Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus
Abstract
Resveratrol is a naturally occurring polyphenolic compound. Numerous animal studies have been reported on its wide-ranging beneficial effects in the biological system including diabetes mellitus (DM). We hypothesized, therefore, that oral supplementation of resveratrol would improve the glycemic control and the associated risk factors in patients with type 2 diabetes mellitus (T2DM). The present clinical study was therefore carried out to test the hypothesis. Sixty-two patients with T2DM were enrolled from Government Headquarters Hospital, Ootacamund, India, in a prospective, open-label, randomized, controlled trial. Patients were randomized into control and intervention groups. The control group received only oral hypoglycemic agents, whereas the intervention group received resveratrol (250 mg/d) along with their oral hypoglycemic agents for a period of 3 months. Hemoglobin A(1c), lipid profile, urea nitrogen, creatinine, and protein were measured at the baseline and at the end of 3 months. The results reveal that supplementation of resveratrol for 3 months significantly improves the mean hemoglobin A(1c) (means ± SD, 9.99 ± 1.50 vs 9.65 ± 1.54; P < .05), systolic blood pressure (mean ± SD, 139.71 ± 16.10 vs 127.92 ± 15.37; P < .05), total cholesterol (mean ± SD, 4.70 ± 0.90 vs 4.33 ± 0.76; P < .05), and total protein (mean ± SD, 75.6 ± 4.6 vs 72.3 ± 6.2; P < .05) in T2DM. No significant changes in body weight and high-density lipoprotein and low-density lipoprotein cholesterols were observed. Oral supplementation of resveratrol is thus found to be effective in improving glycemic control and may possibly provide a potential adjuvant for the treatment and management of diabetes.
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Clinical studies in humans suggest that resveratrol may improve insulin sensitivity and reduce plasma levels of glucose and insulin in patients with T2DM and mimic caloric restriction in obese subjects.
“Clinical studies in humans suggest that resveratrol may improve insulin sensitivity and reduce plasma levels of glucose and insulin in patients with T2DM and mimic CR in obese subjects (253, 254).”
From Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease (2018) · cites this paper as [254]
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- Authors
- Bhatt, J. K., Thomas, S., & Nanjan, M. J.
- Affiliations
- JSS Academy of Higher Education and Research (IN)
- University of Nizwa (OM)
- Corresponding author
- Nanjan, Moola Joghee
- Venue
- Nutrition Research
- Publisher
- Elsevier BV
- Published
- 2012-07
- Volume
- 32
- Issue
- 7
- Pages
- 537-541
- ISSN
- 0271-5317 (ISSN-L)
- OpenAlex
- W2038317187
- Cited by
- 475
- References
- 21
- Citations by year
- 2026: 10 · 2025: 19 · 2024: 29 · 2023: 25 · 2022: 34 · 2021: 36 · 2020: 53 · 2019: 30 · 2018: 58 · 2017: 41 · 2016: 34 · 2015: 40 · 2014: 32 · 2013: 30 · 2012: 1
- FWCI
- 16.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nutrition Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- resveratrol, type 2 diabetes, glycemic control, HbA1c, polyphenols, lipid profile, blood pressure, total cholesterol, oral antidiabetic drugs, adjuvant therapy
- MeSH terms
- Resveratrol, Administration, Oral, Aged, Blood Glucose, Creatinine, Diabetes Mellitus, Type 2, Female, Glycated Hemoglobin, Humans, Hypoglycemic Agents, India, Cholesterol, LDL, Male, Middle Aged, Nitrogen, Prospective Studies, Risk Factors, Stilbenes, Body Mass Index, Dietary Supplements
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