Cited by 271Neuroendocrine regulation and behaviorNeurotransmitter Receptor Influence on BehaviorAutism Spectrum Disorder Research

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Associations between the oxytocin receptor gene (OXTR) and affect, loneliness and intelligence in normal subjects

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Lucht, Michael J., Barnow, Sven, Sonnenfeld, Christine, Rosenberger, Albert, Grabe, Hans Joergen, Schroeder, Winnie, Völzke, Henry, Freyberger, Harald J., Herrmann, Falko H., Kroemer, Heyo, Rosskopf, Dieter·2009·Progress in Neuro-Psychopharmacology and Biological Psychiatry

DOI 10.1016/j.pnpbp.2009.04.004

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Abstract

Associations of oxytocin receptor gene (OXTR) variants and autism spectrum disorders (ASD) have been reported in earlier studies; in one of the studies associations with IQ and daily living skills were found additionally. Variations of the oxytocin receptor gene might also regulate affect, attachment and separation beyond the diagnostic borders of autism. We tested hypotheses of associations between positive and negative affects and social and emotional loneliness (285 adults), IQ (117 adolescents) and polymorphisms of the oxytocin receptor gene (OXTR rs53576, rs2254298 and rs2228485) in normal subjects. Individuals with the oxytocin OXTR rs53576 A/A genotype showed lower positive affect scores (F=5.532, df=1; p=0.019). This effect was restricted to males (F=13.098, df=1; p=0.00047). Haplotypes constructed with the three markers were associated with positive affect (p=0.0012), negative affect (p<0.0001) and emotional loneliness (p<0.0001). Non-verbal intelligence was significantly reduced in rs53576 A/A adolescents (T=2.247, p=0.027). Our findings support a role for the oxytocin receptor haplotypes in the generation of affectivity, emotional loneliness and IQ.

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Authors: Lucht, M. J., Barnow, S., Sonnenfeld, C., Rosenberger, A., Grabe, H. J., Schroeder, W., Völzke, H., Freyberger, H. J., Herrmann, F. H., Kroemer, H., & Rosskopf, D.
Affiliations: Universität Greifswald (DE)
Heidelberg University (DE)
Universitätsmedizin Göttingen (DE)
Corresponding author: Lucht, Michael J.
ORCID: Lucht, Michael J.
Barnow, Sven
Rosenberger, Albert
Grabe, Hans Joergen
Völzke, Henry
Venue: Progress in Neuro-Psychopharmacology and Biological Psychiatry
Publisher: Elsevier BV
Published: 2009-08
Volume: 33
Issue: 5
Pages: 860-866
ISSN: 0278-5846 (ISSN-L)
DOI: 10.1016/j.pnpbp.2009.04.004
OpenAlex: W1992733985
Cited by: 271
References: 43
Citations by year: 2026: 2 · 2025: 9 · 2024: 10 · 2023: 5 · 2022: 8 · 2021: 15 · 2020: 12 · 2019: 14 · 2018: 18 · 2017: 15 · 2016: 26 · 2015: 23 · 2014: 27 · 2013: 31 · 2012: 24
FWCI: 24.28
Type: journal article
Language: en
Open access: green
resolver.sub.uni-goettingen.de
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
GRO (submittedVersion, cc-by)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Keywords: oxytocin receptor gene, OXTR polymorphisms, positive affect, negative affect, emotional loneliness, social loneliness, nonverbal intelligence, haplotypes, rs53576, autism spectrum disorder, sex differences, genetic association
MeSH terms: Adolescent, Adult, Affect, Aged, Autistic Disorder, Child, Female, Genetic Markers, Haplotypes, Humans, Intelligence, Loneliness, Male, Middle Aged, Polymorphism, Genetic, Receptors, Oxytocin, Young Adult

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Associations between the oxytocin receptor gene (OXTR) and affect, loneliness and intelligence in normal subjects

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