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Memory Engram Cells Have Come of Age
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Cites
Hebb, D. O. (2005) · doi:10.4324/9781410612403 · Cited by 9,825
REMEMBERING: A STUDY IN EXPERIMENTAL AND SOCIAL PSYCHOLOGY
Bartlett, F. C., & Burt, C. (1933) · British Journal of Educational Psychology · doi:10.1111/j.2044-8279.1933.tb02913.x · Cited by 7,475
Malenka, R. C., & Bear, M. F. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.012 · Cited by 3,968
Morris, R. G. M., Anderson, E., Lynch, G. S., & Baudry, M. (1986) · Nature · doi:10.1038/319774a0 · Cited by 3,640
Remembering the past to imagine the future: the prospective brain
Schacter, D. L., Addis, D. R., & Buckner, R. L. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2213 · Cited by 2,394 · cited 3×
“Unfortunately, Semon’s contributions were almost completely ignored by mainstream psychologists concerned with the human memory process until the late 1970s and early 1980s, when Daniel Schacter, James Eich, and Endel Tulving revived Semon’s theory (Schacter, 1982; Schacter et al., 1978).”
Invariant visual representation by single neurons in the human brain
Quiroga, R. Q., Reddy, L., Kreiman, G., Koch, C., & Fried, I. (2005) · Nature · doi:10.1038/nature03687 · Cited by 1,988
The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory.
Tsien, J. Z., Huerta, P. T., & Tonegawa, S. (1996) · Cell · doi:10.1016/s0092-8674(00)81827-9 · Cited by 1,782 · cited 2×
“…AP5, supported the notion that LTP is essential for spatial learning (Morris et al., 1986), and the validity of this notion was demonstrated with more specific targeted genetic ablation of the NMDAR in the CA1 region of the hippocampus (Tsien et al., 1996; but see Bannerman et al., 2012).”
Self-citationThe Amygdaloid Complex: Anatomy and Physiology
SAH, P., FABER, E. S. L., LOPEZ DE ARMENTIA, M., & POWER, J. (2003) · Physiological Reviews · doi:10.1152/physrev.00002.2003 · Cited by 1,745
Neuronal signalling of fear memory
Maren, S., & Quirk, G. J. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1535 · Cited by 1,428
Keller, M. B., McCullough, J. P., Klein, D. N., Arnow, B., Dunner, D. L., Gelenberg, A. J., Markowitz, J. C., Nemeroff, C. B., Russell, J. M., Thase, M. E., et al. (2000) · New England Journal of Medicine · doi:10.1056/nejm200005183422001 · Cited by 1,331
Research works printed but not linked: 67
- Anderson, 2001, Lesions of the human amygdala impair enhanced perception of emotionally salient events, Nature, 411, 305, 10.1038/35077083 · DOI · Paper page
- Bailey, 1993, Structural changes accompanying memory storage, Annu. Rev. Physiol., 55, 397, 10.1146/annurev.ph.55.030193.002145 · DOI
- Bannerman, 2012, Dissecting spatial knowledge from spatial choice by hippocampal NMDA receptor deletion, Nat. Neurosci., 15, 1153, 10.1038/nn.3166 · DOI
- Bliss, 1973, Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path, J. Physiol., 232, 331, 10.1113/jphysiol.1973.sp010273 · DOI · Paper page
- Britt, 2012, Synaptic and behavioral profile of multiple glutamatergic inputs to the nucleus accumbens, Neuron, 76, 790, 10.1016/j.neuron.2012.09.040 · DOI · Paper page
- Cabeza, 2001, Can medial temporal lobe regions distinguish true from false? An event-related functional MRI study of veridical and illusory recognition memory, Proc. Natl. Acad. Sci. USA, 98, 4805, 10.1073/pnas.081082698 · DOI · Paper page
- Chen, 2015, Wireless magnetothermal deep brain stimulation, Science, 347, 1477, 10.1126/science.1261821 · DOI · Paper page
- Christian, 2003, Neural substrates of eyeblink conditioning: acquisition and retention, Learn. Mem., 10, 427, 10.1101/lm.59603 · DOI
- Cowansage, 2014, Direct reactivation of a coherent neocortical memory of context, Neuron, 84, 432, 10.1016/j.neuron.2014.09.022 · DOI · Paper page
- Czajkowski, 2014, Encoding and storage of spatial information in the retrosplenial cortex, Proc. Natl. Acad. Sci. USA, 111, 8661, 10.1073/pnas.1313222111 · DOI
- Daoudal, 2003, Long-term plasticity of intrinsic excitability: learning rules and mechanisms, Learn. Mem., 10, 456, 10.1101/lm.64103 · DOI · Paper page
- Deng, 2013, Selection of distinct populations of dentate granule cells in response to inputs as a mechanism for pattern separation in mice, eLife, 2, e00312, 10.7554/eLife.00312 · DOI
- Denny, 2014, Hippocampal memory traces are differentially modulated by experience, time, and adult neurogenesis, Neuron, 83, 189, 10.1016/j.neuron.2014.05.018 · DOI · Paper page
- Do-Monte, 2015, A temporal shift in the circuits mediating retrieval of fear memory, Nature, 519, 460, 10.1038/nature14030 · DOI · Paper page
- Eguchi, 2009, In vivo and in vitro visualization of gene expression dynamics over extensive areas of the brain, Neuroimage, 44, 1274, 10.1016/j.neuroimage.2008.10.046 · DOI
- Ehrlich, 2009, Amygdala inhibitory circuits and the control of fear memory, Neuron, 62, 757, 10.1016/j.neuron.2009.05.026 · DOI · Paper page
- Flavell, 2008, Signaling mechanisms linking neuronal activity to gene expression and plasticity of the nervous system, Annu. Rev. Neurosci., 31, 563, 10.1146/annurev.neuro.31.060407.125631 · DOI · Paper page
- Fuster, 1981, Inferotemporal neurons distinguish and retain behaviorally relevant features of visual stimuli, Science, 212, 952, 10.1126/science.7233192 · DOI · Paper page
- Gelbard-Sagiv, 2008, Internally generated reactivation of single neurons in human hippocampus during free recall, Science, 322, 96, 10.1126/science.1164685 · DOI · Paper page
- Gerber, 2004, An engram found? Evaluating the evidence from fruit flies, Curr. Opin. Neurobiol., 14, 737, 10.1016/j.conb.2004.10.014 · DOI
- Gore, 2015, Neural Representations of Unconditioned Stimuli in Basolateral Amygdala Mediate Innate and Learned Responses, Cell, 162, 134, 10.1016/j.cell.2015.06.027 · DOI
- Goshen, 2011, Dynamics of retrieval strategies for remote memories, Cell, 147, 678, 10.1016/j.cell.2011.09.033 · DOI · Paper page
- Han, 2007, Neuronal competition and selection during memory formation, Science, 316, 457, 10.1126/science.1139438 · DOI · Paper page
- Han, 2009, Selective erasure of a fear memory, Science, 323, 1492, 10.1126/science.1164139 · DOI · Paper page
- Holtmaat, 2006, Experience-dependent and cell-type-specific spine growth in the neocortex, Nature, 441, 979, 10.1038/nature04783 · DOI · Paper page
- Horn, 2004, Pathways of the past: the imprint of memory, Nat. Rev. Neurosci., 5, 108, 10.1038/nrn1324 · DOI · Paper page
- Hsiang, 2014, Manipulating a “cocaine engram” in mice, J. Neurosci., 34, 14115, 10.1523/JNEUROSCI.3327-14.2014 · DOI · Paper page
- Ji, 2008, Differential roles for hippocampal areas CA1 and CA3 in the contextual encoding and retrieval of extinguished fear, Learn. Mem., 15, 244, 10.1101/lm.794808 · DOI
- Kass, 2013, Fear learning enhances neural responses to threat-predictive sensory stimuli, Science, 342, 1389, 10.1126/science.1244916 · DOI
- Kim, 2013, Injectable, cellular-scale optoelectronics with applications for wireless optogenetics, Science, 340, 211, 10.1126/science.1232437 · DOI · Paper page
- Kim, 2014, Memory recall and modifications by activating neurons with elevated CREB, Nat. Neurosci., 17, 65, 10.1038/nn.3592 · DOI
- Koya, 2009, Targeted disruption of cocaine-activated nucleus accumbens neurons prevents context-specific sensitization, Nat. Neurosci., 12, 1069, 10.1038/nn.2364 · DOI · Paper page
- Lashley, 1950, In search of the engram, Symp. Soc. Exp. Biol., 4, 454
- Lee, 2004, Differential contributions of dorsal hippocampal subregions to memory acquisition and retrieval in contextual fear-conditioning, Hippocampus, 14, 301, 10.1002/hipo.10177 · DOI · Paper page
- Leutgeb, 2004, Distinct ensemble codes in hippocampal areas CA3 and CA1, Science, 305, 1295, 10.1126/science.1100265 · DOI
- Liu, 2012, Optogenetic stimulation of a hippocampal engram activates fear memory recall, Nature, 484, 381, 10.1038/nature11028 · DOI
- Loftus, 2003, Our changeable memories: legal and practical implications, Nat. Rev. Neurosci., 4, 231, 10.1038/nrn1054 · DOI
- Marr, 1970, A theory for cerebral neocortex, Proc. R. Soc. Lond. B Biol. Sci., 176, 161, 10.1098/rspb.1970.0040 · DOI
- Martin, 2002, New life in an old idea: the synaptic plasticity and memory hypothesis revisited, Hippocampus, 12, 609, 10.1002/hipo.10107 · DOI · Paper page
- Matsuo, 2015, Irreplaceability of neuronal ensembles after memory allocation, Cell Rep., 11, 351, 10.1016/j.celrep.2015.03.042 · DOI
- Matsuo, 2008, Spine-type-specific recruitment of newly synthesized AMPA receptors with learning, Science, 319, 1104, 10.1126/science.1149967 · DOI · Paper page
- McTighe, 2010, Paradoxical false memory for objects after brain damage, Science, 330, 1408, 10.1126/science.1194780 · DOI
- Miyashita, 1988, Neuronal correlate of visual associative long-term memory in the primate temporal cortex, Nature, 335, 817, 10.1038/335817a0 · DOI · Paper page
- Nabavi, 2014, Engineering a memory with LTD and LTP, Nature, 511, 348, 10.1038/nature13294 · DOI · Paper page
- Nakazawa, 2003, Hippocampal CA3 NMDA receptors are crucial for memory acquisition of one-time experience, Neuron, 38, 305, 10.1016/S0896-6273(03)00165-X · DOI
- Nieh, 2013, Optogenetic dissection of neural circuits underlying emotional valence and motivated behaviors, Brain Res., 1511, 73, 10.1016/j.brainres.2012.11.001 · DOI
- Nonaka, 2014, Synaptic plasticity associated with a memory engram in the basolateral amygdala, J. Neurosci., 34, 9305, 10.1523/JNEUROSCI.4233-13.2014 · DOI
- Ohkawa, 2015, Artificial association of pre-stored information to generate a qualitatively new memory, Cell Rep., 11, 261, 10.1016/j.celrep.2015.03.017 · DOI
- Olds, 1972, Learning centers of rat brain mapped by measuring latencies of conditioned unit responses, J. Neurophysiol., 35, 202, 10.1152/jn.1972.35.2.202 · DOI · Paper page
- Ramirez, 2015, Activating positive memory engrams suppresses depression-like behaviour, Nature, 522, 335, 10.1038/nature14514 · DOI
- Reijmers, 2007, Localization of a stable neural correlate of associative memory, Science, 317, 1230, 10.1126/science.1143839 · DOI
- Roediger, 1995, Creating false memories: Remembering words not presented in lists, J. Exp. Psychol. Learn. Mem. Cogn., 21, 803, 10.1037/0278-7393.21.4.803 · DOI · Paper page
- Romberg, 2012, False recognition in a mouse model of Alzheimer’s disease: rescue with sensory restriction and memantine, Brain, 135, 2103, 10.1093/brain/aws074 · DOI
- Ryan, 2015, Memory. Engram cells retain memory under retrograde amnesia, Science, 348, 1007, 10.1126/science.aaa5542 · DOI · Paper page
- Schacter, 1978, Richard Semon’ s Theory of Memory, J. Verbal Learn. Verbal Behav., 17, 721, 10.1016/S0022-5371(78)90443-7 · DOI
- Scoville, 1957, Loss of recent memory after bilateral hippocampal lesions, J. Neurol. Neurosurg. Psychiatry, 20, 11, 10.1136/jnnp.20.1.11 · DOI · Paper page
- Squire, 2004, Memory systems of the brain: a brief history and current perspective, Neurobiol. Learn. Mem., 82, 171, 10.1016/j.nlm.2004.06.005 · DOI · Paper page
- Tanaka, 2014, Cortical representations are reinstated by the hippocampus during memory retrieval, Neuron, 84, 347, 10.1016/j.neuron.2014.09.037 · DOI
- Tayler, 2013, Reactivation of neural ensembles during the retrieval of recent and remote memory, Curr. Biol., 23, 99, 10.1016/j.cub.2012.11.019 · DOI · Paper page
- Tonegawa, 2015, Memory engram storage and retrieval, Current Opinion in Neuroscience, 35, 101, 10.1016/j.conb.2015.07.009 · DOI · Paper page
- Trouche, 2013, Fear extinction causes target-specific remodeling of perisomatic inhibitory synapses, Neuron, 80, 1054, 10.1016/j.neuron.2013.07.047 · DOI
- Weinberger, 2004, Specific long-term memory traces in primary auditory cortex, Nat. Rev. Neurosci., 5, 279, 10.1038/nrn1366 · DOI · Paper page
- Xie, 2014, In vivo imaging of immediate early gene expression reveals layer-specific memory traces in the mammalian brain, Proc. Natl. Acad. Sci. USA, 111, 2788, 10.1073/pnas.1316808111 · DOI
- Yiu, 2014, Neurons are recruited to a memory trace based on relative neuronal excitability immediately before training, Neuron, 83, 722, 10.1016/j.neuron.2014.07.017 · DOI · Paper page
- Yu, 2006, Drosophila α/β mushroom body neurons form a branch-specific, long-term cellular memory trace after spaced olfactory conditioning, Neuron, 52, 845, 10.1016/j.neuron.2006.10.030 · DOI · Paper page
- Zelikowsky, 2014, Neuronal ensembles in amygdala, hippocampus, and prefrontal cortex track differential components of contextual fear, J. Neurosci., 34, 8462, 10.1523/JNEUROSCI.3624-13.2014 · DOI
- Zhou, 2009, CREB regulates excitability and the allocation of memory to subsets of neurons in the amygdala, Nat. Neurosci., 12, 1438, 10.1038/nn.2405 · DOI
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Metadata
- Authors
- Tonegawa, S., Liu, X., Ramirez, S., & Redondo, R.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2015-09
- Volume
- 87
- Issue
- 5
- Pages
- 918-931
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1920095995
- Cited by
- 604
- References
- 32
- FWCI
- 25.08
- Type
- journal article
- Language
- en
- Open access
- bronze
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 367 d)
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