Cited by 289Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsNeural dynamics and brain function

Pyramidal Cells of the Frontal Lobe: All the More Spinous to Think With

Open access
Elston, Guy N.·2000·The Journal of Neuroscience

Abstract

The basal dendritic arbors of pyramidal cells in prefrontal areas 10, 11, and 12 of the macaque monkey were revealed by intracellular injection in fixed, flat-mounted, cortical slices. The size, number of branches, and spine density of the basal dendrites were quantified and compared with those of pyramidal cells in the occipital, parietal, and temporal lobes. These analyses revealed that cells in the frontal lobe were significantly more spinous than those in the other lobes, having as many as 16 times more spines than cells in the primary visual area (V1), four times more those in area 7a, and 45% more than those in area TE. As each dendritic spine receives at least one excitatory input, the large number of spines reported for layer III cells in prefrontal cortex suggests that they are capable of integrating a greater number of excitatory inputs than layer III pyramidal cells so far studied in the occipital, parietal, and temporal lobes. The ability to integrate a large number of excitatory inputs may be important for the sustained tonic activity characteristic of neurons in prefrontal cortex and their role in memory and cognition.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1523/jneurosci.20-18-j0002.2000

Cites

23 of 23 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • There is evidence for significant neuronal differences between rodents and humans, including distinct membrane and synaptic properties and dendritic complexity of human neurons that might contribute to human-specific signal processing.

    “Indeed there is evidence for significant neuronal differences between rodents and human; for example, distinct membrane8,9 and synaptic10–14 properties and dendritic complexity15–17 of human neurons might contribute to human specific signal processing.”

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Elston, G. N.
Affiliations
The University of Queensland (AU)
Corresponding author
Elston, Guy N.
Venue
The Journal of Neuroscience
Published
2000-09-15
Volume
20
Issue
18
Pages
RC95-RC95
ISSN
  • 0270-6474 (ISSN-L)
  • 1529-2401
OpenAlex
W1824320254
Cited by
289
References
23
Citations by year
2026: 8 · 2025: 8 · 2024: 12 · 2023: 14 · 2022: 6 · 2021: 11 · 2020: 19 · 2019: 13 · 2018: 13 · 2017: 10 · 2016: 14 · 2015: 15 · 2014: 10 · 2013: 11 · 2012: 15
FWCI
5.16
Type
journal article
Language
en
Open access
Locations
  • Journal of Neuroscience (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Medical Research Council
  • National Health and Medical Research Council
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
pyramidal neurons, dendritic spines, prefrontal cortex, basal dendrites, dendritic morphology, excitatory synaptic input, macaque, memory and cognition
MeSH terms
Animals, Dendrites, Female, Fluorescent Dyes, Frontal Lobe, Immunohistochemistry, Isoquinolines, Macaca, Microinjections, Occipital Lobe, Parietal Lobe, Temporal Lobe, Prefrontal Cortex, Pyramidal Cells

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review