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A cannabinoid agonist, WIN 55,212-2, reduces neuropathic nociception induced by paclitaxel in rats
Abstract
Paclitaxel is an effective antineoplastic drug treatment used as an anti-tumoral therapy. Unfortunately its use is associated with unwanted side effects, which include the development of peripheral neuropathies and neuropathic pain, greatly affecting the quality of life of patients. It is well known that agonists of the cannabinoid receptor are able to reduce hyperalgesia and allodynia that develop after nerve injury. Our aim was to evaluate the efficacy of the cannabinoid agonist WIN 55,212-2 to reduce the thermal hyperalgesia and the tactile allodynia induced by administration of paclitaxel in rats. Present results demonstrate that WIN 55,212-2 (1 mg/kg i.p.) significantly reduced the heat (P<0.0001) and the mechanical (P=0.0003) withdrawal thresholds, the dose being smaller than that required to reach similar effects in the sciatic nerve constriction model (1.5 mg/kg). When the cannabinoid tetrad test was evaluated to measure behavioral modifications, it was found that WIN 55,212-2 (1mg/kg) did not induce changes either in body temperature or in immobility time, and only a reduction in spontaneous motility was recorded. This effect was antagonized by SR 141716A, suggesting the involvement of the CB1 receptor, although the participation of CB2 receptors cannot be excluded from this study. When WIN 55,212-2 was administered intraplantar, no differences were observed between the injected paw and the contralateral paw, suggesting that systemic mechanisms are needed to reach effectiveness. From these results we suggest that cannabinoids may be an interesting alternative to reduce neuropathic symptoms induced by paclitaxel, however more work is required to assess this possibility.
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In the citing paper
“It has been reported that mixed CB 1 /CB 2 receptor agonists and CB 2 receptor-selective agonists are effective against paclitaxel-induced peripheral neuropathy (Deng et al, 2015a(Deng et al, , 2015b;;Pascual et al, 2005;Rahn et al, 2008).”
From The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain (2018) · cites this paper as Pascual et al, 2005
In the citing paper
“In one study, paclitaxel118 produced mechanical allodynia starting on day 5 that continued throughout the timecourse, although thermal hyperalgesia was only present from days 18-21.119”
From Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside (2009) · cites this paper as [119]
In the citing paper
“WIN55,212-2 suppressed neuropathic nociception in this model but had no effect on body temperature or immobility.”
From Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside (2009) · cites this paper as [119]
In the citing paper
“WIN55,212-2-induced decreases in spontaneous motor activity were nonetheless observed.119”
From Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside (2009) · cites this paper as [119]
Citations
Cites
Ethical guidelines for investigations of experimental pain in conscious animals.
Zimmermann, M. (1983) · Pain · doi:10.1016/0304-3959(83)90201-4 · Cited by 7,762
A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man
Bennett, G. J., & Xie, Y.-K. (1988) · Pain · doi:10.1016/0304-3959(88)90209-6 · Cited by 5,376
McGuire, W. P., Hoskins, W. J., Brady, M. F., Kucera, P. R., Partridge, E. E., Look, K. Y., Clarke‐Pearson, D. L., & Davidson, M. (1996) · New England Journal of Medicine · doi:10.1056/nejm199601043340101 · Cited by 2,798
Rowinsky, E. K., & Donehower, R. C. (1995) · New England Journal of Medicine · doi:10.1056/nejm199504133321507 · Cited by 1,924
Taxol: A Novel Investigational Antimicrotubule Agent
Rowinsky, E. K., Cazenave, L. A., & Donehower, R. C. (1990) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/82.15.1247 · Cited by 1,093
Clinical toxicities encountered with paclitaxel (Taxol).
Rowinsky, E. K., Eisenhauer, E. A., Chaudhry, V., Sg, A., & Rc, D. (1993) · PubMed · Cited by 692
Cannabinoids reduce hyperalgesia and inflammation via interaction with peripheral CB1 receptors
Richardson, J. D., Kilo, S., & Hargreaves, K. (1998) · Pain · doi:10.1016/s0304-3959(97)00213-3 · Cited by 501
A painful peripheral neuropathy in the rat produced by the chemotherapeutic drug, paclitaxel
Polomano, R. C., Mannes, A. J., Clark, U. S., & Bennett, G. J. (2001) · Pain · doi:10.1016/s0304-3959(01)00363-3 · Cited by 476
Phase I clinical and pharmacokinetic study of taxol.
Wiernik, P. H., Schwartz, E. L., Strauman, J. J., Dutcher, J. P., Lipton, R. B., & Paietta, E. M. (1987) · PubMed · Cited by 452
CB2 cannabinoid receptor-mediated peripheral antinociception
Malan, P. T., Ibrahim, M. M., Deng, H., Liu, Q., Mata, H. P., Vanderah, T., Porreca, F., & Makriyannis, A. (2001) · Pain · doi:10.1016/s0304-3959(01)00321-9 · Cited by 391
Fox, A., Kesingland, A., Gentry, C., McNair, K., Patel, S., Urban, L., & James, I. (2001) · Pain · doi:10.1016/s0304-3959(00)00474-7 · Cited by 379
Chaudhry, V., Rowinsky, E. K., Sartorius, S. E., Donehower, R. C., & Cornblath, D. R. (1994) · Annals of Neurology · doi:10.1002/ana.410350310 · Cited by 362
Taxol produces a predominantly sensory neuropathy
Lipton, R. B., Apfel, S. C., Dutcher, J. P., Rosenberg, R., Kaplan, J., Berger, A., Einzig, A. I., Wiernik, P. H., & Schaumburg, H. H. (1989) · Neurology · doi:10.1212/wnl.39.3.368 · Cited by 317
Herzberg, U., Eliav, E., Bennett, G. J., & Kopin, I. J. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(96)13308-5 · Cited by 307
Vincristine‐induced neuropathy
Sandier, S. G., Tobin, W. E., & Henderson, E. S. (1969) · Neurology · doi:10.1212/wnl.19.4.367 · Cited by 302
Antihyperalgesic effects of spinal cannabinoids
Richardson, J. D., Aanonsen, L., & Hargreaves, K. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(97)01621-x · Cited by 275
Wiernik, P. H., Schwartz, E. L., Einzig, A. I., Strauman, J. J., Lipton, R. B., & Dutcher, J. P. (1987) · Journal of Clinical Oncology · doi:10.1200/jco.1987.5.8.1232 · Cited by 275
Cannabinoid CB1 Receptor Expression in Rat Spinal Cord
Farquhar-Smith, W. P., Egertová, M., Bradbury, E. J., McMahon, S. B., Rice, A. S. C., & Elphick, M. R. (2000) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2000.0844 · Cited by 268
Lichtman, A. H., Cook, S. A., & Martin, B. R. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12310-0 · Cited by 261
Vincristine treatment of advanced cancer: a cooperative study of 392 cases.
Holland, J. F., Scharlau, C., Gailani, S. D., Krant, M. J., Olson, K. B., Horton, J., Shnider, B. I., Lynch, J. J., Owens, A. H., Carbone, P. P., et al. (1973) · PubMed · Cited by 233
Bridges, D., Ahmad, K., & Rice, A. S. C. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704110 · Cited by 222
Spinal and supraspinal components of cannabinoid-induced antinociception.
Lichtman, A. H., & Martin, B. R. (1991) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)20242-7 · Cited by 218
Prospective study of paclitaxel-induced peripheral neuropathy with quantitative sensory testing
Forsyth, P. A., Balmaceda, C. M., Peterson, K., Seidman, A. D., Brasher, P. M. A., & DeAngelis, L. M. (1997) · Journal of Neuro-Oncology · doi:10.1023/a:1005805907311 · Cited by 198
Lim, G., Sung, B., Ji, R.-R., & Mao, J. (2003) · Pain · doi:10.1016/s0304-3959(03)00242-2 · Cited by 195
The ring test: a quantitative method for assessing the ‘cataleptic’ effect of cannabis in mice
Pertwee, R. G. (1972) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1972.tb06900.x · Cited by 189
Vincristine hyperalgesia in the rat: A model of painful vincristine neuropathy in humans
Aley, K. O., Reichling, D. B., & Levine, J. D. (1996) · Neuroscience · doi:10.1016/0306-4522(96)00020-6 · Cited by 185
Cavaletti, G., Tredici, G., Braga, M., & Tazzari, S. (1995) · Experimental Neurology · doi:10.1006/exnr.1995.1008 · Cited by 185
A phase I trial of taxol given by a 6-hour intravenous infusion.
Brown, T., Havlin, K. A., Weiss, G. R., Cagnola, J., Koeller, J. M., Kuhn, J. G., Rizzo, J. D., Craig, J., Phillips, J. L., & Hoff, D. V. (1991) · Journal of Clinical Oncology · doi:10.1200/jco.1991.9.7.1261 · Cited by 180
Martin, W. J., Hohmann, A. G., & Walker, J. M. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-20-06601.1996 · Cited by 172
Description of a short-term Taxol®-induced nociceptive neuropathy in rats
Authier, N., Gillet, J.-P., Fialip, J., Eschalier, A., & Coudore, F. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02910-3 · Cited by 171
Spinal cannabinoids are anti-allodynic in rats with persistent inflammation
Martin, W. J., Loo, C. M., & Basbaum, A. I. (1999) · Pain · doi:10.1016/s0304-3959(99)00045-7 · Cited by 166
Pertwee, R. G., Stevenson, L. A., Elrick, D. B., Mechoulam, R., & Corbett, A. D. (1992) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1992.tb09088.x · Cited by 156
Smith, F. L., Fujimori, K., Lowe, J., & Welch, S. P. (1998) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(97)00583-2 · Cited by 154
Scott, D. A., Wright, C. E., & Angus, J. A. (2004) · Pain · doi:10.1016/j.pain.2004.01.020 · Cited by 129
Vincristine-induced allodynia in the rat
Nozaki‐Taguchi, N., Chaplan, S. R., Higuera, E. S., Ajakwe, R., & Yaksh, T. L. (2001) · Pain · doi:10.1016/s0304-3959(01)00294-9 · Cited by 126
Welch, S. P., Huffman, J. W., & Lowe, J. A., III (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37725-0 · Cited by 120
Anti-edema and analgesic properties of delta9-tetrahydrocannabinol (THC).
Sofia, R. D., Nalepa, S. D., Harakal, J. J., & Vassar, H. B. (1973) · PubMed · Cited by 116
Cannabinoid CB1 receptor upregulation in a rat model of chronic neuropathic pain
Siegling, A., Hofmann, H. A., Denzer, D., Mauler, F., & De Vry, J. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)00798-1 · Cited by 108
Yaksh, T. L. (1981) · The Journal of Clinical Pharmacology · doi:10.1002/j.1552-4604.1981.tb02612.x · Cited by 103
Connelly, E. F., Markman, M. M., KENNEDY, A. W., Webster, K. D., Kulp, B., Peterson, G., & Belinson, J. L. (1996) · Gynecologic Oncology · doi:10.1006/gyno.1996.0210 · Cited by 98
Li, J., Daughters, R. S., Bullis, C., Bengiamin, R. N., Stucky, M. W., Brennan, J., & Simone, D. A. (1999) · Pain · doi:10.1016/s0304-3959(98)00263-2 · Cited by 90
Wasserheit, C., Frazein, A., Oratz, R., Sorich, J., Downey, A., Hochster, H. S., Chachoua, A., Wernz, J., Zeleniuch‐Jacquotte, A., Blum, R. H., et al. (1996) · Journal of Clinical Oncology · doi:10.1200/jco.1996.14.7.1993 · Cited by 88
Kupers, R. C., Nuytten, D., Costa, M. D. C., & Gybels, J. (1992) · Pain · doi:10.1016/0304-3959(92)90117-t · Cited by 85
Monhemius, R., Azami, J., Green, D. L., & Roberts, M. H. T. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02605-1 · Cited by 64
Assessment of allodynia and hyperalgesia after cisplatin administration to rats
Authier, N., Fialip, J., Eschalier, A., & Coudoré, F. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01373-2 · Cited by 63
Besse, D., Lombard, M. C., & Besson, J. (1992) · Brain Research · doi:10.1016/0006-8993(92)90237-4 · Cited by 48
Paclitaxel in Advanced Non-Small Cell Lung Cancer
Akerley, W. (2000) · CHEST Journal · doi:10.1378/chest.117.4_suppl_1.152s · Cited by 37
Gordon, A., Stringer, C. A., Matthews, C. M., Willis, D. L., & Nemunaitis, J. J. (1997) · Journal of Clinical Oncology · doi:10.1200/jco.1997.15.5.1965 · Cited by 34
Chapman, V. (2001) · Neuropharmacology · doi:10.1016/s0028-3908(01)00125-3 · Cited by 25
A model of peripheral mononeuropathy in the rat
Bennett, G. J., & Hargreaves, K. (1990) · Pain · doi:10.1016/0304-3959(90)91170-n · Cited by 15
Striational autoantibodies in myasthenia gravis mainly react with ryanodine receptor
Iwasa, K. (1997) · Muscle & Nerve · doi:10.1002/(sici)1097-4598(199706)20:6 · Cited by 12
Helsing, M., Thaning, L., Sederholm, C., Lamberg, K., Martinsson, J.-E., Ek, L., Månsson, T., Andersson, L., Hero, U., Anjedani, D., et al. (1999) · Lung Cancer · doi:10.1016/s0169-5002(99)00027-6 · Cited by 11
Langer, C. J., McAleer, C., Bonjo, C. A., Litwin, S., Millenson, M. M., Kosierowski, R., Blankstein, K. B., Alexander, R. E., & Ozols, R. F. (2000) · European Journal of Cancer · doi:10.1016/s0959-8049(99)00248-8 · Cited by 9
Research works printed but not linked: 1
- Sofia, 1973, Antiedema and analgesic propierties of delta9-tetrahydrocannabinol (THC)., J Pharmacol Exp Ther, 186, 646
Cited by
Sorted by citations
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Roosterman, D., Goerge, T., Schneider, S. W., Bunnett, N. W., & Steinhoff, M. S. (2006) · Physiological Reviews · doi:10.1152/physrev.00026.2005 · Cited by 693
Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors
Agarwal, N., Pacher, P., Tegeder, I., Amaya, F., Constantin, C. E., Brenner, G. J., Rubino, T., Michalski, C. W., Marsicano, G., Monory, K., et al. (2007) · Nature Neuroscience · doi:10.1038/nn1916 · Cited by 571
Cannabinoids and Pain: New Insights From Old Molecules
Vučković, S., Srebro, D., Vujović, K. S., Vučetić, Č., & Prostran, M. S. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01259 · Cited by 440
Mechanism-based treatment for chemotherapy-induced peripheral neuropathic pain
Sisignano, M., Baron, R., Scholich, K., & Geißlinger, G. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2014.211 · Cited by 340
Ledeboer, A., Jekich, B. M., Sloane, E. M., Mahoney, J. H., Langer, S. J., Milligan, E. D., Martin, D., Maier, S. F., Johnson, K. W., Leinwand, L. A., et al. (2006) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2006.10.012 · Cited by 310
Metadata
- Authors
- Pascual, D., Goicoechea, C., Suardíaz, M., & Martín, M. I.
- Affiliations
- Universidad Rey Juan Carlos (ES)
- Venue
- Pain
- Published
- 2005-11
- Volume
- 118
- Issue
- 1
- Pages
- 23-34
- ISSN
- 0304-3959 (ISSN-L)
- OpenAlex
- W2038770419
- Cited by
- 117
- References
- 56
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 8 · 2023: 6 · 2022: 6 · 2021: 5 · 2020: 10 · 2019: 8 · 2018: 10 · 2017: 3 · 2016: 2 · 2015: 1 · 2014: 6 · 2013: 7 · 2012: 9
- FWCI
- 3.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pain (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Oncology › Cancer Treatment and Pharmacology
- Keywords
- WIN 55,212-2, cannabinoid receptor agonists, paclitaxel-induced peripheral neuropathy, neuropathic pain, thermal hyperalgesia, mechanical allodynia, CB1 receptor, CB2 receptor, SR141716A, peripheral neuropathy, antinociception
- MeSH terms
- Analgesics, Animals, Antineoplastic Agents, Phytogenic, Behavior, Animal, Cannabinoids, Disease Models, Animal, Hot Temperature, Humans, Hyperalgesia, Male, Morpholines, Naphthalenes, Neuralgia, Pain Measurement, Peripheral Nervous System Diseases, Physical Stimulation, Sensory Thresholds, Touch, Treatment Outcome, Rats, Wistar, Paclitaxel, Benzoxazines, Rats
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