CoChat
Sign Up
Cited by 35Attention Deficit Hyperactivity DisorderCognitive Abilities and TestingNeural and Behavioral Psychology Studies

Effects of working memory training on neural correlates of Go/Nogo response control in adults with ADHD: A randomized controlled trial

Liu, Zhong-Xu, Lishak, Victoria, Tannock, Rosemary, Woltering, Steven·2017·Neuropsychologia
DOI 10.1016/j.neuropsychologia.2016.11.023
Open this paper in CoChat — free account

Abstract

Working memory and response control are conceptualized as functions that are part of a closely connected and integrated executive function system mediated by the prefrontal cortex and other related brain structures. In the present paper, we asked whether effects of intensive and adaptive computerized working memory training (CWMT) would generalize to enhancements in response control at behavioral and neural levels. A total of 135 postsecondary students with Attention-Deficit/Hyperactivity Disorder (ADHD), a condition associated with executive function impairments, were randomized into a Standard-length CWMT (45-min /session, 25 sessions), Shortened-length CWMT (15min/session, 25 sessions), and a waitlist group. Both training groups received CWMT for 5 days a week for 5 weeks long. All participants completed a Go-Nogo task while neural activity was measured using Electroencephalography (EEG), before and after CWMT. Behavioral results showed trend level evidence (p=0.061) for benefits of CWMT on response control (i.e., improved accuracy of Go responses). Among several neural measures results showed statistically significant changes after CWMT only for the Go trial ERP N2 and P3 in frontal electrodes (p=0.039 and 0.001, respectively). However, given the lack of relationship between behavioral and neural changes and especially the clear lack of predicted does effects (i.e., standard length > short length > control), we conclude that there is no convincing evidence that the working memory training per se changes neural activation patterns in untrained executive functions. The positive finding of general training related changes in this study should have no clinical implications, but may contribute to the literature in better understanding the relationship between neural plasticity and transfer.

Integrity signals

Registry

Crossref · 10.1016/j.neuropsychologia.2016.11.023

Cites

28 of 28 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Two recent studies showed that training in one cognitive domain does not transfer to other domains.

    “Two recent studies [88,89] showed that training in one cognitive domain does not transfer to other domains”

    From Linking ADHD to the Neural Circuitry of Attention (2017) · cites this paper as [88]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Liu, Z.-X., Lishak, V., Tannock, R., & Woltering, S.
Affiliations
University of Toronto (CA)
Corresponding author
  • Liu, Zhong-Xu
  • Woltering, Steven
ORCID
Venue
Neuropsychologia
Publisher
Elsevier BV
Published
2017-01
Volume
95
Pages
54-72
ISSN
0028-3932 (ISSN-L)
DOI
10.1016/j.neuropsychologia.2016.11.023
OpenAlex
W2560680125
Cited by
35
References
28
Citations by year
2025: 1 · 2023: 4 · 2022: 2 · 2021: 2 · 2020: 10 · 2019: 4 · 2018: 10 · 2017: 2
FWCI
4.74
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuropsychologia (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • CIHR Operating Grant (245899)
  • Canada Research Chair Program
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
working memory training, response control, attention deficit hyperactivity disorder, executive function, go/no-go task, event-related potentials, prefrontal cortex, neuroplasticity, transfer of training, training duration
MeSH terms
Attention Deficit Disorder with Hyperactivity, Brain, Central Nervous System Agents, Electroencephalography, Evoked Potentials, Female, Humans, Inhibition, Psychological, Learning, Male, Memory, Short-Term, Motor Activity, Neuropsychological Tests, Reaction Time, Transfer, Psychology, Cognitive Behavioral Therapy, Treatment Failure, Young Adult, Executive Function

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review