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Cited by 128Retinal Diseases and TreatmentsCardiovascular Health and Risk FactorsOcular Diseases and Behçet’s Syndrome

Age-related macular degeneration is associated with incident myocardial infarction among elderly Americans

Duan, Yinkang, Mo, Jingping, Klein, Ronald, Scott, Ingrid U., Lin, Hung-Mo, Caulfield, Joanne, Patel, Manju, Liao, Duanping·2007·Ophthalmology
DOI 10.1016/j.ophtha.2006.07.045
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Abstract

Objective To investigate whether age-related macular degeneration (AMD) is associated with the development of myocardial infarction (MI) among elderly Americans.Design Population-based cross-sectional and cohort study.Participants Five percent random sample of 2000 to 2003 Medicare enrollees.Methods The cross-sectional study included the first 2-year (2000 and 2001) enrollees who were aged > or =65 years (n = 1,519,086). The cohort study included only baseline MI-free enrollees (n = 1445677).Main outcome measures Chronic conditions (AMD and type, history of MI, hypertension, and diabetes) were defined based on any occurrence of relevant International Classification of Diseases 9 codes in relevant diagnosis fields of the baseline Medicare claim files. A total of 56611 incident MI cases were identified from the follow-up data (2002 and 2003).Results Baseline mean age was 76 years, with 60% women and 88% whites. The prevalence of neovascular AMD was 2.2% (2.3% in women vs. 1.7% in men and 2.3% in whites vs. 1.2% in blacks; P<0.01 for both gender and race differences). The prevalence of nonneovascular AMD was 8.8% (9.9% in women vs. 7.3% in men and 9.5% in whites vs. 4.3% in blacks; P<0.01 for both gender and race differences). Baseline age-, gender-, and race-adjusted prevalences of hypertension, diabetes, and history of MI were 75%, 33%, and 5.00%, respectively, in the neovascular AMD group. In contrast, they were 73%, 27%, and 4.68% in the nonneovascular AMD group, and 65%, 25%, and 4.54% in the non-AMD group (P<0.01 for comparing the prevalence in neovascular and nonneovascular AMD vs. non-AMD groups). Prospectively, baseline age-, gender-, race-, hypertension-, and diabetes-adjusted 2-year incident odds ratios and 95% confidence intervals of MI associated with AMD are 1.19 (1.16-1.22) for all persons with AMD, 1.26 (1.20-1.33) for neovascular AMD, and 1.18 (1.14-1.21) for nonneovascular AMD.Conclusions AMD is associated with older age, female gender, being white, and having a history of MI, hypertension, and diabetes. Furthermore, presence of AMD, especially neovascular AMD, is prospectively associated with a higher risk of incident MI. These findings, if confirmed by other studies that control for smoking and other lifestyle covariables, suggest the possibility of shared common antecedents between MI and AMD.

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  • Using Medicare data, patients with age-related macular degeneration were shown to have an increased risk of myocardial infarction.

    “Using Medicare data—which could be confounded by smoking—patients with age-related macular degeneration were shown to have an increased risk of myocardial infarction.76”

    From Age-related macular degeneration (2008) · cites this paper as [76]

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Authors
Duan, Y., Mo, J., Klein, R., Scott, I. U., Lin, H.-M., Caulfield, J., Patel, M., & Liao, D.
Affiliations
  • Pennsylvania State University (US)
  • Pfizer (United States) (US)
  • University of Wisconsin–Madison (US)
Corresponding author
Liao, Duanping
ORCID
Venue
Ophthalmology
Publisher
Elsevier BV
Published
2007-04
Volume
114
Issue
4
Pages
732-737
ISSN
0161-6420 (ISSN-L)
DOI
10.1016/j.ophtha.2006.07.045
OpenAlex
W2059277692
Cited by
128
References
36
Citations by year
2026: 3 · 2025: 2 · 2024: 5 · 2023: 3 · 2022: 6 · 2021: 4 · 2020: 4 · 2019: 3 · 2018: 5 · 2017: 10 · 2016: 8 · 2015: 10 · 2014: 9 · 2013: 8 · 2012: 9
FWCI
6.55
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Ophthalmology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Pfizer
Topics
  • Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
  • Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
Keywords
age-related macular degeneration, myocardial infarction, neovascular AMD, cardiovascular risk, older adults, hypertension, diabetes mellitus, chronic disease, sex differences, racial differences, Medicare enrollees, comorbidity burden
MeSH terms
Age Factors, Aged, Aged, 80 and over, Cross-Sectional Studies, Female, Humans, Hypertension, Macular Degeneration, Male, Myocardial Infarction, Prospective Studies, Risk Factors, Sex Factors, United States, Prevalence, Odds Ratio, White People, Diabetes Complications

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