Cited by 271Neuroendocrine regulation and behaviorNeurotransmitter Receptor Influence on BehaviorAutism Spectrum Disorder Research

The DOI matches its Crossref record; 42 of the 43 references it cites were found in a registry or an index.

Associations between the oxytocin receptor gene (OXTR) and affect, loneliness and intelligence in normal subjects

Open access

Lucht, Michael J., Barnow, Sven, Sonnenfeld, Christine, Rosenberger, Albert, Grabe, Hans Joergen, Schroeder, Winnie, Völzke, Henry, Freyberger, Harald J., Herrmann, Falko H., Kroemer, Heyo, Rosskopf, Dieter·2009·Progress in Neuro-Psychopharmacology and Biological Psychiatry

DOI 10.1016/j.pnpbp.2009.04.004

Open this paper in CoChat — free account

Abstract

Associations of oxytocin receptor gene (OXTR) variants and autism spectrum disorders (ASD) have been reported in earlier studies; in one of the studies associations with IQ and daily living skills were found additionally. Variations of the oxytocin receptor gene might also regulate affect, attachment and separation beyond the diagnostic borders of autism. We tested hypotheses of associations between positive and negative affects and social and emotional loneliness (285 adults), IQ (117 adolescents) and polymorphisms of the oxytocin receptor gene (OXTR rs53576, rs2254298 and rs2228485) in normal subjects. Individuals with the oxytocin OXTR rs53576 A/A genotype showed lower positive affect scores (F=5.532, df=1; p=0.019). This effect was restricted to males (F=13.098, df=1; p=0.00047). Haplotypes constructed with the three markers were associated with positive affect (p=0.0012), negative affect (p<0.0001) and emotional loneliness (p<0.0001). Non-verbal intelligence was significantly reduced in rs53576 A/A adolescents (T=2.247, p=0.027). Our findings support a role for the oxytocin receptor haplotypes in the generation of affectivity, emotional loneliness and IQ.

Integrity signals

Registry

Crossref · 10.1016/j.pnpbp.2009.04.004

Cites

42 of 42 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Development and validation of brief measures of positive and negative affect: The PANAS scales.
Watson, D., Clark, L. A., & Tellegen, A. (1988) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.54.6.1063 · Cited by 32,433
A simple salting out procedure for extracting DNA from human nucleated cells
Miller, S. A., Dykes, D. D., & Polesky, H. F. (1988) · Nucleic Acids Research · doi:10.1093/nar/16.3.1215 · Cited by 20,341
Oxytocin increases trust in humans
Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., & Fehr, E. (2005) · Nature · doi:10.1038/nature03701 · Cited by 3,690
Genetic Dissection of Complex Traits
Lander, E. S., & Schork, N. J. (1994) · Science · doi:10.1126/science.8091226 · Cited by 3,425
Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress
Heinrichs, M., Baumgartner, T., Kirschbaum, C., & Ehlert, U. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00465-7 · Cited by 2,091
Oxytocin Modulates Neural Circuitry for Social Cognition and Fear in Humans
Kirsch, P., Esslinger, C., Chen, Q., Mier, D., Lis, S., Siddhanti, S., Gruppe, H., Mattay, V. S., Gallhofer, B., & Meyer-Lindenberg, A. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3984-05.2005 · Cited by 1,639
INFANTILE AUTISM: A GENETIC STUDY OF 21 TWIN PAIRS
Folstein, S., & Rutter, M. (1977) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1977.tb00443.x · Cited by 1,361 · cited 2×
“, 2005), and affect in our study population with normal subjects could be expected, as far as the genetic liability for autism is also expressed in normals (Folstein and Rutter, 1977).”
Background
Oxytocin improves “mind-reading” in humans
Domes, G., Heinrichs, M., Michel, A., Berger, C., & Herpertz, S. C. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.07.015 · Cited by 1,298
Oxytocin attenuates amygdala responses to emotional faces regardless of valence
Domes, G., Heinrichs, M., Gläscher, J., Büchel, C., Braus, D. F., & Herpertz, S. C. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.03.025 · Cited by 774
Oxytocin Increases Retention of Social Cognition in Autism
Hollander, E., Bartz, J., Chaplin, W., Phillips, A., Sumner, J., Soorya, L., Anagnostou, E., & Wasserman, S. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.05.030 · Cited by 693
Oxytocin Infusion Reduces Repetitive Behaviors in Adults with Autistic and Asperger's Disorders
Hollander, E., Novotny, S., Hanratty, M., Yaffe, R., DeCaria, C. M., Aronowitz, B. R., & Mosovich, S. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300021 · Cited by 689
Positive Association of the Oxytocin Receptor Gene (OXTR) with Autism in the Chinese Han Population
Wu, S., Jia, M., Ruan, Y., Liu, J., Guo, Y., Mei, S., Gong, X., Zhang, Y., Yang, X., & Zhang, D. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.03.013 · Cited by 565
Study of Health in Pomerania (SHIP): A health examination survey in an east German region: Objectives and design
John, U., Hensel, E., L�demann, J., Piek, M., Sauer, S., Adam, C., Born, G., Alte, D., Greiser, E. M., Haertel, U., et al. (2001) · Sozial- und Präventivmedizin · doi:10.1007/bf01324255 · Cited by 547
Affective sharing in the context of joint attention interactions of normal, autistic, and mentally retarded children
Kasari, C. L., Sigman, M., Mundy, P. C., & Yirmiya, N. (1990) · Journal of Autism and Developmental Disorders · doi:10.1007/bf02206859 · Cited by 508
Oxytocin receptor (OXTR) and serotonin transporter (5-HTT) genes associated with observed parenting
Bakermans-Kranenburg, M. J., & van IJzendoorn, M. H. (2008) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsn004 · Cited by 474
No Gene Is an Island: The Flip-Flop Phenomenon
Lin, P., Vance, J. M., Pericak‐Vance, M. A., & Martin, E. R. (2007) · The American Journal of Human Genetics · doi:10.1086/512133 · Cited by 466
Sex differences in oxytocin and vasopressin: Implications for autism spectrum disorders?
CARTER, C. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.08.025 · Cited by 432
Association of the oxytocin receptor gene (OXTR) in Caucasian children and adolescents with autism
Jacob, S., Brune, C. W., Carter, C. S., Leventhal, B. L., Lord, C., & Cook, E. H. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.02.001 · Cited by 425
Latent-class analysis of recurrence risks for complex phenotypes with selection and measurement error: a twin and family history study of autism.
Pickles, A. R., Bolton, P., Macdonald, H., Bailey, A., Couteur, A. S. L., Sim, C. H., & Rutter, M. L. (1995) · Europe PMC (PubMed Central) · Cited by 388
Association between the oxytocin receptor (OXTR) gene and autism: relationship to Vineland Adaptive Behavior Scales and cognition
Lerer, E., Levi, S., Salomon, S., Darvasi, A., Yirmiya, N., & Ebstein, R. P. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002087 · Cited by 349
Central Nervous System Effects of the Neurohypophyseal Hormones and Related Peptides
de Wied, D., Diamant, M., & Fodor, M. (1993) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1993.1009 · Cited by 327
Feeling the Pain of Social Loss
Panksepp, J. (2003) · Science · doi:10.1126/science.1091062 · Cited by 318
The neuroscience of affiliation: forging links between basic and clinical research on neuropeptides and social behavior
A. Bartz, J., & Hollander, E. (2006) · Hormones and Behavior · doi:10.1016/j.yhbeh.2006.06.018 · Cited by 311
Mental and physical distress is modulated by a polymorphism in the 5-HT transporter gene interacting with social stressors and chronic disease burden
Grabe, H., Lange, M., Wolff, B., Völzke, H., Lucht, M., Freyberger, H., John, U., & Cascorbi, I. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001555 · Cited by 293
Self-citation
The Collateral Effects of Joint Attention Training on Social Initiations, Positive Affect, Imitation, and Spontaneous Speech for Young Children with Autism
Whalen, C., Schreibman, L., & Ingersoll, B. R. (2006) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-006-0108-z · Cited by 267
The psychobiology of emotion: the role of the oxytocinergic system
Uvnäs-Moberg, K., Arn, I., & Magnusson, D. (2005) · International Journal of Behavioral Medicine · doi:10.1207/s15327558ijbm1202_3 · Cited by 238
Network Correlates of Social and Emotional Loneliness in Young and Older Adults
Green, L. R., Richardson, D. R., Lago, T., & Schatten‐Jones, E. C. (2001) · Personality and Social Psychology Bulletin · doi:10.1177/0146167201273002 · Cited by 237
DNA by Mail: An Inexpensive and Noninvasive Method for Collecting DNA Samples from Widely Dispersed Populations
Freeman, B., Powell, J. F., Ball, D., Hill, L., Craig, I., & Plomin, R. J. (1997) · Behavior Genetics · doi:10.1023/a:1025614231190 · Cited by 236
Sensitivity to Intranasal Oxytocin in Adult Men with Early Parental Separation
Meinlschmidt, G., & Heim, C. C. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.09.007 · Cited by 210
Brain Systems for the Mediation of Social Separation‐Distress and Social‐Reward Evolutionary Antecedents and Neuropeptide Intermediariesa
PANKSEPP, J., NELSON, E., & BEKKEDAL, M. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb51914.x · Cited by 210
Genes Controlling Affiliative Behavior as Candidate Genes for Autism
Yrigollen, C. M., Han, S. S., Kochetkova, A., Babitz, T., Chang, J. T., Volkmar, F. R., Leckman, J. F., & Grigorenko, E. L. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.11.015 · Cited by 172
Genome-wide and Ordered-Subset linkage analyses provide support for autism loci on 17q and 19p with evidence of phenotypic and interlocus genetic correlates
McCauley, J. L., Li, C., Jiang, L., Olson, L. M., Crockett, G., Gainer, K., Folstein, S. E., Haines, J. L., & Sutcliffe, J. S. (2005) · BMC Medical Genetics · doi:10.1186/1471-2350-6-1 · Cited by 168
Sexually dimorphic expression of oxytocin binding sites in forebrain and spinal cord of the rat
Uhl-Bronner, S., Waltisperger, E., Martínez-Lorenzana, G., Condes Lara, M., & Freund-Mercier, M. J. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.05.025 · Cited by 123
Decreased cortisol response to awakening is associated with cognitive vulnerability to depression in a nonclinical sample of young adults
Kuehner, C., Holzhauer, S., & Huffziger, S. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2006.12.007 · Cited by 100
Can anthropomorphic analyses of separation cries in other animals inform us about the emotional nature of social loss in humans? Comment on Blumberg and Sokoloff (2001).
Panksepp, J. (2003) · Psychological Review · doi:10.1037/0033-295x.110.2.376 · Cited by 87
A genome-wide search for alleles and haplotypes associated with autism and related pervasive developmental disorders on the Faroe Islands
Lauritsen, M. B., Als, T. D., Dahl, H. A., Flint, T. J., Wang, A. G., Vang, M., Kruse, T. A., Ewald, H., & Mors, O. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001754 · Cited by 82
Self-Regulation and Affective Expression During Play in Children with Autism or Down Syndrome: A Short-Term Longitudinal Study
Bieberich, A. A., & Morgan, S. B. (2004) · Journal of Autism and Developmental Disorders · doi:10.1023/b:jadd.0000037420.16169.28 · Cited by 78
Brief Report: Affective Expression in Children with Autism or Down Syndrome
Bieberich, A. A., & Morgan, S. B. (1998) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1026016804357 · Cited by 51
Salivary cortisol, stress and mood in healthy older adults: The Zenith study
Simpson, E. E. A., McConville, C. F., Rae, G., O’Connor, J. M., Stewart-Knox, B. J., Coudray, C., & Strain, J. (2008) · Biological Psychology · doi:10.1016/j.biopsycho.2007.12.001 · Cited by 50
5.3 Hamburg-Wechsler-Intelligenztest für Kinder, Revision 1983, HAWIK-R (Tewes, 1985)
(2001) · Thieme eBooks · doi:10.1055/b-0034-5327 · Cited by 48
The influence of parental drinking behaviour and antisocial personality disorder on adolescent behavioural problems: Results of the Greifswalder Family Study
Barnow, S., Ulrich, I., Grabe, H.-J., Freyberger, H. J., & Spitzer, C. (2007) · Alcohol and Alcoholism · doi:10.1093/alcalc/agm051 · Cited by 18
Self-citation
Affiliative Behaviors and Beyond: It's the Phenotype, Stupid
Sutcliffe, J. S. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.03.027 · Cited by 2

Sorted by citations

Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine
Meyer-Lindenberg, A., Domes, G., Kirsch, P., & Heinrichs, M. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3044 · Cited by 1,688
Social effects of oxytocin in humans: context and person matter
Bartz, J. A., Zaki, J., Bolger, N., & Ochsner, K. N. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.05.002 · Cited by 1,581
Balance of brain oxytocin and vasopressin: implications for anxiety, depression, and social behaviors
Neumann, I. D., & Landgraf, R. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.08.004 · Cited by 954
A common allele in the oxytocin receptor gene ( OXTR ) impacts prosocial temperament and human hypothalamic-limbic structure and function
Tost, H., Kolachana, B., Hakimi, S., Lemaitre, H., Verchinski, B. A., Mattay, V. S., Weinberger, D. R., & Meyer–Lindenberg, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003296107 · Cited by 564
Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior
Dumais, K. M., & Veenema, A. H. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2015.04.003 · Cited by 520
“…SNP, rs53576, show reduced empathy (Rodrigues et al., 2009; Uzefovsky et al., 2015), and have lower levels of optimism, mastery, and self-esteem (Saphire-Bernstein et al., 2011), whereas reduced positive affect (Lucht et al., 2009) and reward dependence (Tost et al., 2010) were found in men only.”
Background

See all 271

Authors: Lucht, M. J., Barnow, S., Sonnenfeld, C., Rosenberger, A., Grabe, H. J., Schroeder, W., Völzke, H., Freyberger, H. J., Herrmann, F. H., Kroemer, H., & Rosskopf, D.
Affiliations: Universität Greifswald (DE)
Heidelberg University (DE)
Universitätsmedizin Göttingen (DE)
Corresponding author: Lucht, Michael J.
ORCID: Lucht, Michael J.
Barnow, Sven
Rosenberger, Albert
Grabe, Hans Joergen
Völzke, Henry
Venue: Progress in Neuro-Psychopharmacology and Biological Psychiatry
Publisher: Elsevier BV
Published: 2009-08
Volume: 33
Issue: 5
Pages: 860-866
ISSN: 0278-5846 (ISSN-L)
DOI: 10.1016/j.pnpbp.2009.04.004
OpenAlex: W1992733985
Cited by: 271
References: 43
Citations by year: 2026: 2 · 2025: 9 · 2024: 10 · 2023: 5 · 2022: 8 · 2021: 15 · 2020: 12 · 2019: 14 · 2018: 18 · 2017: 15 · 2016: 26 · 2015: 23 · 2014: 27 · 2013: 31 · 2012: 24
FWCI: 24.28
Type: journal article
Language: en
Open access: green
resolver.sub.uni-goettingen.de
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
GRO (submittedVersion, cc-by)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Keywords: oxytocin receptor gene, OXTR polymorphisms, positive affect, negative affect, emotional loneliness, social loneliness, nonverbal intelligence, haplotypes, rs53576, autism spectrum disorder, sex differences, genetic association
MeSH terms: Adolescent, Adult, Affect, Aged, Autistic Disorder, Child, Female, Genetic Markers, Haplotypes, Humans, Intelligence, Loneliness, Male, Middle Aged, Polymorphism, Genetic, Receptors, Oxytocin, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Associations between the oxytocin receptor gene (OXTR) and affect, loneliness and intelligence in normal subjects

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks