The role of nucleus accumbens dopamine in outcome encoding in instrumental and Pavlovian conditioning

Lex, Bjoern; Hauber, Wolfgang

doi:10.1016/j.nlm.2009.11.002

Cited by 61Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesMemory and Neural Mechanisms

The role of nucleus accumbens dopamine in outcome encoding in instrumental and Pavlovian conditioning

Lex, Bjoern, Hauber, Wolfgang·2010·Neurobiology of Learning and Memory

DOI 10.1016/j.nlm.2009.11.002

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Abstract

Considerable evidence suggests that dopamine in the core subregion of the nucleus accumbens is not only involved in Pavlovian conditioning but also supports instrumental performance. However, it is largely unknown whether NAc dopamine is required for outcome encoding which plays an important role both in Pavlovian stimulus-outcome learning and instrumental action-outcome learning. Therefore, we tested rats with 6-hydroxydopamine (6-OHDA) induced dopamine depletion of the NAc core for their sensitivity to outcome devaluation in a Pavlovian and an instrumental task. Results indicate that 6-OHDA-lesioned animals were sensitive to outcome devaluation in an instrumental task. This finding provides support to the notion that NAc core dopamine may not be crucial in encoding action-outcome associations. However, during instrumental conditioning lever pressing rates in 6-OHDA-lesioned animals were markedly lower which could reflect an impaired behavioral activation. By contrast, after outcome-specific devaluation in a Pavlovian task, performance in 6-OHDA-lesioned animals was impaired, i.e. their magazine-directed responding was non-selectively reduced. One possibility to explain non-selective responding is that NAc core DA depletion impaired the ability of conditioned stimuli to activate the memory of the current value of the reinforcer.

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Conditioned responses themselves exhibit sensitivity to outcome devaluation procedures.
“CRs themselves exhibit sensitivity to outcome devaluation procedures”
From Contributions of the striatum to learning, motivation, and performance: an associative account (2012) · cites this paper as [56]
The Nacc core and shell have both been shown to be necessary for the effects of outcome-specific devaluation on preparatory conditioned responses.
“the Nacc core and shell have both been shown to be necessary for the effects of outcome-specific devaluation on preparatory CRs [56,57].”
From Contributions of the striatum to learning, motivation, and performance: an associative account (2012) · cites this paper as [56]

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Research report Nucleus accumbens dopamine depletion impairs both acquisition and performance of appetitiv eP avlovian approach behaviour: implications for mesoaccumbens dopamine function
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Authors: Lex, B., & Hauber, W.
Affiliations: University of Stuttgart (DE)
Corresponding author: Hauber, Wolfgang
ORCID: Hauber, Wolfgang
Venue: Neurobiology of Learning and Memory
Publisher: Elsevier BV
Published: 2010-02
Volume: 93
Issue: 2
Pages: 283-290
ISSN: 1074-7427 (ISSN-L)
DOI: 10.1016/j.nlm.2009.11.002
OpenAlex: W1994772681
Cited by: 61
References: 55
Citations by year: 2024: 1 · 2023: 3 · 2022: 4 · 2020: 2 · 2019: 3 · 2018: 1 · 2017: 5 · 2016: 4 · 2015: 4 · 2014: 6 · 2013: 6 · 2012: 10
FWCI: 3.04
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Neurobiology of Learning and Memory (publishedVersion)
PubMed (publishedVersion)
Funders: Deutsche Forschungsgemeinschaft (HA2340/8-2)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: nucleus accumbens core, dopamine, outcome devaluation, classical conditioning, operant conditioning, 6-hydroxydopamine lesion, action-outcome associations, lever pressing, behavioral activation
MeSH terms: Analysis of Variance, Animals, Conditioning, Classical, Conditioning, Operant, Dopamine, Immunohistochemistry, Male, Neuropsychological Tests, Neurotoxins, Nucleus Accumbens, Reward, Tyrosine 3-Monooxygenase, Oxidopamine, Rats

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The role of nucleus accumbens dopamine in outcome encoding in instrumental and Pavlovian conditioning

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