5-year incidence of age-related maculopathy in the Reykjavik Eye Study
Abstract
Purpose To examine the age- and gender-specific 5-year incidence of age-related maculopathy (ARM) and age-related macular degeneration (AMD) in citizens of Reykjavik.Design Population-based, prospective cohort study.Participants The cohort was a population-based random sample of citizens 50 years and older. Of 1379 eligible subjects, 1045 had a baseline examination in 1996; 846 of the 958 survivors (88.2%) had a 5-year follow-up examination in 2001.Methods The incidence of various characteristics of drusen and pigmentary changes that are typical of ARM were determined using the international classification and grading system for ARM and AMD.Main outcome measures Early ARM and AMD were assessed by masked grading of stereo fundus photographs.Results Hypopigmentation developed at 5 years in 10.7% of people 50 to 59 years of age (95% confidence interval [CI], 6.9-14.4) and in 25.7% those 70 to 79 years of age (95% CI, 18.4-33.0) at baseline. Age-related macular degeneration developed in no one who was 50 to 59 years of age at baseline. Geographic atrophy (GA) developed in 4.6% (95% CI, 1.2-7.9) and exudative AMD in none of those who were 70 years and older at baseline.Conclusions Geographic atrophy is the predominant type of AMD in Iceland, and the ratio of GA to neovascular AMD is higher than in racially similar populations.
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In the Icelandic population, GA outnumbers neovascular AMD by three to one.
“In the Icelandic population under consideration here, however, GA was found to outnumber neovascular AMD by three to one, as reported in the Reykjavik Eye Study [28,29].”
From CFH Y402H confers similar risk of soft drusen and both forms of advanced AMD (2005) · cites this paper as [29]
The 5-year incidence of soft drusen in the Reykjavik Eye Study was similar to that of the Beaver Dam Eye Study and the Blue Mountains Eye Study.
“The 5-y incidence of soft drusen in the Reykjavik Eye Study, a population-based epidemiological study of individuals aged 50 y and older [28,29], was found to be similar to that of the Beaver Dam Eye Study in the US [30], and the Blue Mountains Eye Study in Australia [31].”
From CFH Y402H confers similar risk of soft drusen and both forms of advanced AMD (2005) · cites this paper as [29]
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- Authors
- JONASSON, F., ARNARSSON, A., PETO, T., SASAKI, H., SASAKI, K., & BIRD, A.
- Affiliations
- University of Iceland (IS)
- Kanazawa Medical University (JP)
- Moorfields Eye Hospital (GB)
- ORCID
- BIRD, A
- Venue
- Ophthalmology
- Publisher
- Elsevier BV
- Published
- 2005-01
- Volume
- 112
- Issue
- 1
- Pages
- 132-138
- ISSN
- 0161-6420 (ISSN-L)
- OpenAlex
- W2135882385
- Cited by
- 64
- References
- 25
- Citations by year
- 2024: 3 · 2023: 2 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 3 · 2017: 4 · 2015: 6 · 2014: 1 · 2013: 5 · 2012: 3
- FWCI
- 4.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Ophthalmology (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (Queen's University Belfast) (submittedVersion)
- Hirsla (Landspítali University Hospital) (submittedVersion)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Keywords
- age-related maculopathy, age-related macular degeneration, geographic atrophy, exudative AMD, drusen, retinal pigmentary changes, hypopigmentation, incidence, Iceland, population-based cohort, sex differences
- MeSH terms
- Aged, Aged, 80 and over, Female, Humans, Iceland, Macular Degeneration, Male, Middle Aged, Population Surveillance, Prospective Studies, Cohort Studies, Incidence, Age Distribution, Sex Distribution
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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