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Triethylene glycol, an active component of Ashwagandha (Withania somnifera) leaves, is responsible for sleep induction

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Phlorotannin-rich fraction from Ishige foliacea brown seaweed prevents the scopolamine-induced memory impairment via regulation of ERK-CREB-BDNF pathway

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Botanicals as Modulators of Neuroplasticity: Focus on BDNF

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Withania somnifera (L.) Dunal, a Potential Source of Phytochemicals for Treating Neurodegenerative Diseases: A Systematic Review

Lerose, V., Ponticelli, M., Benedetto, N., Carlucci, V., Lela, L., Tzvetkov, N. T., & Milella, L. (2024) · Plants · doi:10.3390/plants13060771 · Cited by 63 · see citing works

Nootropic and Neuroprotective Effects of Dichrocephala integrifolia on Scopolamine Mouse Model of Alzheimer’s Disease

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Recent Advancements in Extraction Techniques of Ashwagandha ( Withania somnifera ) with Insights on Phytochemicals, Structural Significance, Pharmacology, and Current Trends in Food Applications

Shinde, S., Balasubramaniam, A. K., Mulay, V. P., Saste, G., Girme, A., & Hingorani, L. (2023) · ACS Omega · doi:10.1021/acsomega.3c03491 · Cited by 53 · see citing works

Glioprotective Effects of Ashwagandha Leaf Extract against Lead Induced Toxicity

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Withania somnifera leaf alleviates cognitive dysfunction by enhancing hippocampal plasticity in high fat diet induced obesity model

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Biotechnological interventions inWithania somnifera(L.) Dunal

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M1 muscarinic receptor is a key target of neuroprotection, neuroregeneration and memory recovery by i-Extract from Withania somnifera

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Piracetam Prevents Scopolamine-Induced Memory Impairment and Decrease of NTPDase, 5′-Nucleotidase and Adenosine Deaminase Activities

Marisco, P. C., Carvalho, F. B., da Rosa, M. M., Girardi, B., Gutierres, J. M., Jaques, J. A., Salla, A. P. S., Pimentel, V. C., Schetinger, M. R. C., Leal, D. B. R., et al. (2013) · Neurochemical Research · doi:10.1007/s11064-013-1072-6 · Cited by 50 · see citing works

Treadmill Exercise Ameliorates Short-Term Memory Disturbance in Scopolamine-Induced Amnesia Rats

Heo, Y.-M., Shin, M., Lee, J. M., Kim, C., Baek, S.-B., Kim, K. H., & Baek, S. (2014) · International Neurourology Journal · doi:10.5213/inj.2014.18.1.16 · Cited by 50 · see citing works

Withania somnifera (L.) Dunal ameliorates neurodegeneration and cognitive impairments associated with systemic inflammation

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Involvement of hippocampal Arc in amnesia and its recovery by alcoholic extract of Ashwagandha leaves

Gautam, A., Wadhwa, R., & Thakur, M. K. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.08.009 · Cited by 47 · see citing works

Preparation, Optimization, and Evaluation of Methoxy Poly(ethylene glycol)-co-Poly(ε-caprolactone) Nanoparticles Loaded by Rivastigmine for Brain Delivery

Mohamadpour, H., Azadi, A., Rostamizadeh, K., Andalib, S., Zanjani, M. R. S., & Hamidi, M. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.9b00691 · Cited by 48 · see citing works

Effect of resveratrol on scopolamine-induced cognitive impairment in mice

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Novel Methods to Generate Active Ingredients-Enriched Ashwagandha Leaves and Extracts

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Nootropic potential of Ashwagandha leaves: Beyond traditional root extracts

Wadhwa, R., Konar, A., & Kaul, S. C. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.09.001 · Cited by 43 · see citing works

Taraxerol as a possible therapeutic agent on memory impairments and Alzheimer’s disease: Effects against scopolamine and streptozotocin-induced cognitive dysfunctions

Berté, T. E., Dalmagro, A. P., Zimath, P. L., Gonçalves, A. E., Meyre‐Silva, C., Bürger, C., Weber, C. J., Santos, D., Filho, V. C., & de Souza, M. M. (2018) · Steroids · doi:10.1016/j.steroids.2018.01.002 · Cited by 41 · see citing works

Withania somnifera Leaf Extract Ameliorates Benzo[a]pyrene-Induced Behavioral and Neuromorphological Alterations by Improving Brain Antioxidant Status in Zebrafish ( Danio rerio )

Mohanty, R., Das, S. K., Singh, N. R., & Patri, M. (2016) · Zebrafish · doi:10.1089/zeb.2015.1215 · Cited by 39 · see citing works

A literature review of the studies concerning selected plant-derived adaptogens and their general function in body with a focus on animal studies

Esmaealzadeh, N., Iranpanah, A., Sarris, J. J., & Rahimi, R. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154354 · Cited by 45 · see citing works

Lactoferrin-conjugated pH and redox-sensitive polymersomes based on PEG-S-S-PLA-PCL-OH boost delivery of bacosides to the brain

Goyal, K., Konar, A., Kumar, B. S. H., & Koul, V. (2018) · Nanoscale · doi:10.1039/c8nr03828g · Cited by 38 · see citing works

Attenuation of oxidative damage-associated cognitive decline by Withania somnifera in rat model of streptozotocin-induced cognitive impairment

Ahmed, M. E., Javed, H., Khan, M. M., Vaibhav, K., Ahmad, A., Khan, A., Tabassum, R., Islam, F., Safhi, M. M., & Islam, F. (2013) · PROTOPLASMA · doi:10.1007/s00709-013-0482-2 · Cited by 37 · see citing works

Aqueous Leaf Extract of Withania somnifera as a Potential Neuroprotective Agent in Sleep-deprived Rats: a Mechanistic Study

Manchanda, S., Mishra, R., Singh, R., Kaur, T., & Kaur, G. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9883-5 · Cited by 38 · see citing works

Induction of Senescence in Cancer Cells by a Novel Combination of Cucurbitacin B and Withanone: Molecular Mechanism and Therapeutic Potential

Garg, S., Huifu, H., Kumari, A., Sundar, D., Kaul, S. C., & Wadhwa, R. (2019) · The Journals of Gerontology Series A · doi:10.1093/gerona/glz077 · Cited by 38 · see citing works

Neuroprotection of N-benzylcinnamide on scopolamine-induced cholinergic dysfunction in human SH-SY5Y neuroblastoma cells

Thangnipon, W., Puangmalai, N., Soi‐ampornkul, R., Suwanna, N., Tuchinda, P., & Nobsathian, S. (2017) · Neural Regeneration Research · doi:10.4103/1673-5374.215262 · Cited by 35 · see citing works

Role of nutraceuticals in cognition during aging and related disorders

Singh, P., Sivanandam, T. M., Konar, A., & Thakur, M. K. (2020) · Neurochemistry International · doi:10.1016/j.neuint.2020.104928 · Cited by 35 · see citing works

Ethanolic Extract of Orthosiphon stamineus Improves Memory in Scopolamine-Induced Amnesia Model

Retinasamy, T., Shaikh, M. F., Kumari, Y., & Othman, I. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01216 · Cited by 34 · see citing works

Management of cognitive impairment in bipolar disorder: a systematic review of randomized controlled trials

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Treadmill exercise ameliorates disturbance of spatial learning ability in scopolamine-induced amnesia rats

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Ameliorative Effects of Nutraceuticals in Neurological Disorders

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Molecular Docking Simulation Studies Identifies Potential Natural Product Derived-Antiwolbachial Compounds as Filaricides against Onchocerciasis

Kwofie, S. K., Broni, E., Yunus, F., Nsoh, J., Adoboe, D., Miller, W. A., & Wilson, M. D. (2021) · Biomedicines · doi:10.3390/biomedicines9111682 · Cited by 31 · see citing works

Vdac1 Downregulation Causes Mitochondrial Disintegration Leading to Hippocampal Neurodegeneration in Scopolamine-Induced Amnesic Mice

Baghel, M. S., & Thakur, M. K. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1164-z · Cited by 31 · see citing works

Current insights into transcriptional role(s) for the nutraceutical Withania somnifera in inflammation and aging

Saha, P., Ajgaonkar, S., Maniar, D., Sahare, S., Mehta, D. S., & Nair, S. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1370951 · Cited by 30 · see citing works

Indian Herbs for the Treatment of Neurodegenerative Disease

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Protective effect of ashwagandha (Withania somnifera) against neurotoxicity induced by aluminum chloride in rats

Khadrawy, Y. A., Elhadidy, M. E., Sawie, H. G., & Meguid, N. A. (2018) · Asian Pacific Journal of Tropical Biomedicine · doi:10.4103/2221-1691.221139 · Cited by 29 · see citing works

The effect of baicalein-loaded Y-shaped miktoarm copolymer on spatial memory and hippocampal expression of DHCR24, SELADIN and SIRT6 genes in rat model of Alzheimer

Kiyaseh, M., Andalib, S., Danafar, H., Rostamizadeh, K., & Sharafi, A. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.119546 · Cited by 29 · see citing works

Multiple signaling factors and drugs alleviate neuronal death induced by expression of human and zebrafish tau proteins in vivo

Wu, B.-K., Yuan, R.-Y., Lien, H.-W., Hung, C., Hwang, P., Chen, R. P.-Y., Chang, C., Liao, Y., & Huang, C. (2016) · Journal of Biomedical Science · doi:10.1186/s12929-016-0237-4 · Cited by 29 · see citing works

The removal of percutaneous Kirschner wires used in the stabilisation of fractures in children.

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Effect of Ashwagandha Withanolides on Muscle Cell Differentiation

Wang, J., Zhang, H., Kaul, A., Li, K., Priyandoko, D., Kaul, S. C., & Wadhwa, R. (2021) · Biomolecules · doi:10.3390/biom11101454 · Cited by 30 · see citing works

THE EFFECT OF SCOPOLAMINE ON AVOIDANCE MEMORY AND HIPPOCAMPAL NEURONS IN MALE WISTAR RATS

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The potent effects of ginseng root extract and memantine on cognitive dysfunction in male albino rats

Al-Hazmi, M. A., Rawi, S. M., Arafa, N. M. S., Waggas, A. M., & Montasser, A. O. S. (2013) · Toxicology and Industrial Health · doi:10.1177/0748233713475517 · Cited by 27 · see citing works

Bacopa monniera(CDRI-08) Upregulates the Expression of Neuronal and Glial Plasticity Markers in the Brain of Scopolamine Induced Amnesic Mice

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Epigenetic regulation of neuronal immediate early genes is associated with decline in their expression and memory consolidation in scopolamine-induced amnesic mice

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Verapamil attenuates scopolamine induced cognitive deficits by averting oxidative stress and mitochondrial injury – A potential therapeutic agent for Alzheimer’s Disease

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Phytochemical Genomics of Ashwagandha

Sangwan, N. S., Tripathi, S., Srivastava, Y., Mishra, B., & Pandey, N. (2017) · Springer eBooks · doi:10.1007/978-3-319-59192-6_1 · Cited by 25 · see citing works

Elucidation of plasma protein binding, blood partitioning, permeability, CYP phenotyping and CYP inhibition studies of Withanone using validated UPLC method: An active constituent of neuroprotective herb Ashwagandha

Singh, S. K., Valicherla, G. R., Bikkasani, A. K., Cheruvu, S. H., Hossain, Z., Taneja, I., Ahmad, H., Raju, K. S. R., Sangwan, N. S., Singh, S. K., et al. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.113819 · Cited by 24 · see citing works

Neuroprotective effect of Withania somnifera leaves extract nanoemulsion against penconazole-induced neurotoxicity in albino rats via modulating TGF-β1/Smad2 signaling pathway

Abomosallam, M., Hendam, B. M., Abdallah, A. A., Refaat, R., & El-Hak, H. N. G. (2024) · Inflammopharmacology · doi:10.1007/s10787-024-01461-8 · Cited by 26 · see citing works

Experimental evidence and mechanism of action of some popular neuro-nutraceutical herbs

Kumar, A., Konar, A., Garg, S., Kaul, S. C., & Wadhwa, R. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.105124 · Cited by 24 · see citing works

Pumpkin extract and fermented whey individually and in combination alleviated AFB1- and OTA-induced alterations on neuronal differentiation in vitro

Frangiamone, M., Alonso-Garrido, M., Font, G., Cimbalo, A., & Manyes, L. (2022) · Food and Chemical Toxicology · doi:10.1016/j.fct.2022.113011 · Cited by 24 · see citing works

Valine conjugated polymeric nanocarriers for targeted co-delivery of rivastigmine and quercetin in rat model of Alzheimer disease

Kaboli, Z., Hosseini, M., Sadighian, S., Rostamizadeh, K., Hamidi, M., & Manjili, H. K. (2023) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2023.123418 · Cited by 24 · see citing works

Assessment of Cholinergic Properties of Ashwagandha Leaf-Extract in the Amnesic Mouse Brain

Gautam, A., Wadhwa, R., & Thakur, M. K. (2016) · Annals of Neurosciences · doi:10.1159/000443573 · Cited by 23 · see citing works

Magnoflorine-Loaded Chitosan Collagen Nanocapsules Ameliorate Cognitive Deficit in Scopolamine-Induced Alzheimer’s Disease-like Conditions in a Rat Model by Downregulating IL-1β, IL-6, TNF-α, and Oxidative Stress and Upregulating Brain-Derived Neurotrophic Factor and DCX Expressions

Bashir, D. J., Manzoor, S., Sarfaraj, M., Afzal, S. M., Bashir, M., Nidhi, N., Rastogi, S., Arora, I., & Samim, M. (2023) · ACS Omega · doi:10.1021/acsomega.2c06467 · Cited by 22 · see citing works

Antiamnesic effects of tofisopam against scopolamine-induced cognitive impairments in rats

Üçel, U. İ., Can, Ö. D., Özkay, Ü. D., & Ulupınar, E. (2020) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2020.172858 · Cited by 22 · see citing works

Cytoprotective effect of methanolic extract of Nardostachys jatamansi against hydrogen peroxide induced oxidative damage in C6 glioma cells.

Dhuna, K., Dhuna, V., Bhatia, G., Singh, J., & Kamboj, S. S. (2013) · Acta Biochimica Polonica · doi:10.18388/abp.2013_1946 · Cited by 22 · see citing works

Indian Herbs and their Therapeutic Potential against Alzheimer's Disease and Other Neurological Disorders

Kaur, N., Sarkar, B., Gill, I., Kaur, S., Mittal, S., Dhiman, M., Padala, P. R., Perez‐Polo, R. J., & Mantha, A. K. (2017) · doi:10.1002/9781119155195.ch4 · Cited by 22 · see citing works

Chinese nutraceuticals and physical activity; their role in neurodegenerative tauopathies

Alausa, A. O., Ogundepo, S., Olaleke, B., Adeyemi, R. O., Olatinwo, M., & Ismail, A. (2021) · Chinese Medicine · doi:10.1186/s13020-020-00418-7 · Cited by 20 · see citing works

Potential Therapeutic Agents on Alzheimer's Disease through Molecular Docking and Molecular Dynamics Simulation Study of Plant‐Based Compounds

Borah, K., Bora, K., Mallik, S., & Zhao, Z. (2022) · Chemistry & Biodiversity · doi:10.1002/cbdv.202200684 · Cited by 19 · see citing works

A blend of Withania somnifera (L.) Dunal root and Abelmoschus esculentus (L.) Moench fruit extracts relieves constipation and improves bowel function: A proof-of-concept clinical investigation

Punukollu, R. S., Chadalawada, A. K., Siddabattuni, K., & Gogineni, N. T. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116997 · Cited by 21 · see citing works

Therapeutic effects of hydro-alcoholic leaf extract of Withania somnifera on age-induced changes in daily rhythms of Sirt1, Nrf2 and Rev-erbα in the SCN of male Wistar rats

Kukkemane, K., & Jagota, A. (2020) · Biogerontology · doi:10.1007/s10522-020-09875-x · Cited by 19 · see citing works

Mdivi-1 Rescues Memory Decline in Scopolamine-Induced Amnesic Male Mice by Ameliorating Mitochondrial Dynamics and Hippocampal Plasticity

Mishra, E., & Thakur, M. K. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03397-6 · Cited by 19 · see citing works

Role of Phytochemicals in Neurotrophins Mediated Regulation of Alzheimer’s Disease

Sharma, B. (2017) · International Journal of Complementary & Alternative Medicine · doi:10.15406/ijcam.2017.07.00231 · Cited by 19 · see citing works

Correction: Water Extract of Ashwagandha Leaves Has Anticancer Activity: Identification of an Active Component and Its Mechanism of Action

Wadhwa, R., Singh, R., Gao, R., Shah, N., Widodo, N., Nakamoto, T., Ishida, Y., Terao, K., & Kaul, S. C. (2013) · PLoS ONE · doi:10.1371/annotation/b7059f27-5970-4734-8601-9913adcce984 · Cited by 19 · see citing works

Assessment of Cholinergic Properties of Ashwagandha Leaf-Extract in the Amnesic Mouse Brain

Gautam, A., Wadhwa, R., & Thakur, M. K. (2016) · Annals of Neurosciences · doi:10.1159/000443573 · Cited by 23 · see citing works

Alcoholic Extract of Ashwagandha Leaves Protects Against Amnesia by Regulation of Arc Function

Gautam, A., Kaul, S. C., & Thakur, M. K. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9117-2 · Cited by 19 · see citing works

Annona atemoya Leaf Extract Improves Scopolamine-Induced Memory Impairment by Preventing Hippocampal Cholinergic Dysfunction and Neuronal Cell Death

Sohn, E., Lim, H.-S., Kim, Y. J., Kim, B., & Jeong, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20143538 · Cited by 31 · see citing works

M1 muscarinic receptor is a key target of neuroprotection, neuroregeneration and memory recovery by i-Extract from Withania somnifera

Konar, A., Gupta, R., Shukla, R. K., Maloney, B., Khanna, V. K., Wadhwa, R., Lahiri, D. K., & Thakur, M. K. (2019) · Scientific Reports · doi:10.1038/s41598-019-48238-6 · Cited by 53 · see citing works

Protective effect of ethanolic leaf extract of Bacopa floribunda (r.br.) Wettst on scopolamineinduced memory impairment in rodents: A behavioural and biochemical study

Ishola, I. O., Afolayan, G. O., Popoola, T. D., Ugoanyanwu, V. I., & Adeyemi, O. O. (2015) · West African Journal of Pharmacology and Drug Research · Cited by 4 · see citing works