Cited by 85Smoking Behavior and CessationNicotinic Acetylcholine Receptors StudyNeural and Behavioral Psychology Studies

A double-blind placebo-controlled experimental study of nicotine: II—Effects on response inhibition and executive functioning

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Dawkins, Lynne, Powell, Jane H., West, Robert, Powell, John, Pickering, Alan·2007·Psychopharmacology

Abstract

Rationale Smokers may show abnormal functioning in prefrontal cortex during acute abstinence, reflecting deficient activity in mesocorticolimbic circuitry. Cognitive correlates of this putatively include impaired response inhibition and other aspects of executive functioning.Objectives To investigate whether inhibitory control and other executive functions in smokers are impaired during acute abstinence relative to post-nicotine.Methods 145 smokers were tested twice after overnight abstinence-once after nicotine and once after placebo lozenges (order counterbalanced, double-blind)-on an antisaccade task, a continuous performance task (CPT), a delayed response spatial working memory task and a verbal fluency test.Results Compared with placebo, nicotine was associated with better inhibitory control on the antisaccade task and fewer impulsive responses to filler stimuli (motor errors) on the CPT; at the first assessment only, nicotine also reduced impulsive responses to 'catch' stimuli on the CPT. However, it did not affect CPT response bias (an index of impulsive vs cautious decision-making), spatial working memory, or verbal fluency.Conclusions Smoking abstinence appears to be associated with a difficulty in inhibiting prepotent motor responses, and with nicotine to attenuate this difficulty. However, more 'cognitive' forms of inhibitory control (e.g. decision-making) and the other aspects of executive function tested here appear to be unaffected.

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Crossref · 10.1007/s00213-006-0634-6

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Authors
Dawkins, L., Powell, J. H., West, R., Powell, J., & Pickering, A.
Affiliations
  • University of East London (GB)
  • Goldsmiths University of London (GB)
  • University College London (GB)
Corresponding author
Dawkins, Lynne
Venue
Psychopharmacology
Published
2007-01-05
Volume
190
Issue
4
Pages
457-467
ISSN
  • 0033-3158 (ISSN-L)
  • 1432-2072
OpenAlex
W2112589080
Cited by
85
References
55
Citations by year
2025: 1 · 2024: 2 · 2022: 6 · 2021: 2 · 2020: 1 · 2019: 6 · 2018: 3 · 2017: 3 · 2016: 5 · 2015: 3 · 2014: 7 · 2013: 10 · 2012: 9
FWCI
4.67
Type
journal article
Language
en
Open access
Locations
  • Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • UEL Research Repository (University of East London) (acceptedVersion)
  • Research Open (London South Bank University) (acceptedVersion, cc-by)
  • UEL Research Repository (University of East London) (submittedVersion, cc-by-nd)
  • UCL Discovery (University College London) (submittedVersion)
Funders
U.S. Public Health Service (3527427)
Topics
  • Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
nicotine, smoking abstinence, response inhibition, executive function, inhibitory control, antisaccade task, continuous performance test, spatial working memory, verbal fluency, prefrontal cortex, mesocorticolimbic circuitry, impulsivity
MeSH terms
Adult, Affect, Decision Making, Double-Blind Method, Female, Humans, Inhibition, Psychological, Male, Memory, Mental Processes, Middle Aged, Motor Skills, Nicotine, Reaction Time, Saccades, Smoking, Substance Withdrawal Syndrome, Verbal Behavior, Behavior, Addictive, Nicotinic Agonists

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