Actions of N-arachidonyl-glycine in a rat neuropathic pain model

Vuong, Leeza A.Q.; Mitchell, Vanessa A.; Vaughan, Christopher W.

doi:10.1016/j.neuropharm.2007.05.004

Cited by 91Pain Mechanisms and TreatmentsCannabis and Cannabinoid ResearchIon Channels and Receptors

Actions of N-arachidonyl-glycine in a rat neuropathic pain model

Vuong, Leeza A.Q., Mitchell, Vanessa A., Vaughan, Christopher W.·2008·Neuropharmacology

DOI 10.1016/j.neuropharm.2007.05.004

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Abstract

While cannabinoid receptor agonists reduce the abnormal pain sensations associated with animal models of neuropathic pain states they also produce CB(1) receptor mediated side effects. Recently, a number of arachidonic acid-amino acid conjugates, including N-arachidonyl-glycine (NAGly), have been identified which are structurally related to the endocannabinoid arachidonyl ethanolamide (anandamide). In the present study we examined the effect of NAGly in a rat model of neuropathic pain. Intrathecal administration of NAGly (700 nmol) and the pan-cannabinoid receptor agonist HU-210 (30 nmol) reduced the mechanical allodynia induced by partial ligation of the sciatic nerve. The NAGly induced anti-allodynia was dose dependent and, unlike HU-210, was unaffected by the cannabinoid CB(1) and CB(2) receptor antagonists, AM251 and SR144528 (30 nmol). The NAGly degradation products, arachidonic acid and glycine (700 nmol), did not reduce allodynia. HU-210, but not NAGly produced a reduction in rotarod latency. These findings suggest that NAGly may provide a novel analgesic approach to alleviate neuropathic pain.

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Intrathecal N-arachidonoyl glycine attenuated mechanical allodynia in the Seltzer model, but its anti-hyperalgesic actions are independent of spinal cannabinoid receptors.
“Intrathecal N-arachidonoyl glycine (NaGly), the arachodonic acid conjugate, also attenuated mechanical allodynia in this model, however, the anti-hyperalgesic actions of this compound are independent of spinal cannabinoid receptors.75”
From Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside (2009) · cites this paper as [75]

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Authors: Vuong, L. A. Q., Mitchell, V. A., & Vaughan, C. W.
Affiliations: The University of Sydney (AU)
Corresponding author: Vaughan, Christopher W.
ORCID: Vaughan, Christopher W.
Venue: Neuropharmacology
Publisher: Elsevier BV
Published: 2008-01
Volume: 54
Issue: 1
Pages: 189-193
ISSN: 0028-3908 (ISSN-L)
DOI: 10.1016/j.neuropharm.2007.05.004
OpenAlex: W2018469929
Cited by: 89
References: 30
Citations by year: 2026: 4 · 2025: 4 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 6 · 2018: 5 · 2017: 4 · 2016: 2 · 2015: 3 · 2014: 6 · 2013: 9 · 2012: 6
FWCI: 5.32
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuropharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: National Health and Medical Research Council
National Medical Research Council
Topics: Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Keywords: neuropathic pain, mechanical allodynia, sciatic nerve ligation, cannabinoid receptor agonists, HU-210, CB1 receptor, CB2 receptor, intrathecal administration, analgesia
MeSH terms: Analgesics, Animals, Arachidonic Acids, Camphanes, Disease Models, Animal, Dose-Response Relationship, Drug, Glycine, Hyperalgesia, Male, Pain Measurement, Piperidines, Pyrazoles, Sciatica, Dronabinol, Rats, Sprague-Dawley, Area Under Curve, Rats

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Actions of N-arachidonyl-glycine in a rat neuropathic pain model

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