Enriched environment treatment restores impaired hippocampal synaptic plasticity and cognitive deficits induced by prenatal chronic stress
Abstract
Prenatal stress can cause long-term effects on cognitive functions in offspring. Hippocampal synaptic plasticity, believed to be the mechanism underlying certain types of learning and memory, and known to be sensitive to behavioral stress, can be changed by prenatal stress. Whether enriched environment treatment (EE) in early postnatal periods can cause a recovery from these deficits is unknown. Experimental animals were Wistar rats. Prenatal stress was evoked by 10 foot shocks (0.8 mA for 1s, 2-3 min apart) in 30 min per day at gestational day 13-19. After weaning at postnatal day 22, experimental offspring were given the enriched environment treatment through all experiments until tested (older than 52 days age). Electrophysiological and Morris water maze testing was performed at 8 weeks of age. The results showed that prenatal stress impaired long-term potentiation (LTP) but facilitated long-term depression (LTD) in the hippocampal CA1 region in the slices. Furthermore, prenatal stress exacerbated the effects of acute stress on hippocampal LTP and LTD, and also impaired spatial learning and memory in the Morris water maze. However, all these deficits induced by prenatal stress were recovered by enriched environment treatment. This work observes a phenomenon that may contribute to the understanding of clinically important interactions among cognitive deficit, prenatal stress and enriched environment treatment. Enriched environment treatment on early postnatal periods may be one potentially important target for therapeutic interventions in preventing the prenatal stress-induced cognitive disorders.
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Prenatal stress can alter synaptic plasticity by impairing long-term potentiation and facilitating long-term depression.
“Furthermore, prenatal stress has the potential to alter synaptic plasticity by impairing long-term potentiation but facilitating long-term depression (Yaka et al., 2007; Yang et al., 2007).”
From High pregnancy anxiety during mid-gestation is associated with decreased gray matter density in 6-9-year-old children. (2010) · cites this paper as Yang et al., 2007
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- Authors
- Yang, J., Hou, C., Ma, N., Liu, J., Zhang, Y., Zhou, J., Xu, L., & Li, L.
- Affiliations
- Central South University (CN)
- Corresponding author
- Xu, Lin
- Li, Lingjiang
- Venue
- Neurobiology of Learning and Memory
- Publisher
- Elsevier BV
- Published
- 2007-02
- Volume
- 87
- Issue
- 2
- Pages
- 257-263
- ISSN
- 1074-7427 (ISSN-L)
- OpenAlex
- W1980458726
- Cited by
- 127
- References
- 38
- Citations by year
- 2026: 2 · 2025: 2 · 2023: 4 · 2022: 4 · 2021: 2 · 2020: 9 · 2019: 8 · 2018: 6 · 2017: 7 · 2016: 12 · 2015: 6 · 2014: 7 · 2013: 5 · 2012: 11
- FWCI
- 3.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Learning and Memory (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- prenatal stress, environmental enrichment, hippocampal synaptic plasticity, long-term potentiation, long-term depression, CA1 region, spatial learning and memory, cognitive impairment, acute stress, footshock stress, rat offspring
- MeSH terms
- Animals, Behavior, Animal, Cognition Disorders, Environment, Female, Hippocampus, Neuronal Plasticity, Pregnancy, Prenatal Exposure Delayed Effects, Reaction Time, Stress, Psychological, Rats, Wistar, Maze Learning, Excitatory Postsynaptic Potentials, Rats, In Vitro Techniques
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