A double-blind placebo-controlled experimental study of nicotine: II—Effects on response inhibition and executive functioning
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Rationale Smokers may show abnormal functioning in prefrontal cortex during acute abstinence, reflecting deficient activity in mesocorticolimbic circuitry. Cognitive correlates of this putatively include impaired response inhibition and other aspects of executive functioning.Objectives To investigate whether inhibitory control and other executive functions in smokers are impaired during acute abstinence relative to post-nicotine.Methods 145 smokers were tested twice after overnight abstinence-once after nicotine and once after placebo lozenges (order counterbalanced, double-blind)-on an antisaccade task, a continuous performance task (CPT), a delayed response spatial working memory task and a verbal fluency test.Results Compared with placebo, nicotine was associated with better inhibitory control on the antisaccade task and fewer impulsive responses to filler stimuli (motor errors) on the CPT; at the first assessment only, nicotine also reduced impulsive responses to 'catch' stimuli on the CPT. However, it did not affect CPT response bias (an index of impulsive vs cautious decision-making), spatial working memory, or verbal fluency.Conclusions Smoking abstinence appears to be associated with a difficulty in inhibiting prepotent motor responses, and with nicotine to attenuate this difficulty. However, more 'cognitive' forms of inhibitory control (e.g. decision-making) and the other aspects of executive function tested here appear to be unaffected.
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During nicotine withdrawal smokers have impaired functioning of the low-level brain mechanisms that underlie inhibition.
“There is also emerging evidence that during nicotine withdrawal smokers have impaired functioning of the low-level brain mechanisms that underlie inhibition (13).”
From The Multiple Facets of Cigarette Addiction and What They Mean for Encouraging and Helping Smokers to Stop (2009) · cites this paper as [13]
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Meta-Analysis Of Studies Investigation Of The Effect Of Smoking Cessation On Impatience
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- Authors
- Dawkins, L., Powell, J. H., West, R., Powell, J., & Pickering, A.
- Affiliations
- University of East London (GB)
- Goldsmiths University of London (GB)
- University College London (GB)
- Corresponding author
- Dawkins, Lynne
- Venue
- Psychopharmacology
- Published
- 2007-01-05
- Volume
- 190
- Issue
- 4
- Pages
- 457-467
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W2112589080
- Cited by
- 85
- References
- 55
- Citations by year
- 2025: 1 · 2024: 2 · 2022: 6 · 2021: 2 · 2020: 1 · 2019: 6 · 2018: 3 · 2017: 3 · 2016: 5 · 2015: 3 · 2014: 7 · 2013: 10 · 2012: 9
- FWCI
- 4.67
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Licence
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- UEL Research Repository (University of East London) (acceptedVersion)
- Research Open (London South Bank University) (acceptedVersion, cc-by)
- UEL Research Repository (University of East London) (submittedVersion, cc-by-nd)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- U.S. Public Health Service (3527427)
- Topics
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- nicotine, smoking abstinence, response inhibition, executive function, inhibitory control, antisaccade task, continuous performance test, spatial working memory, verbal fluency, prefrontal cortex, mesocorticolimbic circuitry, impulsivity
- MeSH terms
- Adult, Affect, Decision Making, Double-Blind Method, Female, Humans, Inhibition, Psychological, Male, Memory, Mental Processes, Middle Aged, Motor Skills, Nicotine, Reaction Time, Saccades, Smoking, Substance Withdrawal Syndrome, Verbal Behavior, Behavior, Addictive, Nicotinic Agonists
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