Irisin as a muscle-derived hormone stimulating thermogenesis – A critical update

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810 · see citing works

A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis

Puigserver, P., Wu, Z., Park, C. W., Graves, R., Wright, M., & Spiegelman, B. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81410-5 · Cited by 3,864 · see citing works

Cold-Activated Brown Adipose Tissue in Healthy Men

van Marken Lichtenbelt, W. D., Vanhommerig, J. W., Smulders, N. M., Drossaerts, J. M. A. F. L., Kemerink, G. J., Bouvy, N. D., Schrauwen, P., & Teule, G. J. J. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808718 · Cited by 3,452 · see citing works

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

Wu, J., Boström, P., Sparks, L. M., Li, Y., Choi, J. H., Giang, A.-H., Khandekar, M. J., Virtanen, K. A., Nuutila, P., Schaart, G., et al. (2012) · Cell · doi:10.1016/j.cell.2012.05.016 · Cited by 3,299 · see citing works

Ghrelin enhances appetite and increases food intake in humans

Wren, A. M., Seal, L. J., Cohen, M. A., Brynes, A. E., Frost, G. S., Murphy, K. G., Dhillo, W. S., Ghatei, M. A., & Bloom, S. R. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.12.8111 · Cited by 2,494 · see citing works

PRDM16 controls a brown fat/skeletal muscle switch

Seale, P., Bjork, B., Yang, W., Kajimura, S., Chin, S., Kuang, S., Scimè, A., Devarakonda, S., Conroe, H. M., Erdjument-Bromage, H., et al. (2008) · Nature · doi:10.1038/nature07182 · Cited by 2,347 · see citing works

Unexpected evidence for active brown adipose tissue in adult humans

Nedergaard, J., Bengtsson, T., & Cannon, B. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00691.2006 · Cited by 1,824 · see citing works

FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis

Fisher, F. M., Kleiner, S., Douris, N., Fox, E. C., Mepani, R. J., Verdeguer, F., Wu, J., Kharitonenkov, A., Flier, J. S., Maratos-Flier, E., et al. (2012) · Genes & Development · doi:10.1101/gad.177857.111 · Cited by 1,478 · see citing works

Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway

Wrann, C. D., White, J. P., Salogiannnis, J., Laznik-Bogoslavski, D., Wu, J., Ma, D., Lin, J. D., Greenberg, M. E., & Spiegelman, B. M. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.09.008 · Cited by 1,440 · see citing works

Chronic Peroxisome Proliferator-activated Receptor γ (PPARγ) Activation of Epididymally Derived White Adipocyte Cultures Reveals a Population of Thermogenically Competent, UCP1-containing Adipocytes Molecularly Distinct from Classic Brown Adipocytes

Petrovic, N., Walden, T. B., Shabalina, I. G., Timmons, J. A., Cannon, B., & Nedergaard, J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.053942 · Cited by 1,263 · see citing works

The role of exercise and PGC1α in inflammation and chronic disease

Handschin, C., & Spiegelman, B. M. (2008) · Nature · doi:10.1038/nature07206 · Cited by 1,083 · see citing works

FNDC5 and Irisin in Humans: I. Predictors of Circulating Concentrations in Serum and Plasma and II. mRNA Expression and Circulating Concentrations in Response to Weight Loss and Exercise

Huh, J. Y., Panagiotou, G., Mougios, V., Brinkoetter, M., Vamvini, M. T., Schneider, B. E., & Mantzoros, C. S. (2012) · Metabolism · doi:10.1016/j.metabol.2012.09.002 · Cited by 1,040 · see citing works

Identification of nesfatin-1 as a satiety molecule in the hypothalamus

Oh‐I, S., Shimizu, H., Satoh, T., Okada, S., Adachi, S., Inoue, K., Eguchi, H., Yamamoto, M., Imaki, T., Hashimoto, K., et al. (2006) · Nature · doi:10.1038/nature05162 · Cited by 1,012 · see citing works

Exercise for depression

Cooney, G. M., Dwan, K., Greig, C. A., Lawlor, D. A., Rimer, J., Waugh, F. R., McMurdo, M., & Mead, G. E. (2014) · Advances in Psychiatric Treatment · doi:10.1192/apt.20.1.2 · Cited by 895 · see citing works

Exercise induces transient transcriptional activation of the PGC‐1α gene in human skeletal muscle

Pilegaard, H., Saltin, B., & Neufer, P. D. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2002.034850 · Cited by 885 · see citing works

Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes

Bordicchia, M., Liu, D., Amri, E.-Z., Ailhaud, G., Dessì-Fulgheri, P., Zhang, C., Takahashi, N., Sarzani, R., & Collins, S. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59701 · Cited by 872 · see citing works

Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance

Moreno-Navarrete, J. M., Ortega, F., Serrano, M., Guerra, E., Pardo, G., Tinahones, F., Ricart, W., & Fernández-Real, J. M. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2749 · Cited by 788 · see citing works

Irisin Stimulates Browning of White Adipocytes Through Mitogen-Activated Protein Kinase p38 MAP Kinase and ERK MAP Kinase Signaling

Zhang, Y., Li, R., Meng, Y., Li, S., Donelan, W., Zhao, Y., Qi, L., Zhang, M., Wang, X., Cui, T., et al. (2014) · Diabetes · doi:10.2337/db13-1106 · Cited by 733 · see citing works

Total daily physical activity and the risk of AD and cognitive decline in older adults

Buchman, A. S., Boyle, P. A., Yu, L., Shah, R. C., Wilson, R. S., & Bennett, D. A. (2012) · Neurology · doi:10.1212/wnl.0b013e3182535d35 · Cited by 730 · see citing works

Occurrence of brown adipocytes in rat white adipose tissue: molecular and morphological characterization

Cousin, B., Cinti, S., Morroni, M., Raimbault, S., Ricquier, D., Pénicaud, L., & Casteilla, L. (1992) · Journal of Cell Science · doi:10.1242/jcs.103.4.931 · Cited by 665 · see citing works

FNDC5/irisin is not only a myokine but also an adipokine

Roca-Rivada, A., Castelao, C., Senin, L. L., Landrove, M. O., Baltar, J., Crujeiras, A. B., Seoane, L. M., Casanueva, F. F., & Pardo, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060563 · Cited by 612 · see citing works

The distribution of brown adipose tissue in the human.

Heaton, J. M. (1972) · PubMed · Cited by 606 · see citing works

The effects of acute and chronic exercise on <scp>PGC</scp> ‐1α, irisin and browning of subcutaneous adipose tissue in humans

Norheim, F., Langleite, T. M., Hjorth, M., Holen, T., Kielland, A., Stadheim, H. K., Gulseth, H. L., Birkeland, K. I., Jensen, J., & Drevon, C. A. (2014) · The FEBS Journal · doi:10.1111/febs.12619 · Cited by 563 · see citing works

Circulating irisin in relation to insulin resistance and the metabolic syndrome.

Park, K., Zaichenko, L., Brinkoetter, M. T., Thakkar, B., Sahin-Efe, A., Joung, K., Tsoukas, M. A., Geladari, E., Huh, J., Dinçer, F., et al. (2013) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jc.2013-2373 · Cited by 527 · see citing works

Context Effects and Inefficient Initiation at Non-AUG Codons in Eucaryotic Cell-Free Translation Systems

Kozak, M. (1989) · Molecular and Cellular Biology · doi:10.1128/mcb.9.11.5073-5080.1989 · Cited by 472 · see citing works

Lower circulating irisin is associated with type 2 diabetes mellitus

Liu, J., Wong, M. D. S., Toy, W. C., Tan, C., Liu, S., Ng, X. W., Subramaniam, T., Sum, C. F., & Lim, S. C. (2013) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2013.03.002 · Cited by 446 · see citing works

Circulating levels of irisin in patients with anorexia nervosa and different stages of obesity--correlation with body mass index.

Stengel, A., Hofmann, T., Goebel-Stengel, M., Elbelt, U., Kobelt, P., & Klapp, B. (2013) · Peptides · doi:10.1016/j.peptides.2012.11.014 · Cited by 439 · see citing works

Serum irisin levels in new-onset type 2 diabetes

Choi, Y., Kim, M. K., Bae, K.-H., Seo, H.-A., Jeong, J.-Y., Lee, W.-K., Kim, J., Lee, I., & Park, K. (2013) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2013.01.007 · Cited by 422 · see citing works

Is irisin a human exercise gene?

Timmons, J. A., Baar, K., Davidsen, P. K., & Atherton, P. J. (2012) · Nature · doi:10.1038/nature11364 · Cited by 388 · see citing works

Hepatic FGF21 Expression Is Induced at Birth via PPARα in Response to Milk Intake and Contributes to Thermogenic Activation of Neonatal Brown Fat

Hondares, E., Rosell, M., Gonzalez, F. J., Giralt, M., Iglesias, R., & Villarroya, F. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.02.001 · Cited by 377 · see citing works

Beige Can Be Slimming

Ishibashi, J., & Seale, P. (2010) · Science · doi:10.1126/science.1190816 · Cited by 344 · see citing works

Peroxisome Proliferator-activated Receptor α Activates Transcription of the Brown Fat Uncoupling Protein-1 Gene

Barberà, M. J., Schlüter, A., Pedraza, N., Iglesias, R., Villarroya, F., & Giralt, M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006246200 · Cited by 337 · see citing works

Ghrelin enhances gastric emptying in diabetic gastroparesis: a double blind, placebo controlled, crossover study

Murray, C. D., Martin, N. M., Patterson, M., Taylor, S. A., Ghatei, M. A., Kamm, M. A., Johnston, C., Bloom, S. R., & Emmanuel, A. V. (2005) · Gut · doi:10.1136/gut.2005.069088 · Cited by 320 · see citing works

Evidence against a Beneficial Effect of Irisin in Humans

Raschke, S., Elsen, M., Gassenhuber, J., Sommerfeld, M. R., Schwahn, U., Brockmann, B., Jung, R., Wisløff, U., Tjønna, A. E., Raastad, T., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073680 · Cited by 318 · see citing works

Effect of Acute Exercise on AMPK Signaling in Skeletal Muscle of Subjects with Type 2 Diabetes

Sriwijitkamol, A., Coletta, D. K., Wajcberg, E., Balbontin, G. B., Reyna, S. M., Barrientes, J., Eagan, P. A., Jenkinson, C. P., Cersosimo, E., DeFronzo, R. A., et al. (2007) · Diabetes · doi:10.2337/db06-1119 · Cited by 304 · see citing works

Myostatin Knockout Drives Browning of White Adipose Tissue through Activating the AMPK-PGC1α-Fndc5 Pathway in Muscle

Shan, T., Liang, X., Bi, P., & Kuang, S. (2013) · The FASEB Journal · doi:10.1096/fj.12-225755 · Cited by 301 · see citing works

Are skeletal muscle <i>FNDC5</i> gene expression and irisin release regulated by exercise and related to health?

Pekkala, S., Wiklund, P. K., Hulmi, J. J., Ahtiainen, J. P., Horttanainen, M., Pöllänen, E., Mäkelä, K. A., Kainulainen, H., Häkkinen, K., Nyman, K., et al. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2013.263707 · Cited by 292 · see citing works

Integration of microRNA changes in vivo identifies novel molecular features of muscle insulin resistance in type 2 diabetes

Gallagher, I. J., Schéele, C., Keller, P., Nielsen, A. R., Reményi, J., Fischer, C. P., Roder, K., Babraj, J., Wahlestedt, C., Hutvágner, G., et al. (2010) · Genome Medicine · doi:10.1186/gm130 · Cited by 291 · see citing works

Physical exercise and clinically depressed patients: a systematic review and meta-analysis

Silveira, H., Moraes, H., Oliveira, N., Coutinho, E. S. F., Laks, J., & Deslandes, A. (2013) · Neuropsychobiology · doi:10.1159/000345160 · Cited by 279 · see citing works

The effects of ghrelin on inflammation and the immune system.

Baatar, D., Patel, K., & Taub, D. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.04.019 · Cited by 260 · see citing works

Irisin and exercise training in humans – Results from a randomized controlled training trial

Hecksteden, A., Wegmann, M., Steffen, A., Kraushaar, J., Morsch, A., Ruppenthal, S., Kaestner, L., & Meyer, T. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-235 · Cited by 250 · see citing works

The -Adrenergic Receptors and the Control of Adipose Tissue Metabolism and Thermogenesis

Collins, S. (2001) · Recent Progress in Hormone Research · doi:10.1210/rp.56.1.309 · Cited by 249 · see citing works

The Structure of Irisin Reveals a Novel Intersubunit β-Sheet Fibronectin Type III (FNIII) Dimer

Schumacher, M. A., Chinnam, N. B., Ohashi, T., Shah, R., & Erickson, H. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.516641 · Cited by 240 · see citing works

Irisin-immunoreactivity in neural and non-neural cells of the rodent

Dun, S. L., Lyu, R., Chen, Y., Chang, J. K., Luo, J. J., & Dun, N. J. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.02.050 · Cited by 236 · see citing works

Irisin is inversely associated with intrahepatic triglyceride contents in obese adults

Zhang, H.-J., Zhang, X.-F., Ma, Z.-M., Pan, L.-L., Chen, Z., Han, H.-W., Han, C.-K., Zhuang, X.-J., Lu, Y., Li, X.-J., et al. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.04.030 · Cited by 234 · see citing works

Cold-induced activation of brown adipose tissue and adipose angiogenesis in mice

Lim, S., Honek, J., Xue, Y., Seki, T., Cao, Z., Andersson, P., Yang, X., Hosaka, K., & Cao, Y. (2012) · Nature Protocols · doi:10.1038/nprot.2012.013 · Cited by 228 · see citing works

Effect of endurance training on skeletal muscle myokine expression in obese men: Identification of apelin as a novel myokine

Besse-Patin, A., Montastier, E., Vinel, C., Castan-Laurell, I., Louche, K., Dray, C., Daviaud, D., Mir, L., Marques, M.-A., Thalamas, C., et al. (2014) · International Journal of Obesity · doi:10.1038/ijo.2013.158 · Cited by 227 · see citing works

Irisin and FNDC5 in retrospect

Erickson, H. (2013) · Adipocyte · doi:10.4161/adip.26082 · Cited by 211 · see citing works

Pharmacological concentrations of irisin increase cell proliferation without influencing markers of neurite outgrowth and synaptogenesis in mouse H19-7 hippocampal cell lines

Moon, H., Dincer, F., & Mantzoros, C. S. (2013) · Metabolism · doi:10.1016/j.metabol.2013.04.007 · Cited by 207 · see citing works

Functional thermogenic beige adipogenesis is inducible in human neck fat

Lee, P., Werner, C., Kebebew, E., & Celi, F. S. (2013) · International Journal of Obesity · doi:10.1038/ijo.2013.82 · Cited by 205 · see citing works

Brown adipose tissue in humans

Lean, M. E. J. (1989) · Proceedings of The Nutrition Society · doi:10.1079/pns19890036 · Cited by 199 · see citing works

Expression of the Irisin Precursor FNDC5 in Skeletal Muscle Correlates With Aerobic Exercise Performance in Patients With Heart Failure

Lecker, S. H., Zavin, A., Cao, P., Arena, R. A., Allsup, K., Daniels, K. M., Joseph, J., Schulze, P. C., & Forman, D. E. (2012) · Circulation Heart Failure · doi:10.1161/circheartfailure.112.969543 · Cited by 197 · see citing works

The effect of exercise interventions on cognitive outcome in Alzheimer's disease: a systematic review

Farina, N., Rusted, J. M., & Tabet, N. (2013) · International Psychogeriatrics · doi:10.1017/s1041610213001385 · Cited by 195 · see citing works

Decrease in Irisin in Patients with Chronic Kidney Disease

Wen, M., Wang, C., Lin, S., & Hung, K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064025 · Cited by 192 · see citing works

Inhibition of myostatin protects against diet-induced obesity by enhancing fatty acid oxidation and promoting a brown adipose phenotype in mice

Zhang, C., McFarlane, C., Lokireddy, S., Masuda, S., Ge, X., Gluckman, P. D., Sharma, M., & Kambadur, R. (2012) · Diabetologia · doi:10.1007/s00125-011-2304-4 · Cited by 192 · see citing works

Frcp1 and Frcp2, two novel fibronectin type III repeat containing genes

Teufel, A., Malik, N., Mukhopadhyay, M., & Westphal, H. (2002) · Gene · doi:10.1016/s0378-1119(02)00828-4 · Cited by 183 · see citing works

Resistance exercise enhances the molecular signaling of mitochondrial biogenesis induced by endurance exercise in human skeletal muscle

Wang, L., Mascher, H., Psilander, N., Blomstrand, E., & Sahlin, K. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00086.2011 · Cited by 181 · see citing works

A Transient Elevated Irisin Blood Concentration in Response to Prolonged, Moderate Aerobic Exercise in Young Men and Women

Kraemer, R. R., Shockett, P. E., Webb, N., Shah, U. R., & Castracane, V. D. (2013) · Hormone and Metabolic Research · doi:10.1055/s-0033-1355381 · Cited by 181 · see citing works

Mouse PeP: A novel peroxisomal protein linked to myoblast differentiation and development

Ferrer-Martı́nez, A., Ruiz‐Lozano, P., & Chien, K. R. (2002) · Developmental Dynamics · doi:10.1002/dvdy.10099 · Cited by 169 · see citing works

The identification of irisin in human cerebrospinal fluid: influence of adiposity, metabolic markers, and gestational diabetes

Piya, M. K., Harte, A. L., Sivakumar, K., Tripathi, G., Voyias, P. D., James, S. G., Sabico, S., Al‐Daghri, N. M., Saravanan, P., Barber, T. M., et al. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00308.2013 · Cited by 167 · see citing works

Cardiac, skeletal muscle and serum irisin responses to with or without water exercise in young and old male rats: Cardiac muscle produces more irisin than skeletal muscle

Aydın, S., Kuloğlu, T., Aydin, S., Eren, M. N., Çelik, A., Yılmaz, M., Kalaycı, M. Z., Şahin, İ., Gungor, O., Gürel, A., et al. (2013) · Peptides · doi:10.1016/j.peptides.2013.11.024 · Cited by 165 · see citing works

Human muscle gene expression responses to endurance training provide a novel perspective on Duchenne muscular dystrophy

Timmons, J. A., Larsson, O. S., Jansson, E., Fischer, H., Gustafsson, T. P., Greenhaff, P. L., Ridden, J., Rachman, J., Peyrard‐Janvid, M., Wahlestedt, C., et al. (2005) · The FASEB Journal · doi:10.1096/fj.04-1980com · Cited by 158 · see citing works

Longitudinal variation of circulating irisin after an energy restriction‐induced weight loss and following weight regain in obese men and women

Crujeiras, A. B., Pardo, M., Roca-Rivada, A., Navas‐Carretero, S., Zulet, M. Á., Martínez, J. A., & Casanueva, F. F. (2013) · American Journal of Human Biology · doi:10.1002/ajhb.22493 · Cited by 153 · see citing works

Fndc5 knockdown significantly decreased neural differentiation rate of mouse embryonic stem cells

Hashemi, M. ‐., Ghaedi, K., Salamian, A., Karbalaie, K., Emadi‐Baygi, M., Tanhaei, S., Nasr‐Esfahani, M. H., & Baharvand, H. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.11.041 · Cited by 143 · see citing works

Restraint stress activates nesfatin-1-immunoreactive brain nuclei in rats

Goebel, M., Stengel, A., Wang, L., & Taché, Y. (2009) · Brain Research · doi:10.1016/j.brainres.2009.08.082 · Cited by 122 · see citing works

Alterations of irisin concentrations in saliva and serum of obese and normal-weight subjects, before and after 45min of a Turkish bath or running

Aydın, S., Aydın, S., Kuloğlu, T., Yılmaz, M., Kalayci, M., Sahin, İ., & Cicek, D. (2013) · Peptides · doi:10.1016/j.peptides.2013.09.011 · Cited by 118 · see citing works

Relationship between circulating irisin, renal function and body composition in type 2 diabetes

Liu, J., Liu, S., Wong, M. D. S., Tan, C. S. H., Subramaniam, T., Sum, C. F., & Lim, S. C. (2013) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2013.09.011 · Cited by 114 · see citing works

Irisin as a predictor of glucose metabolism in children: sexually dimorphic effects

Al‐Daghri, N. M., Alkharfy, K. M., Rahman, S., Amer, O. E., Vinodson, B., Sabico, S., Piya, M. K., Harte, A. L., McTernan, P. G., Alokail, M. S., et al. (2013) · European Journal of Clinical Investigation · doi:10.1111/eci.12196 · Cited by 111 · see citing works

Copeptin, adropin and irisin concentrations in breast milk and plasma of healthy women and those with gestational diabetes mellitus

Aydın, S., Kuloğlu, T., & Aydın, S. (2013) · Peptides · doi:10.1016/j.peptides.2013.07.001 · Cited by 109 · see citing works

Common Genetic Variation in the Human FNDC5 Locus, Encoding the Novel Muscle-Derived ‘Browning’ Factor Irisin, Determines Insulin Sensitivity

Staiger, H., Böhm, A., Scheler, M., Berti, L., Machann, J., Schick, F., Machicao, F. E., Fritsche, A., Stefan, N., Weigert, C., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061903 · Cited by 105 · see citing works

Ghrelin Modulates Sympathetic Nervous System Activity and Stress Response in Lean and Overweight Men

Lambert, É., Lambert, G. W., Sari, C. I., Dawood, T., Lee, K., Chopra, R., Straznicky, N. E., Eikelis, N., Drew, S., Tilbrook, A. J., et al. (2011) · Hypertension · doi:10.1161/hypertensionaha.111.171025 · Cited by 87 · see citing works

Serum levels of irisin in gestational diabetes mellitus during pregnancy and after delivery

Ebert, T., Stepan, H., Schrey-Petersen, S., Kralisch, S., Hindricks, J., Hopf, L., Platz, M., Lössner, U., Jeßnitzer, B., Drewlo, S., et al. (2013) · Cytokine · doi:10.1016/j.cyto.2013.11.009 · Cited by 85 · see citing works

Irisin levels correlate with energy expenditure in a subgroup of humans with energy expenditure greater than predicted by fat free mass

Swick, A. G., Orena, S., & O’Connor, A. (2013) · Metabolism · doi:10.1016/j.metabol.2013.02.012 · Cited by 84 · see citing works

Sex-specific differences in the dynamics of cocaine- and amphetamine-regulated transcript and nesfatin-1 expressions in the midbrain of depressed suicide victims vs. controls

Bloem, B., Xu, L., Morava, É., Faludi, G., Palkovits, M., Roubos, E. W., & Kozicz, T. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.07.023 · Cited by 80 · see citing works

Elevated skeletal muscle irisin precursor FNDC5 mRNA in obese OLETF rats

Roberts, M. D., Bayless, D. S., Jenkins, N. T., Padilla, J., Childs, T. E., Martin, J. S., Dalbo, V. J., Booth, F. W., Rector, R. S., & Laughlin, M. H. (2013) · Metabolism · doi:10.1016/j.metabol.2013.02.002 · Cited by 73 · see citing works

Ghrelin and its interactions with growth hormone, leptin and orexins: Implications for the sleep–wake cycle and metabolism

García‐García, F., Juárez‐Aguilar, E., Santiago-Garcı́a, J., & Cardinali, D. P. (2013) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2013.04.003 · Cited by 71 · see citing works

NUCB2/nesfatin-1 is associated with elevated scores of anxiety in female obese patients

Hofmann, T., Stengel, A., Ahnis, A., Buße, P., Elbelt, U., & Klapp, B. F. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.05.013 · Cited by 69 · see citing works

Nesfatin-1/NUCB2 as a Potential New Element of Sleep Regulation in Rats

Vas, S., Ádori, C., Könczöl, K., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059809 · Cited by 63 · see citing works

Greater insulin sensitivity in calorie restricted rats occurs with unaltered circulating levels of several important myokines and cytokines

Sharma, N., Castorena, C. M., & Cartee, G. D. (2012) · Nutrition & Metabolism · doi:10.1186/1743-7075-9-90 · Cited by 62 · see citing works

Resistance exercise training improves age-related declines in leg vascular conductance and rejuvenates acute leg blood flow responses to feeding and exercise

Phillips, B. E., Williams, J. P., Atherton, P. J., Smith, K., Hildebrandt, W., Rankin, D., Greenhaff, P. L., Macdonald, I. A., & Rennie, M. J. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01031.2011 · Cited by 59 · see citing works

Irisin Levels are Not Affected by Physical Activity in Patients with Anorexia Nervosa

Hofmann, T., Elbelt, U., Ahnis, A., Kobelt, P., Rose, M., & Stengel, A. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00202 · Cited by 54 · see citing works

Exercise training does not increase muscle FNDC5 protein or mRNA expression in pigs

Fain, J. N., Booth, F. W., Laughlin, M. H., Padilla, J., Jenkins, N. T., Bahouth, S. W., & Sacks, H. S. (2013) · Metabolism · doi:10.1016/j.metabol.2013.05.021 · Cited by 50 · see citing works

Neural correlates of plasma acylated ghrelin level in individuals with major depressive disorder

Matsuo, K., Nakano, M., Nakashima, M., Watanuki, T., Egashira, K., Matsubara, T., & Watanabe, Y. (2012) · Brain Research · doi:10.1016/j.brainres.2012.07.027 · Cited by 35 · see citing works

Physiology and role of irisin in glucose homeostasis

Perakakis, N., Triantafyllou, G. A., Fernández-Real, J. M., Huh, J. Y., Park, K. H., Seufert, J., & Mantzoros, C. S. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.221 · Cited by 621 · see citing works

A comprehensive immunohistochemical examination of the distribution of the fat-burning protein irisin in biological tissues

Aydin, S., Kuloglu, T., Aydin, S., Kalayci, M., Yilmaz, M., Cakmak, T., Albayrak, S., Gungor, S., Colakoglu, N., & Ozercan, İ. H. (2014) · Peptides · doi:10.1016/j.peptides.2014.09.014 · Cited by 233 · see citing works

Anti-Inflammatory Properties of Irisin, Mediator of Physical Activity, Are Connected with TLR4/MyD88 Signaling Pathway Activation

Mazur-Bialy, A. I., Pocheć, E., & Zarawski, M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18040701 · Cited by 203 · see citing works

Chronic Exercise Training and Circulating Irisin in Adults: A Meta-Analysis

Qiu, S., Cai, X., Sun, Z., Schumann, U., Zügel, M., & Steinacker, J. M. (2015) · Sports Medicine · doi:10.1007/s40279-014-0293-4 · Cited by 129 · see citing works

Muscle Irisin Response to Aerobic vs HIIT in Overweight Female Adolescents

Archundia-Herrera, C., Macias-Cervantes, M., Ruiz-Muñoz, B., Vargas-Ortiz, K., Kornhauser, C., & Perez-Vazquez, V. (2017) · Diabetology &amp; Metabolic Syndrome · doi:10.1186/s13098-017-0302-5 · Cited by 72 · see citing works

Navigating the potential of algal peptides: health effects, market applications, and scientific challenges

Khaliq, M., Noor, Z., Moazzam, M., Saeed, F., Tul-Zohra, K., Tariq, E., Muhammad Shahbaz, H., & Khaliq, K. (2026) · Annals of Medicine · doi:10.1080/07853890.2026.2637282 · Cited by 4 · see citing works

Brown adipose tissue response to cafeteria diet-feeding involves induction of the UCP2 gene and is impaired in female rats as compared to males

Roca, P., Rodríguez, A. M., Oliver, P., Bonet, M. L., Quevedo, S., Picó, C., & Palou, A. (1999) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s004249900107 · Cited by 78 · see citing works

Functional role of NCX1 in brown adipose tissue thermogenesis

Kita, T., Tagashira, H., Nemoto, T., et al. (2021) · Proceedings for Annual Meeting of The Japanese Pharmacological Society · doi:10.1254/jpssuppl.94.0_2-p2-33

Relationship between brown adipose tissue and glucose metabolism

Liu, Y., & Yang, X. (2016) · Int J Endocrinol Metab · doi:10.3760/cma.j.issn.1673-4157.2016.03.14

Functional involvement of Na+/Ca2+ exchanger type 1 in brown adipose tissue thermogenesis

Kita, T., Tagashira, H., Nemoto, T., et al. (2020) · Proceedings for Annual Meeting of The Japanese Pharmacological Society · doi:10.1254/jpssuppl.93.0_3-o-087

Brown adipose tissue: Updates in cellular and molecular biology

Bargut, T. C. L., Águila, M. B., & Mandarim‐de‐Lacerda, C. A. (2016) · Tissue and Cell · doi:10.1016/j.tice.2016.08.001 · Cited by 92 · see citing works