Limited physical contact through a mesh barrier is sufficient for social reward-conditioned place preference in adolescent male rats
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Adolescence is a period of enhanced sensitivity to social influences and vulnerability to drug abuse. Social reward in adolescent rats has been demonstrated with the conditioned place preference (CPP) model, but it is not clear whether limited contact with another rat without play is sufficient to produce reward. We investigated this issue using an apparatus containing two main compartment, each with a wire mesh barrier that allowed rats placed on either side of the barrier to have limited physical contact. Adolescent male rats were given two conditioning sessions/day for 2 or 8 days following baseline preference tests. Rats were placed into their preferred side alone for one daily 10-min session and into their initially non-preferred side (i.e., CS) for the other session during which they either had restricted or unrestricted physical access to another rat (Rat/Mesh or Rat/Phys, respectively) or to a tennis ball (Ball/Mesh or Ball/Phys, respectively) unconditioned stimulus (US). Only the Rat/Phys group exhibited CPP after 2 CS-US pairings; however, after 8 CS-US pairings, the Rat/Mesh and Ball/Phys groups also exhibited CPP. During conditioning, the rat US elicited more robust approach and contact behavior compared to the ball, regardless of physical or restricted access. The incidence of contact and/or approach increased as the number of exposures increased. The results suggest that the rank order of US reward efficacy was physical contact with a rat>limited contact with a rat>physical contact with a ball, and that rough-and-tumble play is not necessary to establish social reward-CPP. The findings have important implications for emerging drug self-administration models in which two rats self-administering drug intravenously have limited physical contact via a mesh barrier shared between their respective operant conditioning chambers.
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Interaction with a conspecific across a similar physical barrier has been shown to be socially rewarding.
“Interaction with a conspecific across a similar physical barrier has been shown to be socially rewarding (Peartree et al., 2012)”
From Social play experience in juvenile rats is indispensable for appropriate socio-sexual behavior in adulthood in males but not females (2023) · cites this paper as Peartree et al., 2012
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“Interaction with a conspecific across a similar physical barrier has been shown to be socially rewarding (Peartree et al., 2012) and to reduce anxiety-like behavior as compared to full isolation, an additional benefit (Klapper-Goldstein et al.”
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- Authors
- Peartree, N. A., Hood, L. E., Thiel, K. J., Sanabria, F., Pentkowski, N. S., Chandler, K. N., & Neisewander, J. L.
- Affiliations
- Arizona State University (US)
- Corresponding author
- Neisewander, Janet L.
- Venue
- Physiology & Behavior
- Publisher
- Elsevier BV
- Published
- 2012-02
- Volume
- 105
- Issue
- 3
- Pages
- 749-756
- ISSN
- 0031-9384 (ISSN-L)
- PMC
- PMC3975131
- OpenAlex
- W2079056297
- Cited by
- 90
- References
- 66
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 4 · 2023: 7 · 2022: 4 · 2021: 4 · 2020: 7 · 2019: 5 · 2018: 7 · 2017: 10 · 2016: 9 · 2015: 8 · 2014: 6 · 2013: 9 · 2012: 6
- FWCI
- 2.78
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Physiology & Behavior (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse
- Arizona State University
- Howard Hughes Medical Institute
- Arizona State University School of Life Sciences
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- social reward, conditioned place preference, adolescence, physical contact, rough-and-tumble play, self-administration, approach behavior
- MeSH terms
- Analysis of Variance, Animals, Animals, Newborn, Conditioning, Operant, Interpersonal Relations, Male, Motor Activity, Pair Bond, Reward, Time Factors, Rats, Sprague-Dawley, Cross-Over Studies, Rats
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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