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Cited by 265Posttraumatic Stress Disorder ResearchMemory Processes and InfluencesTraumatic Brain Injury Research

Corticolimbic blood flow in posttraumatic stress disorder during script-driven imagery

Britton, Jennifer C., Phan, K. Luan, Taylor, Stephan F., Fig, Lorraine M., Liberzon, Israel·2005·Biological Psychiatry
DOI 10.1016/j.biopsych.2004.12.025
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Abstract

Background Functional neuroimaging experiments targeting personal recall of emotional events may help elucidate neural substrates underlying posttraumatic stress disorder (PTSD). Studies suggest that limbic and paralimbic function might be altered in PTSD, as compared with trauma-exposed control subjects; however, little is known about functional changes resulting from traumatic experience itself. The present study examined both PTSD-specific and trauma-specific regional cerebral blood flow (rCBF) patterns during script-driven imagery.Methods Sixteen combat veterans with PTSD (PP); 15 combat veterans without PTSD (CC); and 14 healthy, aged-matched noncombat control subjects (NC) underwent [15O] H20 positron emission tomography (PET) scanning during script-driven imagery of emotionally evocative and neutral autobiographic events.Results Differential patterns of activation were detected in amygdala and medial frontal cortex. Past trauma experience was associated with decreased amygdala activity (i.e., less activity than healthy control subjects); however, combat control subjects deactivated this region (i.e., greater activity to neutral scripts). All subjects deactivated medial frontal cortex; PTSD patients had greater rostral anterior cingulate (rACC) deactivation compared with control groups, who deactivated ventromedial prefrontal cortex (vmPFC).Conclusions Trauma-specific patterns may represent potential compensatory changes to traumatic reminders, while patterns observed only in the PTSD group may reflect neural substrates specific to PTSD pathophysiology.

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  • Britton et al. (2005) found no increased amygdala activation among PTSD patients compared to control groups during exposure to emotional aversive stimulus.

    “Britton et al. (2005) found that, during the exposure of subjects to emotional aversive stimulus, there was no increased amygdala activation among the PTSD patients compared to the control groups.”

    From Neuroimaging research in posttraumatic stress disorder – Focus on amygdala, hippocampus and prefrontal cortex (2019) · cites this paper as Britton et al. (2005)

  • In Britton et al., the control group made up of Vietnam veterans without PTSD showed increased left amygdala activation in response to aversive stimuli.

    “Additionally, the control group made up of Vietnam veterans without PTSD showed increased left amygdala activation in response to aversive stimuli.”

    From Neuroimaging research in posttraumatic stress disorder – Focus on amygdala, hippocampus and prefrontal cortex (2019) · cites this paper as Britton et al. (2005)

  • Early PET studies reported increased insula activity in response to trauma script-driven imagery in individuals with PTSD, though in some studies no more than in combat-exposed controls.

    “early PET studies reported increased insula activity in response to trauma script–driven imagery in individuals with PTSD,24 though in some studies no more than in combat-exposed controls.25”

    From Altered resting-state amygdala functional connectivity in men with posttraumatic stress disorder (2012) · cites this paper as [25]

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Authors
Britton, J. C., Phan, K. L., Taylor, S. F., Fig, L. M., & Liberzon, I.
Affiliations
  • University of Michigan (US)
  • University of Chicago (US)
  • Ann Arbor VA Medical Center (US)
Corresponding author
Liberzon, Israel
ORCID
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2005-04
Volume
57
Issue
8
Pages
832-840
ISSN
0006-3223 (ISSN-L)
DOI
10.1016/j.biopsych.2004.12.025
OpenAlex
W2051751124
Cited by
265
References
45
Citations by year
2026: 3 · 2025: 2 · 2024: 8 · 2023: 4 · 2022: 7 · 2021: 8 · 2020: 18 · 2019: 16 · 2018: 8 · 2017: 13 · 2016: 15 · 2015: 15 · 2014: 20 · 2013: 15 · 2012: 15
FWCI
16.20
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
  • Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
Keywords
post-traumatic stress disorder, script-driven imagery, regional cerebral blood flow, amygdala, medial frontal cortex, rostral anterior cingulate cortex, ventromedial prefrontal cortex, combat veterans, autobiographical memory, emotional memory
MeSH terms
Amygdala, Cerebral Cortex, Cerebrovascular Circulation, Emotions, Female, Galvanic Skin Response, Habituation, Psychophysiologic, Humans, Limbic System, Male, Middle Aged, Photic Stimulation, Psychiatric Status Rating Scales, Stress Disorders, Post-Traumatic, Positron-Emission Tomography

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