Thirty days of resveratrol supplementation does not affect postprandial incretin hormone responses, but suppresses postprandial glucagon in obese subjects
Open accessAbstract
Aims: Resveratrol, a natural polyphenolic compound produced by various plants (e.g. red grapes) and found in red wine, has glucose‐lowering effects in humans and rodent models of obesity and/or diabetes. The mechanisms behind these effects have been suggested to include resveratrol‐induced secretion of the gut incretin hormone glucagon‐like peptide‐1. We investigated postprandial incretin hormone and glucagon responses in obese human subjects before and after 30 days of resveratrol supplementation. Methods: Postprandial plasma responses of the incretin hormones glucagon‐like peptide‐1 and glucose‐dependent insulinotropic polypeptide and glucagon were evaluated in 10 obese men [subjects characteristics (mean ± standard error of the mean): age 52 ± 2 years; BMI 32 ± 1 kg/m 2, fasting plasma glucose 5.5 ± 0.1 mmol/l] who had been given a dietary supplement of resveratrol (Resvida® 150 mg/day) or placebo for 30 days in a randomized, double‐blind, crossover design with a 4‐week washout period. At the end of each intervention period a standardized meal test (without co‐administration of resveratrol) was performed. Results: Resveratrol supplementation had no impact on fasting plasma concentrations or postprandial plasma responses (area under curve values) of glucose‐dependent insulinotropic polypeptide (11.2 ± 2.1 vs. 11.8 ± 2.2 pmol/l, P = 0.87; 17.0 ± 2.2 vs. 14.8 ± 1.6 min × nmol/l, P = 0.20) or glucagon‐like peptide‐1 (15.4 ± 1.0 vs. 15.2 ± 0.9 pmol/l, P = 0.84; 5.6 ± 0.4 vs. 5.7 ± 0.3 min × nmol/l, P = 0.73). Resveratrol supplementation significantly suppressed postprandial glucagon responses (4.4 ± 0.4 vs. 3.9 ± 0.4 min × nmol/l, P = 0.01) without affecting fasting glucagon levels (15.2 ± 2.2 vs. 14.5 ± 1.5 pmol/l, P = 0.56). Conclusions: Our data suggest that 30 days of resveratrol supplementation does not affect fasting or postprandial incretin hormone plasma levels in obese humans, but suppresses postprandial glucagon responses.
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- Authors
- Knop, F. K., Konings, E., Timmers, S., Schrauwen, P., Holst, J. J., & Blaak, E. E.
- Affiliations
- University of Copenhagen (DK)
- Maastricht University Medical Centre (NL)
- Corresponding author
- Knop, F. K.
- Venue
- Diabetic Medicine
- Publisher
- Wiley
- Published
- 2013-06-07
- Volume
- 30
- Issue
- 10
- Pages
- 1214-1218
- ISSN
- 0742-3071 (ISSN-L)
- 1464-5491
- OpenAlex
- W2029212916
- Cited by
- 72
- References
- 17
- Citations by year
- 2026: 5 · 2025: 1 · 2024: 8 · 2023: 5 · 2022: 8 · 2021: 7 · 2020: 4 · 2019: 6 · 2018: 5 · 2017: 5 · 2016: 5 · 2015: 6 · 2014: 5 · 2013: 2
- FWCI
- 2.80
- Type
- journal article
- Language
- en
- Open access
- green
- research.wur.nl
- Locations
- Diabetic Medicine (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (submittedVersion)
- Socio-Environmental Systems Modeling (submittedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- DSM Nutritional Products
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- resveratrol, obesity, incretins, glucagon-like peptide-1, glucose-dependent insulinotropic polypeptide, glucagon, postprandial hormone response, dietary supplementation, polyphenols, glucose metabolism, test meal, insulin secretion, red wine polyphenols, diabetes prevention, hepatic glucose production, hepatic gluconeogenesis
- MeSH terms
- Resveratrol, Antioxidants, Blood Glucose, Double-Blind Method, Fasting, Gastric Inhibitory Polypeptide, Glucagon, Humans, Male, Middle Aged, Obesity, Stilbenes, Time Factors, Treatment Outcome, Cross-Over Studies, Postprandial Period, Dietary Supplements, Glucagon-Like Peptide 1, Incretins
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