quistorff, B., Secher, N. H., & Nielsen, H. B. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.35 · Cited by 522
The Transcriptome and Metabolic Gene Signature of Protoplasmic Astrocytes in the Adult Murine Cortex
Lovatt, D., Sonnewald, U., Waagepetersen, H. S., Schousboe, A., He, W., Lin, J. H.-C., Han, X., Takano, T., Wang, S., Sim, F. J., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3404-07.2007 · Cited by 505
Lactate promotes plasticity gene expression by potentiating NMDA signaling in neurons
Yang, J., Ruchti, E., Petit, J.-M., Jourdain, P., Grenningloh, G., Allaman, I., & Magistretti, P. J. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1322912111 · Cited by 504
Self-citation
Lactate Produced by Glycogenolysis in Astrocytes Regulates Memory Processing
Newman, L. A., Korol, D. L., & Gold, P. E. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028427 · Cited by 492
Elevated gene expression levels distinguish human from non-human primate brains
Cáceres, M., Lachuer, J., Zapala, M. A., Redmond, J. C., Kudo, L., Geschwind, D. H., Lockhart, D. J., Preuss, T. M., & Barlow, C. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2135499100 · Cited by 491
Brain lactate metabolism: the discoveries and the controversies
Dienel, G. A. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2011.175 · Cited by 479
Fundamental Neuroscience
(2013) · Elsevier eBooks · doi:10.1016/c2010-0-65035-8 · Cited by 467
Aerobic glycolysis in the human brain is associated with development and neotenous gene expression
Goyal, M. S., Hawrylycz, M., Miller, J. A., Snyder, A. Z., & Raichle, M. E. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.11.020 · Cited by 459 · cited 1×
“…dorsolateral prefrontal cortex, the superior andmedial frontal gyrus, or the precuneus and posterior cingulate cortex, where it accounts for up to 25% of glucose utilization, whereas in other areas, such as the cerebellum, it is virtually nonexistent (Bauernfeind et al., 2014; Goyal et al., 2014).”
Background
In Vivo Evidence for Lactate as a Neuronal Energy Source
Wyss, M. T., Jolivet, R., Buck, A., Magistretti, P. J., & Weber, B. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0415-11.2011 · Cited by 451
Self-citation
Oxidative phosphorylation, not glycolysis, powers presynaptic and postsynaptic mechanisms underlying brain information processing
Hall, C. N., Klein-Flugge, M. C., Howarth, C., & Attwell, D. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0026-12.2012 · Cited by 451
Energy-Efficient Action Potentials in Hippocampal Mossy Fibers
Alle, H., Roth, A., & Geiger, J. R. P. (2009) · Science · doi:10.1126/science.1174331 · Cited by 429
Selective distribution of lactate dehydrogenase isoenzymes in neurons and astrocytes of human brain
Bittar, P. G., Charnay, Y., Pellerin, L., Bouras, C., & Magistretti, P. J. (1996) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199611000-00001 · Cited by 423
Self-citation
Effect of Photic Stimulation on Human Visual Cortex Lactate and Phosphates Using 1 H and 31 P Magnetic Resonance Spectroscopy
Sappey‐Marinier, D., Calabrese, G., Fein, G., Hugg, J. W., Biggins, C. A., & Weiner, M. W. (1992) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1992.82 · Cited by 413
Targeting LDH enzymes with a stiripentol analog to treat epilepsy
Sada, N., Lee, S., Katsu, T., Otsuki, T., & Inoue, T. (2015) · Science · doi:10.1126/science.aaa1299 · Cited by 413
Role of Astrocytes in Neurovascular Coupling
Petzold, G. C., & Murthy, V. N. (2011) · Neuron · doi:10.1016/j.neuron.2011.08.009 · Cited by 409
Neuronal-glial glucose oxidation and glutamatergic-GABAergic function.
Hyder, F., Patel, A. B., Gjedde, A., Rothman, D. L., Behar, K. L., & Shulman, R. G. (2006) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600263 · Cited by 408
Evolution of the Brain and Intelligence
Gould, S. J. (1974) · Science · doi:10.1126/science.185.4149.400-a · Cited by 394
Monocarboxylic Acid Transport
Halestrap, A. P. (2013) · Comprehensive physiology · doi:10.1002/cphy.c130008 · Cited by 389
The glutamate‐glutamine cycle is not stoichiometric: Fates of glutamate in brain
McKenna, M. C. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21444 · Cited by 385
Glycolysis: a bioenergetic or a survival pathway?
Bolaños, J. P., Almeida, Á., & Moncada, S. (2009) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2009.10.006 · Cited by 374
The Contribution of Blood Lactate to Brain Energy Metabolism in Humans Measured by Dynamic13C Nuclear Magnetic Resonance Spectroscopy
Boumezbeur, F., Petersen, K. F., Cline, G. W., Mason, G. F., Behar, K. L., Shulman, G. I., & Rothman, D. L. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2040-10.2010 · Cited by 362
Lactate-mediated glia-neuronal signalling in the mammalian brain
Tang, F., Lane, S., KORSAK, A. S., Paton, J. F. R., Gourine, A. V., Kasparov, S., & Teschemacher, A. G. (2014) · Nature Communications · doi:10.1038/ncomms4284 · Cited by 356
Vasoactive intestinal polypeptide induces glycogenolysis in mouse cortical slices: a possible regulatory mechanism for the local control of energy metabolism.
Magistretti, P. J., Morrison, J. H., Shoemaker, W. J., Sapin, V., & Bloom, F. E. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.10.6535 · Cited by 351
Self-citation
Scaling of Brain Metabolism with a Fixed Energy Budget per Neuron: Implications for Neuronal Activity, Plasticity and Evolution
Herculano-Houzel, S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017514 · Cited by 343
Evolution of increased glia–neuron ratios in the human frontal cortex
Sherwood, C. C., Stimpson, C. D., Raghanti, M. A., Wildman, D. E., Uddin, M., Grossman, L. I., Goodman, M., Redmond, J. C., Bonar, C. J., Erwin, J. M., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605843103 · Cited by 342
A Temporary Local Energy Pool Coupled to Neuronal Activity: Fluctuations of Extracellular Lactate Levels in Rat Brain Monitored with Rapid‐Response Enzyme‐Based Sensor
Hu, Y., & Wilson, G. S. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69041484.x · Cited by 337
Differential effects of electrical stimulation of sciatic nerve on metabolic activity in spinal cord and dorsal root ganglion in the rat.
Kadekaro, M., Crane, A. M., & Sokoloff, L. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.17.6010 · Cited by 337
Metabolic signaling by lactate in the brain
Barros, L. F. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.04.002 · Cited by 333
Neuroglia: the 150 years after
Kettenmann, H., & Verkhratsky, A. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.09.003 · Cited by 328
Lactate is a Preferential Oxidative Energy Substrate over Glucose for Neurons in Culture
Bouzier-Sore, A.-K., Voisin, P., Canioni, P., Magistretti, P. J., & Pellerin, L. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000091761.61714.25 · Cited by 328
Self-citation
The role of myelin and oligodendrocytes in axonal energy metabolism
Saab, A. S., Tzvetanova, I. D., & Nave, K.-A. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.09.008 · Cited by 324
Plasticity of Astrocytic Coverage and Glutamate Transporter Expression in Adult Mouse Cortex
Genoud, C., Quairiaux, C., Steiner, P., Hirling, H., Welker, E., & Knott, G. W. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040343 · Cited by 321
Dichloroacetate effects on glucose and lactate oxidation by neurons and astroglia in vitro and on glucose utilization by brain in vivo
Itoh, Y., Esaki, T., Shimoji, K., Cook, M., Law, M. J., Kaufman, E., & Sokoloff, L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0831078100 · Cited by 297
Glial Glutamate Transporters Mediate a Functional Metabolic Crosstalk between Neurons and Astrocytes in the Mouse Developing Cortex
Voutsinos‐Porche, B., Bonvento, G., Tanaka, K., Steiner, P., Welker, E., Chatton, J., Magistretti, P. J., & Pellerin, L. (2003) · Neuron · doi:10.1016/s0896-6273(02)01170-4 · Cited by 293
Self-citation
Lactate: A Preferred Fuel for Human Brain Metabolism in Vivo
Smith, D., Pernet, A., Hallett, W. A., Bingham, E., Marsden, P. K., & Amiel, S. A. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000063991.19746.11 · Cited by 282
Neuroprotective Role of Lactate after Cerebral Ischemia
Berthet, C., Lei, H., Thévenet, J., Rolf Gruetter, A., Magistretti, P. J., & Hirt, L. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.97 · Cited by 282
Self-citation
Multifunctional role of astrocytes as gatekeepers of neuronal energy supply
Stobart, J. L., & Anderson, C. M. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00038 · Cited by 280
Cortical energy demands of signaling and nonsignaling components in brain are conserved across mammalian species and activity levels
Hyder, F., Rothman, D. L., & Bennett, M. R. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1214912110 · Cited by 271
Competition between glucose and lactate as oxidative energy substrates in both neurons and astrocytes: a comparative NMR study
Bouzier‐Sore, A., Voisin, P., Bouchaud, V., Bezancon, E., Franconi, J., & Pellerin, L. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05056.x · Cited by 265
Brain Lactate Is an Obligatory Aerobic Energy Substrate for Functional Recovery After Hypoxia: Further In Vitro Validation
Schurr, A., Payne, R. S., Miller, J. J., & Rigor, B. M. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69010423.x · Cited by 262
Metabolic Communication between Astrocytes and Neurons via Bicarbonate-Responsive Soluble Adenylyl Cyclase
Choi, H. B., Gordon, G. R., Zhou, N., Tai, C., Rungta, R. L., Martinez, J., Milner, T. A., Ryu, J. K., McLarnon, J. G., Tresguerres, M., et al. (2012) · Neuron · doi:10.1016/j.neuron.2012.08.032 · Cited by 254
Direct measurement of glutamate release in the brain using a dual enzyme-based electrochemical sensor
Hu, Y., Mitchell, K. M., Albahadily, F., Michaelis, E. K., & Wilson, G. S. (1994) · Brain Research · doi:10.1016/0006-8993(94)90870-2 · Cited by 252
Connexin and pannexin hemichannels in brain glial cells: properties, pharmacology, and roles
Giaume, C., Leybaert, L., Naus, C. C. G., & Sáez, J. C. (2013) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00088 · Cited by 252
The role(s) of astrocytes and astrocyte activity in neurometabolism, neurovascular coupling, and the production of functional neuroimaging signals
Figley, C. R., & Stroman, P. W. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07584.x · Cited by 246
Characterization of the glycogenolysis elicited by vasoactive intestinal peptide, noradrenaline and adenosine in primary cultures of mouse cerebral cortical astrocytes
Sorg, O., & Magistretti, P. J. (1991) · Brain Research · doi:10.1016/0006-8993(91)91538-c · Cited by 241
Self-citation
Sister grouping of chimpanzees and humans as revealed by genome-wide phylogenetic analysis of brain gene expression profiles.
Uddin, M., Wildman, D. E., Liu, G., Xu, W., Johnson, R. M., Hof, P. R., Kapatos, G., Grossman, L. I., & Goodman, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308725100 · Cited by 238
Revisiting the role of neurons in neurovascular coupling
Cauli, B. (2010) · Frontiers in Neuroenergetics · doi:10.3389/fnene.2010.00009 · Cited by 236
Glial Glycogen Stores Affect Neuronal Survival during Glucose Deprivation in vitro
Swanson, R. A., & Choi, D. W. (1993) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1993.19 · Cited by 231
The neurochemical profile quantified by in vivo 1H NMR spectroscopy
Duarte, J. M. N., Lei, H., Mlynárik, V., & Rolf Gruetter, A. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.12.038 · Cited by 230
Interpreting oxygenation-based neuroimaging signals: the importance and the challenge of understanding brain oxygen metabolism
Buxton, R. B. (2010) · Frontiers in Neuroenergetics · doi:10.3389/fnene.2010.00008 · Cited by 229
Transfer of glycogen-derived lactate from astrocytes to axons via specific monocarboxylate transporters supports mouse optic nerve activity
Tekkök, S. B., Brown, A. M., Westenbroek, R., Pellerin, L., & Ransom, B. R. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20573 · Cited by 224
Lactate Modulates the Activity of Primary Cortical Neurons through a Receptor-Mediated Pathway
Bozzo, L., Puyal, J., & Chatton, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071721 · Cited by 222
Predominant enhancement of glucose uptake in astrocytes versus neurons during activation of the somatosensory cortex
Chuquet, J., Quilichini, P., Nimchinsky, E. A., & Buzsáki, G. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.0762-10.2010 · Cited by 217
Nonlinear coupling between cerebral blood flow, oxygen consumption, and ATP production in human visual cortex.
Lin, A.-L., Fox, P. T., Hardies, J., Duong, T. Q., & Gao, J.-H. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909711107 · Cited by 213
Brain glycogen—new perspectives on its metabolic function and regulation at the subcellular level
Obel, L. F., Müller, M. S., Walls, A. B., Sickmann, H. M., Bak, L. K., Waagepetersen, H. S., & Schousboe, A. (2012) · Frontiers in Neuroenergetics · doi:10.3389/fnene.2012.00003 · Cited by 209
Glutamate Uptake Stimulates Na+,K+‐ATPase Activity in Astrocytes via Activation of a Distinct Subunit Highly Sensitive to Ouabain
Pellerin, L., & Magistretti, P. J. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69052132.x · Cited by 209
Self-citation
Cerebral metabolic effects of exogenous lactate supplementation on the injured human brain
Bouzat, P., Sala, N., Suys, T., Zerlauth, J.-B., Marques-Vidal, P. M., Feihl, F., Bloch, J., Messerer, M., Levivier, M., Meuli, R. A., et al. (2014) · Intensive Care Medicine · doi:10.1007/s00134-013-3203-6 · Cited by 206
Self-citation
The human brain utilizes lactate via the tricarboxylic acid cycle: a 13C-labelled microdialysis and high-resolution nuclear magnetic resonance study
Gallagher, C., Carpenter, K. L. H., Grice, P., Howe, D. J., Mason, A., Timofeev, I. S., Menon, D. K., Kirkpatrick, P. J., Pickard, J. D., Sutherland, G. R., et al. (2009) · Brain · doi:10.1093/brain/awp202 · Cited by 201
Fast and Reversible Stimulation of Astrocytic Glycolysis by K+and a Delayed and Persistent Effect of Glutamate
Bittner, C. X., Valdebenito, R., Ruminot, I., Loaiza, A., Larenas, V., Sotelo-Hitschfeld, T., Moldenhauer, H. J., Martín, A. S., Gutiérrez, R., Zambrano, M., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5311-10.2011 · Cited by 190
The in vivo neuron‐to‐astrocyte lactate shuttle in human brain: evidence from modeling of measured lactate levels during visual stimulation
Mangia, S., Simpson, I. A., Vannucci, S. J., & Carruthers, A. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06003.x · Cited by 189
Accelerated evolution of the electron transport chain in anthropoid primates
Grossman, L. I., Wildman, D. E., Schmidt, T. R., & Goodman, M. (2004) · Trends in Genetics · doi:10.1016/j.tig.2004.09.002 · Cited by 186
Direct evidence for activity-dependent glucose phosphorylation in neurons with implications for the astrocyte-to-neuron lactate shuttle
Patel, A. B., Lai, J. C. K., Chowdhury, G. M. I., Hyder, F., Rothman, D. L., Shulman, R. G., & Behar, K. L. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1403576111 · Cited by 186
A mouse model for Glut-1 haploinsufficiency
Wang, D., Pascual, J. M., Yang, H., Engelstad, K., Mao, X., Cheng, J., Yoo, J. H., Noebels, J. L., & Vivo, D. C. D. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl032 · Cited by 185
Role of sodium and potassium ions in regulation of glucose metabolism in cultured astroglia.
Takahashi, S., Driscoll, B. F., Law, M. J., & Sokoloff, L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.10.4616 · Cited by 184
Astrocyte Glycogen Sustains Neuronal Activity during Hypoglycemia: Studies with the Glycogen Phosphorylase Inhibitor CP-316,819 ([R-R*,S*]-5-Chloro-N-[2-hydroxy-3-(methoxymethylamino)-3-oxo-1-(phenylmethyl)propyl]-1 H-indole-2-carboxamide)
Suh, S. W., Bergher, J. P., Anderson, C. M., Treadway, J. L., Fosgerau, K., & Swanson, R. A. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.115550 · Cited by 182
Astrocytes generate Na + -mediated metabolic waves
Bernardinelli, Y., Magistretti, P. J., & Chatton, J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405315101 · Cited by 178
Self-citation
Phosphorylation status of pyruvate dehydrogenase distinguishes metabolic phenotypes of cultured rat brain astrocytes and neurons
Halim, N. D., Mcfate, T., Mohyeldin, A., Okagaki, P., Korotchkina, L. G., Patel, M. S., Jeoung, N. H., Harris, R. A., Schell, M. J., & Verma, A. (2010) · Glia · doi:10.1002/glia.20996 · Cited by 177
Astrocyte glycogen metabolism is required for neural activity during aglycemia or intense stimulation in mouse white matter
Brown, A. M., Sickmann, H. M., Fosgerau, K., Lund, T. M., Schousboe, A., Waagepetersen, H. S., & Ransom, B. R. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20335 · Cited by 169
Specializations of the granular prefrontal cortex of primates: Implications for cognitive processing
Elston, G. N., Benavides‐Piccione, R., Elston, A., Zietsch, B., Defelipe, J., Manger, P., Casagrande, V., & Kaas, J. H. (2006) · The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology · doi:10.1002/ar.a.20278 · Cited by 167
Endogenous Monocarboxylates Sustain Hippocampal Synaptic Function and Morphological Integrity during Energy Deprivation
Izumi, Y., Benz, A. M., Katsuki, H., & Zorumski, C. F. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-24-09448.1997 · Cited by 166
Global and regional brain metabolic scaling and its functional consequences.
Karbowski, J. (2007) · BMC Biology · doi:10.1186/1741-7007-5-18 · Cited by 161
Metabolic and Hemodynamic Events after Changes in Neuronal Activity: Current Hypotheses, Theoretical Predictions and in vivo NMR Experimental Findings
Mangia, S., Giove, F., Tkáč, I., Logothetis, N. K., Henry, P.-G., Olman, C. A., Maraviglia, B., Di Salle, F., & Uğurbil, K. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2008.134 · Cited by 161
New Evidence of Neuroprotection by Lactate after Transient Focal Cerebral Ischaemia: Extended Benefit after Intracerebroventricular Injection and Efficacy of Intravenous Administration
Berthet, C., Castillo, X., Magistretti, P. J., & Hirt, L. (2012) · Cerebrovascular Diseases · doi:10.1159/000343657 · Cited by 155
Self-citation
Cellular bases of functional brain imaging: insights from neuron-glia metabolic coupling11Published on the World Wide Web on 12 October 2000.
Magistretti, P. J. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02945-0 · Cited by 153
Self-citation
NBCe1 Mediates the Acute Stimulation of Astrocytic Glycolysis by Extracellular K +
Ruminot, I., Gutiérrez, R., Peña-Münzenmayer, G., Añazco, C. C., Sotelo-Hitschfeld, T., Lerchundi, R., Niemeyer, M. I., Shull, G. E., & Barros, L. F. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.2310-11.2011 · Cited by 148
The redox switch/redox coupling hypothesis
Cerdán, S., Rodrigues, T. B., Sierra, A., Benito, M., Fonseca, L. L., Fonseca, C. P., & García-Martín, M. L. (2006) · Neurochemistry International · doi:10.1016/j.neuint.2005.12.036 · Cited by 146
Net increase of lactate and glutamate concentration in activated human visual cortex detected with magnetic resonance spectroscopy at 7 tesla
Schaller, B., Ralf Mekle, A., Xin, L., Kunz, N., & Rolf Gruetter, A. (2013) · Journal of Neuroscience Research · doi:10.1002/jnr.23194 · Cited by 146
K+ at concentrations reached in the extracellular space during neuronal activity promotes a Ca2+-dependent glycogen hydrolysis in mouse cerebral cortex
Hof, P. R., Pascale, E., & Magistretti, P. J. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-06-01922.1988 · Cited by 145
Self-citation
INVERSE ENZYMATIC CHANGES IN NEURONS AND GLIA DURING INCREASED FUNCTION AND HYPOXIA
Hamberger, A., & Hydén, H. (1963) · The Journal of Cell Biology · doi:10.1083/jcb.16.3.521 · Cited by 144
Role of the Glyoxalase System in Astrocyte-Mediated Neuroprotection
Bélanger, M., Yang, J.-Y., Petit, J.-M., Laroche, T., Magistretti, P. J., & Allaman, I. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1249-11.2011 · Cited by 140
Self-citation
Blockade of lactate transport exacerbates delayed neuronal damage in a rat model of cerebral ischemia
Schurr, A., Payne, R. S., Miller, J. J., Tseng, M. T., & Rigor, B. M. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02082-0 · Cited by 139
Glutamate mediates acute glucose transport inhibition in hippocampal neurons
Porras, O. H., Loaiza, A., & Barros, L. F. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1882-04.2004 · Cited by 139
Unraveling the complex metabolic nature of astrocytes
Bouzier-Sore, A.-K., & Pellerin, L. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00179 · Cited by 134
Advanced glycation endproducts and their pathogenic roles in neurological disorders
Münch, G. W., Westcott, B., Menini, T., & Gugliucci, A. (2010) · Amino Acids · doi:10.1007/s00726-010-0777-y · Cited by 133
Pyruvate participation in the low molecular weight trophic activity for central nervous system neurons in glia-conditioned media
Selak, I., Skaper, S. D., & Varon, S. S. (1985) · Journal of Neuroscience · doi:10.1523/jneurosci.05-01-00023.1985 · Cited by 133
13C MR Spectroscopy Study of Lactate as Substrate for Rat Brain
Qu, H., Haberg, A. K., Haraldseth, O., Unsgård, G., & Sonnewald, U. (2000) · Developmental Neuroscience · doi:10.1159/000017472 · Cited by 132
Effects of lactate and pyruvate on glucose deprivation in rat hippocampal slices
Izumi, Y., Benz, A. M., Zorumski, C. F., & Olney, J. W. (1994) · Neuroreport · doi:10.1097/00001756-199401000-00021 · Cited by 132
Astrocyte regulation of cerebral vascular tone
Filosa, J. A., & Iddings, J. A. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00359.2013 · Cited by 130
A quantitative overview of glucose dynamics in the gliovascular unit
Barros, L. F., Bittner, C. X., Loaiza, A., & Porras, O. H. (2007) · Glia · doi:10.1002/glia.20375 · Cited by 124
Positron Emission Tomography
Raichle, M. E. (1983) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.06.030183.001341 · Cited by 124
Inhibition of Monocarboxylate Transporter 2 in the Retrotrapezoid Nucleus in Rats: A Test of the Astrocyte–Neuron Lactate-Shuttle Hypothesis
Erlichman, J. S., Hewitt, A. J., Damon, T., Hart, M. P., Kurascz, J., Li, A., & Leiter, J. C. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5430-07.2008 · Cited by 121
Arachidonic acid stimulates glucose uptake in cerebral cortical astrocytes.
Yu, N., Martin, J., Stella, N., & Magistretti, P. J. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.9.4042 · Cited by 120
Self-citation
Brain Energy Metabolism
Allaman, I., & Magistretti, P. J. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-385870-2.00012-3 · Cited by 113
Self-citation
Is lactate a volume transmitter of metabolic states of the brain?
Bergersen, L. H., & GJEDDE, A. H. (2012) · Frontiers in Neuroenergetics · doi:10.3389/fnene.2012.00005 · Cited by 111
13C NMR of Intermediary Metabolism: Implications for Systemic Physiology
Shulman, R. G., & Rothman, D. L. (2001) · Annual Review of Physiology · doi:10.1146/annurev.physiol.63.1.15 · Cited by 110
Multi-timescale Modeling of Activity-Dependent Metabolic Coupling in the Neuron-Glia-Vasculature Ensemble
Jolivet, R., Coggan, J. S., Allaman, I., & Magistretti, P. J. (2015) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1004036 · Cited by 110
Self-citation
The aerobic brain: lactate decrease at the onset of neural activity
Mangia, S., Garreffa, G., Bianciardi, M., Giove, F., Salle, F. D., & Maraviglia, B. (2003) · Neuroscience · doi:10.1016/s0306-4522(02)00792-3 · Cited by 107
Glutamate Transport Decreases Mitochondrial pH and Modulates Oxidative Metabolism in Astrocytes
Azarias, G., Perreten, H., Lengacher, S., Poburko, D., Demaurex, N., Magistretti, P. J., & Chatton, J.-Y. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.4378-10.2011 · Cited by 107
Self-citation
Higher Transport and Metabolism of Glucose in Astrocytes Compared with Neurons: A Multiphoton Study of Hippocampal and Cerebellar Tissue Slices
Jakoby, P., Schmidt, E. M., Ruminot, I., Gutierrez, R., Barros, L. F., & Deitmer, J. W. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhs309 · Cited by 107
The Metabolism of [3‐13C]Lactate in the Rat Brain Is Specific of a Pyruvate Carboxylase‐Deprived Compartment
Bouzier‐Sore, A., Thiaudière, E., Biran, M., Rouland, R., Canioni, P., & Merle, M. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0750480.x · Cited by 105
Aerobic glycolysis in the primate brain: Reconsidering the implications for growth and maintenance
Bauernfeind, A. L., Barks, S. K., Duka, T., Grossman, L. I., Hof, P. R., & Sherwood, C. C. (2014) · Brain Structure and Function · doi:10.1007/s00429-013-0662-z · Cited by 105
The story of the initial dip in fMRI
Hu, X. P., & Yacoub, E. S. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.03.005 · Cited by 102
Rapid metabolic evolution in human prefrontal cortex
Fu, X., Giavalisco, P., Liu, X., Catchpole, G., Fu, N., Ning, Z., Guo, S., Zheng, Y., Somel, M., Pääbo, S., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019164108 · Cited by 101
A coherent neurobiological framework for functional neuroimaging provided by a model integrating compartmentalized energy metabolism
Aubert, A., Pellerin, L., Magistretti, P. J., & Costalat, R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605864104 · Cited by 98
Self-citation
Noradrenaline- and vasoactive intestinal peptide-containing neuronal systems in neocortex: Functional convergence with contrasting morphology
Magistretti, P. J., & Morrison, J. H. (1988) · Neuroscience · doi:10.1016/0306-4522(88)90338-7 · Cited by 94
Self-citation
A Guide to Delineate the Logic of Neurovascular Signaling in the Brain
Kleinfeld, D., Blinder, P., Drew, P. J., Driscoll, J. D., Muller, A., Tsai, P. S., & Shih, A. Y. (2011) · Frontiers in Neuroenergetics · doi:10.3389/fnene.2011.00001 · Cited by 94
SUBSTANCES WHICH SUPPORT RESPIRATION AND METABOLIC RESPONSE TO ELECTRICAL IMPULSES IN HUMAN CEREBRAL TISSUES
MCILWAIN, H. (1953) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.16.4.257 · Cited by 93
Changes in Glucose Uptake Rather than Lactate Shuttle Take Center Stage in Subserving Neuroenergetics: Evidence from Mathematical Modeling
DiNuzzo, M., Mangia, S., Maraviglia, B., & Giove, F. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.232 · Cited by 93
Exceptional Evolutionary Divergence of Human Muscle and Brain Metabolomes Parallels Human Cognitive and Physical Uniqueness
Bozek, K., Wei, Y., Yan, Z., Liu, X., Xiong, J., Sugimoto, M., Tomita, M., Pääbo, S., Pieszek, R., Sherwood, C. C., et al. (2014) · PLoS Biology · doi:10.1371/journal.pbio.1001871 · Cited by 93
Local Injection of Antisense Oligonucleotides Targeted to the Glial Glutamate Transporter GLAST Decreases the Metabolic Response to Somatosensory Activation
Cholet, N., Pellerin, L., Welker, E., Lacombe, P. M., Seylaz, J., Magistretti, P. J., & Bonvento, G. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200104000-00009 · Cited by 90
Self-citation
Cerebral glycolysis: a century of persistent misunderstanding and misconception
Schurr, A. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00360 · Cited by 90
Deciphering neuron-glia compartmentalization in cortical energy metabolism
Jolivet, R. (2009) · Frontiers in Neuroenergetics · doi:10.3389/neuro.14.004.2009 · Cited by 89
Relationship between L-glutamate-regulated intracellular Na+ dynamics and ATP hydrolysis in astrocytes
Magistretti, P. J., & Chatton, J. (2004) · Journal of Neural Transmission · doi:10.1007/s00702-004-0171-6 · Cited by 88
Self-citation
Comment on Recent Modeling Studies of Astrocyte–Neuron Metabolic Interactions
Jolivet, R., Allaman, I., Pellerin, L., Magistretti, P. J., & Weber, B. (2010) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2010.132 · Cited by 83
Self-citation
Lactate and the injured brain
Bouzat, P., & Oddo, M. (2014) · Current Opinion in Critical Care · doi:10.1097/mcc.0000000000000072 · Cited by 81
Scaling laws in the mammalian neocortex: Does form provide clues to function?
Harrison, K. H., Hof, P. R., & Wang, S. S.-H. (2002) · Journal of Neurocytology · doi:10.1023/a:1024178127195 · Cited by 78
Variations in mitochondrial structure and content of neurons and neuroglia in rat brain: An electron microscopic study
Pysh, J. J., & Khan, T. A. (1972) · Brain Research · doi:10.1016/0006-8993(72)90762-7 · Cited by 78
The source of physiologically stimulated glutamate efflux from the striatum of conscious rats.
Miele, M., Boutelle, M. G., & Fillenz, M. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021805 · Cited by 75
Aerobic production and utilization of lactate satisfy increased energy demands upon neuronal activation in hippocampal slices and provide neuroprotection against oxidative stress
Schurr, A. (2011) · Frontiers in Pharmacology · doi:10.3389/fphar.2011.00096 · Cited by 74
Astrocyte-neuron crosstalk regulates the expression and subcellular localization of carbohydrate metabolism enzymes
Mamczur, P., Borsuk, B., Paszko, J., Sas, Z., Mozrzymas, J., Wiśniewski, J. R., Gizak, A., & Rakus, D. (2015) · Glia · doi:10.1002/glia.22753 · Cited by 71
A KINETIC STUDY OF THE NEURON-GLIA RELATIONSHIP
Hydén, H., & Lange, P. W. (1962) · The Journal of Cell Biology · doi:10.1083/jcb.13.2.233 · Cited by 68
On-Site Energy Supply at Synapses through Monocarboxylate Transporters Maintains Excitatory Synaptic Transmission
Nagase, M., Takahashi, Y., Watabe, A. M., Kubo, Y., & Kato, F. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.4687-12.2014 · Cited by 67
Small is fast: astrocytic glucose and lactate metabolism at cellular resolution
Barros, L. F., Martín, A. S., Sotelo-Hitschfeld, T., Lerchundi, R., Fernández‐Moncada, I., Ruminot, I., Gutiérrez, R., Valdebenito, R., Ceballo, S., Alegría, K., et al. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00027 · Cited by 64
Dual-Gene, Dual-Cell Type Therapy against an Excitotoxic Insult by Bolstering Neuroenergetics
Bliss, T. M., Ip, M., Cheng, E., Minami, M., Pellerin, L., Magistretti, P. J., & Sapolsky, R. M. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0805-04.2004 · Cited by 63
Self-citation
Lactate Effectively Covers Energy Demands during Neuronal Network Activity in Neonatal Hippocampal Slices
Ivanov, A., Mukhtarov, M. R., Bregestovski, P. D., & Zilberter, Y. (2011) · Frontiers in Neuroenergetics · doi:10.3389/fnene.2011.00002 · Cited by 62
Positive selection on gene expression in the human brain
Khaitovich, P., Tang, K., Franz, H., Kelso, J. F., Hellmann, I., Enard, W., Lachmann, M., & Pääbo, S. (2006) · Current Biology · doi:10.1016/j.cub.2006.03.082 · Cited by 58
Glial Glutamate Transporters and Maturation of the Mouse Somatosensory Cortex
Voutsinos‐Porche, B. (2003) · Cerebral Cortex · doi:10.1093/cercor/13.10.1110 · Cited by 57
Ex Vivo Analysis of Lactate and Glucose Metabolism in the Rat Brain under Different States of Depressed Activity
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Early acquisition of typical metabolic features upon differentiation of mouse neural stem cells into astrocytes
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Low-Cost Travel in Neurons
Magistretti, P. J. (2009) · Science · doi:10.1126/science.1180102 · Cited by 49
Self-citation
Brain glucose transporter (Glut3) haploinsufficiency does not impair mouse brain glucose uptake
Stuart, C. A., Ross, I. R., Howell, M. E. A., McCurry, M. P., Wood, T. G., Ceci, J. D., Kennel, S. J., & Wall, J. S. (2011) · Brain Research · doi:10.1016/j.brainres.2011.02.014 · Cited by 49
NEURONAL EXTENSION AND GLIAL SUPPLY: FUNCTIONAL SIGNIFICANCE OF GLIA
Friede, R. L., & Houten, W. H. V. (1962) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.48.5.817 · Cited by 43
Ex vivo NMR study of lactate metabolism in rat brain under various depressed states
Serres, S., Bezançon, E., Franconi, J., & Merle, M. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20277 · Cited by 43
β2‐ and β3‐Adrenoceptors activate glucose uptake in chick astrocytes by distinct mechanisms: a mechanism for memory enhancement?
Hutchinson, D. S., Summers, R. J., & Gibbs, M. E. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04789.x · Cited by 42
Adenosine triphosphate and arachidonic acid stimulate glycogenolysis in primary cultures of mouse cerebral cortical astrocytes
Sorg, O., Pellerin, L., Stolz, M., Beggah, S., & Magistretti, P. J. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)11410-x · Cited by 42
Self-citation
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Sampol, D., Ostrofet, E., Jobin, M., Raffard, G., Sanchez, S., Bouchaud, V., Franconi, J., Bonvento, G., & Bouzier‐Sore, A. (2013) · Frontiers in Neuroenergetics · doi:10.3389/fnene.2013.00005 · Cited by 39
Characterization of sustained BOLD activation in the rat barrel cortex and neurochemical consequences
Just, N., Xin, L., Frenkel, H., & Gruetter, R. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.02.042 · Cited by 35
Neuronal functions, feeding behavior, and energy balance inSlc2a3+/−mice
Schmidt, S., Richter, M., Montag, D., Sartorius, T., Gawlik, V., Hennige, A. M., Scherneck, S., Himmelbauer, H., Lutz, S. Z., Augustin, R., et al. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90491.2008 · Cited by 35
Phylogenomic evidence of adaptive evolution in the ancestry of humans
Goodman, M., & Sterner, K. N. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914626107 · Cited by 32
Glycogen function in adult central and peripheral nerves
Evans, R. D., Brown, A. M., & Ransom, B. R. (2013) · Journal of Neuroscience Research · doi:10.1002/jnr.23229 · Cited by 30

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Andriezen, 1893, On a system of fibre-like cells surrounding the blood vessels of the brain of man and mammals, and its physiological significance, Int. Monatsschr. Anat. Physiol., 10, 532

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Self-citation
13 reasons why the brain is susceptible to oxidative stress
Cobley, J. N., Fiorello, M. L., & Bailey, D. M. (2018) · Redox Biology · doi:10.1016/j.redox.2018.01.008 · Cited by 1,215
Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation
Johnson, E. C. B., Dammer, E. B., Duong, D. M., Ping, L., Zhou, M., Yin, L., Higginbotham, L. A., Guajardo, A., White, B., Troncoso, J. C., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0815-6 · Cited by 1,001
Brain Glucose Metabolism: Integration of Energetics with Function
Dienel, G. A. (2018) · Physiological Reviews · doi:10.1152/physrev.00062.2017 · Cited by 911
Cellular mitophagy: Mechanism, roles in diseases and small molecule pharmacological regulation
Lü, Y., Li, Z., Zhang, S., Zhang, T., Liu, Y., & Zhang, L. (2023) · Theranostics · doi:10.7150/thno.79876 · Cited by 738

See all 1,285

Authors: Magistretti, P. J., & Allaman, I.
Affiliations: École Polytechnique Fédérale de Lausanne (CH)
Corresponding author: Magistretti, Pierre J.
ORCID: Magistretti, Pierre J.
Allaman, Igor
Venue: Neuron
Publisher: Elsevier BV
Published: 2015-05
Volume: 86
Issue: 4
Pages: 883-901
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/j.neuron.2015.03.035
OpenAlex: W1797578063
Semantic Scholar: 5422412ef48292717365807c1d50dd7887db3879
Cited by: 1,285
References: 204
Citations by year: 2026: 148 · 2025: 145 · 2024: 136 · 2023: 117 · 2022: 145 · 2021: 128 · 2020: 125 · 2019: 99 · 2018: 103 · 2017: 75 · 2016: 49 · 2015: 14
FWCI: 9.55
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 385 d)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
IRIS (submittedVersion)
King Abdullah University of Science and Technology Repository (King Abdullah University of Science and Technology) (submittedVersion)
SERVAL (Université de Lausanne) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: brain energy metabolism, glucose utilization, neuronal activity, astrocytes, energy metabolism genes, functional MRI, PET, cellular resolution
MeSH terms: Animals, Astrocytes, Brain, Energy Metabolism, Glucose, Humans, Magnetic Resonance Imaging, Neurons

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A Cellular Perspective on Brain Energy Metabolism and Functional Imaging

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