Chronic cocaine administration reduces striatal dopamine terminal density and striatal dopamine release which leads to drug-seeking behaviour

Lee, J.; Parish, C.L.; Tomas, D.; Horne, M.K.

doi:10.1016/j.neuroscience.2010.11.055

Cited by 19Neurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and OutcomesNeuroscience and Neuropharmacology Research

Chronic cocaine administration reduces striatal dopamine terminal density and striatal dopamine release which leads to drug-seeking behaviour

Lee, J., Parish, C.L., Tomas, D., Horne, M.K.·2011·Neuroscience

DOI 10.1016/j.neuroscience.2010.11.055

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Abstract

Drug addiction is associated with altered dopamine (DA) neurotransmission in the basal ganglia. We have previously shown that chronic stimulation of the dopamine D2 receptor (D(2)R) with cocaine results in reduced striatal DA terminal density. The aims of this study were to establish whether this reduction in DA terminal density results in reduced striatal DA release and increased cocaine-seeking behaviour and whether D(2)R antagonism can restore the cocaine-induced alterations in DA neurotransmission and drug-seeking behaviour. Rats were housed individually and either control, cocaine, haloperidol (D(2)R antagonist), or cocaine and haloperidol was administered in the drinking water for 16 weeks. Chronic cocaine treatment, which reduced striatal DA terminal density by 20%, resulted in a reduction in basal (-34%) and cocaine-evoked (-33%) striatal DA release and increased cocaine-seeking behaviour. These cocaine-mediated effects on striatal DA terminal density, DA release and drug-seeking could be prevented by co-administration with haloperidol. Basal and cocaine-evoked DA release in the striatum directly correlated with DA terminal density and with preference for cocaine. We conclude that striatal DA terminal density and DA release is an important factor in maintaining drug preference and should be considered as a factor in drug-seeking behaviour and relapse.

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Dopamine levels are decreased in animals chronically exposed to drugs of abuse.
“Dopamine levels are decreased in animals chronically exposed to drugs of abuse (Castner et al., 2000; Kirkland Henry et al., 2009; Lee et al., 2011; Maisonneuve et al., 1995; Melega et al., 2008; Segal and Kuczenski, 1992; Sorg et al., 1997).”
From Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity (2014) · cites this paper as Lee et al., 2011

Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.
Di Chiara, G., & Imperato, A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.14.5274 · Cited by 4,733 · see citing works
Dopamine receptors: from structure to function
MISSALE, C., NASH, S. R., ROBINSON, S. W., JABER, M., & CARON, M. G. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.1.189 · Cited by 3,633 · see citing works
NEURAL MECHANISMS OF ADDICTION: The Role of Reward-Related Learning and Memory
Hyman, S. E., Malenka, R. C., & Nestler, E. J. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.113009 · Cited by 2,647 · see citing works
The new stereological tools: Disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis
Gundersen, H. J. G., Bagger, P. V., Bendtsen, T. F., Evans, S. M., Korbo, L., Marcussen, N., Møller, A., Nielsen, K. N., Nyengaard, J. R., Pakkenberg, B., et al. (1988) · Apmis · doi:10.1111/j.1699-0463.1988.tb00954.x · Cited by 2,480 · see citing works
Addiction and the brain antireward system
Koob, G. F., & Le Moal, M. (2008) · Annual Review of Psychology · doi:10.1146/annurev.psych.59.103006.093548 · Cited by 1,457 · see citing works
Is there a common molecular pathway for addiction?
Nestler, E. J. (2005) · Nature Neuroscience · doi:10.1038/nn1578 · Cited by 1,388 · see citing works
Addiction, Dopamine, and the Molecular Mechanisms of Memory
Berke, J. D., & Hyman, S. E. (2000) · Neuron · doi:10.1016/s0896-6273(00)81056-9 · Cited by 1,167 · see citing works
The dopamine hypothesis of the reinforcing properties of cocaine
Kuhar, M. J., Ritz, M. C., & Boja, J. W. (1991) · Trends in Neurosciences · doi:10.1016/0166-2236(91)90141-g · Cited by 989 · see citing works
Imaging dopamine's role in drug abuse and addiction
Volkow, N. D., Fowler, J. S., Wang, G. J., Baler, R., & Telang, F. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.05.022 · Cited by 988 · see citing works
Decreased dopamine D2 receptor availability is associated with reduced frontal metabolism in cocaine abusers
Volkow, N. D., Fowler, J. S., Wang, G., Hitzemann, R., Logan, J., Schlyer, D. J., Dewey, S. L., & Wolf, A. P. (1993) · Synapse · doi:10.1002/syn.890140210 · Cited by 924 · see citing works
Decreased striatal dopaminergic responsiveness in detoxified cocaine-dependent subjects
Volkow, N. D., Wang, G.-J., Fowler, J. S., Logan, J., Gatley, S. J., Hitzemann, R., Chen, A. D., Dewey, S. L., & Pappas, N. (1997) · Nature · doi:10.1038/386830a0 · Cited by 854 · see citing works
Regulation of cocaine reward by CREB
Carlezon, W. A., Thome, J., Olson, V. G., Lane-Ladd, S. B., Brodkin, E. S., Hiroi, N., Duman, R. S., Neve, R. L., & Nestler, E. J. (1998) · Science · doi:10.1126/science.282.5397.2272 · Cited by 767 · see citing works
Alterations in the morphology of dendrites and dendritic spines in the nucleus accumbens and prefrontal cortex following repeated treatment with amphetamine or cocaine
Robinson, T. E., & Kolb, B. E. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00576.x · Cited by 726 · see citing works
Regulation of a protein phosphatase cascade allows convergent dopamine and glutamate signals to activate ERK in the striatum
Valjent, E., Pascoli, V., Svenningsson, P., Paul, S., Enslen, H., Corvol, J.-C., Stipanovich, A., Caboche, J., Lombroso, P. J., Nairn, A. C., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408305102 · Cited by 614 · see citing works
Opposing Patterns of Signaling Activation in Dopamine D1and D2Receptor-Expressing Striatal Neurons in Response to Cocaine and Haloperidol
Bertran‐Gonzalez, J., Bosch‐Bouju, C., Maroteaux, M. J., Matamales, M., Hervé, D., Valjent, E., & Girault, J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1039-08.2008 · Cited by 606 · see citing works
Involvement of the Extracellular Signal-Regulated Kinase Cascade for Cocaine-Rewarding Properties
Valjent, E., Corvol, J., Pagès, C., Besson, M., Maldonado, R. J., & Caboche, J. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-23-08701.2000 · Cited by 548 · see citing works
Effect of acute and daily cocaine treatment on extracellular dopamine in the nucleus accumbens
Kalivas, P. W., & Duffy, P. (1990) · Synapse · doi:10.1002/syn.890050104 · Cited by 544 · see citing works
Reward system and addiction: what dopamine does and doesn’t do
DiChiara, G., & Bassareo, V. (2006) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2006.11.003 · Cited by 534 · see citing works
Marked inhibition of mesolimbic dopamine release: a common feature of ethanol, morphine, cocaine and amphetamine abstinence in rats
Rossetti, Z. L., Hmaidan, Y., & GESSA, G. L. (1992) · European Journal of Pharmacology · doi:10.1016/0014-2999(92)90706-a · Cited by 526 · see citing works
Opposite Modulation of Cocaine-Seeking Behavior by D 1 - and D 2 -Like Dopamine Receptor Agonists
Self, D. W., Barnhart, W. J., Lehman, D. A., & Nestler, E. J. (1996) · Science · doi:10.1126/science.271.5255.1586 · Cited by 492 · see citing works
Blockade of cocaine reinforcement in rats with the dopamine receptor blocker pimozide, but not with the noradrenergic blockers phentolamine or phenoxybenzamine.
de Wit, H., & Wise, R. A. (1977) · Canadian Journal of Psychology / Revue canadienne de psychologie · doi:10.1037/h0081662 · Cited by 491 · see citing works
DARPP-32: Regulator of the Efficacy of Dopaminergic Neurotransmission
Fienberg, A. A., Hiroi, N., Mermelstein, P. G., Song, W., Snyder, G. L., Nishi, A., Chéramy, A., O'Callaghan, J. P., Miller, D. B., Cole, D. G., et al. (1998) · Science · doi:10.1126/science.281.5378.838 · Cited by 491 · see citing works
PET imaging of dopamine D2 receptors during chronic cocaine self-administration in monkeys
Nader, M. A., Morgan, D., Gage, H. D., Nader, S. H., Calhoun, T. L., Buchheimer, N., Ehrenkaufer, R., & Mach, R. H. (2006) · Nature Neuroscience · doi:10.1038/nn1737 · Cited by 481 · see citing works
It could be habit forming: drugs of abuse and striatal synaptic plasticity
Gerdeman, G. L., Partridge, J. G., Lupica, C. R., & Lovinger, D. M. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(03)00065-1 · Cited by 480 · see citing works
The neurobiology of addiction: a neuroadaptational view relevant for diagnosis
Koob, G. F. (2006) · Addiction · doi:10.1111/j.1360-0443.2006.01586.x · Cited by 397 · see citing works
Transcriptional mechanisms of addiction: role of ΔFosB
Nestler, E. J. (2008) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2008.0067 · Cited by 392 · see citing works
Amphetamine-induced dopamine release: markedly blunted in cocaine dependence and predictive of the choice to self-administer cocaine
Martinez, D., Narendran, R., Foltin, R. W., Slifstein, M., Hwang, D.-R., Broft, A., Huang, Y., Cooper, T. B., Fischman, M. W., Kleber, H. D., et al. (2007) · American Journal of Psychiatry · doi:10.1176/ajp.2007.164.4.622 · Cited by 351 · see citing works
The Yin and Yang of dopamine release: a new perspective
GOTO, Y., OTANI, S., & GRACE, A. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.07.007 · Cited by 342 · see citing works
Basal extracellular dopamine levels in the nucleus accumbens are decreased during cocaine withdrawal after unlimited-access self-administration
Weiss, F., Markou, A., Lorang, M. T., & Koob, G. F. (1992) · Brain Research · doi:10.1016/0006-8993(92)91327-b · Cited by 318 · see citing works
Profound decrement of mesolimbic dopaminergic neuronal activity during ethanol withdrawal syndrome in rats: electrophysiological and biochemical evidence
Diana, M., Pistis, M., Carboni, S., Gessa, G. L., & Rossetti, Z. L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.7966 · Cited by 309 · see citing works
Cocaine Dependence and D2 Receptor Availability in the Functional Subdivisions of the Striatum: Relationship with Cocaine-Seeking Behavior
Martinez, D., Broft, A., Foltin, R. W., Slifstein, M., Hwang, D.-R., Huang, Y., Perez, A., Frankel, W. G., Cooper, T., Kleber, H. D., et al. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300420 · Cited by 306 · see citing works
Dopamine D1-like Receptors and Reward-related Incentive Learning
Beninger, R. J. (1998) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(97)00019-5 · Cited by 299 · see citing works
Abnormal Synaptic Plasticity in the Striatum of Mice Lacking Dopamine D2 Receptors
Calabresi, P., Saiardi, A., Pisani, A., Baik, J., Centonze, D., Mercuri, N. B., Bernardi, G., & Borrelli, E. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-12-04536.1997 · Cited by 287 · see citing works
Fos B mutant mice: Loss of chronic cocaine induction of Fos-related proteins and heightened sensitivity to cocaine’s psychomotor and rewarding effects
Hiroi, N., Brown, J. R., Haile, C. N., Ye, H., Greenberg, M. E., & Nestler, E. J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.19.10397 · Cited by 285 · see citing works
Cocaine-induced proliferation of dendritic spines in nucleus accumbens is dependent on the activity of cyclin-dependent kinase-5
Norrholm, S. D., Bibb, J. A., Nestler, E. J., Ouimet, C. C., Taylor, J. R., & Greengard, P. (2003) · Neuroscience · doi:10.1016/s0306-4522(02)00560-2 · Cited by 238 · see citing works
Altered Dendritic Spine Plasticity in Cocaine-Withdrawn Rats
Shen, H., Toda, S., Moussawi, K., Bouknight, A., Zahm, D. S., & Kalivas, P. W. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5638-08.2009 · Cited by 213 · see citing works
Axonal sprouting following lesions of the rat substantia nigra
Finkelstein, D. I., Stanić, D., Parish, C. L., Tomas, D., Dickson, K. A., & Horne, M. K. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00009-9 · Cited by 201 · see citing works
Self-citation
Dopamine D1- and D2-Like Receptor Mechanisms in Relapse to Cocaine-Seeking Behavior: Effects of Selective Antagonists and Agonists
Khroyan, T. V., Barrett-Larimore, R. L., Rowlett, J. K., & Spealman, R. D. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39122-0 · Cited by 198 · see citing works
Regulation of drug-taking and-seeking behaviors by neuroadaptations in the mesolimbic dopamine system
Self, D. W. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.07.005 · Cited by 189 · see citing works
Effects of a D1 and a D2 dopamine antagonist on the self-administration of cocaine and piribedil by Rhesus monkeys
Woolverton, W. L. (1986) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(86)90553-8 · Cited by 181 · see citing works
Changes in Extracellular Dopamine Induced by Morphine and Cocaine: Crucial Control by D2 Receptors
Rougé‐Pont, F., Usiello, A., Benoit‐Marand, M., Gonon, F., Piazza, P. V., & Borrelli, E. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-08-03293.2002 · Cited by 177 · see citing works
Striatal dopamine, dopamine transporter, and vesicular monoamine transporter in chronic cocaine users
Wilson, J. M., Shannak, K. S., Kish, S. J., Levey, A. I., Bergeron, C., Deck, J. H. N., Kalasinsky, K. S., Ang, L. F., Peretti, F. J., Adams, V. I., et al. (1996) · Annals of Neurology · doi:10.1002/ana.410400312 · Cited by 170 · see citing works
Functional Roles of Dopamine D2and D3Autoreceptors on Nigrostriatal Neurons Analyzed by Antisense KnockdownIn Vivo
Tepper, J. M., Sun, B.-C., Martin, L. P., & Creese, I. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-07-02519.1997 · Cited by 151 · see citing works
Timecourse of striatal re‐innervation following lesions of dopaminergic SNpc neurons of the rat
Stanić, D., Finkelstein, D. I., Bourke, D. W., Drago, J., & Horne, M. K. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02800.x · Cited by 147 · see citing works
Self-citation
Increases in extracellular dopamine in the nucleus accumbens by cocaine are inversely related to basal levels: effects of acute and repeated administration
Weiss, F., Paulus, M. P., Lorang, M. T., & Koob, G. F. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-11-04372.1992 · Cited by 146 · see citing works
Electrophysiologically identified nigral dopaminergic neurons intracellularly labeled with HRP: light-microscopic analysis
Tepper, J. M., Sawyer, S. F., & Groves, P. M. (1987) · Journal of Neuroscience · doi:10.1523/jneurosci.07-09-02794.1987 · Cited by 138 · see citing works
Synaptic plasticity in the mesolimbic dopamine system
Thomas, M. J., & Malenka, R. C. (2003) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.2002.1236 · Cited by 137 · see citing works
Dopamine D1 Receptors in Cocaine Dependence Measured with PET and the Choice to Self-Administer Cocaine
Martínez, D., Slifstein, M., Narendran, R., Foltin, R. W., Broft, A. I., Hwang, D., Perez, A. Y., Abi‐Dargham, A., Fischman, M. W., Kleber, H. D., et al. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2008.235 · Cited by 129 · see citing works
Dopamine D2receptors regulate tyrosine hydroxylase activity and phosphorylation at Ser40 in rat striatum
Lindgren, N., Xu, Q., Herrera‐Marschitz, M., et al. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2000.01443.x · Cited by 128 · see citing works
The Role of Dopamine Receptors in Regulating the Size of Axonal Arbors
Parish, C. L., Finkelstein, D. I., Drago, J., Borrelli, E., & Horne, M. K. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-14-05147.2001 · Cited by 121 · see citing works
Self-citation
Blockade or stimulation of D1 dopamine receptors attenuates cue reinstatement of extinguished cocaine-seeking behavior in rats
Alleweireldt, A. T., Weber, S. M., Kirschner, K. F., Bullock, B. L., & Neisewander, J. L. (2001) · Psychopharmacology · doi:10.1007/s002130100904 · Cited by 112 · see citing works
Sprouting of dopamine terminals and altered dopamine release and uptake in Parkinsonian dyskinaesia
Lee, J., Zhu, W.-M., Stanić, D., Finkelstein, D. I., Horne, M. H., Henderson, J. M., Lawrence, A. J., O’Connor, L., Tomas, D., Drago, J., et al. (2008) · Brain · doi:10.1093/brain/awn085 · Cited by 94 · see citing works
Self-citation
The effects of eticlopride and naltrexone on responding maintained by food, cocaine, heroin and cocaine/heroin combinations in rats.
Hemby, S. E., Smith, J. E., & Dworkin, S. I. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)13070-x · Cited by 94 · see citing works
Decreasing Striatal 6-FDOPA Uptake with Increasing Duration of Cocaine Withdrawal
Wu, J. C. (1997) · Neuropsychopharmacology · doi:10.1016/s0893-133x(97)00089-4 · Cited by 93 · see citing works
Autoreceptor-mediated changes in dopaminergic terminal excitability: Effects of striatal drug infusions
Tepper, J. M., Nakamura, S., Young, S. J., & Groves, P. M. (1984) · Brain Research · doi:10.1016/0006-8993(84)90598-5 · Cited by 91 · see citing works
Striatal metabotropic glutamate receptor function following experimental parkinsonism and chronic levodopa treatment
Picconi, B. (2002) · Brain · doi:10.1093/brain/awf269 · Cited by 84 · see citing works
Heterogeneity of neurons in the subnucleus interpolaris of the cat
Somers, D., & Panneton, W. M. (1984) · Brain Research · doi:10.1016/0006-8993(84)90599-7 · Cited by 83 · see citing works
In Vivo Mechanisms Underlying Dopamine Release from Rat Nigrostriatal Terminals: II. Studies Using Potassium and Tyramine
Fairbrother, I. S., Arbuthnott, G. W., Kelly, J. S., et al. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb04881.x · Cited by 78 · see citing works
Effects of long‐term treatment with dopamine receptor agonists and antagonists on terminal arbor size
Parish, C. L., Stanić, D., Drago, J., Borrelli, E., Finkelstein, D. I., & Horne, M. K. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02132.x · Cited by 67 · see citing works
Self-citation
Changes in function and ultrastructure of striatal dopaminergic terminals that regenerate following partial lesions of the SNpc
Stanić, D., Parish, C. L., Zhu, W. M., Krstew, E., Lawrence, A. J., Drago, J., Finkelstein, D. I., & Horne, M. K. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01843.x · Cited by 56 · see citing works
Self-citation
In Vivo Mechanisms Underlying Dopamine Release from Rat Nigrostriatal Terminals: I. Studies Using Veratrine and Ouabain
Fairbrother, I. S., Arbuthnott, G. W., Kelly, J. S., et al. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb04880.x · Cited by 46 · see citing works
Modulation of the Ca++-evoked release of [3H]dopamine from striatal synaptosomes by dopamine (D2) agonists and antagonists.
Bowyer, J. F., & Weiner, N. (1987) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-5347(25)00349-0 · Cited by 39 · see citing works
Cocaine Receptors on Dopamine Transporters Mediate Cocaine-Reinforced Behavior
Kuhar, M. J., Ritz, M. C., & Sharkey, J. (1988) · PsycEXTRA Dataset · doi:10.1037/e496572006-002 · Cited by 38 · see citing works
Brain microdialysis studies on the control of dopamine release and metabolism in vivo
Arbuthnott, G. W., Fairbrother, I. S., & Butcher, S. P. (1990) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(90)90044-g · Cited by 32 · see citing works
Long‐term administration of cocaine or serotonin reuptake inhibitors results in anatomical and neurochemical changes in noradrenergic, dopaminergic, and serotonin pathways
Horne, M. K., Lee, J., Chen, F., Lanning, K. M., Tomas, D., & Lawrence, A. J. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05534.x · Cited by 25 · see citing works
Self-citation
Haloperidol treatment reverses behavioural and anatomical changes in cocaine-dependent mice
Parish, C. L., Drago, J., Stanić, D., Borrelli, E., Finkelstein, D. I., & Horne, M. K. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.01.009 · Cited by 16 · see citing works
Self-citation
Olanzapine-Induced Suppression of Cocaine Self-Administration in Rhesus Monkeys
Howell, L. L., Wilcox, K. M., Lindsey, K. P., & Kimmel, H. L. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300828 · Cited by 12 · see citing works
Quantified Assessment of Terminal Density and Innervation
Finkelstein, D. I., Stanić, D., Parish, C. L., Drago, J., & Horne, M. K. (2004) · Current Protocols in Neuroscience · doi:10.1002/0471142301.ns0113s27 · Cited by 11 · see citing works
Self-citation

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Tolliver, B. K., Sganga, M. W., & Sharp, F. R. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00214.x · Cited by 46 · see citing works
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Authors: Lee, J., Parish, C. L., Tomas, D., & Horne, M. K.
Affiliations: The University of Melbourne (AU)
Corresponding author: Horne, M.K.
ORCID: Lee, J.
Parish, C.L.
Tomas, D.
Horne, M.K.
Venue: Neuroscience
Publisher: Elsevier BV
Published: 2011-02
Volume: 174
Pages: 143-150
ISSN: 0306-4522 (ISSN-L)
DOI: 10.1016/j.neuroscience.2010.11.055
OpenAlex: W2064960613
Cited by: 19
References: 68
Citations by year: 2020: 1 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 2 · 2013: 6 · 2012: 3
FWCI: 1.29
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: chronic cocaine administration, dopamine release, dopamine D2 receptor, haloperidol, dopamine D2 receptor antagonism, drug addiction, basal ganglia, relapse
MeSH terms: Animals, Cocaine, Corpus Striatum, Dopamine, Haloperidol, Male, Synaptic Transmission, Rats, Wistar, Presynaptic Terminals, Rats, Drug-Seeking Behavior, Dopamine D2 Receptor Antagonists

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

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Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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Chronic cocaine administration reduces striatal dopamine terminal density and striatal dopamine release which leads to drug-seeking behaviour

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