Peripheral nerve injury induces cannabinoid receptor 2 protein expression in rat sensory neurons

Wotherspoon, G.; Fox, A.; McIntyre, P.; Colley, S.; Bevan, S.; Winter, J.

doi:10.1016/j.neuroscience.2005.06.009

Cited by 255Cannabis and Cannabinoid ResearchPain Mechanisms and TreatmentsNerve injury and regeneration

Peripheral nerve injury induces cannabinoid receptor 2 protein expression in rat sensory neurons

Wotherspoon, G., Fox, A., McIntyre, P., Colley, S., Bevan, S., Winter, J.·2005·Neuroscience

DOI 10.1016/j.neuroscience.2005.06.009

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Abstract

We have localized cannabinoid receptor 2 protein in rat and mouse somatic sensory nervous system, using an antibody that recognizes mouse cannabinoid receptor 2. Little or no cannabinoid receptor 2 immunoreactivity was found in sections of naive rat or mouse dorsal root ganglia or spinal cord. This was in accord with the lack of detectable cannabinoid receptor 2 mRNA in (dorsal root ganglion) neurons by in situ hybridization experiments described in the literature. However, we could detect cannabinoid receptor 2 immunoreactivity following unilateral nerve damage-either by sciatic nerve section, or by spinal nerve ligation. It was localized to the superficial laminae of the dorsal horn of the spinal cord, ipsilateral to the nerve damage, coincident with the area of termination of damaged afferents which was marked by loss of isolectin B4 binding. This upregulation was not seen in cannabinoid receptor 2 null mice. The cannabinoid receptor 2 protein in spinal cord appeared to be expressed on sensory neuron afferent terminals as it colocalized with two markers of damaged afferents, namely growth associated protein-43 and the neuropeptide galanin. Moreover, it did not colocalize with markers of activated microglial cells (OX-42) or astroglial cells (glial fibrillary acidic protein) in rat spinal cord. In the peripheral nerve, accumulation of cannabinoid receptor 2 immunoreactivity was seen in nerve sections proximal, but not distal, to the ligation site, suggesting transport down the nerve from the cell bodies. Although convincing cannabinoid receptor 2 immunoreactivity was seen in neither uninjured nor injured dorsal root ganglion neuron cell bodies in tissue sections, expression was detectable in isolated, cultured neurons that had received a prior axotomy in vivo. This clear demonstration of CB(2) receptors on sensory neurons suggests an additional cellular target for CB(2) agonist induced analgesia, at least in neuropathic models.

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Upregulation of CB2 receptor immunoreactivity or mRNA is observed in sites implicated in nociceptive processing under conditions of induced neuropathy.
“However, an upregulation of CB2 receptor immunoreactivity or mRNA is observed in sites implicated in nociceptive processing under conditions of induced neuropathy.17, 18”
From Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside (2009) · cites this paper as [18]
Upregulation of CB2 receptor immunoreactivity on sensory afferent terminals in the spinal cord has been reported following SNL.
“Upregulation of CB2 receptor immunoreactivity on sensory afferent terminals in the spinal cord has also been reported following SNL.18”
From Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside (2009) · cites this paper as [18]
These observations correspond to preclinical observations of cannabinoid receptor upregulation following nerve injury.
“These observations correspond to preclinical observations of cannabinoid receptor upregulation following nerve injury.18”
From Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside (2009) · cites this paper as [18]

An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat
Ho Kim, S., & Mo Chung, J. (1992) · Pain · doi:10.1016/0304-3959(92)90041-9 · Cited by 3,069 · see citing works
GAP-43: an intrinsic determinant of neuronal development and plasticity
Benowitz, L. I., & Routtenberg, A. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10072-2 · Cited by 1,332 · see citing works
Neuropathic pain and spinal microglia: a big problem from molecules in ‘small’ glia
Tsuda, M., Inoue, K., & Salter, M. W. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.12.002 · Cited by 795 · see citing works
Cannabinoid receptors and pain
Pertwee, R. G. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00031-9 · Cited by 741 · see citing works
Modulation of transmitter release via presynaptic cannabinoid receptors
Schlicker, E., & Kathmann, M. (2001) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01805-8 · Cited by 671 · see citing works
Nonpsychotropic Cannabinoid Receptors Regulate Microglial Cell Migration
Walter, L. M., Franklin, A. A., Witting, A., Wade, C. B., Xie, Y., Kunos, G., Mackie, K., & Stella, N. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-04-01398.2003 · Cited by 666 · see citing works
HU-308: A specific agonist for CB 2 , a peripheral cannabinoid receptor
Hanus, L. O., Breuer, A., Tchilibon, S., Shiloah, S., Goldenberg, D., Horowitz, M., Pertwee, R. G., Ross, R. A., Mechoulam, R., & Fride, E. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.25.14228 · Cited by 574 · see citing works
Cannabinoid receptors and their ligands
Pertwee, R. G., & Ross, R. A. (2002) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.2001.0341 · Cited by 558 · see citing works
The cannabinoid system and immune modulation
Klein, T., Newton, C. A., Larsen, K. A., Lu, L. D., Perkins, I., Nong, L., & Friedman, H. P. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0303101 · Cited by 524 · see citing works
CB 2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids
Ibrahim, M. M., Porreca, F., Lai, J., Albrecht, P. J., Rice, F. L., Khodorova, A., Davar, G., Makriyannis, A., Vanderah, T. W., Mata, H. P., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409888102 · Cited by 521 · see citing works
Activation of CB 2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: Pain inhibition by receptors not present in the CNS
Ibrahim, M. M., Deng, H., Zvonok, A., Cockayne, D. A., Kwan, J., Mata, H. P., Vanderah, T. W., Lai, J., Porreca, F., Makriyannis, A., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1834309100 · Cited by 491 · see citing works
The Effect of Site and Type of Nerve Injury on Spinal Glial Activation and Neuropathic Pain Behavior
Colburn, R. W., Rickman, A. J., & DeLeo, J. A. (1999) · Experimental Neurology · doi:10.1006/exnr.1999.7065 · Cited by 434 · see citing works
Are cannabinoids an effective and safe treatment option in the management of pain? A qualitative systematic review
Campbell, F. A., Tramèr, M. R., Carroll, D., Reynolds, D. J. M., Moore, R. A., & McQuay, H. J. (2001) · BMJ · doi:10.1136/bmj.323.7303.13 · Cited by 422 · see citing works
Cannabinoids Promote Oligodendrocyte Progenitor Survival: Involvement of Cannabinoid Receptors and Phosphatidylinositol-3 Kinase/Akt Signaling
Molina‐Holgado, E., Vela, J. M., Arévalo‐Martín, Á., Almazán, G., Molina‐Holgado, F., Borrell, J. I., & Guaza, C. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-22-09742.2002 · Cited by 420 · see citing works
Induction of CB2 receptor expression in the rat spinal cord of neuropathic but not inflammatory chronic pain models
Zhang, J., Hoffert, C., Vu, H. K., Groblewski, T., Ahmad, S., & O'Donnell, D. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02704.x · Cited by 419 · see citing works
CB2 cannabinoid receptor-mediated peripheral antinociception
Malan, P. T., Ibrahim, M. M., Deng, H., Liu, Q., Mata, H. P., Vanderah, T., Porreca, F., & Makriyannis, A. (2001) · Pain · doi:10.1016/s0304-3959(01)00321-9 · Cited by 391 · see citing works
The role of central and peripheral Cannabinoid1 receptors in the antihyperalgesic activity of cannabinoids in a model of neuropathic pain
Fox, A., Kesingland, A., Gentry, C., McNair, K., Patel, S., Urban, L., & James, I. (2001) · Pain · doi:10.1016/s0304-3959(00)00474-7 · Cited by 379 · see citing works
Self-citation
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Kruman, I. I., Guo, Q., & Mattson, M. P. (1998) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19980201)51:3 · Cited by 377 · see citing works
Differential expression of the CB2 cannabinoid receptor by rodent macrophages and macrophage-like cells in relation to cell activation
Carlisle, S. J., Marciano‐Cabral, F., Staab, A., LUDWICK, C., & Cabral, G. A. (2002) · International Immunopharmacology · doi:10.1016/s1567-5769(01)00147-3 · Cited by 344 · see citing works
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Distribution of cannabinoid receptor 1 (CB1) and 2 (CB2) on sensory nerve fibers and adnexal structures in human skin
Ständer, S., Schmelz, M., Metze, D., Luger, T. A., & Rukwied, R. (2005) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2005.01.007 · Cited by 300 · see citing works
Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy
Valenzano, K. J., Tafesse, L., Lee, G., Harrison, J. E., Boulet, J. M., Gottshall, S. L., Mark, L., Pearson, M. S., Miller, W., Shan, S., et al. (2005) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.12.008 · Cited by 288 · see citing works
Structure-activity relationship for the endogenous cannabinoid, anandamide, and certain of its analogues at vanilloid receptors in transfected cells and vas deferens
Ross, R. A., Gibson, T. M., Brockie, H. C., Leslie, M., Pashmi, G., Craib, S. J., Di Marzo, V., & Pertwee, R. G. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703850 · Cited by 237 · see citing works
CB cannabinoid receptor agonists: pain relief without psychoactive effects?
MALANJR, T., IBRAHIM, M., LAI, J., Vanderah, T. W., Makriyannis, A., & Porreca, F. (2003) · Current Opinion in Pharmacology · doi:10.1016/s1471-4892(02)00004-8 · Cited by 223 · see citing works
Neurophysiology of Pruritus
Ständer, S., Steinhoff, M. S., Schmelz, M., Weißhaar, E., Metze, D., & Luger, T. A. (2003) · Archives of Dermatology · doi:10.1001/archderm.139.11.1463 · Cited by 220 · see citing works
The endogenous cannabinoid system and its role in nociceptive behavior
Cravatt, B. F., & Lichtman, A. H. (2004) · Journal of Neurobiology · doi:10.1002/neu.20080 · Cited by 203 · see citing works
Cannabinoid receptors undergo axonal flow in sensory nerves
Hohmann, A. G., & Herkenham, M. A. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00220-1 · Cited by 192 · see citing works
Endocannabinoids and pain: spinal and peripheral analgesia in inflammation and neuropathy
Rice, A. S. C., Farquhar-Smith, W. P., & Nagy, I. (2002) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.2001.0362 · Cited by 183 · see citing works
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Self-citation
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Ross, R. A., Coutts, A. A., McFarlane, S. M., Anavi-Goffer, S., Irving, A. J., Pertwee, R. G., MacEwan, D. J., & Scott, R. H. (2001) · Neuropharmacology · doi:10.1016/s0028-3908(00)00135-0 · Cited by 172 · see citing works
Evidence for the presence of CB2-like cannabinoid receptors on peripheral nerve terminals
Griffin, G., Fernando, S. R., Ross, R. A., McKay, N. G., Ashford, M. L. J., Shire, D. J., Huffman, J. W., Yu, S., Lainton, J. A. H., & Pertwee, R. G. (1997) · European Journal of Pharmacology · doi:10.1016/s0014-2999(97)01336-8 · Cited by 171 · see citing works
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Spinal and peripheral mechanisms of cannabinoid antinociception: behavioral, neurophysiological and neuroanatomical perspectives
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The neuronal distribution of cannabinoid receptor type 1 in the trigeminal ganglion of the rat
Price, T. J., Helesic, G., Parghi, D., Hargreaves, K., & Flores, C. M. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00333-6 · Cited by 145 · see citing works
Nerve growth factor (NGF) differentially regulates the chemosensitivity of adult rat cultured sensory neurons
Bevan, S., & Winter, J. M. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-07-04918.1995 · Cited by 145 · see citing works
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Fride, E., Foox, A., Rosenberg, E., Faigenboim, M., Cohen, V., Barda, L., Blau, H., & Mechoulam, R. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01295-0 · Cited by 138 · see citing works
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Δ9-Tetrahydrocannabinol and Cannabinol Activate Capsaicin-Sensitive Sensory Nerves via a CB1 and CB2 Cannabinoid Receptor-Independent Mechanism
Zygmunt, P. M., Andersson, D. A., & Högestätt, E. D. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-11-04720.2002 · Cited by 112 · see citing works
Activation of Cannabinoid CB2Receptors Suppresses C-Fiber Responses and Windup in Spinal Wide Dynamic Range Neurons in the Absence and Presence of Inflammation
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Inhibition of pain responses by activation of CB2 cannabinoid receptors
Malan, T. P., Ibrahim, M. M., Vanderah, T. W., Makriyannis, A., & Porreca, F. (2002) · Chemistry and Physics of Lipids · doi:10.1016/s0009-3084(02)00155-x · Cited by 99 · see citing works
Inhibition of guinea‐pig and human sensory nerve activity and the cough reflex in guinea‐pigs by cannabinoid (CB2) receptor activation
Patel, H. J., Birrell, M. A., Crispino, N., Hele, D. J., Venkatesan, P., Barnes, P. J., Yacoub, M. H., & Belvisi, M. G. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705435 · Cited by 90 · see citing works
Evidence for the presence of CB1 cannabinoid receptors on peripheral neurones and for the existence of neuronal non-CB1 cannabinoid receptors
Pertwee, R. G. (1999) · Life Sciences · doi:10.1016/s0024-3205(99)00282-9 · Cited by 84 · see citing works
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Monory, K., Tzavara, E. T., Lexime, J., Ledent, C. A., Parmentier, M., Borsodi, A. D., & Hanoune, J. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2002.6635 · Cited by 75 · see citing works
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Raap, U., Ikoma, A., & Kapp, A. (2006) · Der Hautarzt · doi:10.1007/s00105-006-1125-8 · Cited by 26 · see citing works
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Kerr, B. J., Wynick, D., Thompson, S., & McMahon, S. B. (2000) · Progress in brain research · doi:10.1016/s0079-6123(00)29016-x · Cited by 19 · see citing works

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Duncan, M., Mouihate, A., Mackie, K., Keenan, C. M., Buckley, N. E., Davison, J. S., Patel, K. D., Pittman, Q. J., & Sharkey, K. A. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90285.2008 · Cited by 145 · see citing works
In vitroandin vivocharacterization of A‐796260: a selective cannabinoid CB2receptor agonist exhibiting analgesic activity in rodent pain models
Yao, B. B., Hsieh, G. C., Frost, J. M., Fan, Y., Garrison, T. R., Daza, A. V., Grayson, G. K., Zhu, C. Z., Pai, M., Chandran, P., et al. (2008) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707568 · Cited by 140 · see citing works
Central and peripheral sites of action for CB 2 receptor mediated analgesic activity in chronic inflammatory and neuropathic pain models in rats
Hsieh, G. C., Pai, M., Chandran, P., Hooker, B. A., Zhu, C. Z., Salyers, A. K., Wensink, E. J., Zhan, C., Carroll, W. A., Dart, M. J., et al. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.01046.x · Cited by 139 · see citing works
Interactions of the opioid and cannabinoid systems in reward: Insights from knockout studies
Befort, K. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00006 · Cited by 134 · see citing works
Activation of cannabinoid receptors by the pentacyclic triterpene α,β-amyrin inhibits inflammatory and neuropathic persistent pain in mice
da Silva, K. A. B. S., Paszcuk, A. F., Passos, G. F., da Silva, E. S., Bento, A. F., Meotti, F. C., & Calixto, J. Β. (2011) · Pain · doi:10.1016/j.pain.2011.04.005 · Cited by 134 · see citing works
Minocycline Treatment Inhibits Microglial Activation and Alters Spinal Levels of Endocannabinoids in a Rat Model of Neuropathic Pain
Guasti, L., Richardson, D. S., Jhaveri, M. D., Eldeeb, K., Barrett, D. A., Elphick, M. R., Alexander, S. P. H., Kendall, D. A., Michael, G. J., & Chapman, V. (2009) · Molecular Pain · doi:10.1186/1744-8069-5-35 · Cited by 133 · see citing works
The endocannabinoid system in pain and inflammation: Its relevance to rheumatic disease
Barrie, N., & Manolios, N. (2017) · European Journal of Rheumatology · doi:10.5152/eurjrheum.2017.17025 · Cited by 133 · see citing works
Expression of the mRNA coding the cannabinoid receptor 2 in the pallidal complex of Macaca fascicularis
Lanciego, J. L., Barroso‐Chinea, P., Rico, A. J., Conte-Perales, L., Callén, L., Roda, E., Gómez-Bautista, V., López, I. P., Lluís, C., Labandeira-García, J. L., et al. (2010) · Journal of Psychopharmacology · doi:10.1177/0269881110367732 · Cited by 130 · see citing works
Cannabis-Based Medicines and Pain: A Review of Potential Synergistic and Entourage Effects
Anand, U., Pacchetti, B., Anand, P., & Sodergren, M. H. (2021) · Pain Management · doi:10.2217/pmt-2020-0110 · Cited by 128 · see citing works
Control of Spasticity in a Multiple Sclerosis Model is mediated by CB1, not CB2, Cannabinoid Receptors
Pryce, G., & Baker, D. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707003 · Cited by 127 · see citing works
The endocannabinoid system is modulated in response to spinal cord injury in rats
García‐Ovejero, D., Arévalo‐Martín, Á., Petrosino, S., Docagne, F., Hagen, C., Bisogno, T., Watanabe, M., Guaza, C., Marzo, V. D., & Molina‐Holgado, E. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.09.015 · Cited by 125 · see citing works
Role of CB2 receptors in neuroprotective effects of cannabinoids
Fernández‐Ruíz, J., Pazos, M. R., Garcı́a-Arencibia, M., Sagredo, O., & Ramos, J. A. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.01.001 · Cited by 125 · see citing works
Prospects for cannabinoid therapies in basal ganglia disorders
Fernández‐Ruíz, J., Moreno‐Martet, M., Rodríguez‐Cueto, C., Palomo‐Garo, C., Gómez‐Cañas, M., Valdeolivas, S., Guaza, C., Romero, J., Guzmán, M., Mechoulam, R., et al. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01365.x · Cited by 123 · see citing works
Spinal Cannabinoid Receptor Type 2 Activation Reduces Hypersensitivity and Spinal Cord Glial Activation after Paw Incision
Romero-Sandoval, A. E., & Eisenach, J. C. (2007) · Anesthesiology · doi:10.1097/01.anes.0000264765.33673.6c · Cited by 122 · see citing works
Current evidence of cannabinoid‐based analgesia obtained in preclinical and human experimental settings
Lötsch, J., Weyer-Menkhoff, I., & Tegeder, I. (2017) · European Journal of Pain · doi:10.1002/ejp.1148 · Cited by 118 · see citing works
Selective Activation of Cannabinoid CB2 Receptors Suppresses Neuropathic Nociception Induced by Treatment with the Chemotherapeutic Agent Paclitaxel in Rats
Rahn, E. J., Zvonok, A. M., Thakur, G. A., Khanolkar, A. D., Makriyannis, A., & Hohmann, A. G. (2008) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.141994 · Cited by 116 · see citing works
1-(2′,4′-dichlorophenyl)-6-methyl-N-cyclohexylamine-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxamide, a novel CB2 agonist, alleviates neuropathic pain through functional microglial changes in mice
Luongo, L., Palazzo, E., Tambaro, S., Giordano, C. S. D. S., Gatta, L., Scafuro, M. A., Rossi, F., Lazzari, P., Pani, L., de Novellis, V., et al. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.09.021 · Cited by 113 · see citing works
The peripheral cannabinoid receptor knockout mice: an update
Buckley, N. E. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707527 · Cited by 112 · see citing works
Signaling via CNS cannabinoid receptors
Mackie, K. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.01.022 · Cited by 112 · see citing works
What we know and do not know about the cannabinoid receptor 2 (CB2)
Malfitano, A. M., Basu, S., Maresz, K., Bifulco, M., & Dittel, B. N. (2014) · Seminars in Immunology · doi:10.1016/j.smim.2014.04.002 · Cited by 112 · see citing works
Involvement of cannabinoid receptors in inflammatory hypersensitivity to colonic distension in rats
Sanson, M., Bueno, L. P., & Fioramonti, J. (2006) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2006.00819.x · Cited by 111 · see citing works
Cannabinoids and the Brain
Köfalvi, A. (2007) · Springer eBooks · doi:10.1007/978-0-387-74349-3 · Cited by 110 · see citing works
Neuroprotective Effects of β-Caryophyllene against Dopaminergic Neuron Injury in a Murine Model of Parkinson’s Disease Induced by MPTP
Paredes, J. M. V., González-Castañeda, R. E., Gertsch, J., Chaparro-Huerta, V., López-Roa, R. I., Vázquez-Valls, E., Beas‐Zárate, C., Camins, A., & Flores-Soto, M. E. (2017) · Pharmaceuticals · doi:10.3390/ph10030060 · Cited by 109 · see citing works
The role of endocannabinoids in pain modulation
Zogopoulos, P., Vasileiou, I., Patsouris, E., & Theocharis, S. E. (2013) · Fundamental and Clinical Pharmacology · doi:10.1111/fcp.12008 · Cited by 106 · see citing works
Activation of peripheral cannabinoid CB1and CB2receptors suppresses the maintenance of inflammatory nociception: a comparative analysis
Gutierrez, T., Farthing, J. N., Zvonok, A. M., Makriyannis, A., & Hohmann, A. G. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706984 · Cited by 106 · see citing works
Targeting cannabinoid agonists for inflammatory and neuropathic pain
Cheng, Y., & Hitchcock, S. A. (2007) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.16.7.951 · Cited by 103 · see citing works
Detection of cannabinoid receptors CB1 and CB2 within basal ganglia output neurons in macaques: changes following experimental parkinsonism
Sierra, S., Luquin, N., Rico, A. J., Gómez-Bautista, V., Roda, E., Dopeso‐Reyes, I. G., Vázquez, A., Martínez‐Pinilla, E., Labandeira-García, J. L., Franco, R., et al. (2014) · Brain Structure and Function · doi:10.1007/s00429-014-0823-8 · Cited by 103 · see citing works
The endocannabinoid system and migraine
Greco, R., Gasperi, V., Maccarrone, M., & Tassorelli, C. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2010.03.029 · Cited by 100 · see citing works
Synergistic attenuation of chronic pain using mu opioid and cannabinoid receptor 2 agonists
Grenald, S. A., Young, M. A., Wang, Y., Ossipov, M. H., Ibrahim, M. M., Largent-Milnes, T. M., & Vanderah, T. W. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.12.008 · Cited by 97 · see citing works
Effects of palmitoylethanolamide on release of mast cell peptidases and neurotrophic factors after spinal cord injury
Esposito, E., Paterniti, I., Mazzon, E., Genovese, T., Paola, R. D., Galuppo, M., & Cuzzocrea, S. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.02.006 · Cited by 97 · see citing works
A cannabinoid 2 receptor agonist attenuates bone cancer-induced pain and bone loss
Lozano‐Ondoua, A. N., Wright, C., Vardanyan, A. R., King, T. E., Largent‐Milnes, T. M., Nelson, M. A., Jiménez‐Andrade, J. M., Mantyh, P. W., & Vanderah, T. W. (2010) · Life Sciences · doi:10.1016/j.lfs.2010.02.014 · Cited by 95 · see citing works
Anatomical Distribution of Receptors, Ligands and Enzymes in the Brain and in the Spinal Cord: Circuitries and Neurochemistry
Marsicano, G., & Kuner, R. (2007) · Springer eBooks · doi:10.1007/978-0-387-74349-3_10 · Cited by 95 · see citing works
Some Prospective Alternatives for Treating Pain: The Endocannabinoid System and Its Putative Receptors GPR18 and GPR55
Alba, R. G., Barragán‐Iglesias, P., González‐Hernández, A., Valdez-Moráles, E. E., Granados‐Soto, V., Condés‐Lara, M., Rodríguez, M. G., & Marichal‐Cancino, B. A. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01496 · Cited by 94 · see citing works
The CB2 cannabinoid receptor-selective agonist O-3223 reduces pain and inflammation without apparent cannabinoid behavioral effects
Kinsey, S. G., Mahadevan, A., Zhao, B., Sun, H., Naidu, P. S., Razdan, R. K., Selley, D. E., Damaj, M. I., & Lichtman, A. H. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.09.004 · Cited by 94 · see citing works
Species‐specificin vitropharmacological effects of the cannabinoid receptor 2 (CB2) selective ligand AM1241 and its resolved enantiomers
Bingham, B., JONES, P. G., Uveges, A. J., Kotnis, S., Lu, P., Smith, V. A., Sun, S., Resnick, L., Chlenov, M., He, Y., et al. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707303 · Cited by 93 · see citing works
Interaction of the cannabinoid and opioid systems in the modulation of nociception
Welch, S. P. (2009) · International Review of Psychiatry · doi:10.1080/09540260902782794 · Cited by 92 · see citing works
Role of Cannabinoids in the Treatment of Pain and (Painful) Spasticity
Karst, M., Wippermann, S., & Ahrens, J. (2010) · Drugs · doi:10.2165/11585260-000000000-00000 · Cited by 91 · see citing works
Validating Antibodies to the Cannabinoid CB2 Receptor
Marchalant, Y., Brownjohn, P. W., Bonnet, A., Kleffmann, T., & Ashton, J. C. (2014) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155414530995 · Cited by 91 · see citing works
Actions of N-arachidonyl-glycine in a rat neuropathic pain model
Vuong, L. A. Q., Mitchell, V. A., & Vaughan, C. W. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.05.004 · Cited by 89 · see citing works
Cannabinoid CB2 Receptor-Mediated Anti-nociception in Models of Acute and Chronic Pain
Jhaveri, M. D., Sagar, D. R., Elmes, S. J. R., Kendall, D. A., & Chapman, V. (2007) · Molecular Neurobiology · doi:10.1007/s12035-007-8007-7 · Cited by 89 · see citing works
Evidence for a novel functional role of cannabinoid CB2 receptors in the thalamus of neuropathic rats
Jhaveri, M. D., Elmes, S. J. R., Richardson, D., Barrett, D. A., Kendall, D. A., Mason, R., & Chapman, V. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06162.x · Cited by 88 · see citing works
2,3‐Dihydro‐1‐Benzofuran Derivatives as a Series of Potent Selective Cannabinoid Receptor 2 Agonists: Design, Synthesis, and Binding Mode Prediction through Ligand‐Steered Modeling
Diaz, P., Phatak, S. S., Xu, J. J., Fronczek, F. R., Astruc‐Diaz, F., Thompson, C. M., Cavasotto, C. N., & Naguib, M. (2009) · ChemMedChem · doi:10.1002/cmdc.200900226 · Cited by 88 · see citing works
Medical Cannabis for Neuropathic Pain
Lee, G., Grovey, B., Furnish, T. J., & Wallace, M. S. (2018) · Current Pain and Headache Reports · doi:10.1007/s11916-018-0658-8 · Cited by 87 · see citing works
Spinal and peripheral analgesic effects of the CB2 cannabinoid receptor agonist AM1241 in two models of bone cancer‐induced pain
Curto-Reyes, V., Llames, S. G., Hidalgo, A., Menéndez, L., & Baamonde, A. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00629.x · Cited by 84 · see citing works
MDA7: a novel selective agonist for CB2 receptors that prevents allodynia in rat neuropathic pain models
Naguib, M., Diaz, P., Xu, J. J., Astruc‐Diaz, F., Craig, S., Vivas‐Mejia, P., & Brown, D. L. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.340 · Cited by 82 · see citing works
Topical analgesics for neuropathic pain: Preclinical exploration, clinical validation, future development
Sawynok, J. (2013) · European Journal of Pain · doi:10.1002/j.1532-2149.2013.00400.x · Cited by 79 · see citing works
Mice lacking cannabinoid CB1-, CB2-receptors or both receptors show increased susceptibility to trinitrobenzene sulfonic acid (TNBS)-induced colitis.
Engel, M. A., Kellermann, C. A., Burnat, G., Hahn, E. G., Rau, T. T., & Konturek, P. C. (2010) · PubMed · Cited by 79 · see citing works
Supraspinal modulation of pain by cannabinoids: the role of GABA and glutamate
Rea, K., Roche, M., & Finn, D. P. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707440 · Cited by 79 · see citing works
Paradoxical effects of the cannabinoid CB2 receptor agonist GW405833 on rat osteoarthritic knee joint pain
Schuelert, N., Zhang, C., Mogg, A. J., Broad, L. M., Hepburn, D. L., Nisenbaum, E. S., Johnson, M. P., & McDougall, J. J. (2010) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2010.09.005 · Cited by 77 · see citing works
Actions of N-Arachidonyl-Glycine in a Rat Inflammatory Pain Model
Succar, R., Mitchell, V. A., & Vaughan, C. W. (2007) · Molecular Pain · doi:10.1186/1744-8069-3-24 · Cited by 77 · see citing works
Endocannabinoids alleviate proinflammatory conditions by modulating innate immune response in muller glia during inflammation
Krishnan, G., & Chatterjee, N. (2012) · Glia · doi:10.1002/glia.22380 · Cited by 77 · see citing works
Dynamic changes to the endocannabinoid system in models of chronic pain
Sagar, D. R., Burston, J. J., Woodhams, S. G., & Chapman, V. (2012) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2011.0390 · Cited by 76 · see citing works
Increasing 2-arachidonoyl glycerol signaling in the periphery attenuates mechanical hyperalgesia in a model of bone cancer pain
Khasabova, I. A., Chandiramani, A., Harding-Rose, C., Simone, D. A., & Seybold, V. S. (2011) · Pharmacological Research · doi:10.1016/j.phrs.2011.03.007 · Cited by 75 · see citing works
Peripherally Selective Cannabinoid 1 Receptor (CB1R) Agonists for the Treatment of Neuropathic Pain
Seltzman, H. H., Shiner, C., Hirt, E. E., Gilliam, A. F., Thomas, B. F., Maitra, R., Snyder, R. W., Black, S. R., Patel, P. R., Mulpuri, Y., et al. (2016) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6b00516 · Cited by 75 · see citing works
Altered presymptomatic AMPA and cannabinoid receptor trafficking in motor neurons of ALS model mice: implications for excitotoxicity
Zhao, P., Ignacio, S., Beattie, E. C., & Abood, M. E. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06041.x · Cited by 75 · see citing works
The therapeutic potential of novel cannabinoid receptors
Kreitzer, F. R., & Stella, N. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.01.005 · Cited by 74 · see citing works
Self-medication of a cannabinoid CB2 agonist in an animal model of neuropathic pain
Gutierrez, T., Crystal, J. D., Zvonok, A. M., Makriyannis, A., & Hohmann, A. G. (2011) · Pain · doi:10.1016/j.pain.2011.03.038 · Cited by 71 · see citing works
6-Methoxy-N-alkyl Isatin Acylhydrazone Derivatives as a Novel Series of Potent Selective Cannabinoid Receptor 2 Inverse Agonists: Design, Synthesis, and Binding Mode Prediction
Diaz, P., Phatak, S. S., Xu, J. J., Astruc‐Diaz, F., Cavasotto, C. N., & Naguib, M. (2008) · Journal of Medicinal Chemistry · doi:10.1021/jm801353p · Cited by 71 · see citing works
Type-2 cannabinoid receptors in neurodegeneration
Bisogno, T., Oddi, S., Piccoli, A., Fazio, D., & Maccarrone, M. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.07.021 · Cited by 71 · see citing works
Cannabinoid receptor 2 is increased in acutely and chronically inflamed bladder of rats
Merriam, F. V., Wang, Z.-Y., GUÉRIOS, S. D., & Bjorling, D. E. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.08.076 · Cited by 70 · see citing works
Design and Synthesis of a Novel Series ofN-Alkyl Isatin Acylhydrazone Derivatives that Act as Selective Cannabinoid Receptor 2 Agonists for the Treatment of Neuropathic Pain
Diaz, P., Xu, J. J., Astruc‐Diaz, F., Pan, H.-M., Brown, D. L., & Naguib, M. (2008) · Journal of Medicinal Chemistry · doi:10.1021/jm8002203 · Cited by 69 · see citing works
Pharmacological Evaluation of a Novel Cannabinoid 2 (CB2) Ligand, PF-03550096, In Vitro and In Vivo by Using a Rat Model of Visceral Hypersensitivity
Kikuchi, A., Ohashi, K., Sugie, Y., Sugimoto, H., & Omura, H. (2008) · Journal of Pharmacological Sciences · doi:10.1254/jphs.fp0071599 · Cited by 68 · see citing works
The Selective Monoacylglycerol Lipase Inhibitor MJN110 Produces Opioid-Sparing Effects in a Mouse Neuropathic Pain Model
Wilkerson, J. L., Niphakis, M. J., Grim, T. W., Mustafa, M. A., Abdullah, R. A., Poklis, J. L., Dewey, W. L., Akbarali, H. I., Banks, M. L., Wise, L. E., et al. (2016) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.115.229971 · Cited by 67 · see citing works
A Lipid Gate for the Peripheral Control of Pain
Piomelli, D., Hohmann, A. G., Seybold, V. S., & Hammock, B. D. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.3475-14.2014 · Cited by 65 · see citing works
The Role of Nitric Oxide in the Local Antiallodynic and Antihyperalgesic Effects and Expression of δ-Opioid and Cannabinoid-2 Receptors during Neuropathic Pain in Mice
Hervera, A., Negrete, R., Leánez, S., Martín-Campos, J. M., & Pol, O. (2010) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.167585 · Cited by 64 · see citing works
Characterization of chronic constriction of the saphenous nerve, a model of neuropathic pain in mice showing rapid molecular and electrophysiological changes
Walczak, J., Pichette, V., Leblond, F., Desbiens, K., & Beaulieu, P. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.20821 · Cited by 62 · see citing works
Cannabinoid receptor-mediated antinociception with acetaminophen drug combinations in rats with neuropathic spinal cord injury pain
Hama, A. T., & Sagen, J. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.12.010 · Cited by 61 · see citing works
Pharmacological characterization of AM1710, a putative cannabinoid CB2 agonist from the cannabilactone class: Antinociception without central nervous system side-effects
Rahn, E. J., Thakur, G. A., Wood, J. A. T., Zvonok, A. M., Makriyannis, A., & Hohmann, A. G. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.02.024 · Cited by 57 · see citing works
Spinal cannabinoid CB2 receptors as a target for neuropathic pain: an investigation using chronic constriction injury
Brownjohn, P. W., & Ashton, J. C. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.12.028 · Cited by 57 · see citing works
Targeting the cannabinoid system for pain relief?
Chiou, L., Hu, S. S., & Ho, Y. (2013) · Acta anaesthesiologica Taiwanica · doi:10.1016/j.aat.2013.10.004 · Cited by 57 · see citing works
Intrathecal Administration of the Cannabinoid 2 Receptor Agonist JWH015 Can Attenuate Cancer Pain and Decrease mRNA Expression of the 2B Subunit of N-Methyl-D-Aspartic Acid
Gu, X., Mei, F.-M., Liu, Y., Zhang, R., Zhang, J., & Ma, Z. (2011) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e31821d1062 · Cited by 56 · see citing works
The Endocannabinoid/Cannabinoid Receptor 2 System Protects Against Cisplatin-Induced Hearing Loss
Ghosh, S., Sheth, S., Sheehan, K. E., Mukherjea, D., Dhukhwa, A., Borse, V., Rybak, L. P., & Ramkumar, V. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00271 · Cited by 52 · see citing works

Bilateral changes of cannabinoid receptor type 2 in the dorsalroot ganglia of different rat neuropathic pain models
Svíženská, I. H., Klusáková, I., Brázda, V., & Dubový, P. (2009)
The expression of cannabinoid receptor type 2 in the dorsalroot ganglia in rats after peripheral nerve injury
Svíženská, I. H., Klusáková, I., & Dubový, P. (2005)
Morphine Induces Upregulation of Neuronally Expressed CB2 Receptors in the Spinal Dorsal Horn of Rats
Grenier, P., Sunavsky, A., & Olmstead, M. C. (2020) · Cannabis and Cannabinoid Research · doi:10.1089/can.2020.0004 · Cited by 6 · see citing works
Bilateral Changes of Cannabinoid Receptor Type 2 Protein and mRNA in the Dorsal Root Ganglia of a Rat Neuropathic Pain Model
Svíženská, I. H., Brázda, V., Klusáková, I., & Dubový, P. (2013) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155413491269 · Cited by 52 · see citing works
CB2 receptor protein and mRNA expression in dorsal root gangliaof two rat neuropathic pain models.
Svíženská, I. H., Klusáková, I., Brázda, V., & Dubový, P. (2011)

Authors: Wotherspoon, G., Fox, A., McIntyre, P., Colley, S., Bevan, S., & Winter, J.
Affiliations: Novartis (Switzerland) (CH)
Corresponding author: Winter, J.
ORCID: Fox, A.
McIntyre, P.
Bevan, S.
Venue: Neuroscience
Publisher: Elsevier BV
Published: 2005-01
Volume: 135
Issue: 1
Pages: 235-245
ISSN: 0306-4522 (ISSN-L)
DOI: 10.1016/j.neuroscience.2005.06.009
OpenAlex: W2036912145
Cited by: 251
References: 47
Citations by year: 2026: 2 · 2025: 1 · 2024: 3 · 2023: 6 · 2022: 11 · 2021: 10 · 2020: 9 · 2019: 9 · 2018: 10 · 2017: 9 · 2016: 11 · 2015: 6 · 2014: 16 · 2013: 14 · 2012: 11
FWCI: 12.33
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience (publishedVersion)
PubMed (publishedVersion)
Research Portal (King's College London) (submittedVersion)
Topics: Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Keywords: CB2 receptor, peripheral nerve injury, neuropathic pain, sensory neurons, dorsal root ganglia, dorsal horn, sciatic nerve section, spinal nerve ligation, axotomy, galanin, growth-associated protein 43
MeSH terms: Animals, Astrocytes, Ganglia, Spinal, Cricetinae, Immunohistochemistry, Ligation, Male, Mice, Inbred C57BL, Neurons, Afferent, Pain, Peripheral Nervous System Diseases, Spinal Cord, Spinal Nerves, CHO Cells, Rats, Wistar, Microglia, DNA Primers, Mice, Knockout, Receptor, Cannabinoid, CB2, Mice, Rats, Peripheral Nerve Injuries

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Peripheral nerve injury induces cannabinoid receptor 2 protein expression in rat sensory neurons

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