Evidence for the involvement of genetic variation in the oxytocin receptor gene (OXTR) in the etiology of autistic disorders on high‐functioning level
Abstract
An increasing number of animal studies advert to a substantial role of the neuropeptide oxytocin in the regulation of social attachment and affiliation. Furthermore, animal studies showed anxiety and stress‐reduced effects of oxytocin. First human studies confirm these findings in animal studies and implicate a crucial role of oxytocin in human social attachment behavior and in social interactions. Thus, the oxytocin system might be involved in the impairment of social interaction and attachment in autism spectrum disorders (ASD). The human oxytocin receptor gene (OXTR) represents a plausible candidate gene for the etiology of ASD. To analyze whether genetic variants in the OXTR gene are associated with ASD we performed family‐based single‐marker and haplotype association analyses with 22 single nucleotide polymorphisms (SNPs) in the OXTR and its 5′ region in 100 families with autistic disorders on high‐functioning level (Asperger syndrome (AS), high‐functioning autism (HFA), and atypical autism (AA)). Single‐marker and haplotype association analyses revealed nominally significant associations of one single SNP and one haplotype with autism, respectively. Furthermore, employing a “reverse phenotyping” approach, patients carrying the haplotype associated with autism showed nominally significant impairments in comparison to noncarriers of the haplotype in items of the Autism Diagnostic Interview‐Revised algorithm describing aspects of social interaction and communication. In conclusion, our results implicate that genetic variation in the OXTR gene might be relevant in the etiology of autism on high‐functioning level. © 2009 Wiley‐Liss, Inc.
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Polymorphisms in the human OXTR gene are significantly associated with an ASD diagnosis and/or predict the severity of ASD.
“many of these genetic studies have found that polymorphisms in the human OXT receptor (OXTR) gene are significantly associated with an ASD diagnosis and/or predict the severity of ASD4–12.”
From Effect of age and autism spectrum disorder on oxytocin receptor density in the human basal forebrain and midbrain (2018) · cites this paper as [11]
11 carriers of the T-G-T-T haplotype at rs237851-rs6791619-rs53576-rs237884 have more impairment than 89 noncarriers in social interaction and communication domains of the Autism Diagnostic Interview-Revised in individuals with ASD.
“Wermter et al.37 found that 11 carriers of the T–G–T–T haplotype at rs237851–rs6791619–rs53576–rs237884 have more impairment than 89 noncarriers in social interaction and communication domains of the Autism Diagnostic Interview-Revised56 in individuals with ASD.”
From Oxytocin efficacy is modulated by dosage and oxytocin receptor genotype in young adults with high-functioning autism: a 24-week randomized clinical trial (2016) · cites this paper as [37]
The SNP rs6791619 is considered a part of a haplotype associated with impairment of core ASD symptoms.
“the SNP is considered a part of haplotype associated with impairment of core ASD symptoms.37”
From Oxytocin efficacy is modulated by dosage and oxytocin receptor genotype in young adults with high-functioning autism: a 24-week randomized clinical trial (2016) · cites this paper as [37]
Cites
Haploview: analysis and visualization of LD and haplotype maps
Barrett, J., Fry, B., Maller, J., & Daly, M. (2005) · Bioinform. · doi:10.1093/bioinformatics/bth457 · Cited by 15,086 · see citing works
Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Leventhal, B. L., DiLavore, P. C., Pickles, A., & Rutter, M. (2000) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1005592401947 · Cited by 7,520 · see citing works
Oxytocin increases trust in humans
Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., & Fehr, E. (2005) · Nature · doi:10.1038/nature03701 · Cited by 3,690 · see citing works
Oxytocin Modulates Neural Circuitry for Social Cognition and Fear in Humans
Kirsch, P., Esslinger, C., Chen, Q., Mier, D., Lis, S., Siddhanti, S., Gruppe, H., Mattay, V. S., Gallhofer, B., & Meyer-Lindenberg, A. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3984-05.2005 · Cited by 1,639 · see citing works
Oxytocin improves “mind-reading” in humans
Domes, G., Heinrichs, M., Michel, A., Berger, C., & Herpertz, S. C. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.07.015 · Cited by 1,298 · see citing works
An efficient procedure for genotyping single nucleotide polymorphisms
Ye, S. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.17.e88 · Cited by 1,013 · see citing works
Time to give up on a single explanation for autism
Happé, F., Ronald, A., & Plomin, R. (2006) · Nature Neuroscience · doi:10.1038/nn1770 · Cited by 987 · see citing works
Autism and the pervasive developmental disorders
Volkmar, F. R., & Klin, A. (2012) · doi:10.1093/med/9780199696758.003.0214 · Cited by 931 · see citing works
Pervasive social deficits, but normal parturition, in oxytocin receptor-deficient mice
Takayanagi, Y., Yoshida, M., Bielsky, I. F., Ross, H. E., Kawamata, M., Onaka, T., Yanagisawa, T., Kimura, T., Matzuk, M. M., Young, L. J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505312102 · Cited by 806 · see citing works
Oxytocin increases gaze to the eye region of human faces
Guastella, A. J., Mitchell, P. B., & Dadds, M. R. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.06.026 · Cited by 798 · see citing works
Oxytocin attenuates amygdala responses to emotional faces regardless of valence
Domes, G., Heinrichs, M., Gläscher, J., Büchel, C., Braus, D. F., & Herpertz, S. C. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.03.025 · Cited by 774 · see citing works
Oxytocin Increases Retention of Social Cognition in Autism
Hollander, E., Bartz, J., Chaplin, W., Phillips, A., Sumner, J., Soorya, L., Anagnostou, E., & Wasserman, S. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.05.030 · Cited by 693 · see citing works
Neuropeptidergic regulation of affiliative behavior and social bonding in animals
Lim, M. M., & Young, L. J. (2006) · Hormones and Behavior · doi:10.1016/j.yhbeh.2006.06.028 · Cited by 624 · see citing works
Autism and pervasive developmental disorders
Volkmar, F. R., Lord, C., Bailey, A., Schultz, R. T., & Klin, A. (2004) · Journal of Child Psychology and Psychiatry · doi:10.1046/j.0021-9630.2003.00317.x · Cited by 616 · see citing works
Positive Association of the Oxytocin Receptor Gene (OXTR) with Autism in the Chinese Han Population
Wu, S., Jia, M., Ruan, Y., Liu, J., Guo, Y., Mei, S., Gong, X., Zhang, Y., Yang, X., & Zhang, D. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.03.013 · Cited by 553 · see citing works
Neuropeptides and social behaviour: effects of oxytocin and vasopressin in humans
HEINRICHS, M., & DOMES, G. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00428-7 · Cited by 479 · see citing works
Understanding autism: Insights from mind and brain
Hill, E. L., & Frith, U. (2003) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.2002.1209 · Cited by 452 · see citing works
Association of the oxytocin receptor gene (OXTR) in Caucasian children and adolescents with autism
Jacob, S., Brune, C. W., Carter, C. S., Leventhal, B. L., Lord, C., & Cook, E. H. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.02.001 · Cited by 425 · see citing works
DNA Binding Specificity of Different STAT Proteins
Ehret, G. B., Reichenbach, P., Schindler, U., Horvath, C. M., Fritz, S., Nabholz, M., & Bucher, P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m001748200 · Cited by 369 · see citing works
Lerer, E., Levi, S., Salomon, S., Darvasi, A., Yirmiya, N., & Ebstein, R. P. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002087 · Cited by 349 · see citing works
A. Bartz, J., & Hollander, E. (2006) · Hormones and Behavior · doi:10.1016/j.yhbeh.2006.06.018 · Cited by 311 · see citing works
Oxytocin, vasopressin and pair bonding: implications for autism
Hammock, E. A. D., & Young, L. J. (2006) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2006.1939 · Cited by 289 · see citing works
Genomic screen and follow‐up analysis for autistic disorder
Shao, Y., Wolpert, C. M., Raiford, K. L., Menold, M. M., Donnelly, S. L., Ravan, S. A., Bass, M. P., McClain, C., von Wendt, L., Vance, J. M., et al. (2001) · American Journal of Medical Genetics · doi:10.1002/ajmg.10153 · Cited by 248 · see citing works
Maximum‐likelihood estimation of haplotype frequencies in nuclear families
Becker, T., & Knapp, M. (2004) · Genetic Epidemiology · doi:10.1002/gepi.10323 · Cited by 195 · see citing works
Genes Controlling Affiliative Behavior as Candidate Genes for Autism
Yrigollen, C. M., Han, S. S., Kochetkova, A., Babitz, T., Chang, J. T., Volkmar, F. R., Leckman, J. F., & Grigorenko, E. L. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.11.015 · Cited by 172 · see citing works
Defining the Phenotype in Human Genetic Studies: Forward Genetics and Reverse Phenotyping
Schulze, T. G., & McMahon, F. J. (2004) · Human Heredity · doi:10.1159/000083539 · Cited by 169 · see citing works
McCauley, J. L., Li, C., Jiang, L., Olson, L. M., Crockett, G., Gainer, K., Folstein, S. E., Haines, J. L., & Sutcliffe, J. S. (2005) · BMC Medical Genetics · doi:10.1186/1471-2350-6-1 · Cited by 168 · see citing works
A Powerful Strategy to Account for Multiple Testing in the Context of Haplotype Analysis
Becker, T., & Knapp, M. (2004) · The American Journal of Human Genetics · doi:10.1086/424390 · Cited by 166 · see citing works
Transmission/Disequilibrium Tests Using Multiple Tightly Linked Markers
Zhao, H., Zhang, S., Merikangas, K. R., Trixler, M., Wildenauer, D. B., Sun, F., & Kídd, K. K. (2000) · The American Journal of Human Genetics · doi:10.1086/303073 · Cited by 159 · see citing works
Rethinking the nature of genetic vulnerability to autistic spectrum disorders
Skuse, D. H. (2007) · Trends in Genetics · doi:10.1016/j.tig.2007.06.003 · Cited by 147 · see citing works
Oxytocin and experimental therapeutics in autism spectrum disorders
BARTZ, J., & HOLLANDER, E. (2008) · Progress in Brain Research · doi:10.1016/s0079-6123(08)00435-4 · Cited by 139 · see citing works
Search for autism loci by combined analysis of Autism Genetic Resource Exchange and Finnish families
Ylisaukko‐oja, T., Alarcón, M., Cantor, R. M., Auranen, M., Vanhala, R., Kempas, E., von Wendt, L., Järvelä, I. E., Geschwind, D. H., & Peltonen, L. (2005) · Annals of Neurology · doi:10.1002/ana.20722 · Cited by 136 · see citing works
Detection of genotyping errors and pseudo‐SNPs via deviations from Hardy‐Weinberg equilibrium
Leal, S. M. (2005) · Genetic Epidemiology · doi:10.1002/gepi.20086 · Cited by 129 · see citing works
Structure of the Autism Symptom Phenotype
GEORGIADES, S., SZATMARI, P., ZWAIGENBAUM, L., DUKU, E., BRYSON, S., ROBERTS, W., GOLDBERG, J., & MAHONEY, W. (2007) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000242236.90763.7f · Cited by 119 · see citing works
Hinney, A., Barth, N., Ziegler, A., von Prittwitz, S., Hamann, A., Hennighausen, K., Pirke, K. M., Heils, A., Rosenkranz, K., Roth, H., et al. (1997) · Life Sciences · doi:10.1016/s0024-3205(97)00888-6 · Cited by 113 · see citing works
Self-citationQuantification of the Power of Hardy-Weinberg Equilibrium Testing to Detect Genotyping Error
Cox, D. G., & Kraft, P. (2006) · Human Heredity · doi:10.1159/000091787 · Cited by 87 · see citing works
Lauritsen, M. B., Als, T. D., Dahl, H. A., Flint, T. J., Wang, A. G., Vang, M., Kruse, T. A., Ewald, H., & Mors, O. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001754 · Cited by 82 · see citing works
Oxytocin receptors in brain cortical regions are reduced in haploinsufficient (+/−) reeler mice
Liu, W., Pappas, G. D., & Carter, C. S. (2005) · Neurological Research · doi:10.1179/016164105x35602 · Cited by 73 · see citing works
Structural equation analysis of a hypothesised symptom model in the autism spectrum
van Lang, N. D. J., Boomsma, A., Sytema, S., de Bildt, A. A., Kraijer, D. W., Ketelaars, C., & Minderaa, R. B. (2006) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2005.01434.x · Cited by 70 · see citing works
Family-Based Association Analysis with Tightly Linked Markers
Knapp, M., & Becker, T. (2003) · Human Heredity · doi:10.1159/000073727 · Cited by 56 · see citing works
Kamp‐Becker, I., Ghahreman, M., Smidt, J., & Remschmidt, H. (2008) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-008-0656-5 · Cited by 55 · see citing works
Self-citationADI-R. Diagnostisches Interview für Autismus – Revidiert
Bölte, S., & Barkmann, C. (2011) · Cited by 23 · see citing works
Search for potential autism treatments turns to 'trust hormone'
Opar, A. (2008) · Nature Medicine · doi:10.1038/nm0408-353 · Cited by 22 · see citing works
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Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine
Meyer-Lindenberg, A., Domes, G., Kirsch, P., & Heinrichs, M. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3044 · Cited by 1,688 · see citing works
Neumann, I. D., & Landgraf, R. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.08.004 · Cited by 954 · see citing works
Tost, H., Kolachana, B., Hakimi, S., Lemaitre, H., Verchinski, B. A., Mattay, V. S., Weinberger, D. R., & Meyer–Lindenberg, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003296107 · Cited by 564 · see citing works
The impact of atypical sensory processing on social impairments in autism spectrum disorder
Thye, M. D., Bednarz, H. M., Herringshaw, A. J., Sartin, E. B., & Kana, R. K. (2018) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2017.04.010 · Cited by 513 · see citing works
Autism, oxytocin and interoception
Quattrocki, E., & Friston, K. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.09.012 · Cited by 393 · see citing works
Sensitive Parenting Is Associated with Plasma Oxytocin and Polymorphisms in the OXTR and CD38 Genes
Feldman, R., Zagoory-Sharon, O., Weisman, O., Schneiderman, I., Gordon, I., Maoz, R., Shalev, I., & Ebstein, R. P. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.12.025 · Cited by 393 · see citing works
Exogenous and evoked oxytocin restores social behavior in the <i>Cntnap2</i> mouse model of autism
Peñagarikano, O., Lázaro, M. T., Lu, X.-H., Gordon, A., Dong, H., Lam, H. A., Peles, E., Maidment, N. T., Murphy, N. P., Yang, X. W., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.3010257 · Cited by 378 · see citing works
Feldman, R., Monakhov, M., Pratt, M., & Ebstein, R. P. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.08.008 · Cited by 352 · see citing works
The oxytocin receptor gene (OXTR) is associated with autism spectrum disorder: a meta-analysis
LoParo, D., & Waldman, I. D. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.77 · Cited by 343 · see citing works
The neuroendocrinology of the microbiota-gut-brain axis: a behavioural perspective
Cussotto, S., Sandhu, K. V., Dinan, T. G., & Cryan, J. F. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.04.002 · Cited by 326 · see citing works
The contributions of oxytocin and vasopressin pathway genes to human behavior
Ebstein, R. P., Knafo, A., Mankuta, D., Chew, S. H., & Lai, P. S. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.12.014 · Cited by 283 · see citing works
Prosocial effects of oxytocin and clinical evidence for its therapeutic potential
Striepens, N., Kendrick, K. M., Maier, W., & Hurlemann, R. (2011) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2011.07.001 · Cited by 283 · see citing works
Cochran, D. M., Fallon, D., Hill, M., & Frazier, J. A. (2013) · Harvard Review of Psychiatry · doi:10.1097/hrp.0b013e3182a75b7d · Cited by 267 · see citing works
The association between oxytocin receptor gene polymorphism (OXTR) and trait empathy
Wu, N., Li, Z., & Su, Y. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.01.009 · Cited by 221 · see citing works
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Modi, M. E., & Young, L. J. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.12.010 · Cited by 218 · see citing works
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Variation in the Oxytocin Receptor Gene Is Associated with Pair-Bonding and Social Behavior
Walum, H., Lichtenstein, P., Neiderhiser, J. M., Reiss, D., Ganiban, J. M., Spotts, E. L., Pedersen, N. L., Anckarsäter, H., Larsson, H., & Westberg, L. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.09.002 · Cited by 211 · see citing works
Oxytocin receptor genetic variation promotes human trust behavior
Krueger, F., Parasuraman, R., Iyengar, V., Thornburg, M., Weel, J., Lin, M., Clarke, E., McCabe, K., & Lipsky, R. H. (2012) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2012.00004 · Cited by 207 · see citing works
Riedl, R., & Javor, A. (2011) · Journal of Neuroscience Psychology and Economics · doi:10.1037/a0026318 · Cited by 180 · see citing works
Two genetic variants of CD38 in subjects with autism spectrum disorder and controls
Munesue, T., Yokoyama, S., Nakamura, K., Anitha, A., Yamada, K., Hayashi, K., Asaka, T., Liu, H.-X., Jin, D., Koizumi, K., et al. (2010) · Neuroscience Research · doi:10.1016/j.neures.2010.03.004 · Cited by 177 · see citing works
Campbell, D. B., Datta, D., Jones, S. T., Batey Lee, E., Sutcliffe, J. S., Hammock, E. A. D., & Levitt, P. (2011) · Journal of Neurodevelopmental Disorders · doi:10.1007/s11689-010-9071-2 · Cited by 170 · see citing works
Association between the oxytocin receptor gene and amygdalar volume in healthy adults
Inoue, H., Yamasue, H., Tochigi, M., Abe, O., Liu, X., Kawamura, Y., Takei, K., Suga, M., Yamada, H., Rogers, M. A., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.07.019 · Cited by 164 · see citing works
Domes, G., Kumbier, E., Heinrichs, M., & Herpertz, S. C. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2013.254 · Cited by 160 · see citing works
Anagnostou, E., Soorya, L., Brian, J., Dupuis, A., Mankad, D., Smile, S., & Jacob, S. (2014) · Brain Research · doi:10.1016/j.brainres.2014.01.049 · Cited by 155 · see citing works
Miller, M., Bales, K. L., Taylor, S. L., Yoon, J., Hostetler, C. M., Carter, C. S., & Solomon, M. (2013) · Autism Research · doi:10.1002/aur.1270 · Cited by 151 · see citing works
Keebaugh, A. C., Barrett, C. E., Laprairie, J. L., Jenkins, J. J., & Young, L. J. (2015) · Social Neuroscience · doi:10.1080/17470919.2015.1040893 · Cited by 150 · see citing works
Yamasue, H., Yee, J. R., Hurlemann, R., Rilling, J. K., Chen, F. S., Meyer-Lindenberg, A., & Tost, H. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.3327-12.2012 · Cited by 149 · see citing works
Oxytocin, vasopressin, and the motivational forces that drive social behaviors
Caldwell, H. K., & Albers, H. E. (2015) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2015_390 · Cited by 129 · see citing works
Autism and Oxytocin: New Developments in Translational Approaches to Therapeutics
Green, J. J., & Hollander, E. (2010) · Neurotherapeutics · doi:10.1016/j.nurt.2010.05.006 · Cited by 124 · see citing works
Montag, C., Brockmann, E.-M., Lehmann, A. I., Müller, D. J., Rujescu, D., & Gallinat, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051882 · Cited by 123 · see citing works
Oxytocin in the socioemotional brain: implications for psychiatric disorders
Kirsch, P. (2015) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2015.17.4/pkirsch · Cited by 122 · see citing works
Kosaka, H., Okamoto, Y., Munesue, T., Yamasue, H., Inohara, K., Fujioka, T., Anme, T., Orisaka, M., Ishitobi, M., Jung, M., et al. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.152 · Cited by 117 · see citing works
McPartland, J. C., & Volkmar, F. R. (2012) · Handbook of clinical neurology · doi:10.1016/b978-0-444-52002-9.00023-1 · Cited by 117 · see citing works
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Carter, M. D., Shah, C. R., Muller, C. L., Crawley, J. N., Carneiro, A. M. D., & Veenstra-VanderWeele, J. M. (2011) · Autism Research · doi:10.1002/aur.180 · Cited by 112 · see citing works
Primate paternal care: Interactions between biology and social experience
Storey, A. E., & Ziegler, T. E. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.07.024 · Cited by 111 · see citing works
Apicella, C. L., Cesarini, D. A., Johannesson, M., Dawes, C. T., Lichtenstein, P., Wallace, B., Beauchamp, J. P., & Westberg, L. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011153 · Cited by 110 · see citing works
Polymorphisms in the oxytocin receptor gene are associated with the development of psychopathy
Dadds, M. R., Moul, C., Cauchi, A., Dobson‐Stone, C., Hawes, D. J., Brennan, J., Urwin, R., & Ebstein, R. P. (2013) · Development and Psychopathology · doi:10.1017/s0954579413000485 · Cited by 108 · see citing works
Oxytocin and oxytocin receptor gene polymorphisms and risk for schizophrenia: A case–control study
Montag, C., Brockmann, E.-M., Bayerl, M., Rujescu, D., Müller, D. J., & Gallinat, J. (2012) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2012.677547 · Cited by 104 · see citing works
Cataldo, I., Azhari, A., & Esposito, G. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00027 · Cited by 95 · see citing works
CD38 and its role in oxytocin secretion and social behavior
Higashida, H., Yokoyama, S., Kikuchi, M., & Munesue, T. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.12.011 · Cited by 98 · see citing works
Oxytocin Gene Polymorphisms Influence Human Dopaminergic Function in a Sex-Dependent Manner
Love, T. M., Enoch, M.-A., Hodgkinson, C. A., Peciña, M., Mickey, B., Koeppe, R. A., Stohler, C. S., Goldman, D., & Zubieta, J.-K. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.01.033 · Cited by 97 · see citing works
Stavropoulos, K. K. M., & Carver, L. J. (2013) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12061 · Cited by 95 · see citing works
Genetic Influences on Social Cognition
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Antiaggressive activity of central oxytocin in male rats
Calcagnoli, F., de Boer, S. F., Althaus, M., den Boer, J. A., & Koolhaas, J. M. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3124-7 · Cited by 90 · see citing works
Rijlaarsdam, J., van IJzendoorn, M. H., Verhulst, F. C., Jaddoe, V. W. V., Felix, J. F., Tiemeier, H. W., & Bakermans‐Kranenburg, M. J. (2016) · Autism Research · doi:10.1002/aur.1681 · Cited by 89 · see citing works
Sauer, C., Montag, C., Wörner, C., Kirsch, P., & Reuter, M. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.333 · Cited by 89 · see citing works
Freeman, S. M., Palumbo, M. C., Lawrence, R. H., Smith, A. L., Goodman, M. M., & Bales, K. L. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0315-3 · Cited by 82 · see citing works
Park, J., Willmott, M., Vetuz, G., Toye, C., Kirley, A., Hawi, Z., Brookes, K. J., Gill, M., & Kent, L. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.03.029 · Cited by 82 · see citing works
Husarova, V. M., Lakatošová, S., Pivovarciova, A., Babinská, K., Bakoš, J., Durdiaková, J., Kubranská, A., Ondrejka, I., & Ostatníková, D. (2016) · Psychiatry Investigation · doi:10.4306/pi.2016.13.2.174 · Cited by 78 · see citing works
Examining Autism Spectrum Disorders by Biomarkers: Example From the Oxytocin and Serotonin Systems
Hammock, E. A. D., Veenstra-VanderWeele, J. M., Yan, Z., Kerr, T. M., Morris, M., Anderson, G. M., Carter, C. S., Cook, E. H., & Jacob, S. (2012) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2012.04.010 · Cited by 79 · see citing works
Zhang, R., Zhang, H.-F., Han, J., & Han, S. (2017) · Neuroscience Bulletin · doi:10.1007/s12264-017-0120-7 · Cited by 78 · see citing works
Higashida, H., Yokoyama, S., Huang, J., Liu, L., Ma, W., Akther, S., Higashida, C., Kikuchi, M., Minabe, Y., & Munesue, T. (2012) · Neurochemistry International · doi:10.1016/j.neuint.2012.01.030 · Cited by 74 · see citing works
Is oxytocin a maternal-foetal signalling molecule at birth? Implications for development
Kenkel, W. M., Yee, J. R., & Carter, C. S. (2014) · Journal of Neuroendocrinology · doi:10.1111/jne.12186 · Cited by 70 · see citing works
Cataldo, I., Azhari, A., Lepri, B., & Esposito, G. (2017) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2017.10.007 · Cited by 70 · see citing works
ASD and Genetic Associations with Receptors for Oxytocin and Vasopressin—AVPR1A, AVPR1B, and OXTR
Francis, S. M., Kim, S., Kistner‐Griffin, E., Guter, S. J., Cook, E. H., & Jacob, S. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00516 · Cited by 62 · see citing works
Caldwell, H. K. (2012) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4614-1704-0_12 · Cited by 58 · see citing works
Laursen, H. R., Siebner, H. R., Haren, T., Madsen, K., Grønlund, R., Hulme, O., & Henningsson, S. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00423 · Cited by 56 · see citing works
Single Nucleotide Polymorphisms Predict Symptom Severity of Autism Spectrum Disorder
Jiao, Y., Chen, R., Ke, X., Cheng, L., Chu, K., Lu, Z., & Herskovits, E. H. (2011) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-011-1327-5 · Cited by 55 · see citing works
Imaging-genetics of sex differences in ASD: distinct effects of OXTR variants on brain connectivity
Hernandez, L. M., Lawrence, K. E., Padgaonkar, N. T., Inada, M., Hoekstra, J. N., Lowe, J. K., Eilbott, J., Jack, A., Aylward, E., Gaab, N., et al. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0750-9 · Cited by 54 · see citing works
Oxytocin receptor gene variations predict neural and behavioral response to oxytocin in autism
Watanabe, T., Otowa, T., Abe, O., Kuwabara, H., Aoki, Y., Natsubori, T., Takao, H., Kakiuchi, C., Kondo, K., Ikeda, M., et al. (2017) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsw150 · Cited by 54 · see citing works
Staes, N., Koski, S. E., Helsen, P., Fransén, E., Eens, M., & Stevens, J. M. G. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.08.006 · Cited by 52 · see citing works
The association between an oxytocin receptor gene polymorphism and cultural orientations
Luo, S., & Han, S. (2014) · Culture and Brain · doi:10.1007/s40167-014-0017-5 · Cited by 54 · see citing works
Autism spectrum disorders: Integration of the genome, transcriptome and the environment
Vijayakumar, N. T., & Judy, M. V. (2016) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2016.03.026 · Cited by 52 · see citing works
Lucas-Thompson, R. G., & Holman, E. A. (2013) · Hormones and Behavior · doi:10.1016/j.yhbeh.2013.02.015 · Cited by 51 · see citing works
Kohlhoff, J. R., Cibralic, S., Hawes, D. J., & Eapen, V. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104573 · Cited by 50 · see citing works
The oxytocin receptor gene predicts brain activity during an emotion recognition task in autism
Uzefovsky, F., Bethlehem, R. A. I., Shamay-Tsoory, S., Ruigrok, A., Holt, R., Spencer, M., Chura, L., Warrier, V., Chakrabarti, B., Bullmore, E., et al. (2019) · Molecular Autism · doi:10.1186/s13229-019-0258-4 · Cited by 49 · see citing works
Kranz, T. M., Kopp, M., Waltes, R., Sachse, M., Duketis, E., Jarczok, T. A., Degenhardt, F., Görgen, K., Meyer, J., Freitag, C. M., et al. (2016) · Autism Research · doi:10.1002/aur.1597 · Cited by 46 · see citing works
Additive effects of oxytocin receptor gene polymorphisms on reward circuitry in youth with autism
Hernandez, L. M., Krasileva, K., Green, S. A., Sherman, L. E., Ponting, C., McCarron, R., Lowe, J. K., Geschwind, D. H., Bookheimer, S. Y., & Dapretto, M. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.209 · Cited by 43 · see citing works
Variant in OXTR gene and functional connectivity of the hypothalamus in normal subjects
Wang, J., Qin, W., Liu, B., Wang, D., Zhang, Y., Jiang, T., & Yu, C. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.05.029 · Cited by 42 · see citing works
Ma, W.-J., Hashii, M., Munesue, T., Hayashi, K., Yagi, K., Yamagishi, M., Higashida, H., & Yokoyama, S. (2013) · Molecular Autism · doi:10.1186/2040-2392-4-22 · Cited by 42 · see citing works
Yang, S., Dong, X., Guo, X., Han, Y., Song, H., Gao, L., Dai, W., Su, Y., & Zhang, X. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00221 · Cited by 40 · see citing works
Novel oxytocin receptor variants in laboring women requiring high doses of oxytocin
Reinl, E. L., Goodwin, Z. A., Raghuraman, N., Lee, G. Y., Jo, E. Y., Gezahegn, B. M., Pillai, M. K., Cahill, A. G., Strong, C. D. G., & England, S. K. (2017) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.04.036 · Cited by 40 · see citing works
Nyffeler, J., Walitza, S., Bobrowski, E., Gundelfinger, R., & Grünblatt, E. (2014) · Journal of Molecular Psychiatry · doi:10.1186/2049-9256-2-1 · Cited by 40 · see citing works
Tops, S., Habel, U., & Radke, S. (2018) · Hormones and Behavior · doi:10.1016/j.yhbeh.2018.03.002 · Cited by 39 · see citing works
The Role of Intranasal Oxytocin in the Treatment of Patients with Schizophrenia: A Systematic Review
Berardis, D. D., Marini, S., Iasevoli, F., Tomasetti, C., de Bartolomeis, A., Mazza, M., Valchera, A., Fornaro, M., Cavuto, M., Srinivasan, V., et al. (2013) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527311312020012 · Cited by 38 · see citing works
Biomarker discovery for disease status and symptom severity in children with autism
Oztan, O., Jackson, L. P., Libove, R. A., Sumiyoshi, R. D., Phillips, J. M., Garner, J. P., Hardan, A. Y., & Parker, K. J. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.12.022 · Cited by 37 · see citing works
Autism - A Neurodevelopmental Journey from Genes to Behaviour
Eapen, V. (2011) · InTech eBooks · doi:10.5772/974 · Cited by 36 · see citing works
Flasbeck, V., Moser, D., Kumsta, R., & Brüne, M. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00359 · Cited by 34 · see citing works
Interplay between the oxytocin and opioid systems in regulating social behaviour
Putnam, P. T., & Chang, S. W. C. (2022) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2021.0050 · Cited by 33 · see citing works
Ceroni, F., Sagar, A., Simpson, N. H., Gawthrope, A. J. T., Newbury, D. F., Pinto, D., Francis, S. M., Tessman, D. C., Cook, E. H., Monaco, A. P., et al. (2014) · Autism Research · doi:10.1002/aur.1365 · Cited by 34 · see citing works
Are retinoids potential therapeutic agents in disorders of social cognition including autism?
Ebstein, R. P., Mankuta, D., Yirmiya, N., & Malavasi, F. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.05.004 · Cited by 31 · see citing works
Patin, A., & Hurlemann, R. (2015) · Handbook of experimental pharmacology · doi:10.1007/978-3-319-16522-6_10 · Cited by 32 · see citing works
Oxytocin receptor and G-protein polymorphisms in patients with depression and separation anxiety
Costa, B., Pini, S., Baldwin, D. S., Silove, D. M., Manicavasagar, V. L., Abelli, M., Coppedè, F., & Martini, C. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.03.056 · Cited by 30 · see citing works
Morphofunctional Alterations of the Hypothalamus and Social Behavior in Autism Spectrum Disorders
Carìa, A., Ciringione, L., & de Falco, S. (2020) · Brain Sciences · doi:10.3390/brainsci10070435 · Cited by 29 · see citing works
Sexually dimorphic effects of oxytocin receptor gene (OXTR) variants on Harm Avoidance
Stankova, T., Eichhammer, P., Langguth, B., & Sand, P. G. (2012) · Biology of Sex Differences · doi:10.1186/2042-6410-3-17 · Cited by 27 · see citing works
Harrison, A. J., Gamsiz, E. D., Berkowitz, I. C., Nagpal, S., & Jerskey, B. A. (2015) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32377 · Cited by 26 · see citing works
Francis, S. M., Kistner‐Griffin, E., Yan, Z., Guter, S. J., Cook, E. H., & Jacob, S. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00195 · Cited by 26 · see citing works
Neuroimaging Markers of Risk and Pathways to Resilience in Autism Spectrum Disorder
Molnar-Szakacs, I., Kupis, L. B., & Uddin, L. Q. (2020) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2020.06.017 · Cited by 28 · see citing works
Advanced Pharmacotherapy Evidenced by Pathogenesis of Autism Spectrum Disorder
Lee, Y. J., Oh, S. H., Park, C., Hong, M., Lee, A. R., Yoo, H. J., Shin, C. Y., Cheon, K.-A. A., & Bahn, G. H. (2014) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2014.12.1.19 · Cited by 25 · see citing works
Are We There Yet? The Clinical Potential of Intranasal Oxytocin in Psychiatry
Liu, J. C., McErlean, R. A., & Dadds, M. R. (2012) · Current Psychiatry Reviews · doi:10.2174/157340012798994902 · Cited by 24 · see citing works
Parkinson, J. R. C., Chaudhri, O. B., & Bell, J. D. (2008) · Neuroendocrinology · doi:10.1159/000163751 · Cited by 24 · see citing works
Jiao, Y., Chen, R.-H., Ke, X., Cheng, L., Chu, K., Lu, Z., & Herskovits, E. H. (2011) · Advances in Medical Sciences · doi:10.2478/v10039-011-0042-y · Cited by 24 · see citing works
Vanya, M., Szücs, S., Vetró, Á., & Bártfai, G. (2016) · Psychiatry Research · doi:10.1016/j.psychres.2016.12.007 · Cited by 24 · see citing works
Ocakoğlu, F. T., Köse, S., Özbaran, B., & Onay, H. (2018) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2018.01.002 · Cited by 23 · see citing works
Mayer, A. V., Wermter, A.-K., Stroth, S., Alter, P., Haberhausen, M., Stehr, T., Paulus, F. M., Krach, S., & Kamp-Becker, I. (2021) · Scientific Reports · doi:10.1038/s41598-021-94407-x · Cited by 23 · see citing works
Self-citationCommon EIF4E variants modulate risk for autism spectrum disorders in the high-functioning range
Waltes, R., Gfesser, J., Haslinger, D., Schneider-Momm, K., Biscaldi, M., Voran, A., Freitag, C. M., & Chiocchetti, A. G. (2014) · Journal of Neural Transmission · doi:10.1007/s00702-014-1230-2 · Cited by 23 · see citing works
Wilczyński, K. M., Siwiec, A., & Janas-Kozik, M. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00380 · Cited by 21 · see citing works
Drug treatment of autism spectrum disorder and its comorbidities in children and adolescents
Santosh, P., & Singh, J. (2016) · BJPsych Advances · doi:10.1192/apt.bp.115.014597 · Cited by 21 · see citing works
Social Neuroscience and Theory of Mind
Westby, C. E. (2014) · Folia Phoniatrica et Logopaedica · doi:10.1159/000362877 · Cited by 20 · see citing works
- Authors
- Wermter, A., Kamp‐Becker, I., Hesse, P., Schulte‐Körne, G., Strauch, K., & Remschmidt, H.
- Affiliations
- Philipps University of Marburg (DE)
- Corresponding author
- Wermter, Anne‐Kathrin
- Venue
- American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
- Publisher
- Wiley
- Published
- 2010-02-18
- Volume
- 153B
- Issue
- 2
- Pages
- 629-639
- ISSN
- 1552-4841 (ISSN-L)
- 1552-485X
- OpenAlex
- W2171723215
- Cited by
- 163
- References
- 43
- Citations by year
- 2026: 2 · 2024: 5 · 2023: 8 · 2022: 5 · 2021: 4 · 2020: 6 · 2019: 2 · 2018: 8 · 2017: 12 · 2016: 14 · 2015: 11 · 2014: 16 · 2013: 18 · 2012: 22
- FWCI
- 8.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Medical Genetics Part B Neuropsychiatric Genetics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- oxytocin receptor gene, oxytocin receptor, autism spectrum disorder, high-functioning autism, Asperger syndrome, atypical autism, genetic association, single nucleotide polymorphisms, haplotype association, oxytocin, social interaction, social attachment, candidate genes
- MeSH terms
- Adolescent, Adult, Autistic Disorder, Child, Female, Genetic Markers, Genotype, Humans, Male, Models, Genetic, Genetic Variation, Linkage Disequilibrium, Receptors, Oxytocin, Polymorphism, Single Nucleotide, Asperger Syndrome
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