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Cited by 660

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

Polyunsaturated fatty acids and fatty acid-derived lipid mediators: Recent advances in the understanding of their biosynthesis, structures, and functions

Open access
Dyall, Simon C., Balas, Laurence, Bazan, Nicolas G., Brenna, J. Thomas, Chiang, Nan, da Costa Souza, Felipe, Dalli, Jesmond, Durand, Thierry, Galano, Jean-Marie, Lein, Pamela J., Serhan, Charles N., Taha, Ameer Y.·2022·Progress in Lipid Research
DOI 10.1016/j.plipres.2022.101165
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Abstract

Polyunsaturated fatty acids (PUFAs) are structural components of membrane phospholipids, and influence cellular function via effects on membrane properties, and also by acting as a precursor pool for lipid mediators. These lipid mediators are formed via activation of pathways involving at least one step of dioxygen-dependent oxidation, and are consequently called oxylipins. Their biosynthesis can be either enzymatically-dependent, utilising the promiscuous cyclooxygenase, lipoxygenase, or cytochrome P450 mixed function oxidase pathways, or nonenzymatic via free radical-catalyzed pathways. The oxylipins include the classical eicosanoids, comprising prostaglandins, thromboxanes, and leukotrienes, and also more recently identified lipid mediators. With the advent of new technologies there is growing interest in identifying these different lipid mediators and characterising their roles in health and disease. This review brings together contributions from some of those at the forefront of research into lipid mediators, who provide brief introductions and summaries of current understanding of the structure and functions of the main classes of nonclassical oxylipins. The topics covered include omega-3 and omega-6 PUFA biosynthesis pathways, focusing on the roles of the different fatty acid desaturase enzymes, oxidized linoleic acid metabolites, omega-3 PUFA-derived specialized pro-resolving mediators, elovanoids, nonenzymatically oxidized PUFAs, and fatty acid esters of hydroxy fatty acids.

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Metadata

Authors
Dyall, S. C., Balas, L., Bazan, N. G., Brenna, J. T., Chiang, N., da Costa Souza, F., Dalli, J., Durand, T., Galano, J.-M., Lein, P. J., Serhan, C. N., & Taha, A. Y.
Venue
Progress in Lipid Research
Publisher
Elsevier BV
Published
2022-04
Volume
86
Pages
101165
ISSN
0163-7827 (ISSN-L)
DOI
10.1016/j.plipres.2022.101165
OpenAlex
W4225278778
Cited by
660
References
35
FWCI
63.46
Type
journal article
Language
en
Open access
hybrid

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