The aging brain: morphomolecular senescence of cortical circuits

Hof, Patrick R.; Morrison, John H.

doi:10.1016/j.tins.2004.07.013

Cited by 411Dementia and Cognitive Impairment ResearchNeuroscience and Neuropharmacology ResearchAlzheimer's disease research and treatments

The aging brain: morphomolecular senescence of cortical circuits

Hof, Patrick R., Morrison, John H.·2004·Trends in Neurosciences

DOI 10.1016/j.tins.2004.07.013

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Abstract

The human brain is uniquely powerful with respect to cognitive abilities, yet the hippocampal and neocortical circuits that mediate such complex functions are highly vulnerable to aging. Their selective vulnerability is profoundly manifested in Alzheimer's disease (AD), where degeneration of select neurons leads to a near complete loss of cognitive abilities. Most of us will avoid AD as we age. However, many will experience age-associated cognitive impairment - a decline in cognitive status presenting as deficits in memory and key capacities for strategic use of acquired information. Animal studies suggest that both AD and age-associated cognitive impairment reflect vulnerability of the same circuits. However, neuron death predominates in the former, whereas the latter is probably mediated by synaptic alterations in otherwise intact circuits. Fortunately, such age-related synaptic alterations could be reversible, as suggested by recent studies of hormone replacement.

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From Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature (2012) · cites this paper as [310]

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Does Alzheimer's disease begin in the brainstem?
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Altered synaptic dynamics during normal brain aging.
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Oligomeric Aβ in the monkey brain impacts synaptic integrity and induces accelerated cortical aging
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Aerobic glycolysis in the primate brain: Reconsidering the implications for growth and maintenance
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Authors: Hof, P. R., & Morrison, J. H.
Affiliations: Icahn School of Medicine at Mount Sinai (US)
Corresponding author: Hof, Patrick R.
Morrison, John H.
ORCID: Hof, Patrick R.
Morrison, John H.
Venue: Trends in Neurosciences
Publisher: Elsevier BV
Published: 2004-10
Volume: 27
Issue: 10
Pages: 607-613
ISSN: 0166-2236 (ISSN-L)
DOI: 10.1016/j.tins.2004.07.013
OpenAlex: W1986909933
Semantic Scholar: c2aa7b91af8ee18914834cb098e0abb77d244130
Cited by: 411
References: 70
Citations by year: 2026: 4 · 2025: 7 · 2024: 15 · 2023: 17 · 2022: 13 · 2021: 17 · 2020: 22 · 2019: 13 · 2018: 21 · 2017: 17 · 2016: 15 · 2015: 21 · 2014: 20 · 2013: 32 · 2012: 32
FWCI: 3.27
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Trends in Neurosciences (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (AG16765, AG05138, AG06647, AG02219)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords: brain aging, Alzheimer's disease, hippocampal circuitry, neocortical circuits, neuronal vulnerability, synaptic changes, memory decline, hormone replacement therapy, neurodegeneration
MeSH terms: Aging, Animals, Cerebral Cortex, Humans, Nerve Net, Neurons, Synapses, Cellular Senescence, Neurodegenerative Diseases

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The aging brain: morphomolecular senescence of cortical circuits

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