Molecular and neuronal mechanisms underlying the effects of adolescent nicotine exposure on anxiety and mood disorders
Abstract
Tobacco addiction is highly co-morbid with a variety of mental health conditions, including schizophrenia, mood and anxiety disorders. Nicotine, the primary psychoactive compound in tobacco-related products is known to functionally modulate brain circuits that are disturbed in these disorders. Nicotine can potently regulate the transmission of various neurochemicals, including dopamine (DA), γ-amino-butyric acid (GABA) and glutamate, within various mesocorticolimbic structures, such as the ventral tegmental area (VTA), nucleus accumbens (NAc) and prefrontal cortex (PFC), all of which show pathologies in these disorders. Many neuropsychiatric diseases have etiological origins during neurodevelopment, typically occurring during vulnerable periods of adolescent or pre-natal brain development. During these neurodevelopmental periods, exposure to extrinsic drug insults can induce enduring and long-term pathophysiological sequelae that ultimately increase the risk of developing chronic mental health disorders in later life. These vulnerability factors are of growing concern given rising rates of adolescent nicotine exposure via traditional tobacco use and the increasing use of alternative nicotine delivery formats such as vaping and e-cigarettes. A large body of clinical and pre-clinical evidence points to an important role for adolescent exposure to nicotine and increased vulnerability to developing mood and anxiety disorders in later life. This review will examine current clinical and pre-clinical evidence that pinpoints specific mechanisms within the mesocorticolimbic circuitry and molecular biomarkers linked to the association between adolescent nicotine exposure and increased risk of developing mood and anxiety-related disorders. This article is part of the special issue on 'Vulnerabilities to Substance Abuse'.
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Many of ANE's effects on anxiety and depression-like behavior are thought to be related to changes in mesolimbic function.
“Many of ANE’s effects on anxiety and depression-like behavior are thought to be related to changes in mesolimbic function [185].”
From Consequences of adolescent drug use (2023) · cites this paper as [185]
Nicotine modulates multiple neurotransmitter systems, including dopamine, GABA, glutamate, serotonin, and acetylcholine.
“Nicotine also modulates multiple neurotransmitter systems, including dopamine, GABA, glutamate, serotonin, and acetylcholine, all of which require regulation by precise neurodevelopmental mechanisms [185].”
From Consequences of adolescent drug use (2023) · cites this paper as [185]
Nicotine treatment of adolescent rats, but not adults, results in increased impulsive behavior and decreased attention in adulthood.
“Nicotine treatment of adolescent rats, but not adults, results in increased impulsive behavior and decreased attention in adulthood [116].”
From Nicotine on the developing brain. (2023) · cites this paper as [116]
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Consequences of adolescent drug use
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“Nicotine also modulates multiple neurotransmitter systems, including dopamine, GABA, glutamate, serotonin, and acetylcholine, all of which require regulation by precise neurodevelopmental mechanisms [185].”
BackgroundNicotine on the developing brain.
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Self-citation
- Authors
- Laviolette, S. R.
- Affiliations
- Western University (CA)
- Corresponding author
- Laviolette, Steven R.
- Venue
- Neuropharmacology
- Publisher
- Elsevier BV
- Published
- 2021-02
- Volume
- 184
- Pages
- 108411
- ISSN
- 0028-3908 (ISSN-L)
- OpenAlex
- W3110009284
- Cited by
- 57
- References
- 117
- Citations by year
- 2026: 8 · 2025: 10 · 2024: 17 · 2023: 14 · 2022: 5 · 2021: 3
- FWCI
- 0.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- adolescent nicotine exposure, nicotine, anxiety disorders, mood disorders, tobacco dependence, mesocorticolimbic circuitry, ventral tegmental area, nucleus accumbens, prefrontal cortex, dopamine, GABA, glutamate, brain development, electronic cigarettes, vaping, molecular biomarkers
- MeSH terms
- Vaping, Adolescent, Adolescent Behavior, Animals, Anxiety Disorders, Brain, Humans, Nicotine, Mood Disorders, Tobacco Use, Electronic Nicotine Delivery Systems
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