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Cited by 138Retinal Diseases and TreatmentsRetinal Imaging and AnalysisOphthalmology and Visual Impairment Studies

Prevalence and Risk Factors for Age-Related Macular Degeneration in an Adult Japanese Population

Kawasaki, Ryo, Wang, Jie Jin, Ji, Gui-jin, Taylor, Bronwen, Oizumi, Toshihide, Daimon, Makoto, Kato, Takeo, Kawata, Sumio +5 more·2008·Ophthalmology
DOI 10.1016/j.ophtha.2007.11.015
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Abstract

Objective To describe the prevalence and risk factors for age-related macular degeneration (AMD) in a Japanese population and to compare these with data from a white population.Design Population-based cross-sectional epidemiologic study.Participants A population-based sample of Japanese persons 35 years or older from Funagata, Japan.Methods The Funagata study is a population-based study of 1758 (43% of eligible) Japanese persons 35 years or older from Funagata, Japan. In 2000 to 2002, 1625 (92.4%) participants had a nonmydriatic fundus photograph of one eye with sufficient quality for grading of AMD lesions, using the Wisconsin protocol. Age-standardized prevalence rates compared with the Blue Mountains Eye Study (BMES) population, odds ratios (ORs), and 95% confidence intervals (CIs) were calculated. Risk factors were assessed by logistic regression.Main outcome measures Early and late AMD.Results Of 1625 participants, early AMD and late AMD were present in 3.5% and 0.5%, respectively. Age-standardized early AMD prevalence in right eyes was 4.1%, similar to the corresponding prevalence of 4.4% in the BMES. For men, age-standardized prevalences of late AMD in right eyes were 1.1% and 1.2% in the BMES; for women, the corresponding prevalences were 0.3% and 2.1%, respectively. Increasing age (per 10 years; gender-adjusted OR, 2.27; 95% CI, 1.10-4.67) and current cigarette smoking (age- and gender-adjusted OR, 5.03; 95% CI, 1.00-25.47) were associated with late AMD.Conclusions In this Japanese population, prevalence of early AMD was similar to that for whites in the BMES. Although the late AMD prevalence was lower in Japanese women, in Japanese men it was similar to that in whites. This could have resulted from the substantially high proportion of Japanese men who are smokers. Cigarette smoking and increasing age were the 2 principal factors found associated with late AMD.

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  • The systematic review included 18 prospective and cross-sectional studies and 8 case control studies, contributing 94,058 patients and 3,178 late AMD cases.

    “In total, data from 18 prospective, cross-sectional studies and 8 case control studies [12,24-26,28,30,31,33-47,49-54,57-73] were included in the final analysis, contributing a sample of some 94,058 patients (ranging from 261 to 22,071) including 3,178 (ranging from 8 to 776) late AMD cases.”

    From Clinical risk factors for age-related macular degeneration: a systematic review and meta-analysis (2010) · cites this paper as [30]

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Authors
Kawasaki, R., Wang, J. J., Ji, G.-J., Taylor, B., Oizumi, T., Daimon, M., Kato, T., Kawata, S., Kayama, T., Tano, Y., Mitchell, P., Yamashita, H., & Wong, T. Y.
Affiliations
  • Yamagata University (JP)
  • The University of Sydney (AU)
  • The University of Osaka (JP)
  • The University of Melbourne (AU)
Corresponding author
Kawasaki, Ryo
ORCID
Venue
Ophthalmology
Publisher
Elsevier BV
Published
2008-08
Volume
115
Issue
8
Pages
1376-1381.e2
ISSN
0161-6420 (ISSN-L)
DOI
10.1016/j.ophtha.2007.11.015
OpenAlex
W2065621562
Cited by
138
References
33
Citations by year
2026: 3 · 2025: 3 · 2024: 3 · 2023: 5 · 2022: 3 · 2021: 6 · 2020: 2 · 2019: 6 · 2018: 8 · 2017: 8 · 2016: 9 · 2015: 11 · 2014: 15 · 2013: 7 · 2012: 8
FWCI
13.85
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Ophthalmology (publishedVersion)
  • PubMed (publishedVersion)
  • National University of Singapore (submittedVersion)
Topics
  • Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
  • Health Sciences › Medicine › Epidemiology › Ophthalmology and Visual Impairment Studies
Keywords
age-related macular degeneration, prevalence, risk factors, Japanese population, early AMD, late AMD, cigarette smoking, age, sex differences, non-mydriatic fundus photography
MeSH terms
Adult, Aged, Cross-Sectional Studies, Female, Humans, Japan, Macular Degeneration, Male, Middle Aged, Risk Factors, Prevalence, Odds Ratio

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