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Cited by 223Advanced Neuroimaging Techniques and ApplicationsFunctional Brain Connectivity StudiesNeural and Behavioral Psychology Studies

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Distinct subdivisions of the cingulum bundle revealed by diffusion MRI fibre tracking: Implications for neuropsychological investigations

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Jones, D.K., Christiansen, K.F., Chapman, R.J., Aggleton, J.P.·2013·Neuropsychologia
DOI 10.1016/j.neuropsychologia.2012.11.018PMC PMC3611599
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Abstract

The cingulum is a prominent white matter tract that supports prefrontal, parietal, and temporal lobe interactions. Despite being composed of both short and long association fibres, many MRI-based reconstructions (tractography) of the cingulum depict an essentially uniform tract that almost encircles the corpus callosum. The present study tested the validity of dividing this tract into subdivisions corresponding to the 'parahippocampal', 'retrosplenial', and 'subgenual' portions of the cingulum. These three cingulum subdivisions occupied different medial-lateral locations, producing a topographic arrangement of cingulum fibres. Other comparisons based on these different reconstructions indicate that only a small proportion of the total white matter in the cingulum traverses the length of the tract. In addition, both the radial diffusivity and fractional anisotropy of the subgenual subdivision differed from that of the retrosplenial subdivision which, in turn, differed from that of the parahippocampal subdivision. The extent to which the radial diffusivity scores and the fractional anisotropy scores correlated between the various cingulum subdivisions proved variable, illustrating how one subdivision may not act as a proxy for other cingulum subdivisions. Attempts to relate the status of the cingulum, as measured by MRI-based fibre tracking, with cognitive or affective measures will, therefore, depend greatly on how and where the cingulum is reconstructed. The present study provides a new framework for subdividing the cingulum, based both on its known connectivity and MRI-based properties.

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  • Some researchers using constrained spherical deconvolution for fibre tracking have divided the cingulum three-ways into subgenual, retrosplenial (supracallosal), and parahippocampal (ventral) components.

    “Other researchers using the constrained spherical deconvolution algorithm (Tournier et al., 2004) for fibre tracking have divided the tract three-ways, e.g., into its ‘subgenual’, ‘retrosplenial’ (supracallosal), and ‘parahippocampal’ (ventral) components (Jones et al., 2013; see Fig. 6C).”

    From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Jones et al., 2013

  • The three subdivisions of the cingulum (subgenual, retrosplenial, parahippocampal) exhibit distinct FA measures and occupy different medial-lateral positions within the bundle, even in areas where they overlapped.

    “These three subdivisions were found to exhibit distinct FA measures and occupied different medial-lateral positions within the bundle, even in areas where they overlapped (Jones et al., 2013).”

    From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Jones et al., 2013

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Metadata

Authors
Jones, D. K., Christiansen, K. F., Chapman, R. J., & Aggleton, J. P.
Affiliations
Cardiff University (GB)
Corresponding author
Aggleton, J.P.
ORCID
Venue
Neuropsychologia
Publisher
Elsevier BV
Published
2013-01
Volume
51
Issue
1
Pages
67-78
ISSN
0028-3932 (ISSN-L)
DOI
10.1016/j.neuropsychologia.2012.11.018
PMC
PMC3611599
OpenAlex
W2137517639
Cited by
223
References
4
Citations by year
2026: 9 · 2025: 19 · 2024: 10 · 2023: 11 · 2022: 18 · 2021: 21 · 2020: 18 · 2019: 26 · 2018: 26 · 2017: 22 · 2016: 18 · 2015: 13 · 2014: 10 · 2013: 2
FWCI
6.04
Type
journal article
Language
en
Open access
Licence
Locations
  • Neuropsychologia (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • ORCA Online Research @Cardiff (Cardiff University) (acceptedVersion)
  • Research Bank (Australian Catholic University) (submittedVersion, cc-by)
Funders
  • Wellcome Trust (096646, 096646/Z/11/Z)
  • European Commission (EU-FP7)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
cingulum, white matter tractography, radial diffusivity, fractional anisotropy, corpus callosum, neuropsychological correlates
MeSH terms
Adult, Brain Mapping, Corpus Callosum, Female, Gyrus Cinguli, Humans, Image Processing, Computer-Assisted, Neuropsychological Tests, Photic Stimulation, Reproducibility of Results, Anisotropy, Observation

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